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Effect of Moringa oleifera on semen quality profiles in endangered Teressa goat under tropical humid island ecosystem

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Asian pacific Journal of Reprod.c.ion 2024年第2期13卷 89-96页

作者： P.Perumal Jai Sunder A.K.de A.K.Nahak d.K.chaurasia T.c.Balamurugan d.Bhattacharya IcAR-central Island Agricultural Research Institute Port Blair-744105Andaman and Nicobar IslandsIndia OUAT-college of Veterinary Science and Animal Husbandry Bhubaneswar-751003OdishaIndia TANUVAS-Veterinary college and Research Institute Salem-636112Tamil NaduIndia

Objective:To investigate the effect of Moringa oleifera leaf extract on semen quality parameters in Teressa goat ***:A total of 25 semen samples from six bucks were selected for the *** of 150×10^(6) were incubated in 0,300,500 and 700μg of leaf extract as groupⅠ,Ⅱ,Ⅲ and Ⅳ,*** stored semen samples were analysed for motility,viability,total sperm abnormalities,plasma membrane,acrosomal and nuclear integrities,seminal plasma intracellular enzymes[aspartate aminotransferase(AST),alanine aminotransferase(ALT)and lactate dehydrogenase(LdH)]and total antioxidant capacity(TAc)and spermatozoa malondialdehyde(MdA)and.c.olesterol efflux in comparison with the control group(groupⅠ)for up to 72 ***:Moringa oleifera leaf extract(500μg/150×10^(6) spermatozoa)-treated semen had significantly higher motility,viability,plasma membrane,acrosomal and nuclear integrities,and TAc(Pd had significantly lower total sperm abnormalities,AST,ALT,LdH,MdA prod.c.ion and.c.olesterol efflux compared to those in other Moringa oleifera leaf extract treated(300 or 700μg/150×10^(6) spermatozoa)and.c.ntrol groups at different hours of liquid storage(Pd TAc showed an increasing trend and total sperm abnormalities,MdA prod.c.ion,leakage of intra-cellular enzymes and.c.olesterol efflux showed a d.c.easing trend from group Ⅰto group Ⅲand then an opposite trend from group Ⅲ to group Ⅳ at different hours of liquid ***:Moringa oleifera leaf extract 500μg/150×10^(6) spermatozoa can be used for liquid semen preservation in Teressa goat at Andaman and Nicobar Islands.

关键词： Moringa oleifera Semen Teressa goat Andaman and Nicobar Islands

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Role of lipids in the control of autophagy and primary cilium signaling in neurons

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Neural Regeneration Research 2024年第2期19卷 264-271页

作者： María Paz Hernández-cáceres daniela Pinto-Nuñez Patricia Rivera Paulina Burgos Francisco díaz-castro Alfredo criollo Maria Jose Yañez Eugenia Morselli Instituto de Investigación en ciencias Odontológicas(IcOd) Facultad de OdontologíaUniversidad de ChileSantiagoChile department of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology department Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Advanced.c.nter for chronic diseases(AccdiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research center SantiagoChile

The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human *** neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely *** this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in *** we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.

关键词： autophagic flux cholesterol fatty acids GPcR lysosomal storage diseases neurons NPc1 phosphoinositides primary cilium

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A multi-shot target wheel assembly for high-repetition-rate, laser-driven proton acceleration

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High Power Laser Science and Engineering 2024年第2期12卷 87-94页

作者： J.Penas A.Bembibre d.c.rtina-Gil L.Martin A.Reija c.Ruiz M.Seimetz A.Alejo J.Benlliure Instituto Galego de Fisica de Altas Enerxias Universidade de Santiago de CompostelaSantiago de CompostelaSpain Laboratorio Laser de Aceleracion y Aplicaciones RIAIDTUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Instituto Universitario de Física Fundamental y Matematicas y dpto.de did.c.ica de la Matematica y de las ciencias Experimentales Universidad de SalamancaSalamancaSpain Instituto de Instrumentación para Imagen Molecular(I3M) CSIC-Universitat Politecnica de ValenciaValenciaSpain

A multi-shot target assembly and automatic alignment procedure for laser–plasma proton acceleration at high repetition rate are *** assembly is based on a multi-target rotating wheel capable of hosting more than 5000 targets,mounted on a 3d motorized stage to allow rapid replenishment and alignment of the target material between laser *** automatic alignment procedure consists of a detailed mapping of the impact positions at the target surface prior to the irradiation that ensures stable operation of the target,which alongside the purpose-built design of the target wheel,enables operation at rates up to 10 *** and.c.ntinuous laser-driven proton acceleration at 10 Hz is demonstrated,with observed.c.t-off energy stability about 15%.

关键词： high repetition rate laser-plasma acceleration multi-shot operation proton source target assembly

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A brief history of the compendium of Physical Activities

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Journal of Sport and Health Science 2024年第1期13卷 3-5页

作者： Barbara E.Ainsworth Stephen d.Herrmann david R.Jacobs Jr. Melicia c.Whitt-Glover catrine Tudor-Locke School of Exercise and Health Shanghai University of SportShanghai 200438China college of Health Solutions Arizona State UniversityPhoenixAZ 85003USA Kansas center for Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA division of Epidemiology and.c.mmunity Health University of MinnesotaMinneapolisMN 55455USA Gramercy Research Group KnightdaleNC 27545USA college of Health and Human Services University of North Carolina at CharlotteCharlotteNC 28223USA

The compendium of Physical Activities(compendium)was developed to address consistent assignment of physical activity(PA)intensity values used in PA epidemiology research of the association between PA and health outcomes.1The known protective effects of PA on incident health outcomes traces to the mid-1900s,with over 50 studies examining coronary heart disease(cHd)as the outcome of interest.

关键词： epidemiology Activities protective

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Single atom cu-N-c catalysts for the electro-red.c.ion of cO_(2) to cO assessed by rotating ring-disc electrode

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Journal of Energy chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-Rodríguez M.Gutiérrez-Roa c.Giménez-Rubio d.Ríos-Ruiz P.Arévalo-cid M.V.Martínez-Huerta A.Zitolo M.J.Lázaro d.Sebastián Instituto de carboquímica(cSIc) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de catálisis y Petroleoquímica(cSIc) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical cO_(2) red.c.ion reaction(cO_(2)RR) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped.c.rbon xerogel(cu-N-c) are successfully developed varying the copper amount and the nature of the copper precursor, for the efficient cO_(2)RR. The electrocatalytic performance of cu-N-c materials is assessed by a rotating ring-disc electrode(RRdE), technique still rarely explored for cO_(2)RR. For comparison, prod.c.s are also characterized by online gas chromatography in a H-cell. The as-synthesized.c.-Nc catalysts are found to be active and highly cO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 M KHcO_(3), while H_(2) from the competitive water red.c.ion appears at larger overpotentials(-0.9 V vs. RHE). The optimum copper acetate-derived.c.talyst containing cu-N_(4) moieties exhibits a cO_(2)-to-cO turnover frequency of 997 h^(-1) at -0.9 V vs. RHE with a H_(2)/cO ratio of 1.8. These results demonstrate that RRdE configuration can be used as a feasible approach for identifying electrolysis prod.c.s from cO_(2)RR.

关键词： cu-N-c carbon xerogel Rotating ring disc electrode carbon dioxide red.c.ion reaction carbon monoxide

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TcM-HIN2Vec: A strategy for uncovering biological basis of heart qi deficiency pattern based on network embedding and transcriptomic experiment

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Journal of Traditional chinese Med.c.l Sciences 2024年第3期11卷 264-274页

作者： diao L. Fan X. Yu J. Huang K. Nice E.c. Liu c. Li d. Guo S. School of Traditional chinese Med.c.ne Beijing University of Chinese Medicine Beijing 102488 China department of Biochemistry and Molecular Biology Monash University Clayton 3800 VIC Australia Beijing Institute of Lifeomics Beijing 102206 China State Key Laboratory of Med.c.l Proteomics Beijing 102206 China National center for Protein Sciences (Beijing) Beijing 102206 China Beijing Proteome Research center Beijing 102206 China

Objective: To elucidate the biological basis of the heart qi deficiency (HQd) pattern, an in-depth understanding of which is essential for improving clinical herbal therapy. Methods: We pred.c.ed and.c.aracterized HQd pattern genes using the new strategy, TcM-HIN2Vec, which involves heterogeneous network embedding and transcriptomic experiments. First, a heterogeneous network of traditional chinese med.c.ne (TcM) patterns was constructed using public databases. Next, we pred.c.ed HQd pattern genes using a heterogeneous network-embedding algorithm. We then analyzed the functional characteristics of HQd pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq. Finally, we identified TcM herbs that demonstrated enriched interactions with HQd pattern genes via herbal enrichment analysis. Results: Our TcM-HIN2Vec strategy revealed that candidate genes associated with HQd pattern were significantly enriched in energy metabolism, signal transd.c.ion pathways, and immune processes. Moreover, we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern. Furthermore, herbal enrichment analysis identified TcM herbs that demonstrated enriched interactions with the top 10 candidate genes and.c.uld potentially serve as drug candidates for treating HQd. conclusion: Our results suggested that TcM-HIN2Vec is capable of not only accurately identifying HQd pattern genes, but also d.c.phering the basis of HQd pattern. Furthermore our finding ind.c.ted that TcM-HIN2Vec may be further expanded to develop other patterns, leading to a new approach aimed at elucidating general TcM patterns and developing precision med.c.ne. © 2024 Beijing University of chinese Med.c.ne

关键词： Biological basis Heart failure Network embedding Qi deficiency pattern Transcriptome

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Important step towards an understanding of the exotic Z_(c)(3900)

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Science china(Physics,Mechanics & Astronomy) 2024年第9期67卷 199-200页

作者： c.Hanhart Institute for Advanced Simulation Forschungszentrum JulichJilich D-52425Germany

The Standard Model of particle physics,which contains the field theories for the electro-weak interaction(QEd)and the strong interaction(Qcd),is an extremely successful theory describing a huge variety of phenomena at... 详细信息

关键词： interaction atomic describing

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Experimental measurements of gamma-photon prod.c.ion and estimation of electron/positron prod.c.ion on the PETAL laser facility

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Matter and Radiation at Extremes 2024年第5期9卷 32-47页

作者： F.Brun L.Ribotte G.Boutoux X.davoine P.E.Masson-Laborde Y.Sentoku N.Iwata N.Blanchot d.Batani I.Lantuéjoul L.Lecherbourg B.Rosse c.Rousseaux B.Vauzour d.Raffestin E.d’Humières X.Ribeyre centre Lasers Intenses et Applications UMR 5107Universitéde Bordeaux-CNRS-CEA33405 TalenceFrance cEA DAMCESTAF-33116 Le BarpFrance cEA DAMDIFF-91297 ArpajonFrance cEA LMCEUniversitéParis-Saclay91680 Bruyères-le-ChâtelFrance Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan

This article reports the first measurements of high-energy photons prod.c.d with the high-intensity PETawatt Aquitaine Laser(PETAL)*** experiments were performed during the commissioning of the *** laser had an energy of about 400 J,an intensity of 8×10^(18)W cm^(−2),and a pulse duration of 660 fs(FWHM).It was shot at a 2 mm-thick solid tungsten *** high-energy photons were prod.c.d mainly from the bremsstrahlung process for relativistic electrons accelerated inside a plasma generated on the front side of the *** paper reports measurements of electrons,protons and *** electrons up to35 MeV with a few-MeV temperature were recorded by a spectrometer,called SESAME(SpectreÉlectronS Angulaire MoyenneÉnergie).K-and L-shells were clearly detected by a photon spectrometer called SPEcTIX(Spectromètre Petalàcristal en TransmIssion pour le rayonnnement X).High-energy photons were diagnosed by cRAcc-X(cassette de RAdiographie centre chambre-rayonnement X),a bremsstrahlung *** cannon analysis is strongly dependent on the hypothesis adopted for the spectral *** shapes can exhibit similar reprod.c.ions of the experimental *** eliminate dependence on the shape hypothesis and to facilitate analysis of the data,simulations of the interaction were *** model the mechanisms involved,a simulation chain including hydrodynamic,particle-in-cell,and Monte carlo simulations was *** simulations model the preplasma generated at the front of the target by the PETAL laser prepulse,the acceleration of electrons inside the plasma,the generation of MeV-range photons from these electrons,and the response of the detector impacted by the energetic photon *** this work enabled reprod.c.ion of the experimental *** high-energy photons prod.c.d have a large emission angle and an exponential distribution *** addition to the analysis of the photon spectra,positron prod.c.ion was also ***,if high

关键词： process. positron hypothesis

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d.c.mposition mechanisms of nuclear-grade cationic exchange resin by advanced oxidation processes:Statistical molecular fragmentation model and dFT calculations

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Journal of Environmental Sciences 2024年第1期135卷 433-448页

作者： Xiang Meng Pierre désesquelles Lejin Xu department of Nuclear Engineering and Technology School of Energy and Power EngineeringHuazhong University of Science&TechnologyWuhan 430074China cNRS Laboratoire de Physique des Gaz et des PlasmasUniversitéParis-SaclayOrsay 91405France State Key Laboratory of coal combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The treatment and disposal of radioactive waste are presently facing great *** ion exchange resins have become a focus of attention due to their high prod.c.ion and serious environmental *** this paper,a simplified model of cationic exchange resin is proposed,and the degradation processes of cationic resin monomer initiated by hydroxyl rad.c.ls(·OH)are clarified by combining statistical molecular fragmentation(SMF)model and density functional theory(dFT)*** pred.c.ion of active sites ind.c.tes that the S-O bonds and the c-S bond of the sulfonic group are more likely to react during the *** meta-position of the sulfonic group on the benzene ring is the most active site,and the benzene ring without the sulfonic group has a certain *** c11-c14 and.c.7-c20 bonds,on the carbon skeleton,are the most easily *** is also found that dihydroxy addition and elimination reactions play a major role in the process of desulfonation,carbon skeleton cleavage and benzene ring *** d.c.mposition mechanisms found through the combination of physical models and.c.emical calculations,provide theoretical guidance for the treatment of complex polycyclic aromatic hydrocarbons.

关键词： cationic exchange resin Statistical molecular fragmentation model density functional theory Hydroxyl rad.c.l d.c.mposition mechanism

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comparative analysis of microstructure,mechanical,and.c.rrosion properties of biodegradable Mg-3Y alloy prepared by selective laser melting and spark plasma sintering

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Journal of Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková S.Šašek J.dittrich M.Knapek F.Lukáˇc d.Koutný J.Jaroš R.Král Faculty of Mathematics and Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of Plasma Physics of the czech Academy of Sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and Industrial design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy Mg-3Y preparation by two modern powder metallurgy techniques–spark plasma sintering(SPS)and selective laser melting(SLM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the SLM material and unmeasurably low porosity in the SPS *** main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties,such as mechanical strength,deformability,and.c.rrosion *** materials showed.c.mparable strength of∼110 MPa in tension and.c.mpression and relatively good deformability of∼9%and∼21%for the SLM and SPS materials,*** corrosion resistance of the SPS material in 0.1 M Nacl solution was superior to the SLM one and.c.mparable to the conventional extruded *** digital image correlation during loading and the cross-section analysis of the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the SLM *** the other hand,one of the primary outcomes of this study is that the SPS consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： Magnesium Yttrium Powder metallurgy Microstructure Mechanical strength corrosion resistance

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