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Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder

Chinese Journal of Integrative Medicine 2021年第1期27卷 39-46页

作者： bombi lee Gwang Muk Choi Bongjun Sur Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoul(02447)Republic of Korea Center for Converging Humanities Kyung Hee UniversitySeoul(02447)Republic of Korea The Graduate School of Basic Science of Medicine College of MedicineKyung Hee UniversitySeoul(02447)Republic of Korea Dopartmont of Molcoular Mcdicine and TIDRC School of MedicineEwha Womans UniversitySeoul(07985)Republic of Korea

Objective:Post-traumatic stress disorder(PTSD)is a psychiatric disorder characterized by depression and anxiety,that arises due to an imbalance of neurotransmitters in response to excessive stress.Hesperidin(HSD)is a naturally occurring flavonoid shown to exert a variety of biological activities,including antioxidant,anti-inflammatory,and neuroprotective effects.Methods:This study was used the open field test(OFT)and forced swimming test(FST)to examine the effects of HSD on the depression-like response of rats after exposure to a single prolonged stress(SPS)leading to the dysregulation of the serotonergic activation system.Male rats were given HSD(20,50,and 100 mg/kg,intraperitoneal injection,n=6–7 per group)once daily for 14 days after exposure to SPS.The influence of administration of HSD on SPS-induced behavioral responses and concentrations of serotonin(5-HT),5-hydroxyindoleacetic acid(5-HIAA),and monoamine oxidase-A(MAO-A)in the rat brain were also investigated using enzyme-linked immunoassays(ELISAs).Results:Daily HSD administration significantly improved depression-like behaviors in the FST(P<0.05),increased the number of lines crossed in the central zone of the OFT(P<0.01),and reduced freezing behavior both in contextual and cued fear conditioning.HSD treatment also attenuated the reduction in SPS-induced 5-HT concentrations in the hippocampus and amygdala.This increase in 5-HT concentrations during HSD treatment was partially attributed to a decrease in the 5-HIAA/5-HT ratio in the hippocampus of rats with PTSD.Furthermore,HSD treatment inhibited activity of MAO-A and decreases of tryptophan hydroxylase-1 expression in the hippocampus.Conclusion:HSD was shown to exert antidepressant effects in rats exposed to SPS,suggesting that this natural flavonoid may be an effective medicine for PTSD.

关键词： hesperidin post-traumatic stress disorder depression serotonin

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ACUPUNCTURE STIMULATION IMPROVES MEMORY IMPAIRMENT INDUCED BY SCOPOLAMINE IN RATS

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Journal of Integrative Medicine 2014年第3期 255-255页

作者： bombi lee Bongjun Sur Jinhee Park Sung-Hun Kim Mijung Yeom Insop Shim Hyejung lee Dae-Hyun Hahm Kyung Hee University

Objective: The purpose of this study was to examine whether acupuncture stimulation at the Baihui(GV20) improves memory defects caused by administration of scopolamine(SCO) to the rats.The effects of acupuncture stimulation at the GV20 on the cholinergic system as well as the expression of brain-derived neurotrophic factor(BDNF) and cAMP-response element-binding protein(CREB) in the hippocampus were also investigated.Methods: Male rats were administered with SCO(2 mg/kg, i.p.) once daily for 14 days.Acupuncture stimulation at GV20 was performed for 5 min before SCO injection.Results: Acupuncture stimulation at GV20 improved memory impairment as measured by the passive avoidance test(PAT) and reduced the escape latency for finding the platform in the Morris water maze(MWM) test.Acupuncture stimulation at the GV20 significantly alleviated memory-associated decreases in the expression levels of choline acetyltransferase(ChAT), BDNF and CREB proteins in the hippocampus.Additionally, acupuncture stimulation at the GV20 significantly restored the expression of choline transporter 1(CHT1), vesicular acetylcholine transporter(VAChT), BDNF and CREB mRNAs in the hippocampus.Conclusion: These results demonstrated that acupuncture stimulation at the GV20 has significant neuroprotective effects against neuronal impairment and memory dysfunction caused by SCO in rats.Thus, these findings suggested that acupuncture stimulation at the GV20 might be a useful therapy in various neurodegenerative diseases for the improvement of cognitive functioning via stimulating cholinergic enzyme activities and regulating BDNF and CREB expression in the brain.

关键词： CREB BDNF SCO ACUPUNCTURE STIMULATION IMPROVES MEMORY IMPAIRMENT INDUCED BY SCOPOLAMINE IN RATS

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