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Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients

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World Journal of Gastroenterology 2008年第27期14卷 4352-4358页

作者： Eugeniy P Smorodin Oleg A Kurtenkov boris L sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev Department of Oncology & Immunology National Institute for Health Development Oncological Centre North-Estonian Regional Hospital

AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric canc

关键词： IgG antibodies Thomsen-Friedenreich Tn αGal Gastrointestinal cancer Immunosuppression CA 19-9

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Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients

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World Journal of Gastroenterology 2013年第23期19卷 3573-3582页

作者： Kristel Kodar Jelena Izotova Kersti Klaamas boris sergeyev Lilian Jrvekülg Oleg Kurtenkov Department of Oncology and Immunology National Institute for Health Development11619 Tallinn Estonia Tallinn University of Technology Institute of Gene Technology12618 Tallinn Estonia

AIM: To study whether alterations in the glycosylation of immunoglobulin G (IgG) specific to the ThomsenFriedenreich glycotope (TF) have diagnostic and prognostic potential in gastric cancer. METHODS: Serum samples were obtained from patients with histologically verified gastric carcinoma (n = 89), healthy blood donors (n = 40), and patients with benign stomach diseases (n = 22). The lectin-enzymelinked immunosorbent assay-based glycoprofiling of TF-specific IgG (anti-TF IgG) was performed using synthetic TF-polyacrylamide conjugate as antigen, total IgG purified by affinity chromatography on protein G sepharose, and lectins of various sugar specificities: mannose-specific concanavalin A (ConA), fucose-specificAleuria aurantia lectin (AAL) and sialic acid-specific Sambucus nigra agglutinin (SNA). The sensitivity and specificity of the differences between cancer patients and controls were evaluated by receiver operator characteristic (ROC) curve analysis. Overall survival was analyzed by the Kaplan-Meier method. Time-dependent ROC curve statistics were applied to determine cut-off values for survival analysis. All calculations and comparisons were performed using the GraphPad Prism 5 and SPSS 15.0 ***: The level of TF-specific IgG was significantly increased in cancer patients compared with non-cancer controls (P < 0.001). This increase was pronounced mostly in stage 1 of the disease. Cancer patients showed a higher level of ConA binding to antiTF-IgG (P < 0.05) and a very low level of SNA lectin binding (P = 0.0001). No appreciable stage-dependency of the binding of any lectin to anti-TF IgG was found. A strong positive correlation between the binding of AAL and SNA was found in all groups studied (r = 0.71-0.72; P < 0.0001). The changes in ConA reactivity were not related to those of the fucoseor sialic acid-specific lectin. Changes in the SNA binding index and the ConA/SNA binding ratio demonstrated good sensitivity and specificity for stomach cancer:

关键词： Thomsen-Friedenreich antigen Anticarbohydrate antibodies Stomach cancer IgG glycosylation Survival Lectins

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Are population cycles recovering?

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Integrative Zoology 2024年第3期19卷 538-547页

作者： Vasily D.YAKUSHOV boris I.SHEFTEL A.N.Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences MoscowRussia

The dynamics of populations of small mammals of Central Siberia was *** studies were carried out at the Yenisei ecological station“Mirnoye”of the *** Institute of Ecology and Evolution,Russian Academy of *** time series analysis was performed by the wavelet transform using the statistical data processing language *** the 20th century,the dynamics of the population of the community and some of its constituent species(Sorex araneus;***;***;***;***;Craseomys rufocanus;Clethrionomys rutilus;Microtus oeconomus;***)were characterized by a 4-year *** type of dynamics changed to noncyclic by the nineties,but by 2022,four species(***,***,***,and ***)and the community as a whole showed a tendency toward recovery of population *** remaining species were characterized by consistently low numbers with irregular low amplitude fluctuations.

关键词： population cycles small mammals time-series analysis wavelet transform

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Non-coding RNAs in exercise immunology:A systematic review

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Journal of Sport and Health Science 2024年第3期13卷 311-338,I0002页

作者： Mona Kotewitsch Melina Heimer boris Schmitz Frank C.Mooren Department of Rehabilitation Sciences Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV Clinic Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physical exercise has been recognized as a potent modulator of immune function,with its effects including enhanced immune surveillance,reduced inflammation,and improved overall *** strong evidence exists that physical exercise affects the specific expression and activity of non-coding RNAs(ncRNAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exercise protocols exists,and a condensed list of functional,exercise-dependent ncRNAs with known targets in the immune system is missing from the literature.A systematic review and qualitative analysis was used to identify and categorize ncRNAs participating in immune modulation by physical *** combined approaches were used:(a)a systematic literature search for“ncRNA and exercise immunology”,(b)and a database search for microRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reactome database,combined with a systematic literature search for“ncRNA and exercise”.Literature searches were based on PubMed,Web of Science,and SPORTDiscus;and miRNA databases were filtered for targets validated by in vitro experimental *** were eligible if they reported on exercise-based interventions in healthy *** duplicate removal,95 studies were included reporting on 164 miRNAs,which were used for the qualitative *** studies reporting on long-noncoding RNAs(lncRNAs)or circular RNAs were also *** were analyzed using ordering tables that included exercise modality(endurance/resistance exercise),acute or chronic interventions,as well as the consistency in reported change between *** criteria were defined as“validated”with 100%of≥3 independent studies showing identical direction of regulation,“plausible”(≥80%),or“suggestive”(≥70%).For resistance exercise,upregulation of miR-206 was validated while downregulation of miR-133a appeared *** endurance exer

关键词： Immune system Inflammation MicroRNA ncRNA Physical exercise

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Cross-continental insights into liver cancer: an East vs. West epidemiology

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 739-741页

作者： Mohamad Azhar Meerun boris Guiu Department of Radiology St-Eloi University HospitalMontpellierFrance

Liver cancer,encompassing both primary and secondary forms,presents a formidable global health *** to the GLOBOCAN 2020 database,liver cancer ranks as the sixth most common cancer globally in terms of incidence,yet it stands as the third leading cause of cancer-related mortality worldwide(1).By 2040,liver cancer cases and deaths are expected to rise by 55.0%and 56.4%,respectively(2).The geographical distribution of incidence and mortality rates for these cancers varies,with the highest occurrence noted in Eastern Asia,Northern Africa,and South-Eastern Asia(2).This variation arises from a complex interplay of factors,encompassing sociodemographic aspects like age and gender,environmental exposures to viruses such as hepatitis B virus(HBV)and hepatitis C virus(HCV),and cultural habits including alcohol consumption(3,4).

关键词： Hepatocellular carcinoma(HCC) intrahepatic cholangiocarcinoma(ICC) epidemiology

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A global analysis of the introduction pathways and characteristics associated with non-native fish species introduction, establishment, and impacts

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Ecological Processes 2024年第2期13卷 16-31页

作者： Camille Bernery Céline Bellard Franck Courchamp Sébastien Brosse boris Leroy CNRS Agro Paris Tech Ecologie Systématique Evolution Université Paris-Saclay Unité Biologie des Organismes et Ecosystèmes Aquatiques (BOREA UMR 8067) Muséum National d’Histoire Naturelle Sorbonne Universités Université de Caen Normandie Université des Antilles CNRS IRD Laboratoire évolution & Diversité Biologique (EDB UMR5174) Université Paul Sabatier-Toulouse 3 CNRS IRD UPS

Background The invasion success of introduced freshwater fishes is influenced by many factors, including ecological, species, and socioeconomic characteristics. Most studies that document the importance of these characteristics are conducted at local scales and/or focus on a single step of the invasion process. In this study, we aim to determine the species characteristics, ecological characteristics, and socioeconomic characteristics of non-native freshwater fish invasions. Our assessment was done at the global scale and considers all three steps of the invasion(i.e., introduction, establishment, and impact). For this purpose, we applied generalized linear models to 20 variables collected for 307 non-native species and modeled them as a function of ecological characteristics(i.e., environmental features), species traits(i.e., functional and morphological), and socioeconomic characteristics(i.e., human use and introduction pathways). We considered the number of countries in which each species was introduced, established, or had ecological impacts as a proxy of invasion step success. We also explored the specifics of species introduced through the aquaculture and the ornamental fish trade *** We found that non-native freshwater fishes with broad diets, high parental care, and multiple introduction pathways are the most widely introduced and established worldwide. The number of countries with impacts reported was best explained by the type of introduction pathway(i.e., aquaculture or fisheries). Moreover, among non-native species introduced through aquaculture, those belonging to Cypriniformes and having broad diets were the most widely introduced and established species. In contrast, the species introduced through the ornamental fish trade pathway belonged to various taxonomic orders but were mainly native to tropical *** Considering several types of factors is important when analyzing the invasion success of freshwater fish and disentang

关键词： Aquaculture Ecology Exotic Freshwater fish Introduction pathway Invasion step Morphology Ornamental fish trade Socioeconomic Trait

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Zooplankton community response to eddy during dinoflagellate Noctiluca scintillans blooms off Pakistan,northern Arabian Sea

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Journal of Oceanology and Limnology 2024年第5期42卷 1557-1570页

作者： Mahugnon boris DEDO Xiping LIAN Kaizhi LI Chenhui XIANG Yehui TAN Key Laboratory of Tropical Marine Bioresources and Ecology Guangdong Provincial Key Laboratory of Applied Marine BiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 100049China Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of Sciences(ISEECAS)Guangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 510301China

Eddies are major elements of ocean dynamics that affect ocean *** their effects on plankton distribution may help understand the dynamics of harmful phytoplankton *** studies on the effects of eddies in the northern Arabian Sea have primarily focused on the zooplankton community,and few have observed zooplankton dynamics during winter blooms of Noctiluca *** investigated zooplankton community structure and the related environmental variability during a *** bloom that was affected by an eddy in February *** sampling stations were deployed at eddy core and eddy edge distinguished in salinity,temperature,and *** show that *** bloomed at the eddy core with high-velocity currents induced by warm eddies that moved from eddy core to eddy *** a result,blooms significantly changed the zooplankton community ***-bloom stations had higher zooplankton diversity than bloom *** at non-bloom stations were dominated by either tunicates or copepods,such as Thalia democratica and Pleuromamma *** addition to the influence of *** blooms,the velocity of eddy currents was a crucial factor on the similarities in the zooplankton community composition between eddy edge and eddy ***,the lower abiotic factors in bloom area contribute to the structuring of the zooplankton community during *** blooms.

关键词： eddy zooplankton community Noctiluca scintillans northern Arabian Sea

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Why people should run after positive affective experiences instead of health benefits

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Journal of Sport and Health Science 2024年第4期13卷 445-450页

作者： Silvio Maltagliati Philippe Sarrazin Layan Fessler Mael Lebreton boris Cheval University of Grenoble Alpes SENSGrenoble 38000France Paris School of Economics Paris 75014France Swiss Center for Affective Sciences University of GenevaGeneva 1202Switzerland Laboratory for Behavioral Neurology and Imaging of Cognition Department of Fundamental NeurosciencesUniversity of GenevaGeneva 1202Switzerland Laboratory for the Study of Emotion Elicitation and Expression(E3Lab) Department of PsychologyUniversity of GenevaGeneva 1202Switzerland

Over time,physical activity(PA)has shifted from being a necessity to being an *** a result,levels of PA have sharply decreased.1 Today,we are facing a worldwide pandemic of physical inactivity,with one death every 6 s attributed to insufficient PA.2 To counteract this trend,a tremendous effort is being made to promote regular PA across the lifespan,mainly through the dissemination of knowledge about the health benefits of accumulating sufficient PA.

关键词： sharply benefits attributed

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Rheological properties of rare earth minerals flotation pulp in the presence of anions

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Journal of Rare Earths 2024年第11期42卷 2172-2182页

作者： Moonchul Jung Bogale Tadesse Craig Dick Alex Logan Laurence Dyer boris Albijanic Western Australia School of Mines Curtin University Lynas Rare Earths Ltd

Water quality has been found to significantly influence the flotation operations due to the alteration of surface properties of *** effect of cations on the flotation of RE minerals has been studied,however,there are still very limited information regarding the effect of *** present study examined the impact of specific anions such as Cl-,SO42-,and HCO3-on the flotation performance of rare earth（RE） *** study integrates flotation experiments,rheology measurements,entrainment experiments,zeta potential measurements and settling *** is observed that an increase in the concentration of these anions lead to a decrease in the recovery of RE minerals and an increase in the recovery of FeO minerals and thus negatively affecting flotation *** adverse effect is most pronounced with Cl-and least noticeable with HCO3-.An increase in the non-selective entrainment of gangue minerals is observed when the flotation pulp has higher *** reduction in the zeta potential of fine particles in the presence of these results in a higher pulp viscosity due to increased attractive forces between *** findings were verified by settling experiments and calculations based on the DLVO theory.

关键词： Flotation Rare earth ore Anions Pulp rheology Entrainment DLVO theory

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Two-dimensional anisotropic vortex quantum droplets in dipolar Bose−Einstein condensates

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Frontiers of physics 2024年第2期19卷 205-211页

作者： Guilong Li Xunda Jiang Bin Liu Zhaopin Chen boris A.Malomed Yongyao Li School of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528225China Physics Department and Solid-State Institute TechnionHaifa 32000Israel Department of Physical Electronics School of Electrical EngineeringFaculty of EngineeringTel Aviv UniversityTel Aviv 69978Israel Instituto de Alta Investigación Universidad de TarapacáCasilla 7DAricaChile Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro−Nano Optoelectronic Technology Foshan UniversityFoshan 528225China

Creation of stable intrinsically anisotropic self-bound states with embedded vorticity is a challenging ***,no such states in Bose−Einstein condensates(BECs)or other physical settings were *** BEC suggests a unique possibility to predict stable two dimensional anisotropic vortex quantum droplets(2D-AVQDs).We demonstrate that they can be created with the vortex axis oriented perpendicular to the polarization of *** stability area and characteristics of the 2D-AVQDs in the parameter space are revealed by means of analytical and numerical ***,the rotation of the polarizing magnetic field is considered,and the largest angular velocities,up to which spinning 2D-AVQDs can follow the rotation in clockwise and anti-clockwise directions,are *** between moving 2D-AVQDs are studied too,demonstrating formation of bound states with a vortex−antivortex−vortex structure.A stability domain for such stationary bound states is *** dipolar states,that can be readily implemented by means of phase imprinting,quickly transform into robust 2D-AVQDs,which suggests a straightforward possibility for the creation of these states in the experiment.

关键词： dipolar Bose−Einstein condensate anisotropic vortex quantum droplets

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