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Bronchoalveolar lavage fluid assessment facilitates precision medicine for lung cancer

Cancer Biology & Medicine 2024年第3期21卷 230-251页

作者： Hantao Zhang Dan deng Shujun Li Jing Ren Wei Huang Dan Liu Weiya Wang Department of Pathology West China HospitalSichuan UniversityChengdu 610000China West China Biobank West China HospitalSichuan UniversityChengdu 610000China Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengdu 610000China

Lung cancer is the most common and fatal malignant disease worldwide and has the highest mortality rate among tumor-related causes of *** diagnosis and precision medicine can significantly improve the survival rate and prognosis of lung cancer *** present,the clinical diagnosis of lung cancer is challenging due to a lack of effective non-invasive detection methods and biomarkers,and treatment is primarily hindered by drug resistance and high tumor *** biopsy is a method for detecting circulating biomarkers in the blood and other body fluids containing genetic information from primary tumor *** lavage fluid(BALF)is a potential liquid biopsy medium that is rich in a variety of bioactive substances and cell *** contains information on the key characteristics of tumors,including the tumor subtype,gene mutation type,and tumor environment,thus BALF may be used as a diagnostic supplement to lung *** this review,the current research on BALF in the diagnosis,treatment,and prognosis of lung cancer is *** advantages and disadvantages of different components of BALF,including cells,cell-free Dna,extracellular vesicles,and micro Rna are *** particular,the great potential of extracellular vesicles in precision diagnosis and detection of drug-resistant for lung cancer is *** addition,the performance of liquid biopsies with different body fluid sources in lung cancer detection are compared to facilitate more selective studies involving BALF,thereby promoting the application of BALF for precision medicine in lung cancer patients in the future.

关键词： Lung cancer bronchoalveolar lavage fluid extracellular vesicles liquid biopsy precision medicine

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Discussion on 'Was the 2008 Wenchuan earthquake triggered by Zipingpu Reservoir?'

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Earthquake Science 2010年第6期23卷 577-581页

作者： Shiyong Zhou Kai deng Cuiping Zhao Wanzheng Cheng School of Earth and Space Sciences Peking University Beijing 100871 China Institute of Earthquake Science China Earthquake Administration Beijing 100036 China Earthquake Administration of Sichuan Province Chengdu 610041 China

Some recent publications presented a result suggesting that Zipingpu reservoir hastened the occurrence of the 2008 Ms8.0 Wenchuan earthquake by tens to hundreds of years. Their researches calculated the Coulomb stress change induced by Zipingpu reservoir on the rupturing fault of Wenchuan earthquake. Their results, however, are critically dependent upon the 3-D event location, reservoir location, and the fault plane orientation. We repeated Ge et al.＇s work in this paper and found that an improper dip angle parameter of their 2-D fault model might lead to a wrong conclusion. both the modeling results based on the 2-D model and 3-D model with proper fault parameters will show Coulomb stress changes alone were neither large enough nor had the correct orientation to affect the occurrence of Wenchuan earthquake, which supports our recent argument based on the local seismicity analysis and the induced Coulomb stress change calculation with a 3-D model.

关键词： Wenchuan earthquake reservoir induced seismicity Coulomb stress

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Role of microRna-7 in digestive system malignancy

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World Journal of Gastrointestinal Oncology 2016年第1期8卷 121-127页

作者： wan-qun chen ling hu geng-xin chen hai-xia deng guangdong provincial hospital of chinese medicine Guangzhou 510120Guangdong ProvinceChina institute of gastroenterology guangzhou university of chinese medicineGuangzhou 510004Guangdong ProvinceChina guangdong provincial hospital of chinese medicine guangdong provincial key laboratory of clinical research on traditional chinese medicine syndromeGuangzhou 510120Guangdong ProvinceChina

There are several malignancies of the digestive system(including gastric, pancreatic and colorectal cancers, and hepatocellular carcinoma), which are the most common types of cancer and a major cause of death worldwide. MicroRna(miR)-7 is abundant in the pancreas, playing an important role in pancreatic development and endocrine function. Expression of miR-7 is downregulated in digestive system malignancies compared with normal tissue. Although there are contrasting results for miR-7 expression, almost all research reveals that miR-7 is a tumor suppressor, by targeting various genes in specific pathways. Moreover, miR-7 can target different genes simultaneously in different malignancies of the digestive system. By acting on many cytokines, miR-7 is also involved in many gastrointestinal inflammatory diseases as a significant carcinogenic factor. Consequently, miR-7 might be a biomarker or therapeutic target gene in digestive system malignancies.

关键词： MicroRna-7 Digestive system malignancy Tumor biomarker Target gene Inflammation

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The Redefinition on Formation Time of the Lapeiquan Group in the Hongliugou Area, North Altyn: Constrains from New Detrital Zircon LA-ICP-MS U-Pb Ages

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Acta Geologica Sinica(English Edition) 2019年第6期93卷 1971-1973页

作者： DONG Shunli YAN Zhaokun REN Jing WANG Xinwei ZHAO Shaoze deng Tao State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu 610059China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Key Laboratory of Sedimentary Basin and Oil and Gas Resources Ministry of Land and ResourcesChengdu 610081China Chengdu Center China Geological SurveyChengdu 610081China

Objective The Early Paleozoic tectonic events such as oceanic subduction and collision-orogeny in the North Altyn have been extensively *** Lapeiquan Group,distributed in the Hongliugou ophiolite melange belt(Fig.1),w... 详细信息

关键词： tectonic Ordovician Paleozoic

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Fabrication of flexible α-MnO_2 nanowire membranes with superior mechanical strength

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Chinese Science Bulletin 2014年第13期59卷 1454-1458页

作者： Xingyue Zhao Xiaochong Zhao Jianbao Li Xiangyun deng Hong Lin State Key Laboratory of New Ceramics & Fine Processing School of Materials Science and Engineering Tsinghua University Science and Technology on Surface Physics and Chemistry Laboratory Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources Hainan University College of Physics and Electronic Information Tianjin Normal University

The Assembly of one-dimensional(1D)nanostructures such as nanowires/nanorods/nanotubes into twodimensional(2D)macrostructured films is attracting considerable research interest because of their unique properties and wide *** this study,flexible membranes were successfully fabricated using a-MnO2nanowires synthesized through a hydrothermal *** effects of thickness and post-annealing temperature on the mechanical properties of the membranes were investigated in ***-indentation measurements showed that the modulus of the as-prepared 11.75 lm-thick membrane reached5.765 GPa,and the modulus increased with the increasing post-annealing ***,the fabricated membranes with superior mechanical strength can have potential applications such as in photocatalysis,filtering,and supporting substrates.

关键词：机械强度二氧化锰纳米线制造膜退火温度机械性能水热法合成

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流通技术在我国农产品批发市场中的应用研究

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北京工商大学学报（社会科学版） 2010年第6期25卷 11-16页

作者：李丽邓博文中国社会科学院财政与贸易经济研究所北京100836 北京工商大学经济学院北京100048

以流通中的商流、物流和信息流为主线,分析了流通技术在我国农产品批发市场中的应用现状和存在的问题,提出发展电子商务,增强农产品批发市场商流模式的多元化、建立物流配送中心,不断完善农产品物流网络、积极进行信息化建设,建立一体... 详细信息

以流通中的商流、物流和信息流为主线,分析了流通技术在我国农产品批发市场中的应用现状和存在的问题,提出发展电子商务,增强农产品批发市场商流模式的多元化、建立物流配送中心,不断完善农产品物流网络、积极进行信息化建设,建立一体化的网络系统等建议,最后展望了流通技术在我国农产品批发市场中的应用前景。

关键词：流通技术农产品批发市场

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Crystal face dependent intrinsic wettability of metal oxide surfaces

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national Science Review 2021年第1期8卷 109-116页

作者： Zhongpeng Zhu Zhenwei Yu Frank F.Yun deng Pan Ye Tian Lei Jiang Xiaolin Wang Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of Sciences Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang University Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of Wollongong

Knowledge of intrinsic wettability at solid/liquid interfaces at the molecular level perspective is significant in understanding crucial progress in some fields, such as electrochemistry, molecular biology and earth science. It is generally believed that surface wettability is determined by the surface chemical component and surface topography. However, when taking molecular structures and interactions into consideration,many intriguing phenomena would enrich or even redress our understanding of surface wettability. From the perspective of interfacial water molecule structures, here, we discovered that the intrinsic wettability of crystal metal oxide is not only dependent on the chemical components but also critically dependent on the crystal faces. For example, the （1■02） crystal face of α-Al;O;is intrinsically hydrophobic with a water contact angle near 90°, while another three crystal faces are intrinsically hydrophilic with water contact angles nalysis, it is found that the total surface energy, polar component and Lewis base portion of the hydrophobic crystal face are all smaller than the other three hydrophilic crystal faces indicating that they have different surface states. DFT simulation further revealed that the adsorbed interfacial water molecules on each crystal face hold various orientations. Herein, the third crucial factor for surface wettability from the perspective of the molecular level is presented, that is the orientations of adsorbed interfacial water molecules apart from the macro-level chemical component and surface topography. This study may serve as a source of inspiration for improving wetting theoretical models and designing controllable wettability at the molecular/atomic level.

关键词： anisotropic wettability α-Al2O3 interfacial water layer surface energy DFT simulation

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Paleomagnetic study on volcanic rocks in Pulu, Xinjiang

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Chinese Science Bulletin 1997年第6期42卷 481-484页

作者： Meng, ZF Li, YG deng, YS Fu, BH Sun, DJ Lanzhou Institute of Geology Chinese Academy of Sciences Lanzhou China Institute of Geology and Mineral Resources BGMR Xinjiang Urumqi China

MOST of the preexisting paleomagnetic studies on the Tarim Basin were conducted within its northern ànd northwestern margins with the exception that few people have paid their attention to starting paleomagnetism study along the southern and southwestern rims of the basin. Here we report our new results from volcanic rocks distributed in Pulu area

关键词： Tarim Pulu paleomagnetism Qinghai-Xizang Plateau.

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A historical overview of nano-optics:From near-field optics to plasmonics

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Chinese Physics B 2024年第5期33卷 134-145页

作者：邓妙怡朱星 Department of History of Science Technology and MedicineAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China School of Physics Peking UniversityBeijing 100871China

nano-optics is an emergent research field in physics that appeared in the 1980s,which deals with light–matter optical interactions at the nanometer *** early studies of nano-optics,the main concern focus is to obtain higher optical resolution over the diffraction *** researches of near-field imaging and spectroscopy based on scanning near-field optical microscopy(SNOM)are *** exploration of improving SNOM probe for near-field detection leads to the emergence of surface *** the sense of resolution and wider application,there has been a significant transition from seeking higher resolution microscopy to plasmonic near-field modulations in the nano-optics community during the nano-optic ***,studies of nano-optics prefer the investigation of plasmonics in different material *** this article,the history of the development of near-field optics is briefly *** difficulties of conventional SNOM to achieve higher resolution are *** an alternative solution,surface plasmons have shown the advantages of higher resolution,wider application,and flexible nano-optical modulation for new *** typical studies in different periods are introduced and characteristics of nano-optics in each stage are *** this way,the evolution progress from near-field optics to plasmonics of nano-optics research is *** future development of nano-optics is discussed then.

关键词： nano-optics near-field optics surface plasmon plasmonic modulation

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呈味肽的制备、纯化与鉴定

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中国酿造 2017年第4期36卷 142-148页

作者：邓莉郝学财刘娜天津春发生物科技集团有限公司研发中心天津市风味食品配料企业重点实验室天津300300

采用酶解法以鸡肉为原料进行鸡肉蛋白多肽的制备,通过葡聚糖凝胶柱层析法对混合多肽进行不同分子质量片断的分离,确定最优的分离填料为G25、洗脱液为乙醇-水,在此条件下,分子质量5 000 u的组分含量达78%、分子质量1 000~5 000 u的组分... 详细信息

采用酶解法以鸡肉为原料进行鸡肉蛋白多肽的制备,通过葡聚糖凝胶柱层析法对混合多肽进行不同分子质量片断的分离,确定最优的分离填料为G25、洗脱液为乙醇-水,在此条件下,分子质量5 000 u的组分含量达78%、分子质量1 000~5 000 u的组分含量达70%。通过感官评价、电子舌分析发现,不同分子质量片段多肽提供的风味侧重点不同,分子质量<1 000 u的多肽热反应产物在醇厚感、嗜好性方面最优。利用高效液相色谱、液质联用仪对该肽段进一步纯化与鉴定,找到其中5条呈味肽,并采用固相合成法制备,经感官评价验证其呈味功能,发现在清水评价中,合成的5条多肽呈味效果以酸、甜、鲜味为主;在鸡粉溶液加香评价中,呈现鲜味最强的多肽为γ-L-Glu-L-Glu和γ-L-Glu-L-Val-Gly;呈现醇厚感最强的多肽为L-GSH。

关键词：呈味肽酶解分离纯化鉴定

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