检索结果-南通市图书馆

One-step laparoscopic pancreatic necrosectomy verse surgical step-up approach for infected pancreatic necrosis:a case-control study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2022年第4期13卷 274-282页

作者： sheng-bo han Ding Chen Qing-yong Chen Ping Hu Hai Zheng Jin-huang Chen Peng Xu Chun-you Wang Gang Zhao Department of Emergency Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Pancreatic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

BACKGROUND:The surgical step-up approach often requires multiple debridements and might not be suitable for infected pancreatic necrosis(IPN)patients with various abscesses or no safe route for percutaneous catheter drainage(PCD).This case-control study aimed to investigate the safety and effectiveness of one-step laparoscopic pancreatic necrosectomy(LPN)in treating ***:This case-control study included IPN patients undergoing one-step LPN or surgical step-up in our center from January 2015 to December *** short-term and long-term complications after surgery,length of hospital stay,and postoperative ICU stays in both groups were *** and multivariate logistic regression analyses were performed to explore the risk factors of major complications or ***:A total of 53 IPN patients underwent one-step LPN and 37 IPN patients underwent surgical step-up approach in this *** was no significant difference in the incidence of death,major complications,new-onset diabetes,or new-onset pancreatic exocrine insufficiency between the two ***,the length of hospital stay in the one-step LPN group was significantly shorter than that in the surgical step-up *** regression analysis showed that the surgical approach(one-step/step-up)was not the risk factor for major complications or *** logistic regression analysis indicated that computed tomography(CT)severity index,American Society of Anesthesiologists(ASA)class IV,and white blood cell(WBC)were the significant risk factors for major complications or ***:One-step LPN is as safe and effective as the surgical step-up approach for treating IPN patients,and reduces total hospital stay.

关键词： Infected pancreatic necrosis One-step laparoscopic pancreatic necrosectomy Surgical step-up approach

在线全文

学校读者我要写书评

暂无评论

低温余热驱动的工业除湿系统性能研究

工程热物理学报 2017年第10期38卷 2054-2060页

作者：苏博生韩巍徐聪隋军中国科学院工程热物理研究所分布式冷热电联供系统北京市重点实验室北京100190 中国科学院大学北京100190

针对传统冷凝除湿方法耗电量大的问题,提出一种利用低温余热的双级溶液除湿系统,余热的高温部分通过再生器将稀溶液转换成浓溶液,余热的低温部分驱动单效吸收式制冷机制冷,实现了余热的梯级利用。浓溶液在第一级除湿器完成空气的初步除... 详细信息

针对传统冷凝除湿方法耗电量大的问题,提出一种利用低温余热的双级溶液除湿系统,余热的高温部分通过再生器将稀溶液转换成浓溶液,余热的低温部分驱动单效吸收式制冷机制冷,实现了余热的梯级利用。浓溶液在第一级除湿器完成空气的初步除湿,中间浓溶液经过吸收式制冷机降温提高吸收能力后,进入第二级除湿器对初步除湿的空气进行深度除湿。新系统与冷凝除湿系统相比,相对节电率达到96.17%,余热折合发电效率达到6.94%。通过研究双级除湿过程驱动力的匹配,发现除湿过程除湿工质与湿空气之间的表面水蒸气分压力更加匹配,除湿过程平均水蒸气分压力差比冷凝除湿过程减少20%以上。本研究提供了一种利用低温余热实现空气深度除湿的新型除湿系统流程与方案。

关键词：余热利用溶液除湿节电性工业应用水蒸气分压力

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan bo Ma Wenyong Xie Na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng han bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

在线全文

学校读者我要写书评

暂无评论

重大工程供应链协同合作利益分配研究

中国管理科学 2017年第5期25卷 42-51页

作者：时茜茜朱建波盛昭瀚南京大学工程管理学院江苏南京210093

本文以重大工程中承包商与供应商协同合作问题为研究对象,考虑到决策主体的决策环境、决策顺序和决策目的的不同,从分散决策模式、集中决策模式两种模式分别建立相应的协同合作动态博弈模型,模型构建考虑到承包商与供应商的异质性,从而... 详细信息

本文以重大工程中承包商与供应商协同合作问题为研究对象,考虑到决策主体的决策环境、决策顺序和决策目的的不同,从分散决策模式、集中决策模式两种模式分别建立相应的协同合作动态博弈模型,模型构建考虑到承包商与供应商的异质性,从而突出两者对协同合作贡献的不同权重,并分析给出不同模式下的最优利益分配机制、最优努力程度和供应链系统最优收益,最后进行比较分析与数值模拟。研究结果表明:当承包商和供应商的努力都对产出有影响时,不管哪种决策模式,承包商与供应商的协同合作必须要分享收益才可以激发合作积极性,而收益分配系数只与双方的产出贡献权重有关;存在双边道德风险时,承包商在分散决策模式下的收益高于集中决策模式,因而承包商倾向于选择分散决策模式,而供应商则相反,但承包商与供应商选择集中决策模式对供应链系统整体收益最优。

关键词：协同合作决策模式重大工程利益分配

Anomaly monitoring and early warning of electric moped charging device with infrared image

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年第3期 136-141页

作者： LI Jiamin han bo JIANG Mingshun School of Control Science and Engineering Shandong University

Potential high-temperature risks exist in heat-prone components of electric moped charging devices, such as sockets,interfaces, and controllers. Traditional detection methods have limitations in terms of real-time performance and monitoring scope. To address this, a temperature detection method based on infrared image processing has been proposed:utilizing the median filtering algorithm to denoise the original infrared image, then applying an image segmentation algorithm to divide the image.

关键词：

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli han bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

人工韧带与自体肌腱重建前交叉韧带的meta分析

在线全文

学校读者我要写书评

暂无评论

第二军医大学学报 2016年第10期37卷 1298-1305页

作者：邱勤业范震波胡汉生曾勉东余升华尹德龙李远辉广州医科大学附属第三医院骨科广州510000

目的系统评价LARS人工韧带及自体移植物在前交叉韧带重建中的安全性和有效性。方法通过检索PubMed数据库、中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBMdisc）、万方数据库获得已公开发表的LARS人工韧带与自体移植... 详细信息

目的系统评价LARS人工韧带及自体移植物在前交叉韧带重建中的安全性和有效性。方法通过检索PubMed数据库、中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBMdisc）、万方数据库获得已公开发表的LARS人工韧带与自体移植物进行前交叉韧带重建的文献。提取相关数据进行meta分析。结果本研究共纳入了9篇文献,总病例数456例,结果显示LARS人工韧带术后患者膝关节Lysholm评分及Tegner评分较术前有明显提高（Lysholm：MD=50.05,95%CI 48.41-51.68;Tegner：MD=4.41,95%CI 3.40-5.42）;并且在术后2年其Lysholm评分及Tegner评分改善较自体肌腱移植仍更明显（Lysholm：MD=0.20,95%CI 0.04-0.35;Tegner：MD=0.18,95%CI 0.04-0.32）。同时,术后2年LARS人工韧带组滑膜炎等并发症发生率低,与自体移植物无明显差异。结论 LARS人工韧带具有良好的临床疗效和安全性,并且在术后2年其稳定性较自体肌腱移植仍具有明显优势,但该结论仍需长随访、高质量的临床研究进一步证实。

关键词：前交叉韧带 LARS 自体移植 meta分析

Metal-organic frameworks (MOFs) in aqueous batteries (ABs):unlocking potential through innovative materials design

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： bo han Erhai Hu Bei-Er Jia Ziyang Liu Shuen Tso Afriyanti Sumboja Ivandini T.Anggraningrum Anne Zulfia Syahrial Qingyu Yan SCARCE Laboratory Energy Research Institute NTU (ERIN) Nanyang Technological University School of Materials Science and Engineering Nanyang Technological University Material Science and Engineering Research Group Faculty of Mechanical and Aerospace Engineering Institut Teknologi Bandung Department of Chemistry University of Indonesia Metallurgical & Materials Engineering Department Fakultas Teknik Universitas Indonesia

Metal-organic frameworks (MOFs) represent a revolutionary class of materials in the field of energy storage,particularly for aqueous batteries (ABs).Distinguished by their large surface area,tuneable porosity,and adaptable chemical activity,MOFs offer significant advantages over conventional materials in battery *** article provides a thorough analysis of the crucial role that MOFs play in improving the efficiency of *** includes a concise review of the current research progress,emphasizing the fundamental processes by which MOFs enhance electrochemical ***,the review examines the synthesis and design strategies for the structure of MOFs to maximize ion transport,improve conductivity,and enhance *** structural advantages,chemical versatility,stability,durability and functionalization potential of MOFs are comprehensively ***,we explore the distinct advantages of MOFs in overcoming common challenges encountered in ABs,such as declining capacity,inadequate cycling stability,and limited energy *** paper also highlights the future research directions needed to fully harness their *** goal is to develop a fundamental understanding and stimulate further progress in the use of MOFs for advanced energy storage solutions.

关键词：