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建筑技艺 2009年第6期15卷 22-29页

作者： Kim Herforth Nielsen bo boje larsen Kim Chri-stiansen Adam mork 3XN

萨索银行（Saxo）是一家主营在线交易的网络银行，通过自我研发的萨索交易平台，负责货币、股票与期货交易。Saxo银行1992年在丹麦成立，目前拥有自35个国家的超过850名来员工为115个不同国家的客户服务。

关键词：网络银行在线交易交易平台期货交易客户服务

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奥斯塔德学院

建筑技艺 2009年第6期15卷 30-35页

作者： Kim Herforth Nielsen bo boje larsen Kim Christiansen Sфren Jensen A/S Adam Mфrk 3XN

2007年竣工的奥斯塔德（Orestad）学院是丹麦国内第一个新型教育学院，面积12000平方米。综合考虑了主修科目，组织和教学系统。交流，内部沟通与协作是学校的重要课题。此项目为大家展示了可视化的开放性与灵活性，考虑到了从小组到班... 详细信息

2007年竣工的奥斯塔德（Orestad）学院是丹麦国内第一个新型教育学院，面积12000平方米。综合考虑了主修科目，组织和教学系统。交流，内部沟通与协作是学校的重要课题。此项目为大家展示了可视化的开放性与灵活性，考虑到了从小组到班级直至集合体的不同容量人群的空间需求，力求展现出更加动态化和生活化学习环境、引进发展建筑智能化技术的国际趋势。这种尝试也潜移默化的增强了学生学习的自主性与能动性，独立完成工作之余更加注重团队合作精神的培养。

关键词：教育学院团队合作精神学习环境智能化技术教学系统内部沟通空间需求

Trajectories of response in schizophrenia-spectrum disorders: A one-year prospective cohort study of antipsychotic effectiveness

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World Journal of Psychiatry 2022年第3期12卷 521-532页

作者： Petros Drosos Erik Johnsen Christoffer Andreas Bartz-Johannessen Tor Ketil larsen Solveig Klæbo Reitan Maria Rettenbacher Rune Andreas Kroken TIPS-Network for Clinical Research in Psychosis Clinic For Adult Mental HealthStavanger University HospitalStavanger 4011Norway NORMENT Division of PsychiatryHaukeland University HospitalBergen 5036Norway Department of Clinical Medicine University of BergenBergen 5007Norway Institute for Mental Health St Olav's University HospitalTrondheim 7030Norwa Department of Mental Health Norwegian University of Natural Science and TechnologyTrondheim 7491Norway Department of Psychiatry and Psychotherapy Medical University InnsbruckInnsbruck 6020Austria

BACKGROUND Antipsychotic drugs remain the mainstay of schizophrenia treatment;however,their effectiveness has been questioned,and it is not possible to predict the response to a specific antipsychotic drug in an individual ***,it is important to compare the effectiveness of the various antipsychotics and search for possible response *** To investigate the effectiveness of antipsychotic drugs,we examined response trajectories and predictors for belonging to different trajectory *** The Bergen-Stavanger-Innsbruck-Trondheim(BeSt InTro)trial compared the effectiveness of three atypical antipsychotics-amisulpride,aripiprazole,and olanzapine-in a prospective,semirandomized,rater-blind,head-to-head *** participants with a schizophrenia spectrum disorder diagnosis,according to international classification of diseases,Tenth Revision(ICD-10)F20–29,were *** were followed for a period of 12 mo,with assessments at baseline;after one,three and six weeks;and after three,six,nine and 12 mo.A latent class mixed model was fitted to our *** three-trajectory model based on the Positive and Negative Syndrome Scale(PANSS)total score reduction was found to have adequate fit,and the study drugs,as well as various demographic and clinical parameters,were tested as predictors for belonging to the different trajectory *** Overall,144 participants were included,and 41%completed the 12-mo study *** largest trajectory group,consisting of 74%of participants,showed a PANSS total score reduction of 59%from baseline to 12 mo(Good response group).A trajectory group comprising 13%of participants had their PANSS total score reduced by 82.5%at 12 mo(Strong response group),while the last response trajectory group comprising 13%of the participants had a PANSS total score reduction of 13.6%(Slight response group).The largest part of the total reduction for the Good and Strong response groups occurred at six weeks of treatment,

关键词： Schizophrenia Response Trajectories Treatment Antipsychotic drugs

A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

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Nano Research 2016年第2期9卷 537-548页

作者： Sara Capolla Nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto Francesca Vita Ruben Spretz Gustavo larsen Sandra Noriega Eduardo Mansilla Michele Dal bo Valter Gattei Gabriele Pozzato Luis Nunez Paolo Macor Department of Life Sciences University of Trieste 34127 Trieste Italy Department of Human Pathology University of Palermo 90133 Sicilia Italy Molecular Oncology Unit National Laboratory Consorzio Interuniversitatio per le Biotecnologie (CIB) 34012 Trieste Italy Dipartimento Universitario Clinico di Scienze mediche Chirurgiche e della Salute University of Trieste 34149 Trieste Italy LNK Chemsolutions LLC Lincoln NE 68521 USA Bio-Target Inc. Chicago IL 60637 USA Centro Unico Coordinador de Ablacion e Implante Provincia de Buenos Aires (C.U.CA.I.B.A.) Ministry of Health La Plata Buenos AiresArgentina Clinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico Istituto di Ricerca e Cura a Carattere Scientifico(I.R.C.C.S.) 33081 Aviano Italy Callerio Foundation Onlus Institutes of Biological Researches 34127 Trieste Italy

Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to reducing the long-term side- effects of therapeutics for all leukemia patients, there is an urgent need for novel therapeutic strategies for difficult-to-treat leukemia cases. Due to the cytotoxicity of drugs, the major challenge currently is to deliver the therapeutic agents to neoplastic cells while preserving the viability of non-malignant ceils. In this study, we propose a therapeutic approach in which high doses of hydroxychloroquine and chlorambucil were loaded into biodegradable polymeric nanopartides coated with an anti-CD20 *** first demonstrated the ability of the nanoparticles to target and internalize in tumor B-cells. Moreover, these nanoparticles could kill not only p53-mutated]deleted leukemia cells expressing a low amount of CD20, but also circulating primary ceils isolated from chronic lymphocytic leukemia patients. The safety of these nanoparticles was also demonstrated in healthy mice, and their therapeutic effects were shown in a new model of aggressive leukemia. These results showed that anti-CD20 nanoparticles containing hydroxychloroquine and chlorambucil can be effective in controlling aggressive leukemia and provided a rationale for adopting this approach for the treatment of other B-cell disorders.

关键词： chronic lymphocytic leukemia immune targeted nanoparticles treatment xenograft model

Valuable Biomolecules from Nine North Atlantic Red Macroalgae: Amino Acids, Fatty Acids, Carotenoids, Minerals and Metals

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Natural Resources 2016年第4期7卷 157-183页

作者： Behnaz Razi Parjikolaei Annette Bruhn Karin Loft Eybye Martin Mørk larsen Michael bo Rasmussen Knud Villy Christensen Xavier C. Fretté Department of Chemical Engineering Biotechnology and Environmental Technology University of Southern Denmark Odense Denmark Department of Bioscience Aarhus University Silkeborg Denmark Food Technology Department Life Science Division Danish Technological Institute Aarhus Denmark Department of Bioscience Aarhus University Roskilde Denmark

In modern society, novel marine resources are scrutinized pursuing compounds of use in the medical, pharmaceutical, biotech, food or feed industry. Few of the numerous marine macroalgae are currently exploited. In this study, the contents of nutritional compounds from nine common North Atlantic red macroalgae were compared: the lipid content was low and constant among the species, whereas the fatty acid profiles indicated that these species constitute interesting sources of polyunsaturated fatty acids (PUFA). The dominating essential and non-essential amino acids were lysine and leucine, aspartic acid, glutamic acid, and arginine, respectively. The amino acid score of the nine algae varied from 44% to 92%, the most commonly first limiting amino acid being histidine. Lutein, β-carotene, and zeaxanthin were the identified carotenoids. Contents of all macro and trace minerals, with the exception of phosphorus, were higher than those described for conventional food. Low sodium/potassium ratios (0.08 - 2.54) suggested a potential for using the ash fraction for sodium salt replacement. The algae constituted rich sources of carbohydrates (40% to 71% of DM) which show their potential for a broader commercial exploitation. In some species, the concentrations of arsenic, cadmium, and lead exceeded limit values for application in food or feed. In conclusion, the nine algae represent promising potential sources of health promoting additives for human and animal diets, in whole or in a biorefinery concept.

关键词： Protein Lipid Carotenoids Dry Matter Arsenic

海洋纤毛虫黄色伪角毛虫无性生殖期间的形态发生

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动物学报 2005年第1期51卷 81-88页

作者：孙萍宋微波中国海洋大学教育部海水养殖重点实验室青岛266003

利用蛋白银染色技术研究了海洋纤毛虫———黄色伪角毛虫Pseudokeronopsisflava (Cohn ,186 6 )Wirns berger,larsen&Uhlig ,1987无性生殖期间的细胞发生学。其主要特征为 :1)前仔虫口原基以独立发生的方式出现并独特地形成于口前庭右... 详细信息

利用蛋白银染色技术研究了海洋纤毛虫———黄色伪角毛虫Pseudokeronopsisflava (Cohn ,186 6 )Wirns berger,larsen&Uhlig ,1987无性生殖期间的细胞发生学。其主要特征为 :1)前仔虫口原基以独立发生的方式出现并独特地形成于口前庭右侧的皮层深处 ,由其对老口围带进行完全的更新 ;2 )老口器不参与新口器的形成 ,完全被吸收 ;3)前仔虫的额 -腹 -横棘毛原基同样为独立发生 ,老结构可能不参加其随后的发育 ;4 )后仔虫的口原基、波动膜原基及额 -腹 -横棘毛原基均来自最初排列无序的毛基粒发生场 ;5 )背触毛及缘棘毛的更新发生在老的结构中 ,并向前后延伸取代老结构 ;6 )在整个发生过程中 ,无大核融合现象。

关键词：原基海洋纤毛虫无性生殖系统学意义大核动物学形态发生银染色膜原前庭

马鞍山公铁两用长江大桥Z3号墩承台施工关键技术

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世界桥梁 2022年第3期50卷 39-44页

作者：徐京海潘博中国铁路上海局集团有限公司建设部上海200071 中铁大桥局集团有限公司湖北武汉430050

马鞍山公铁两用长江大桥主航道桥为(112+392+2×1120+392+112)m三塔钢桁梁斜拉桥,Z3号墩基础承台为哑铃形结构,顶、底面高程分别为+4.5 m、-5.0 m,平面尺寸为36.8 m×81.8 m。结合桥位处地质情况,承台采用PC工法组合桩围堰进行基础施工... 详细信息

马鞍山公铁两用长江大桥主航道桥为(112+392+2×1120+392+112)m三塔钢桁梁斜拉桥,Z3号墩基础承台为哑铃形结构,顶、底面高程分别为+4.5 m、-5.0 m,平面尺寸为36.8 m×81.8 m。结合桥位处地质情况,承台采用PC工法组合桩围堰进行基础施工,围堰平面尺寸为87.6 m×42.2 m、高30 m,其侧板采用∅820 mm×14 mm锁口钢管桩+拉森Ⅵ型钢板桩交替布置的组合桩形式,围堰高度范围内设3层内支撑,经验算围堰结构满足规范要求。施工中,采用基准桩定位、分阶段消除累积误差以及精确调整合龙等技术保证围堰顺利合龙;通过深基坑井点降水开挖技术保证开挖面始终处于无水环境;通过动态监测技术对基坑支护结构受力及变形实施动态监测确保深基坑施工安全;采用优化原材料配合比及承台混凝土内分层布设循环冷却水管等措施有效减小混凝土水化热,保证承台混凝土施工质量。

关键词：斜拉桥承台 PC工法组合桩围堰深基坑井点降水开挖施工监测大体积混凝土施工技术

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larsen模糊推理算法的直觉化扩展

空军工程大学学报（自然科学版） 2007年第5期8卷 78-80页

作者：雷英杰王坚杜蓬勃空军工程大学导弹学院陕西三原713800 空军工程大学训练部陕西西安710051

对larsen模糊推理算法进行了直觉化扩展。首先将larsen定义的模糊关系Rp进行直觉化扩展,然后推出了其对应的直觉模糊取式推理算法和直觉模糊拒式推理算法。最后以具体算例叙述了推理计算过程中的细节,验证了该方法的正确性和有效性。结... 详细信息

对larsen模糊推理算法进行了直觉化扩展。首先将larsen定义的模糊关系Rp进行直觉化扩展,然后推出了其对应的直觉模糊取式推理算法和直觉模糊拒式推理算法。最后以具体算例叙述了推理计算过程中的细节,验证了该方法的正确性和有效性。结果证明直觉化扩展后的larsen模糊推理算法是一种性能比较好的直觉模糊推理算法。

关键词：模糊集合直觉模糊逻辑推理

流体静压力对Al_(y)Ga_(1-y)N/Al xGa_(1-x)N三角量子阱中磁极化子回旋频率与回旋质量的影响

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内蒙古师范大学学报（自然科学版） 2021年第3期50卷 189-196页

作者：赵博赵凤岐内蒙古师范大学物理与电子信息学院内蒙古呼和浩特010022

运用larsen的微扰方法,研究纤锌矿Al_(y)Ga_(1-y)N/Al_(x)Ga_(1-x)N三角量子阱与GaN/Al_(x)Ga_(1-x)N方量子阱中磁极化子回旋频率与回旋质量随流体静压力、外磁场强度及组分的变化关系。在理论推导中,计入声子频率、介电常数、电子有效... 详细信息

运用larsen的微扰方法,研究纤锌矿Al_(y)Ga_(1-y)N/Al_(x)Ga_(1-x)N三角量子阱与GaN/Al_(x)Ga_(1-x)N方量子阱中磁极化子回旋频率与回旋质量随流体静压力、外磁场强度及组分的变化关系。在理论推导中,计入声子频率、介电常数、电子有效质量对压力P和坐标z的依赖性,并考虑其各向异性。结果显示,在外磁场强度不变的情况下,随着流体静压力的增加,在纤锌矿Al_(y)Ga_(1-y)N/Al_(0.3)Ga_(0.7)N三角量子阱与GaN/Al_(0.3)Ga_(0.7)N方量子阱中磁极化子回旋频率逐渐减小,回旋质量逐渐增大。在纤锌矿Al_(y)Ga_(1-y)N/Al_(0.3)Ga_(0.7)N三角量子阱与GaN/Al_(0.3)Ga_(0.7)N方量子阱(压力为定值)中,磁极化子回旋频率随外磁场强度的增大而增大;三角阱(方阱)中的磁极化子回旋质量随外磁场强度的增大逐渐增大。当组分作为变量时,随着组分的变化,Al_(y)Ga_(1-y)N/Al_(x)Ga_(1-x)N三角阱中磁极化子的回旋频率与回旋质量变化较大而GaN/Al_(x)Ga_(1-x)N方阱中的变化较小。Al_(y)Ga_(1-y)N/Al_(x)Ga_(1-x)N三角量子阱中的磁极化子回旋频率比GaN/Al_(x)Ga_(1-x)N方量子阱中的小,而三角量子阱中的磁极化子回旋质量比方量子阱中的大。

关键词：三角量子阱流体静压力磁极化子回旋频率

市政管网基坑单层支撑拉森钢板桩支护参数选择

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宁德师范学院学报（自然科学版） 2022年第1期34卷 32-35,51页

作者：彭富波张磊郑先灿李围中国水利水电第十四工程局有限公司云南昆明650041 莆田学院土木工程学院福建莆田351100

结合东莞市水生态建设五期工程常平镇范围管网工程,就全风化花岗岩条件下对不同基坑深度单层支撑拉森钢板桩进行力学行为分析.针对不同深度基坑设计了拉森钢板桩单层支撑支护结构参数,并结合强度和稳定性验算,提出了基坑深度分别为3.5、... 详细信息

结合东莞市水生态建设五期工程常平镇范围管网工程,就全风化花岗岩条件下对不同基坑深度单层支撑拉森钢板桩进行力学行为分析.针对不同深度基坑设计了拉森钢板桩单层支撑支护结构参数,并结合强度和稳定性验算,提出了基坑深度分别为3.5、5.0、6.5和8.0 m的拉森钢板桩型号、总长度以及围檩H型钢和内支撑钢管参数,可供类似市政管网工程基坑支护结构的选择提供参考.

关键词：市政管网基坑单层支撑拉森钢板桩支护参数