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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han bo lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

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Significantly enhanced of tungsten diselenide functionalization optoelectronic performance phototransistor via surface

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Nano Research 2017年第4期10卷 1282-1291页

作者： bo lei Department of Physics National University of Singapore Singapore 117542 Singapore 2 Centre forAdvanced D Materials and Graphene Research Centre National University of Singapore Singapore 117546 Singapore Department of Chemistry National University of Singapore Singapore 117543 Singapore SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology Shenzhen University Shenzhen 518060 China National University of Singapore (Suzhou) Research Institute 377 Lin Quan Street Suzhou Industrial Park Suzhou 215123 China

Two-dimensional （2D） layered transition metal dichalcogenides （TMDs） have attracted enormous research interests and efforts towards the development of versatile electronic and optical devices, owing to their extraordinary and unique fundamental properties and remarkable prospects in nanoelectronic applications. Among the TMDs, tungsten diselenide （WSe2） exhibits tunable ambipolar transport characteristics and superior optical properties such as high quantum efficiency. Herein, we demonstrate significant enhancement in the device performance of WSe2 phototransistor by in situ surface functionalization with cesium carbonate （Cs2CO3）. WSe2 was found to be strongly doped with electrons after Cs2CO3 modification. The electron mobility of WSe2 increased by almost one order of magnitude after surface functionalization with 1.6-nm-thick Cs2CO3 decoration. Furthermore, the photocurrent of the WSe2-based phototransistor increased by nearly three orders of magnitude with the deposition of 1.6-nm-thick Cs2CO3. Characterizations by in situ photoelectron spectroscopy techniques confirmed the significant surface charge transfer occurring at the Cs2COB/WSe2 interface. Our findings coupled with the tunable nature of the surface transfer doping method establish WSe2 as a promising candidate for future 2D materials- based optoelectronic devices.

关键词： WSe2 in situ surface transfer doping performance enhancement phototransistor cesium carbonate

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(K_(0.5)Na_(0.5))Nb_(1-x)Ta_(x)O_(3)铁电性的第一性原理研究

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原子与分子物理学报 2025年第4期42卷 138-146页

作者：褚新建雷博程刘晨曦刘纪博新疆科技学院信息科学与工程学院库尔勒841000 新疆大学物理科学与技术学院新疆固体物理与器件重点实验室乌鲁木齐830046 西安工业大学光电工程学院西安710032

随着铅基陶瓷的大量使用,造成了严重的环境和健康问题,为了能够找寻替代铅基陶瓷的材料,人们开始了对无铅陶瓷材料的探索.(K_(0.5)Na_(0.5))Nbo_(3)材料由于其优异的铁电压电性能,成为了无铅陶瓷材料的代表,但是碱性组分在高温下的高挥... 详细信息

随着铅基陶瓷的大量使用,造成了严重的环境和健康问题,为了能够找寻替代铅基陶瓷的材料,人们开始了对无铅陶瓷材料的探索.(K_(0.5)Na_(0.5))Nbo_(3)材料由于其优异的铁电压电性能,成为了无铅陶瓷材料的代表,但是碱性组分在高温下的高挥发性使其应用范围受到了极大的限制.基于这样的考虑,本文基于密度泛函理论的第一性原理方法,探究了(K_(0.5)Na_(0.5))Nb_(1-x)TaxO_(3)(x=0.125,0.25,0.375,0.5,0.625,0.75,0.875,1)九种体系的铁电性能,结果表明:随着Ta浓度的增加,晶格常数发生了突变,由此猜测KNN材料随着Ta浓度的增加,发生了正交-单斜的相变;Ta的掺入能够降低KNN材料的烧结难度,且随着Ta浓度的增加,形成难度逐渐降低;掺杂体系中,Ta-4f轨道与Na-3p,K-4p以及O-2s轨道电子发生了杂化,使导带底Nb-4d与Na-3p电子的态密度峰向高能区移动,禁带宽度呈现增加的趋势;在分析KNN材料铁电性作用机理时发现KNN的铁电极化类型是离子位移型极化,且在[001]方向上不具有极化能力.分析掺杂后各个体系的极化强度,发现随着Ta浓度的增加,极化强度逐渐降低,但是在低浓度掺杂时极化有向上增加的趋势,这可能是体系在低浓存在着正交与单斜的准同型相界(Morphotropic phase boundary,MPB)导致的,由此可以判断,低浓度掺杂有利于提高KNN材料的铁电性能.

关键词：第一性原理钙钛矿结果 KNN 铁电性

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Bioactive nanoglass regulating the myogenic differentiation and skeletal muscle regeneration

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Regenerative Biomaterials 2023年第1期10卷 1202-1211页

作者： Dagogo Dorothy Winston Ting Li bo lei Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyFrontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710000China Xi’an Jiaotong University Xi’an 710000China State-Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710054China

Bioactive glass nanoparticles(BGNs)are widely used in the field of biomedicine,including drug delivery,gene therapy,tumor therapy,bioimaging,molecular markers and tissue *** are interested in using BGNs in bone,heart and skin ***,there is inadequate information on skeletal muscle tissue engineering,limited information on the biological effects of BGNs on myoblasts,and the role of bioactive glass composite materials on myogenic differentiation is ***,we report the effects of BGNs with different compositions(60Si-BGN,80Si-BGN,100Si-BGN)on the myogenic differentiation in C2C12 cells and in vivo skeletal tissue *** results showed that 80Si-BGN could efficiently promote the myogenic differentiation of C1C12 cells,including the myotube formation and myogenic gene *** in vivo experiment in a rat skeletal muscle defect model also confirmed that 80Si-BGN could significantly improve the complete regeneration of skeletal muscle tissue during 4 weeks *** work firstly demonstrated evidence that BGN could be the bioactive material in enhancing skeletal muscle regeneration.

关键词： bioactive materials bioactive ceramic bioactive glass nanoparticles skeletal tissue engineering

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Evaluation of the thermal performance of radiant floor heating system with the influence of unevenly distributed solar radiation based on the theory of discretization

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Building Simulation 2023年第1期16卷 105-120页

作者： Jiacheng Zheng Tao Yu bo lei Xiujing Luo School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China

In the building with many transparent envelopes,solar radiation can irradiate on the local surface of floor and cause *** local thermal comfort in the room will be dissatisfactory and the thermal performance of radiant floor will be strongly ***,in many current calculation models,solar radiation on the floor surface is assumed to be uniformly distributed,resulting in the inaccurate evaluation of the thermal performance of the radiant *** this paper,a calculation model based on the theory of discretization and the RC thermal network is proposed to calculate the dynamic thermal performance of radiant floor with the consideration of unevenly distributed solar ***,the discretization model is experimentally validated and is used to simulate a radiant floor heating system of an office room in *** is found that with the unevenly distributed solar radiation,the maximum surface temperature near the south exterior window can reach up to 35.6℃,which exceeds the comfort temperature limit and is nearly 8.5℃higher than that in the north ***,the heating capacity of the radiant floor in the irradiated zone can reach up to 171 W/m^(2),while that in the shaded zone is only 79 W/m^(2).The model with the assumption of uniformly distributed solar radiation ignores the differences between the south and north zones and fails to describe local overheating in the irradiated *** contrast,the discretization model can more accurately evaluate the thermal performance of radiant floor with the influence of real solar *** on this discretization model,novel design and control schemes of radiant floor heating system can be proposed to alleviate local overheating and reduce heating capacity in the irradiated zone.

关键词： radiant floor heating solar radiation simplified model thermal performance

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Optimization design containing dimension and buffer parameters of landing legs for reusable landing vehicle

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Chinese Journal of Aeronautics 2022年第3期35卷 234-249页

作者： bo lei Ming ZHANG Hanyu LIN Hong NIE Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle Nanjing University of Aeronautics and AstronauticsNanjing 210016China State Key Laboratory of Mechanics and Control of Mechanical Structure Nanjing University of Aeronautics and AstronauticsNanjing 210016China

For the landing legs with single air chamber in the buffer structure of the reusable landing vehicle,the geometric topological models and the dynamic model associated with the hard points of the landing legs are *** geometric constraint relationship in the design of the landing legs is also *** whole vehicle dropping test is conducted,and the test results agree well with that of the simulation model,which validates the dynamic *** on the verified model,the effect of hard point positions on the performance of the landing system is *** multidisciplinary collaborative optimization algorithm and archive-based micro genetic algorithm(CO-AMGA)are used to optimize the design parameters that contain the hard points and the *** with artificial iteration,the maximum landing impact acceleration response of the vehicle and the buffer struct maximum force are reduced by 30.70%and 14.51%respectively,and the maximum length of retractable pillar decreases by 8.54%while the design margin increases by 69.11%.The proposed optimization method is efficient and can greatly facilitate the design of landing legs.

关键词： Dynamics Impact test Landing system Optimization design Reusable landing vehicle

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Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering

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Bioactive Materials 2023年第1期19卷 511-537页

作者： Min Wang Peng Xu bo lei Honghui Hospital Xi’an Jiaotong UniversityXi’an710000China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an710000China Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an710000China State-Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710000China State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an710000China

Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative ***-based polymers are the few bioactive polymer biomaterials used in biomedicine because of their facile synthesis,controllable structure,biocompatibility,biomimetic viscoelastic mechanical behavior,and functional groups available for *** recent years,various multifunctional designs and biomedical applications,including cardiovascular,orthopedic,muscle tissue,skin tissue,nerve and spinal cord,bioimaging,and drug or gene delivery based on citrate-based polymers,have been extensively studied,and many of them have good clinical application *** this review,we summarize recent progress in the multifunctional design and biomedical applications of citrate-based *** also discuss the further development of multifunctional citrate-based polymers with tailored properties to meet the requirements of various biomedical applications.

关键词： Bioactive materials Bioactive polymers Citrate-based biomaterials Multifunctional modification Tissue engineering

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Solving DCLAP-MSN based on hybrid genetic algorithm

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Journal of Systems Engineering and Electronics 2010年第5期21卷 806-811页

作者： Hongtao lei bo Guo Tao Zhang College of Information Systems and Management National University of Defense Technology Changsha 410073 E R. China

The dynamic capacitated location allocation problem in the military supportive network（DCLAP-MSN） is a representative of combinative optimization problems,and its optimization process is *** this reason,a dynamic capacitated location allocation model is provided ***,a hybrid heuristic algorithm which combines genetic algorithm,repair algorithm of solutions and greedy search,is proposed as the solving *** optimization performance is improved by effectively integrating the repair algorithm of solutions and greedy search with genetic *** experiment results indicate that the proposed algorithm is a feasible and effective method for the problem.

关键词： dynamic location allocation military supportive network genetic algorithm repair algorithm greedy search.

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Polynomial network autoregressive models with divergent orders

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Science China Mathematics 2023年第5期66卷 1073-1086页

作者： bo lei Wei Lan Nengsheng Fang Jing Zhou School of Statistics and Center of Statistical Research Southwestern University of Finance and EconomicsChengdu 611130China School of Finance Southwestern University of Finance and EconomicsChengdu 611130China School of International Business Southwestern University of Finance and EconomicsChengdu 611130China

We propose a novel polynomial network autoregressive model by incorporating higher-order connected relationships to simultaneously model the effects of both direct and indirect connections. A quasimaximum likelihood estimation method is proposed to estimate the unknown influence parameters, and we demonstrate its consistency and asymptotic normality without imposing any distribution assumption. Moreover,an extended Bayesian information criterion is set for order selection with a divergent upper order. The application of the proposed polynomial network autoregressive model is demonstrated through both the simulation and the real data analysis.

关键词： diverging order extended Bayesian information criterion polynomial network autoregressive model quasi-maximum likelihood estimation

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Effect of DH treatment on microstructure and mechanical properties of an LM28-0.3wt.%Nd hypereutectic aluminum silicon alloy

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Rare Metals 2007年第6期26卷 578-583页

作者： GAO bo CHEN lei YU Fuxiao SUN Shuchen TU Ganfeng School of Materials and Metallurgy Northeastern University Shenyang 110004 China

In this article, a novel heat treatment method, deformation heat （DH） treatment （extrusion ＋ aging）, was employed on a hypereutectic aluminum silicon alloy （LM28-0.3wt.%Nd）, and its effect on microstructure and mechanical properties of this alloy was investigated. It can be concluded that the eutectic microstructure disappears after the DH treatment, in the meantime the morphology of α（Al） solid solution was transformed from fir-troe and cellular to equiaxed, Si was refined with grain sizes of about 1-10 μn and distributed dispersedly, even some of them became globular shape, which can reduce stress accumulation effectively. Mechanical properties test indicated that the DH treatment could significantly improve the room-ternperature strength and have little effect on the high-temperature strength of LM28-0.3wt.%Nd alloy. The fracture mechanism is ductile fracture by fracture morphology analysis.

关键词： Al-Si alloys Nd deformation heat treatment mechanical properties

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