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Colorectal cancer screening:20 years of development and recent progress

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World Journal of Gastroenterology 2014年第14期20卷 3825-3834页

作者： Miroslav Zavoral Stepan Suchanek Ondrej Majek Premysl Fric Petra Minarikova Marek Minarik bohumil seifert Ladislav Dusek Department of Medicine 1st Faculty of MedicineMilitary University HospitalCharles University Institute of Biostatistics and Analyses Masaryk University Genomac Research Institute Centre for Applied Genomics of Solid Tumors Institute of General Medicine 1st Faculty of MedicineCharles University

Colorectal cancer(CRC)is the second most common cancer in Europe and its incidence is steadily *** trend could be reversed through timely secondary prevention(screening).In the last twenty years,CRC screening programs across Europe have experienced considerable improvements(fecal occult blood testing;transition from opportunistic to population based program settings).The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality *** year,approximately 8000 people are diagnosed with CRC and some 4000 die from this *** years ago,the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in ***,this program was based on the guaiac fecal occult blood test(FOBT)offered by general practitioners,followed by colonoscopy in cases of FOBT *** program has continuously evolved,namely with the implementation of immunochemical FOBTs and screening colonoscopy,as well as the involvement of *** the establishment of the Czech CRC Screening Registry in 2006,2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening *** overall program expanded to cover 25.0%of the target population by ***,stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation,which is currently being prepared.

关键词： Colorectal cancer Population-based screening program Colonoscopy Fecal occult blood test

Blood pressure and stature in Helicobacter pylori positive and negative persons

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World Journal of Gastroenterology 2014年第19期20卷 5625-5631页

作者： Marcela Kopacova Ilona Koupil bohumil seifert Miluska Skodova Fendrichova Jana Spirkova Viktor Vorisek Stanislav Rejchrt Tomas Douda Ilja Tacheci Jan Bures 2~(nd)Department of Internal Medicine-Gastroenterology Charles University in PrahaFaculty of Medicine at Hradec KraloveUniversity Teaching Hospital50005 Hradec KraloveCzech Republic Centre for Health Equity Studies Stockholm UniversityKarolinska Institute17177 StockholmSweden Institute of General Practice First Faculty of MedicineCharles University12002 PrahaCzech Republic Institute of Clinical Biochemistry and Diagnostics Charles University in PrahaFaculty of Medicine at Hradec KraloveUniversity Teaching Hospital50005 Hradec KraloveCzech Republic

To evaluate vital signs and body indices in Helicobacter pylori (H. pylori) positive and negative persons. A total of 22 centres entered the study. They were spread over the whole country, corresponding well to the geographical distribution of the Czech population. A total of 1818 subjects (aged 5-98 years) took part in the study, randomly selected out of 38147 subjects. H. pylori infection was investigated by means of a 13C-urea breath test. Data on height, weight, systolic and diastolic blood pressure and heart rate were collected at the clinics of general practitioners. The overall prevalence of H. pylori infection was 30.4% (402/1321) in adults (≥ 18 year-old) and 5.2% (26/497) in children and adolescents (≤ 17 year-old). Once adjusted for age and gender, only a difference in body mass index remained statistically significant with H. pylori positive adults showing an increase of 0.6 kg/m2 in body mass index. Once adjusted for age and gender, we found a difference in height between H. pylori positive and H. pylori negative children and adolescents. On further adjustment for place of residence, this difference became statistically significant, with H. pylori positive children and adolescents being on average 3.5 cm shorter. H. pylori positive adults were significantly older compared to H. pylori negative subjects. Once adjusted for age and gender, H. pylori infection had no impact on body weight, body mass index and vital signs either in adults or children and adolescents. Chronic H. pylori infection appeared to be associated with short stature in children. H. pylori infection did not influence blood pressure, body weight and body mass index either in adults or children and adolescents.

关键词： Epidemiology Helicobacter pylori Czech Republic 13C-urea breath test Blood pressure Heart rate Weight Stature Body mass index

How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?

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World Journal of Gastroenterology 2016年第36期22卷 8103-8111页

作者： Stepan Suchanek Tomas Grega Ondrej Ngo Gabriela Vojtechova Ondrej Majek Petra Minarikova Nagyija Brogyuk Bohus Bunganic bohumil seifert Ladislav Dusek Miroslav Zavoral Department of Internal Medicine 1st Faculty of Medicine Charles University Military University Hospital Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Institute of General Medicine 1st Faculty of Medicine Charles University

The incidence and prevalence of metabolic syndrome(MS) and colorectal cancer(CRC) has been rising in developed countries. The association between these two diseases has been widely studied and reported. Less evidence is available about the relationship between MS and CRC precancerous lesions(adenomatous polyps, adenomas). The aim of this paper is to present an overview of our scientific understanding of that topic and its implication in clinical practice. One of the principal goals of current CRC secondary prevention efforts is to detect and remove the precancerous lesions in individuals with an average CRC risk to prevent the development of invasive cancer. MS is not currently considered a high-risk CRC factor and is therefore not included in the guidelines of organized screening programs. However, in light of growing scientific evidence, the approach to patients with MS should be changed. Metabolic risk factors for the development of adenomas and cancers are the same- obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy to use in clinical practice, which would identify individuals with high metabolic risk of colorectal neoplasia and would be used for individual CRC secondary prevention strategies. Currently, such scoring systems have been published based on Asian(Asia-Pacific Colorectal Screening Score; APCS) and Polish populations.

关键词： Metabolic syndrome Diabetes mellitus type 2 Heart ischemic disease Colorectal neoplasia

Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic

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World Journal of Gastroenterology 2012年第32期18卷 4412-4418页

作者： Jan Bure Marcela Kopáová Ilona Koupil bohumil seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí Second Department of Medicine Gastroenterology Charles University in PrahaFaculty of Medicine at Hradec KrálovéUniversity Teaching Hospital50005 Hradec KrálovéCzech Republic Centre for Health Equity Studies Karolinska InstituteStockholm University17177 StockholmSweden First Faculty of Medicine Institute of General PracticeCharles University12108 PrahaCzech Republic Institute of Clinical Biochemistry and Diagnostics Charles University in PrahaFaculty of Medicine at Hradec KrálovéUniversity Teaching Hospital50005 Hradec KrálovéCzech Republic

AIM:To study possible decrease in prevalence of Helicobacter pylori(***) infection in the Czech Republic within a 10-year ***:A total of 22 centres entered the *** catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general *** infection was investigated by means of a 13 C-urea breath *** samples in duplicates were analysed using isotope ratio mass *** cut-off point was *** and demographic characteristics were based on data from self-completed ***:The overall prevalence of *** infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or *** was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).*** infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of *** infection was 39.8%(252/633,P < 0.001).The highest prevalence of *** infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of *** infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of *** infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted *** was no significant difference in the prevalence of *** infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).Ther

关键词： Epidemiology Helicobacter pylori Czech Republic 13 C-urea breath test Decline of prevalence