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Introduction to Neural Plasticity Mechanism

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Journal of Behavioral and Brain Science 2017年第2期7卷 41-49页

作者： bogdan Feliks Kania Danuta Wronska Dorota Zieba Veterinary Institute University Center for Veterinary Medicine Jagiellonian University&Agriculture UniversityHugon Kollataj Agricultural University in CracowCracowPoland Department of Physiology and Endocrinology of Animals Faculty of Animal SciencesHugon Kollataj Agricultural University in CracowCracowPoland Department of Animal Biotechnology Faculty of Animal SciencesHugon Kollataj Agricultural University in Cracowul.Redzina1BCracowPoland

In researches that examine neuroplasticity, many studies that are performed directly on isolated neurons in the pyramidal cells of CA1 area (CA1) and slices of the hippocampus indicate that changes occur at the molecular and cellular levels during long-term synaptic potentiation (LTP), and these changes are dependent on N-methyl-D-aspartate (NMDA) acid receptors and/or purinergic receptors. Electrophysiological studies and the chemical induction of LTP of synaptic neurotransmissions provide key evidence that LTP is dependent on the volume of Ca2+ influx through postsynaptic NMDA receptors, in addition to the subsequent activation and autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and the increase in the density of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors on postsynaptic neuronal membranes. The primary peculiarity of LTP in the central nervous system (CNS) excitatory synapses is the synthesis of additional AMPA receptors in the postsynaptic elements. Furthermore, the proteolysis of the extracellular matrix (ECM) has an important role in the synaptic neuroplasticity of the CNS. Proteases from the serine family and metalloproteinases of the extracellular matrix are localized within the synapses and are released into the extracellular space in proportion to the degree of neuronal excitation. These enzymes cause changes in the morphology, shape and size, as well as the overall number of synapses and synthesize new synaptic connections. The proteinases also change the function of receptors, and consequently, the secretions of neurotransmitters from the presynaptic elements are strengthened or weakened.

关键词： Neuroplasticity Heterosynaptic Metaplasticity Subjects

Perception and Attitude of the General Population on the Risk of Infection with SARS-CoV-2

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Journal of Biosciences and Medicines 2021年第6期9卷 1-10页

作者： Cristian Cojocaru Elena Cojocaru Steluta Radu bogdan Gurzu Medical III Department Faculty of Medicine “Grigore T. Popa” University of Medicine and Pharmacy Iasi Romania Morpho-Functional Sciences II Department Faculty of Medicine “Grigore T. Popa” University of Medicine and Pharmacy Iasi Romania Netconsult SRL Iasi Romania University of Agriculture Science and Veterinary Medicine Iasi Romania

Current state of knowledge on the impact of emotions and perceptions of the population towards the risk of infection with the SARS-CoV-2 should be the basis for disease control measures as well as for community awareness programs. Due to differences in perceptions, concerns, culture, beliefs, different populations may react differently to the same challenges. Ninety adults were interviewed, without symptoms suggestive of SARS-CoV-2 infection, using the Romanian version of the Fear of COVID-19 Scale. The emotional reactions expressed by various psychotic or mental disorders, the main actions are taken to protect against the SARS-CoV-2 infection, as well as the hypothetical illness behavior were investigated. The total score, as well as each item of the Fear of COVID-19 Scale, indicates a low-to-moderate emotional level regarding to the risk of coronavirus infection. The data are supported by the choice to be treated at home in case of illness. There are differences in perception between sexes and between professional categories (employees vs. retirees). Knowledge of social phenomena caused by major epidemiological crises such as SARS-CoV-2 infection should be the basis of education, disease prevention and control programs to avoid the occurrence of psychosocial risks in the population.

关键词： SARS-COV-2 Fear of COVID-19 Scale Psychosocial Risk Comorbidities Treatment

Hydrodynamics of Liquid Flow in the Model of Theoretical Stage with Perfect Displacement

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Journal of Chemistry and Chemical Engineering 2011年第1期5卷 25-29页

作者： Volodymyr Maletal Vitaliy Taran bogdan Maleta Maleta Cyclic Distillation LLC Ukraine Department of Machines and Equipment National University of Food Technologies Kiev Ukraine

For the cyclic process of mass transfer in tray columns there are considered the hydrodynamic models of liquid flow during steam supply and during overflow of liquid from tray to tray. During steam supply, the hydrodynamic model is determined as perfect displacement model, and during liquid overflow, it is described as cell model. There were received the characteristics of liquid flow as follows： average residence time of liquid, degree of dispersion around the mean on the tray, number of perfect mixing cells depending on multiplication factor of exchange of liquid delay. In Y-X coordinates there is depicted a work line and theoretical stage of perfect displacement model. There were considered the conditions of mutual transfer of theoretical stage and theoretical stage with perfect displacement. The advantages of the mass transfer cyclic process to the stationary one arc stated.

关键词： mass transfer cyclic distillation theoretical stage the theoretical stage model with perfect displacement residence time

Discrete-Time Sliding-Mode Control of Four Driving-Steering Wheels Autonomous Vehicle 30th

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Discrete-Time Sliding-Mode Control of Four Driving-Steering ...

对离心情况下轴颈轴承的Reynolds模型推导(英文)

第三十届中国控制会议

作者： DUMITRASCU bogdan FILIPESCU Adrian MINZU Viorel VODA Alina MINCA Eugenia Department of Automation and Electrical Engineering University“Dunarea de Jos”of Galati Department of Control Systems GIPSA-labGrenoble University Joseph Fourier38000 GrenobleFrance

ISBN: (纸本)9781457706776

＜正＞A discrete-time sliding-mode control for the trajectory tracking problem of four driving-steering wheels（4DW/SW） autonomous vehicle SEEKUR is presented in this *** is a holonomic,all-wether,outdoor robot platform for outdor security,inspection and ***’s unique shape and omni-directional steering allow truly holonomic movement.A discrete-time nonholonomic model of SEEKUR is used for the design of the controller,instead of the usual continuous-time model,thus avoiding problems caused by the discretization of the continuous-time *** effectiveness of the proposed controller is proven by simulation results.

关键词： Discrete-time sliding-mode control Trajectory tracking Nonholonomic

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工程数学学报 2013年第4期30卷 501-516页

作者： bogdan N.Nicolescu Tudor C.Petrescu 皮特什蒂大学数学系罗马尼亚

本文的主要结果是在轴颈轴承背景下两轴不叠合时离心情况下构造了一个精确Reynolds方程.该方程是在假设极半径方向的润滑膜厚度很小并考虑到接触面曲率影响的情况下得到的.与标准的Reynolds方程的相比,针对方程的系数我们得到了一个新... 详细信息

本文的主要结果是在轴颈轴承背景下两轴不叠合时离心情况下构造了一个精确Reynolds方程.该方程是在假设极半径方向的润滑膜厚度很小并考虑到接触面曲率影响的情况下得到的.与标准的Reynolds方程的相比,针对方程的系数我们得到了一个新的非线性格式.通过对圆柱坐标下的新Reynolds方程系数的泰勒级数展开以及忽略掉其四阶项,最终我们得到了标准方程的一般形式.

关键词： Reynolds方程轴颈轴承流体动力学润滑剂

Metabolomics: From liver chiromancy to personalized precision medicine in advanced chronic liver disease

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World Journal of Hepatology 2018年第3期10卷 371-378页

作者： bogdan Procopet Petra Fischer Oana Farcau Horia Stefanescu 3~(rd) Medical Clinic University of Medicine and Pharmacy Hepatology Unit Regional Institute of Gastroenterology and Hepatology

Currently there is a lack of accurate biomarkers for diagnosis and prognosis in advanced liver diseases. Either the occurrence of first decompensation, or diagnosis of acute on chronic liver failure, severe alcoholic hepatitis, or hepatocellular carcinoma(HCC), none of the available biomarkers are satisfactory. Metabolomics is the newest of omics, being much closer than the others to the actual phenotype and pathologic changes that characterizes a certain condition. It deals with a much wider spectrum of low molecular weight bio-compounds providing a powerful platform for discovering novel biomarkers and biochemical pathways to improve diagnostic, prognostication and therapy. Until now metabolomics was applied in a wide spectrum of liver conditions, but the findings were contradictory. This review proposes a synthesis of the existing evidences of metabolomics use in advanced chronic liver diseases, decompensated liver cirrhosis, severe alcoholic hepatitis and HCC.

关键词： Metabolomics Biomarker Prediction Advanced chronic liver disease Decompensation Alcoholic hepatitis Hepatocellular carcinoma

Primary parahiatal hernias:A case report and review of the literature

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World Journal of Clinical Cases 2019年第23期7卷 4020-4028页

作者： Silviu Daniel Preda Stefan Patrascu bogdan Silviu Ungureanu Daniel Cristian Vasile Bintintan Cristian M Nica Valentin Calu Victor Strambu Konstantinos Sapalidis Valeriu Marin Surlin 1^(st) Clinic of Surgery Clinical Emergency Hospital of CraiovaUniversity of Medicine and Pharmacy of CraiovaCraiova 200642DoljRomania Gastroenterology Clinic Clinical Emergency Hospital of CraiovaUniversity of Medicine and Pharmacy of CraiovaCraiova 200642DoljRomania Departament of General Surgery “Coltea”Clinical HospitalCarol Davilla University of Medicine and PharmacyBucharest 030171Romania 1^(st) Clinic of Surgery of Cluj Napoca Iuliu Hatieganu University of Medicine and Pharmacy Cluj NapocaCluj Napoca 400006ClujRomania 3^(rd) Clinic of Surgery Timisoara Emergency Clinical County Hospital“Victor Babes”University of Medicine and Pharmacy of TimisoaraTimisoara 300723Romania Clinic of Surgery “Elias”Emergency University Hospital BucharestUniversity of Medicine and Pharmacy“Carol Davila”Bucharest 011461Romania Clinic of Surgery of“Dr.Carol Davila”Nephrology Clinical Hospital University of Medicine and Pharmacy“Carol Davila”Bucharest 010731Romania 3^(rd) Surgery Clinic University General Hospital of ThessalonikiAristotle University of ThessalonikiSalonic 54636Greece

BACKGROUND Parahiatal hernias(PHHs)are rare occurring disease,with a reported incidence of 0.2%-0.35%in patients undergoing surgery for hiatal *** found only a handful of cases of primary PHHs in the *** aim of this paper is to present a case of a primary PHH and perform a systematic review of the *** SUMMARY We report the case of a 60-year-old Caucasian woman with no history of thoracoabdominal surgery or trauma,which accused epigastric pain,starting 2 years prior,pseudo-angina and *** on imagistic findings the patient was diagnosed with a PHH and an associated type I hiatal *** underwent laparoscopic surgery and we found an opening in the diaphragm of 7 cm diameter,lateral to the left crus,through which 40%-50% of the stomach had herniated in the thorax,and a small sliding hiatal hernia with an anatomically intact hiatal orifice but slightly *** performed closure of the defect,suture hiatoplasty and a“floppy”Nissen *** outcome was uneventful,with the patient discharged on the fifth postoperative *** performed a review of the literature and identified eight articles regarding primary *** data was compiled into one tabled and *** Primary PHHs are rare entities,with similar clinical and imagistic findings with paraesophageal *** usually includes laparoscopic approach with closure of the defect and the esophageal hiatus should be dissected and *** outcome is favorable in all cases reviewed and no recurrence is cited in the literature.

关键词： Parahiatal Hernia Review Literature Case report

Malnutrition and non-compliance to nutritional recommendations in patients with cirrhosis are associated with a lower survival

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World Journal of Hepatology 2020年第10期12卷 829-840页

作者： Dana Crisan bogdan Procopet Alexandra Epure Horia Stefanescu Alina Suciu Andreea Fodor Emil Mois Rares Craciun Nicolae Crisan Internal Medicine Department “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400126Romania 3rd Medical Clinic “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400126Romania Hepatology Unit “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162Romania Surgery Department “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400126Romania Hepatology Unit “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400126Romania

BACKGROUND Malnutrition is frequently encountered in patients with cirrhosis and appears to significantly impact their *** evaluating the burden of malnutrition in cirrhosis is gathering momentum,as suggested by multiple recently published reports,there is still a persistent scarcity of solid data in the field,especially with regards to the role of nutritional *** To assess the prevalence of malnutrition in patients with advanced cirrhosis and to evaluate its impact on *** One hundred and one consecutive patients with advanced cirrhosis were screened for malnutrition using the Subjective Global Assessment(SGA)criteria and the mid-arm circumference(MAC).Malnutrition was defined as SGA class B and C and MAC<10th *** patients were interviewed regarding their food intake using an adapted ***,total energy intake was calculated and further subdivided in main *** data were then compared to the available recommendations at the time of analysis to assess *** 54/79 patients(68.4%)in the decompensated group had malnutrition,while only 3/22 patients(13.6%)were malnourished in the compensated *** a median follow-up time of 27 mo(0-53),the overall mortality was 70%.Survival was significantly lower among patients with *** mortality rates were 50%at 1 year and 63%at 2 years for the patients with malnutrition,compared to 21%at 1 year and 30%at 2 years for patients without malnutrition(P=0.01).On multivariate analysis,the factors independently associated with mortality were age,creatinine level and adherence to the protein intake *** mortality was lower in patients with the appropriate protein intake:8%at 1 year and 28%at 2 years in the adherent group,compared to 47%at 1 year and 56%at 2 years in the non-adherent *** The prevalence of malnutrition is high among patients with advanced cirrhosis and might be related in part to a low adherenc

关键词： Malnutrition Decompensated cirrhosis Survival Subjective global assessment Protein intake

Optimum Design of Outrigger and Belt Truss Systems Using Genetic Algorithm

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Journal of Civil Engineering and Architecture 2014年第6期8卷 709-715页

作者： Radu Hulea Bianca Parv Monica Nicoreac bogdan Petrina Department of Structural Mechanics Faculty of Civil Engineering Technical University of Cluj-Napoca Cluj-Napoca 400020Romania

There are many structural lateral systems used in tall buildings： rigid frames, braced frames, shear walls, tubular structures and core structures. The outrigger and belt truss systems are efficient structures for drift control and base moment reduction in tall buildings where the core alone is not rigid enough to resist lateral loads. Perimeter columns are mobilized for increasing the effective width of the structure, and they developed tension in the windward columns and compression in the leeward columns. Optimum locations for the outriggers have been studied because of the influence on the top displacement and base moment in the core. It was analyzed the optimal position for two to seven outriggers and belt trusses, aiming to achieve minimum bending moment and minimum drift.

关键词： Outrigger system optimum location genetic algorithm.