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Two-Dimensional Variational Analysis of Near-Surface Moisture from Simulated Radar Refractivity-Related Phase Change Observations

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Advances in Atmospheric Sciences 2013年第2期30卷 291-305页

作者： Ken-ichi SHIMOSE Ming XUE Robert D.PALMER Jidong GAO boon leng cheong David J.BODINE Center for Analysis and Prediction of Storms University of OklahomaNorman OKUSA Department of Earth and Planetary Sciences Kyushu UniversityFukuokaJapan School of Meteorology University of OklahomaNorman OKUSA Atmospheric Radar Research Center University of OklahomaNorman OKUSA National Severe Storms Laboratory NOAANorman OKUSA

Because they are most sensitive to atmospheric moisture content, radar refractivity observations can provide high-resolution information about the highly variable low-level moisture field. In this study, simulated radar refractivity-related phase-change data were created using a radar simulator from realistic highresolution model simulation data for a dryline case. These data were analyzed using the 2DVAR system developed specifically for the phase-change data. Two sets of experiments with the simulated observations were performed, one assuming a uniform target spacing of 250 m and one assuming nonuniform spacing between 250 m to 4 km. Several sources of observation error were considered, and their impacts were examined. They included errors due to ground target position uncertainty, typical random errors associated with radar measurements, and gross error due to phase wrapping. Without any additional information, the 2DVAR system was incapable of dealing with phase-wrapped data directly. When there was no phase wrapping in the data, the 2DVAR produced ex- cellent analyses, even in the presence of both position uncertainty and random radar measurement errors. When a separate pre-processing step was applied to unwrap the phase-wrapped data, quality moisture anal- yses were again obtained, although the analyses were smoother due to the reduced effective resolution of the observations by interpolation and smoothing involved in the unwrapping procedure. The unwrapping procedure was effective even when significant differences existed between the analyzed state and the state at a reference time. The results affirm the promise of using radar refractivity phase-change measurements for near-surface moisture analysis.

关键词： radar refractivity variational analysis low-level moisture

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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

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Detection of Entamoeba histolytica in experimentally induced amoebic liver abscess:comparison of three staining methods

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Asian Pacific Journal of Tropical Biomedicine 2012年第1期2卷 61-65页

作者： Tan Zi Ning Wong Weng Kin Shaymoli Mustafa Arefuddin Ahmed Rahmah Noordin Tan Gim cheong Olivos-Garcia Alfonso Lim boon Huat School of Health Sciences Universiti Sains Malaysia Institute for Research in Molecular Medicine Universiti Sains Malaysia Department of Medical Microbiology ParasitologySchool of Medical SciencesUniversiti Sains Malaysia Departamento de Medicina Experimental Facultad de Medicina.Universidad National Autonoma de Mexico

Objective:To compare the efficacy of three different tissue stains,namely haematoxylin and eosin(H&E),periodic-acid Schiff(PAS)and immunohistochemical(1HC)stains for detection of Entamoeba histolytica(***)trophozoites in abscessed liver tissues of ***:Amoebic liver abscess was experimentally induced in a hamster by injecting 1×10~6of axenically cultured virulent *** trophozoites(HM1-IMSS strain)into the portal *** a week post-inoculation,the hamster was sacrificed and the liver tissue sections were stained with H&E,PAS and IHC stains to delect the amoebic ***:The three stains revealed tissue necrosis and amoebic trophozoites,but with varying clarity.H&E and PAS stained the trophozoites pink and magenta,respectively,however it was difficult to differentiate the stained trophozoites from the macrophages because of their similarity in size and *** the other hand,IHC stain revealed distinct brown appearance of the trophozoites in the infected liver ***:It can be concluded that out of the three *** is the best for identification of *** trophozoites in tissue sections.

关键词： Entamoeba histolytica Amoebic liver abscess H&E PAS IHC Trophozoite

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Factors influencing COVID-19 vaccination intention among university students:A cross-sectional study in Malaysia

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Biosafety and Health 2023年第1期5卷 37-44页

作者： Chee Yin Wong Jen Sern Tham Chai Nien Foo Foong leng Ng Saleha Shahar Mohd Nizam Zahary Mohd Nazri Ismail Cheng Siang Tan boon Peng Hoh Subbiah Vijay Kumar Yang Mooi Lim Center for Cancer Research Universiti Tunku Abdul RahmanKajang 43000Malaysia M.Kandiah Faculty of Medicine&Health Sciences Universiti Tunku Abdul RahmanKajang 43000Malaysia Department of Communication Faculty of Modern Languages and CommunicationUniversiti Putra MalaysiaSerdang 43400Malaysia UPM-UNICEF C4D Faculty of Modern Languages and CommunicationUniversiti Putra MalaysiaSerdang 43400Malaysia Faculty of Science Universiti Teknologi MalaysiaJohor Bahru 81310Malaysia Faculty of Health Sciences Universiti Sultan Zainal AbidinKuala Nerus 21300Malaysia Analytical Biochemistry Research Centre Universiti Sains MalaysiaBayan Lepas 11900Malaysia Faculty of Medicine and Health Sciences Universiti Malaysia SarawakKota Samarahan 94300Malaysia Faculty of Medicine and Health Sciences UCSI UniversityCheras 56000Malaysia Biotechnology Research Institute Universiti Malaysia SabahKota Kinabalu 88400Malaysia

Vaccination is crucial in controlling the spread of the coronavirus disease 2019(COVID-19)that triggered the pandemic,but herd immunity can only work with high vaccination coverage in the *** study aims to measure the COVID-19 knowledge level and determine the factors influencing COVID-19 vaccination intention among university students in Malaysia.A cross-sectional online survey was carried out with 1,274 Malaysian university students in July *** and multivariate analyses were employed to examine the relationships between the study *** showed that the majority of university students had an acceptable level of knowledge of *** knowledge,risk perception of COVID-19,social norms,and perceived benefit of COVID-19 vaccination were positively associated with vaccination ***,perceived trust in information sources of COVID-19 vaccination and the government's response to COVID-19 did not affect the university students’desire to receive the *** findings are essential for health policymakers and healthcare providers to implement evidence-based interventions to increase COVID-19 vaccination uptake among university students.

关键词： Behavioral intention COVID-19 Influencing factor SARS-CoV-2 University student Vaccination

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建筑垃圾在公路路基填筑中的有效应用

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工业建筑 2021年第10期51卷 I0031-I0031页

作者：尤忆 Chew boon cheong 台州职业技术学院建工学院台州职业技术学院台州绿色智能建筑研究中心马来西亚马六甲技术大学

社会经济飞速发展的时代背景为建筑行业提供了良好的发展机会,虽然建筑不断增多象征着国家综合实力提高,但是在建设过程中会产生很多建筑垃圾,如果不及时处理,就会对居民生活和周边环境造成不利影响。实践表明,将建筑垃圾用于公路路基填... 详细信息

社会经济飞速发展的时代背景为建筑行业提供了良好的发展机会,虽然建筑不断增多象征着国家综合实力提高,但是在建设过程中会产生很多建筑垃圾,如果不及时处理,就会对居民生活和周边环境造成不利影响。实践表明,将建筑垃圾用于公路路基填筑,可以有效缓解建筑垃圾破坏生态环境的现状。据此相关部门应该加强对建筑垃圾在公路路基填筑中应用策略的研究力度,旨在推动建筑行业更好、更快的发展。

关键词：建筑垃圾应用策略生态环境公路路基填筑有效应用建筑行业研究力度及时处理

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常見革蘭氏陰性菌耐藥性與抗菌藥使用情況相關性分析

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镜湖医学 2023年第2期23卷 41-44,64,F0002页

作者：張兆嫻何兆滿李雪齡澳門鏡湖醫院藥劑科中國澳門

目的分析中國澳門鏡湖醫院(簡稱“本院”)常見革蘭氏陰性菌耐藥性與其抗菌藥物使用情況的相關性,為規範使用抗菌藥物提供參考依據。方法收集由2018年1月~2021年12月(共4年)的常見革蘭氏陰性菌的耐藥率,並與同期住院患者的抗菌藥物的使... 详细信息

目的分析中國澳門鏡湖醫院(簡稱“本院”)常見革蘭氏陰性菌耐藥性與其抗菌藥物使用情況的相關性,為規範使用抗菌藥物提供參考依據。方法收集由2018年1月~2021年12月(共4年)的常見革蘭氏陰性菌的耐藥率,並與同期住院患者的抗菌藥物的使用頻度及使用強度(antimicrobial use density,AUD)進行分析。結果肺炎克雷伯菌耐藥率與慶大霉素的AUD相關,相關系數r=0.997(P=0.003),鮑曼不動桿菌耐藥率與左氧氟沙星的AUD相關,相關系數r=0.963(P=0.037)。結論肺炎克雷伯菌、鮑曼不動桿菌的耐藥性與抗菌藥物使用強度成正向關係。

关键词：抗菌藥物耐藥性使用強度

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肿瘤-睾丸抗原与肿瘤免疫治疗

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继续医学教育 2006年第9期20卷 45-48页

作者：彭吉润郭立民陈红松冷希圣北京大学人民医院肝胆外科中心 100044 北京大学肝病研究中心

1肿瘤-睾丸抗原的发现Van der Bruggen和Terry boon等人发现了第一个人类肿瘤特异性抗原--MAGE-A1,在恶性黑色素瘤患者中它能诱发针对自身肿瘤细胞的特异性细胞毒T细胞(Cytotoxic T Lymphocyte,CTL)反应.目前已经发现了24个MAGE家族成员... 详细信息

1肿瘤-睾丸抗原的发现Van der Bruggen和Terry boon等人发现了第一个人类肿瘤特异性抗原--MAGE-A1,在恶性黑色素瘤患者中它能诱发针对自身肿瘤细胞的特异性细胞毒T细胞(Cytotoxic T Lymphocyte,CTL)反应.目前已经发现了24个MAGE家族成员,它们均位于X染色体上,根据其在染色体上分布的区域不同,将MAGE家族分为A、B、C、D、E、F六个亚家族.MAGE-A亚家族由12个成员组成,位于人染色体Xq28,长约45 kb,有三个外显子,各成员之间高度同源(80%～99%),MAGE家族中的A、B、C三个亚家族具有独特的表达特征:(1)在正常组织中,除了睾丸组织和胎盘组织外,几乎不表达;(2)可表达于以恶性黑色素瘤为主的多种组织学来源的肿瘤组织中,研究发现,除了肾细胞癌和髓性白血病以外,人类半数以上的各种组织类型的肿瘤均表达至少一种MAGE基因.而MAGE-D、E、F亚家族在多种肿瘤组织和正常组织中均有不同程度的表达.

关键词：肿瘤免疫治疗肿瘤-睾丸抗原 Lymphocyte MAGE基因特异性细胞毒T细胞恶性黑色素瘤家族成员肿瘤特异性抗原自身肿瘤细胞 X染色体

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