Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder

作     者：Bombi Lee Gwang Muk Choi Bongjun Sur Bombi Lee;Gwang Muk Choi;Bongjun Sur

作者机构：Acupuncture and Meridian Science Research CenterCollege of Korean MedicineKyung Hee UniversitySeoul(02447)Republic of Korea Center for Converging HumanitiesKyung Hee UniversitySeoul(02447)Republic of Korea The Graduate School of Basic Science of MedicineCollege of MedicineKyung Hee UniversitySeoul(02447)Republic of Korea Dopartmont of Molcoular Mcdicine and TIDRCSchool of MedicineEwha Womans UniversitySeoul(07985)Republic of Korea 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2021年第27卷第1期

页      面：39-46页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the National Research Foundation of Korea funded by the Korean government(No.2016R1D1A1A09917012) 

主　　题：hesperidin post-traumatic stress disorder depression serotonin 

摘      要：Objective:Post-traumatic stress disorder(PTSD)is a psychiatric disorder characterized by depression and anxiety,that arises due to an imbalance of neurotransmitters in response to excessive ***(HSD)is a naturally occurring flavonoid shown to exert a variety of biological activities,including antioxidant,anti-inflammatory,and neuroprotective ***:This study was used the open field test(OFT)and forced swimming test(FST)to examine the effects of HSD on the depression-like response of rats after exposure to a single prolonged stress(SPS)leading to the dysregulation of the serotonergic activation *** rats were given HSD(20,50,and 100 mg/kg,intraperitoneal injection,n=6–7 per group)once daily for 14 days after exposure to *** influence of administration of HSD on SPS-induced behavioral responses and concentrations of serotonin(5-HT),5-hydroxyindoleacetic acid(5-HIAA),and monoamine oxidase-A(MAO-A)in the rat brain were also investigated using enzyme-linked immunoassays(ELISAs).Results:Daily HSD administration significantly improved depression-like behaviors in the FST(P0.05),increased the number of lines crossed in the central zone of the OFT(P0.01),and reduced freezing behavior both in contextual and cued fear *** treatment also attenuated the reduction in SPS-induced 5-HT concentrations in the hippocampus and *** increase in 5-HT concentrations during HSD treatment was partially attributed to a decrease in the 5-HIAA/5-HT ratio in the hippocampus of rats with ***,HSD treatment inhibited activity of MAO-A and decreases of tryptophan hydroxylase-1 expression in the ***:HSD was shown to exert antidepressant effects in rats exposed to SPS,suggesting that this natural flavonoid may be an effective medicine for PTSD.