检索结果-南通市图书馆

COVID-19 vaccines: progress and understanding on quality control and evaluation

Signal Transduction and Targeted Therapy 2021年第6期6卷 1646-1652页

作者： Qunying Mao Miao Xu Qian He Changgui Li Shufang Meng Yiping Wang bopei cui Zhenglun Liang Junzhi Wang National Institutes for Food and Drug Control BeijingChina

The outbreak of COVID-19 has posed a huge threat to global health and *** have revolutionized norms for working,socializing,learning,and ***,vaccines have been considered as most effective tools to combat with *** of the beginning of 2021,>200 COVID-19 vaccine candidates,covering nearly all existing technologies and platforms,are being research and development(R&D)by multiple manufacturers *** has posed a huge obstacle to the quality control and evaluation of those candidate vaccines,especially in China,where five vaccine platforms are deployed in *** accelerate the R&D progress of COVID-19 vaccines,the guidances on R&D of COVID-19 vaccine have been issued by National Regulatory Authorities or organizations *** Center for Drug Evaluation and national quality control laboratory in China have played a leading role in launching the research on quality control and evaluation in collaboration with relevant laboratories involved in the vaccine R&D,which greatly supported the progression of vaccines R&D,and accelerated the approval for emergency use and conditional marketing of currently vaccine *** this paper,the progress and experience gained in quality control and evaluation of COVID-19 vaccines developed in China are summarized,which might provide references for the R&D of current and next generation of COVID-19 vaccines worldwide.

关键词： approval gained travel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Construction and verification of an infectious cDNA clone of coxsackievirus B5

引用

Virologica Sinica 2022年第3期37卷 469-471页

作者： Lifang Song bopei cui Jinghuan Yang Xiaotian Hao Xujia Yan Jialu Zhang Dong Liu Ziyang Song Qian Wang Qunying Mao Zhenglun Liang National Institute for Food and Drug Control Beijing 102629China Wuhan Institute of Biological Products CO. LTDWuhan 430070China

Dear Editor,Enteroviruses belonging to the family Picornaviridae are nonenveloped RNA viruses that cause hand-foot-mouth disease(HFMD),which can lead to severe neurological *** genomes represent a single open reading ... 详细信息

关键词： neurological envelope translated

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors

引用

Signal Transduction and Targeted Therapy 2023年第10期8卷 5069-5084页

作者： bopei cui Lifang Song Qian Wang Kelei Li Qian He Xing Wu Fan Gao Mingchen Liu Chaoqiang An Qiushuang Gao Chaoying Hu Xiaotian Hao Fangyu Dong Jiuyue Zhou Dong Liu Ziyang Song Xujia Yan Jialu Zhang Yu Bai Qunying Mao Xiaoming Yang Zhenglun Liang Division of Hepatitis and Enterovirus Vaccines NHC Key Laboratory of Research on Quality and Standardization of Biotech ProductsNMPA Key Laboratory for Quality Research and Evaluation of Biological ProductsInstitute of Biological ProductsNational Institutes for Food and Drug ControlBejingChina National Engineering Technology Research Center for Combined Vaccines WuhanChina Beijing Minhai Biotechnology Co LtdBeijingChina Taibang Biologic Group BeijingChina Changchun Institute of Biological Products Co. LtdChangchunChina Shanghai Institute of Biological Products Co LtdShanghaiChina China National Biotec Group Company Limited BeijingChina

With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer *** fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer *** enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses.

关键词： damage enterovirus cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

siRNA抑制Mcl-1基因表达对胃癌细胞MGC-803生物学行为的影响

引用

天津医药 2014年第4期42卷 297-300,I0001页

作者：刘金禄王震陈俊强崔希刚马鹏飞黎伯培广西医科大学第一附属医院胃肠腺体外科 530021

目的探讨siRNA抑制Mcl-1基因表达后对胃癌细胞MGC-803生物学行为的影响。方法合成针对Mcl-1的靶向siRNA(Mcl-1 siRNA组),以空白细胞(空白对照组)和分别转染脂质体试剂(脂质体对照组)及阴性对照siRNA(阴性对照组)作为对照组。噻唑蓝(MTT... 详细信息

目的探讨siRNA抑制Mcl-1基因表达后对胃癌细胞MGC-803生物学行为的影响。方法合成针对Mcl-1的靶向siRNA(Mcl-1 siRNA组),以空白细胞(空白对照组)和分别转染脂质体试剂(脂质体对照组)及阴性对照siRNA(阴性对照组)作为对照组。噻唑蓝(MTT)实验检测Mcl-1 siRNA对MGC-803细胞增殖能力的影响;流式细胞术观察各组细胞凋亡及周期变化情况;转染48 h后应用Transwell小室分析细胞侵袭、迁移能力的变化。结果 Mcl-1 siRNA组转染后24 h、48 h、72 h的A值低于3个对照组(P<0.05),其细胞增殖抑制率分别为8.9%、21.6%和18.8%。转染48 h后,Mcl-1 siRNA组细胞凋亡率高于空白对照组、脂质体对照组和阴性对照组(%:19.61±1.66 vs3.69±0.37 vs 3.54±0.47 vs 3.68±0.55,F=12.230,P<0.05)。Mcl-1 siRNA组G0/G1[(41.03±1.86)%]、G2/M期[(1.80±0.46)%]比例均低于3个对照组,S期比例[(57.17±1.72)%]高于3个对照组(均P<0.05)。Mcl-1 siRNA组侵袭、迁移实验中的穿膜细胞数(分别是42.00±4.00、76.33±3.51)均低于空白对照组(分别是79.33±3.51、108.00±3.61)、脂质体对照组(分别是74.67±2.52、110.67±4.04)和阴性对照组(分别是77.33±3.06、109.33±4.51)。以上指标在3个对照组间差异均无统计学意义。结论抑制Mcl-1表达可有效降低胃癌细胞的增殖、侵袭及迁移能力,并促进肿瘤细胞凋亡。

关键词：胃肿瘤 RNA,小分子干扰细胞增殖细胞凋亡细胞侵袭细胞迁移髓样细胞白血病-1基因

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：