Bioactive nanoglass regulating the myogenic differentiation and skeletal muscle regeneration

作     者：Dagogo Dorothy Winston Ting Li Bo Lei 

作者机构：Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of StomatologyFrontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710000China Xi’an Jiaotong UniversityXi’an 710000China State-Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710054China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2023年第10卷第1期

页      面：1202-1211页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the Special Support Program for High Level Talents of Shaanxi Province of China(grant No.TZ0278) the key R&D plan of Shaanxi Province of China(grant No.2021GXLH-Z-052) the Instrument Analysis Center of Xi’an Jiaotong University(for TEM and BET measurements) State Key Laboratory for Manufacturing Systems Engineering of China(grant No.sklms2021006) Young Talent Support Plan of Xi’an Jiaotong University of China(grant No.QY6J003) the key Project of Jiangxi Natural Science Foundation(No.2020ACBL214008) Jiangxi Provincial Natural Science Foundation(No.20224BAB204020) 

主　　题：bioactive materials bioactive ceramic bioactive glass nanoparticles skeletal tissue engineering 

摘      要：Bioactive glass nanoparticles(BGNs)are widely used in the field of biomedicine,including drug delivery,gene therapy,tumor therapy,bioimaging,molecular markers and tissue *** are interested in using BGNs in bone,heart and skin ***,there is inadequate information on skeletal muscle tissue engineering,limited information on the biological effects of BGNs on myoblasts,and the role of bioactive glass composite materials on myogenic differentiation is ***,we report the effects of BGNs with different compositions(60Si-BGN,80Si-BGN,100Si-BGN)on the myogenic differentiation in C2C12 cells and in vivo skeletal tissue *** results showed that 80Si-BGN could efficiently promote the myogenic differentiation of C1C12 cells,including the myotube formation and myogenic gene *** in vivo experiment in a rat skeletal muscle defect model also confirmed that 80Si-BGN could significantly improve the complete regeneration of skeletal muscle tissue during 4 weeks *** work firstly demonstrated evidence that BGN could be the bioactive material in enhancing skeletal muscle regeneration.