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Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis

Bioactive Materials 2022年第1期7卷 14-25页

作者： bo-bae seo Youngjoong Kwon Jun Kim Ki Hyun Hong Sung-Eun Kim Hae-Ryong Song Young-Min Kim Soo-Chang Song Center for Biomaterials Korea Institute of Science&TechnologySeoul02792South Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul02792South Korea Department of Orthopedic Surgery and Rare Diseases Institute Korea University Medical College Guro HospitalSeoul08308South Korea

Treatment of osteoarthritis(OA)by administration of corticosteroids is a commonly used method in clinics using anti-inflammatory *** administration or intra-articular injection of corticosteroids can reduce the pain and progress of cartilage degeneration,but they are usually insufficient to show local and long-term anti-inflammatory effects because of their fast clearance in the *** this study,we suggest an injectable anti-OA drug depot system for sustained drug release that provides long-term effective therapeutic *** poly(organophosphazene),which has temperature-dependent nanoparticle forming and sol-gel transition behaviors when dissolved in aqueous solution,was synthesized for triamcinolone acetonide(TCA)*** hydrophobic parts of the polymer can interact with hydrophobic parts of the TCA,the TCA was encapsulated into the self-assembled polymeric *** TCA-encapsulated polymeric nanoparticles(TePNs)were well dispersed in an aqueous solution below room temperature so that they can be easily injected as a sol state into an intra-articular ***,the TePNs solution transforms immediately to a viscose 3D hydrogel like a synovial fluid in the intra-articular region via the conducted body *** in vitro TCA release study showed sustained TCA release for six ***-time injection of the TePN hydrogel system in an early stage of OA-induced rat model showed a great inhibition effect against further OA *** OA-induced knees completely recovered as a healthy cartilage without any abnormal symptoms.

关键词： Thermosensitive hydrogel Triamcinolone acetonide Polymer nanoparticle Osteoarthritis Sustained release

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Effect of friction on the contact stress of a coated polymer gear

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Friction 2020年第6期8卷 1169-1177页

作者： Su-Min bae Kuk-Jin seo Dae-Eun KIM Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea

Polymer gears are used extensively in various ***,durability issues have been emerging because of friction at gear tooth contact *** extend the lifetime of polymer gears,a low-frictional coating has been considered as a possible *** this study,a finite element simulation method was performed to investigate the contact stress between a pair of coated polymer *** simulation included various friction coefficients(COFs)for studying the effects of friction during the *** results revealed that the friction causes the contact stress to shift over the roll angle,which is attributed to the direction of the sliding friction based on a free-body *** also investigated the effects of coating and found that a thin coating has little effect on the bulk deformation behavior of the ***,the stress distribution in the coating at the pitch point was investigated as the COF *** zero friction,three notable stress regions were observed:1)the center of the surface,2)the end of the contact,and 3)the overall contact *** COF was increased in the micro-slip region of the contact interface,both tensile and compressive stresses in the coating *** study provides significant aid to engineers for understanding the stress response of the coating applied to polymer gears to achieve an optimal design.

关键词： coating contact stress finite element method(FEM) friction polymer gear

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Mg Alloy Foam Fabrication via Melt Foaming Method

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Journal of Materials Science & Technology 2008年第3期24卷 302-304页

作者： Changhwan seo bo-Young HUR i-Cube Center ERISchool of Nano & Advanced Materials EngineeringGyeongsang National University

For the first time AZ91 （MgAl9Zn1） and AM60 （MgAl6） Mg alloy foams with homogeneous pore structures were prepared successfully via melt foaming method using CaCO3 as blowing agent. It is revealed that the blowing gas to foam the melt is not CO2 but CO, which comes from liquid-solid reaction between Mg melt. The reaction temperature is more than 100℃ lower than CaCO3 decomposition, which makes Mg alloy melts foam into cellular structure much more easily in the temperature range from 690℃ to 750℃.

关键词： Mg alloy foam CaCO3 Blowing gas

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Full‑Fiber Auxetic‑Interlaced Yarn Sensor for Sign‑Language Translation Glove Assisted by Artificial Neural Network

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Nano-Micro Letters 2022年第8期14卷 269-282页

作者： Ronghui Wu Sangjin seo Liyun Ma Juyeol bae Taesung Kim Department of Mechanical Engineering Ulsan National Institute of Science and Technology(UNIST)50 UNIST‑GilUlsan 44919Republic of Korea College of Physical Science and Technology Xiamen UniversityXiamen 361005People’s Republic of China

Yarn sensors have shown promising application prospects in wearable electronics owing to their shape adaptability, good flexibility, and weavability. However, it is still a critical challenge to develop simultaneously structure stable, fast response, body conformal, mechanical robust yarn sensor using full microfibers in an industrial-scalable manner. Herein, a full-fiber auxetic-interlaced yarn sensor(AIYS) with negative Poisson’s ratio is designed and fabricated using a continuous, mass-producible, structure-programmable, and low-cost spinning technology. Based on the unique microfiber interlaced architecture, AIYS simultaneously achieves a Poisson’s ratio of-1.5, a robust mechanical property(0.6 c N/dtex), and a fast train-resistance responsiveness(0.025 s), which enhances conformality with the human body and quickly transduce human joint bending and/or stretching into electrical signals. Moreover, AIYS shows good flexibility, washability, weavability, and high repeatability. Furtherly, with the AIYS array, an ultrafast full-letter sign-language translation glove is developed using artificial neural network. The sign-language translation glove achieves an accuracy of 99.8% for all letters of the English alphabet within a short time of 0.25 s. Furthermore, owing to excellent full letter-recognition ability, real-time translation of daily dialogues and complex sentences is also demonstrated. The smart glove exhibits a remarkable potential in eliminating the communication barriers between signers and non-signers.

关键词： Negative Poisson’s ratio yarns Interlaced yarn sensors Smart glove Deep learning Sign-language translation

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Callus proliferation-induced hypoxic microenvironment decreases shoot regeneration competence in Arabidopsis

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Molecular Plant 2024年第3期17卷 395-408页

作者： Dohee Koo Hong Gil Lee Soon Hyung bae Kyounghee Lee Pil Joon seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Research Institute of Basic Sciences Seoul National UniversitySeoul 08826Korea

Plants are aerobic organisms that rely on molecular oxygen for respiratory energy *** conditions,with oxygen levels ranging between 1%and 5%,usually limit aerobic respiration and affect plant growth and ***,we demonstrate that the hypoxic microenvironment induced by active cell proliferation during the two-step plant regeneration process intrinsically represses the regener-ation competence of the callus in Arabidopsis *** showed that hypoxia-repressed plant regener-ation is mediated by the RELATED TO APETALA2.12(RAP2.12)protein,a memberof the Ethylene Response Factor VIl(ERF-Vll)*** found that the hypoxia-activated RAP2.12 protein promotes salicylic acid(SA)biosynthesis and defense responses,thereby inhibiting pluripotency acquisition and de novo shoot regeneration in *** and genetic analyses revealed that RAP2.12 could bind directly to the SALICYLIC ACID INDUCTION DEFICIENT 2(SID2)gene promoter and activate SA biosynthesis,repressing plant regeneration possibly via a PLETHORA(PLT)-dependent ***,the rap2.12 mutant calli exhibits enhanced shoot regeneration,which is impaired by SA *** together,these find-ings uncover that the cell proliferation-dependent hypoxic microenvironment reduces cellular pluripotency and plant regeneration through the RAP2.12-SID2 module.

关键词： callus cell proliferation-induced hypoxia SID2 plant regeneration salicylic acid RAP2.12

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Process of establishing design requirements and selecting alternative configurations for conceptual design of a VLA

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Chinese Journal of Aeronautics 2017年第2期30卷 738-751页

作者： bo-Young bae Sangho Kim Jae-Woo Lee Nhu Van Nguyen bong-Cheul Chung Department of Aerospaee Information Engineering Konkuk University Seoul 143-701 Republic of Korea Konkuk Aerospace Design Airworthiness Research Institute Konkuk University Seoul 143-701 Republic of Korea

In this study,a process for establishing design requirements and selecting alternative configurations for the conceptual phase of aircraft design has been *** proposed process uses system-engineering-based requirement-analysis techniques such as objective tree,analytic hierarchy process,and quality function deployment to establish logical and quantitative ***,in order to perform a logical selection of alternative aircraft configurations,it uses advanced decision-making methods such as morphological matrix and technique for order preference by similarity to the ideal *** addition,a preliminary sizing tool has been developed to check the feasibility of the established performance requirements and to evaluate the flight performance of the selected *** present process has been applied for a two-seater very light aircraft（VLA）,resulting in a set of tentative design requirements and two families of VLA configurations：a high-wing configuration and a low-wing *** resulting set of design requirements consists of three categories：customer requirements,certification requirements,and performance *** performance requirements include two mission requirements for the flight range and the endurance by reflecting the customer *** flight performances of the two configuration families were evaluated using the sizing tool developed and the low-wing configuration with conventional tails was selected as the best baseline configuration for the VLA.

关键词： Aircraft configuration Conceptional design Design requirements Requirement analysis Very light aircraft (VLA)

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Clinical significance of tumor-infiltrating lymphocytes for gastric cancer in the era of immunology

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World Journal of Gastrointestinal Oncology 2017年第7期9卷 293-299页

作者： Byung Woog Kang Jong Gwang Kim In Hee Lee Han Ik bae An Na seo Department of Hematology/Oncology Kyungpook National University Hospital Kyungpook National University School of Medicine Department of Pathology Kyungpook National University Hospital Kyungpook National University School of Medicine

Immunotherapy has begun to revolutionize cancer treatment, by introducing therapies that target the host immune system instead of the tumor, therapies that possess unique adverse event profiles, and therapies that may cure certain types of cancer. The immune microenvironment of tumors is emerging as the most important means of understanding the relationship between a patient' immune system and their cancer, informing prognosis, and guiding immunotherapy, such as an antibody blockade of immune checkpoints. For some solid tumors, simple quantitation of lymphocyte infiltration would seem to have prognostic significance, suggesting that lymphocyte infiltration is not passive but may actively promote or inhibit tumor growth. For gastric cancers, several studies have provided strong evidence that immune cells contribute to determining prognosis. However, the exact role of immune cells in gastric cancer remains unclear. Therefore, this review focuses on the clinical significance of immune cells, especially tumor-infiltrating lymphocytes, in gastric cancer.

关键词： Gastric cancer Tumor-infiltrating lymphocytes Immunotherapy

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Crashworthiness assessment of thin-walled double bottom tanker: Influences of seabed to structural damage and damage-energy formulae for grounding damage calculations

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Journal of Ocean Engineering and Science 2020年第4期5卷 387-400页

作者： Aditya Rio Prabowo bo Cao Jung Min Sohn Dong Myung bae Department of Mechanical Engineering Universitas Sebelas MaretSurakartaIndonesia China Shipbuilding Industry Corporation Economic Research Center BeijingChina Department of Naval Architecture and Marine Systems Engineering Pukyong National UniversityBusanSouth Korea

This work presents results of numerical analyses with focus on structural performance accounting for seabed topology,and investigation of energy formulae for application in calculation of grounding *** in this work is divided into three stages,*** element method(FEM)verification using laboratory experiment,numerical calculation of ship grounding using FEM,and comparison of the FEM results with empirical formulae of damage-energy *** formula of Minorsky is considered with other improvement expression,such as Woisin and *** suggested that the recent-developed expression produces the closest estimation to the verified FEM *** the other hand,fundamental formulae of Minorsky is the farthest compared to the FEM,which indicates constant value in the expression needs to be more specific as improved in the Woisin formula.

关键词： Ship grounding impact test finite element method damage-energy formula crashworthiness criteria

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Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity

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World Journal of Gastroenterology 2009年第38期15卷 4799-4805页

作者： Sae-Kwang Ku Bu-Il seo Ji-Ha Park Gyu-Yeol Park Young-bae seo Jae-Soo Kim Hyeung-Sik Lee seong-Soo Roh Department of Histology and Anatomy College of Oriental MedicineDaegu Haany University Department of Herbology College of Oriental MedicineDaegu Haany University Department of Herbology College of Oriental MedicineDaejeon University Department of Acupuncture & Moxibustion College of Oriental MedicineDaegu Haany University Department of Clinical Laboratory Science College of Health and TherapyDaegu Haany University

AIM： To observe the effects of traditional antiinflammatory medicine Lonicerae FIos （LF） on rat reflux esophagitis （RE） induced by pylorus and forestomach ligation compared with the well-known proton antioxidant, α-tocopherol. METHODS： Rats were pretreated with three different dosages of LF （500, 250 and 125 mg/kg） orally, once a day for 14 d before pylorus and forestomach ligation. Nine hours after pylorus and forestomach ligation, changes to the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal lipid peroxidation, superoxide dismutase （SOD）, catalase （CAT）, malondialdehyde （MDA）, myeloperoxidase and glutathione （GSH） levels, and collagen contents （marker of flexibility） were observed on the esophageal and fundic histopathology. The results were compared with an α-tocopherol （once orally, 1 h before operation, 30 mg/kg） treated group in which the effects on RE were already ***： Pylorus and forestomach ligations caused marked increases of gross esophageal and gastric mucosa lesion areas, which corresponded with histopathological changes. In addition, increases of esophageal lipid peroxidation, decreases of SOD, CAT, and GSH-free radical scavengers, increases of collagen were observed. However, these pylorus and forestomach ligation induced RE were dose-dependently inhibited by treatment of 500, 250 and 125 mg/kg of LF extract, mediated by antioxidant effects. RE at 250 mg/kg showed similar effects α-tocopherol. CONCLUSION： The results suggest that antioxidant effects of LF could attenuate the severity of RE and prevent the esophageal mucosal damage, and validate its therapeutic use in esophageal reflux disease.

关键词： Reflux esophagitis Tocopherol LoniceraeFlos Antioxidant Myeloperoxidase Pylorus and forestomach ligations

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Mechanical properties of aluminum-based nanocomposite reinforced with fullerenes

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 47-52页

作者： Kwangmin CHOI Jiyeon seo Donghyun bae Hyunjoo CHOI School of Advanced Materials Engineering Kookmin University School of Advanced Materials Engineering Yonsei University

The strengthening effect of fullerenes in aluminum matrix composites was investigated. The composites are produced using a two-step ball-milling technique combined with a hot rolling process. First, fullerene aggregates, where fullerene molecules initially come together to form giant particles(~200 μm in diameter) via van der Waals bonding, are shattered into smaller particles(~1 μm in diameter) by planetary milling. Second, primarily ball-milled fullerenes are dispersed in aluminum powder via attrition milling. Finally, aluminum/fullerene composite powder is consolidated by hot-rolling at 480 °C. For the composite sheet, grain refinement strengthening and dispersion hardening by fullerenes are accomplished at the same time, thereby exhibiting HV ~222 of Vickers hardness(e.g., ~740 MPa of yield strength) with only 2%(volume fraction) of fullerenes.

关键词： aluminum fullerenes ball-milling powder metallurgy composites

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