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Enhanced straw fermentation process based on microbial electrolysis cell coupled anaerobic digestion

Chinese Journal of Chemical Engineering 2022年第4期35卷 239-245页

作者： Xinyu Yan bobo wang Hongxia Liang Jie Yang Jie Zhao Fabrice Ndayisenga Hongxun Zhang Zhisheng Yu Zhi Qian College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Research Center for Eco-Environmental Sciences-Institute of Microbiology Chinese Academy of Sciences-University of Chinese Academy of Sciences(RCEES-IMCAS-UCAS)Joint-Lab of Microbial Technology for Environmental ScienceBeijing 100085China Received:2020-11-12 Revised:2021-05-08 Online:2022-04-28 Published:2022-06-18

The low quality and yield of methane severely hinder the industrial application of straw biogas fermentation, and no effective solution has been found so far. In this study, a novel method was developed when a microbial electrolysis cell(MEC) was coupled with normal anaerobic fermentation to enhance methane yield and purity. The fermentation process achieved a methane purity of more than 85%, which is considerably higher than that of previously published reports. With microbial stimulation and an electric current, the degradation of fibers has been greatly enhanced. The MEC system substantially improved the yield and purity of biogas, bringing a new path to the synthesis of methane by carbon dioxide and hydrogen ions in solution under electron irradiation. Electrochemical index analysis showed extra methane synthesis, due to the external circuit electron transfer. The results of the gas chromatography and solid degradation rate showed that the carbon source of extra methane was CO_(2) produced during normal fermentation and additional volatile solid degradation. These results show that the MEC considerably enhanced the quality and yield of methane in the straw fermentation process, providing insights into normal anaerobic fermentation.

关键词： Microbial electrolysis cell(MEC) Methane Straw Fermentation Bioenergy

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Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer

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Cancer Biology & Medicine 2019年第1期16卷 66-78页

作者： Yuxiang wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan bobo wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng Division of Anti-Tumor Pharmacology Shanghai Institute of Materia Medica Chinese Academy of Sciences University of Chinese Academy of Sciences Division of Anti-Tumor Pharmacology State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Department of Medicinal Chemistry Shanghai Institute of Materia Medica Chinese Academy of Sciences

Objective: Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer(NSCLC).However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI3K signaling plays an important role in tumorigenesis and drug resistance in NSCLC. The activity of PI3Kα-selective inhibition against KRAS-mutated NSCLC remains largely ***: Cell proliferation was detected by sulforhodamine B assay. Cell cycle distribution and apoptosis were measured by flow cytometry. Cell signaling was assessed by Western blot and immunohistochemistry. RNA interference was used to down-regulate the expression of cyclin D1. Human NSCLC xenografts were employed to detect therapeutic efficacy in ***: CYH33 possessed variable activity against a panel of KRAS-mutated NSCLC cell lines. Although CYH33 blocked AKT phosphorylation in all tested cells, Rb phosphorylation decreased in CYH33-sensitive, but not in CYH33-resistant cells, which was consistent with G1 phase arrest in sensitive cells. Combined treatment with the CDK4/6 inhibitor, PD0332991, and CYH33 displayed synergistic activity against the proliferation of both CYH33-sensitive and CYH33-resistant cells, which was accompanied by enhanced G1-phase arrest. Moreover, down-regulation of cyclin D1 sensitized NSCLC cells to CYH33. Reciprocally, CYH33 abrogated the PD0332991-induced up-regulation of cyclin D1 and phosphorylation of AKT in A549 cells. Co-treatment with these two drugs demonstrated synergistic activity against A549 and H23 xenografts, with enhanced inhibition of Rb ***: Simultaneous inhibition of PI3Kα and CDK4/6 displayed synergistic activity against KRAS-mutated NSCLC. These data provide a mechanistic rationale for the combination of a PI3Kα inhibitor and a CDK4/6 inhibitor for the treatment of KRASmutated NSCLC.

关键词： PI3Kα CDK4/6 KRAS NSCLC CYH33

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Prevalence and molecular characterization of Pentatrichomonas hominis in Siberian tigers(Panthera tigris altaica)in northeast China

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Integrative Zoology 2022年第4期17卷 543-549页

作者： Hongbo ZHANG Nan ZHANG Pengtao GONG Shuqin CHENG Xiaocen wang Xin LI Zhijun HOU Chang LIU Tianqi BI bobo wang Yidan CHENG Jianhua LI Xichen ZHANG Key Laboratory of Zoonosis Research by Ministry of Education Institute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchunChina College of Wildlife and Protected Area Northeast Forestry UniversityHarbinChina Changchun Animal and Plant Park ChangchunChina

INTRODUCTION Pentatrichomonas hominis,an anaerobic flagellated protozoan that inhabits the large intestines of mammals and belongs to the Trichomonadidae family(Wenrich 1944;Kim et al.2010;Li et al.2014b,2016,2018a,2020;Maritz et al.2014;Zhang et al.2019),is mainly transmitted through the fecal-oral *** was originally presumed to be a commensal protozoan(Tolbert et al.2012)but was found to cause gastrointestinal symptoms.

关键词： Panthera Penta northeast

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基于数据融合的ECT图像重建算法

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仪器仪表学报 2015年第12期36卷 2798-2803页

作者：马敏王伯波薛倩中国民航大学航空自动化学院天津300300

针对固定电极的ECT成像独立测量值较少和因电极位置的影响而导致重建图像失真等问题,提出了基于旋转电极ECT系统模型和数据融合方法来提高重建图像质量。本模型对16电极的ECT模型进行5次旋转,得到的数据采用两种方式进行处理:一是5组数... 详细信息

针对固定电极的ECT成像独立测量值较少和因电极位置的影响而导致重建图像失真等问题,提出了基于旋转电极ECT系统模型和数据融合方法来提高重建图像质量。本模型对16电极的ECT模型进行5次旋转,得到的数据采用两种方式进行处理:一是5组数据分别采用线性反投影(LBP)和修正共轭梯度法(MCG)进行重建,再对重建数据进行主分量分析(PCA)的数据融合;二是直接用PCA数据融合再分别进行LBP和MCG图像重建。实验证明:通过增加测量电容数,结合两种数据处理方式可明显提高重构图像质量,降低成像误差。

关键词： ECT PCA 旋转模型数据融合

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Zbtb1 gene promotes lymphoid development and inhibits myeloid generation in mice

Zbtb1 gene promotes lymphoid development and inhibits myeloi...

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第十二届全国免疫学学术大会

作者： xue yujia Cao Xin wang Chen Du Jianglong Xu Qiang wang bobo Ma Xiaoxia Cai Kuizheng Ma Zhongren 西北民族大学

Expression of the transcription factor Zbtb1 is required for normal lymphoid *** report in the present study that the hematopoietic stem cells of Zbtb1-mutant(ScanT) mice become myeloid cells under lymphoid-inductive conditions in ***,overexpression of the anti-apoptotic gene Bcl2 in the hematopoietic stem cells of Zbtb1-mutant(ScanT) mice only partially recovered their early T-cell development,without reverting their myeloid *** addition,overexpression of the Zbtb1 gene in the wild type hematopoietic stem cells could suppress myeloid development under myeloid-inductive ***,Zbtb1 gene can promote lymphoid development possibly by suppressing apoptosis,while it can inhibit myeloid developent by modulating the transcriptional level of Csf1 r.

关键词： Zbtbl gene lymphocyte myeloid cells Csflr

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A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants

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Molecular Plant 2018年第11期11卷 1400-1417页

作者： Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao bobo wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang Collaborative Innovation Center of Henan Grain Crops Henan Agricultural UniversityZhengzhou 450002China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Department of Kinesiology and Integrative Physiology Life Science and Technology institutedMichigan Technological UniversityHoughtonMI 49931USA School of Technology Michigan Technological UniversityHoughtonMI 49931USA Guangdong Provincial Key Laboratory for Plant Epigenetics College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060P.R.China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083P.R.China Key Laboratory of Plant Stress Biology State Key Laboratory of Cotton BiologySchool of Life SciencesHenan UniversityKaifeng 475004China Department of Biotechnology Sharda UniversityGreater Noida201306India Key Laboratory of Rice Biology in Henan Province Henan Agricultural UniversityZhengzhou 450002China Department of Biological Sciences Ufe Science and Technology InstituteMichigan Technological UniversityHoughtonMI 49931USA Department of Botany and Plant Sciences Institute of Integrative Genome BiologyUniversity of CaliforniaRiversideCA 92521USA School of Forest Resources and Environmental Science Life Science and Technology InstituteMichigan Technological UniversityHoughtonMI 49931USA Department of Computer Science Michigan Technological UniversityHoughtonMI 49931USA Anhui Province Key Laboratory of Medical Physics and Technology Center of Medical Physics and TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhuiChina Hefei Cancer Hospital Chinese Academy of SciencesHefeiAnhuiChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina

microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene *** previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in ***,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of *** not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and ***-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA *** facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (https://***/***) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants.

关键词： short tandem target mimic (STTM) miRNA RNA-seq Arabidopsis crop

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选煤厂机械设备维护方法探究

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能源与节能 2020年第8期 115-116页

作者：王博博大同煤矿集团公司精煤分公司燕子山选煤厂山西大同037037

以选煤厂机械设备的维护方法为对象,围绕加压过滤机的维护管控开展全面探究,在分析加压过滤机结构与运行原理的基础上,对加压过滤机日常维护进行综合分析,希望能够为其他矿井相似工程的开展提供借鉴和参考。

关键词：选煤厂机械设备加压过滤机日常维护

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基于物联网技术的地铁通信传输系统设计

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通信电源技术 2024年第13期41卷 49-51页

作者：王博博中铁十二局电气化工程有限公司天津300300

文章针对地铁运营管理面临的效率、安全、服务等挑战,提出了一种基于物联网技术的地铁通信传输系统设计方案。该方案采用模块化架构,由数据采集、数据传输、系统应用3个功能模块组成。系统综合利用多种通信技术和人工智能算法,实现了地... 详细信息

文章针对地铁运营管理面临的效率、安全、服务等挑战,提出了一种基于物联网技术的地铁通信传输系统设计方案。该方案采用模块化架构,由数据采集、数据传输、系统应用3个功能模块组成。系统综合利用多种通信技术和人工智能算法,实现了地铁全场景、全过程、全方位的智慧管控。通过系统验证实验,证明了文章设计的物联网地铁通信传输系统在关键性能指标上较传统系统取得了显著提升。

关键词：物联网地铁通信传输智能化

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新时代国土空间规划体系下村庄规划探析

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城市建筑 2021年第18期18卷 57-59页

作者：王波波四川省国土科学技术研究院(四川省卫星应用技术中心) 四川成都610000

随着社会发展和经济的稳定增长,各行各业都得到了快速的发展。在国土空间规划工作开展中,乡村振兴规划要结合乡村发展建设,落实规划方案编制工作,不断发掘乡村发展优势,持续进行乡村地区的整体建设。相关部门要明确乡村规划定位和发展目... 详细信息

随着社会发展和经济的稳定增长,各行各业都得到了快速的发展。在国土空间规划工作开展中,乡村振兴规划要结合乡村发展建设,落实规划方案编制工作,不断发掘乡村发展优势,持续进行乡村地区的整体建设。相关部门要明确乡村规划定位和发展目标,并积极进行乡村区域专项规划的科学研究,完善乡村规划体系,以此来实现乡村振兴战略所提出的生态宜居、生活富足的建设目标。对于乡村规划中所出现的问题要进行科学的分析并采取有效的解决对策,以此来促进社会和谐稳定发展。

关键词：新时代国土空间规划体系村庄规划因地制宜

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基于两个细则的超临界机组AGC快速响应优化

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重庆电力高等专科学校学报 2019年第5期24卷 27-29页

作者：王波波华电内蒙古能源有限公司土默特发电分公司

介绍了华电土右电厂660 MW超临界机组基于电网“两个细则”的AGC快速响应优化相关内容,以及优化后的成果。通过协调子模块优化,以及引入超前响应、模糊控制等先进控制技术,在确保机组协调控制系统品质的同时,实现对机组负荷指令的快速... 详细信息

介绍了华电土右电厂660 MW超临界机组基于电网“两个细则”的AGC快速响应优化相关内容,以及优化后的成果。通过协调子模块优化,以及引入超前响应、模糊控制等先进控制技术,在确保机组协调控制系统品质的同时,实现对机组负荷指令的快速响应。

关键词：超临界机组 AGC响应协调控制优化

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