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Exploring the Interplay between Local Chain Structure and Stress Distribution in Polymer Networks

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Chinese Journal of Polymer Science 2024年第6期42卷 874-885页

作者： Jin-Tong Xue Yang bai Li Peng Xian-bo Huang Zhao-Yan Sun School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China National-certified Enterprise Technology Center Kingfa Science and Technology Co.Ltd.Guangzhou510663China

The mechanical behavior of polymer networks is intrinsically correlated with the local chain topology and chain connectivity.In this study,we delve into this relationship through the lens of coarse-grained molecular dynamics(CG-MD)simulations.Our aim is to illuminate the intricate interplay between local topology and stress distribution within polymer monomers,cross-linkers,and various components with distinct cross-link connections,thereby elucidating their collective impact on the mechanical properties of polymer networks.We mainly focus on how specific local structures contribute to the overall mechanical response of the network.In particular,we employ local stress analysis to unravel the mechanics of these structures.Our findings reveal the diverse responses of individual components,such as junctions,strands,cross-linkers between junctions,and dangling chain ends,when subjected to stretching.Notably,we observe that these components exhibit varying degrees of deformation tolerance,underscoring the significance of their roles in determining the mechanical characteristics of the network.Our investigations highlight junctions as primary contributors to stress accumulation,and particles with higher local stress showing a stronger correlation between stress and Voronoi volume.Moreover,our results indicate that both strands and cross-linkers between junctions exhibit heightened stress levels as strand lengths decrease.This study enhances our understanding of the multifaceted factors governing the mechanical attributes of cross-linked polymer systems at the microstructural level.

关键词： Local chain structure Local stress Molecular dynamics simulation

Identifying the effective combination of acupuncture and traditional Chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 212-219页

作者： REN Ping WANG Quanwu bai Wei SUN Miao LIU Zheling GAO Ming WANG Liang PENG bo XU Liguang Department of Health Management the Third Affiliated Clinical Hospital of Changchun University of Chinese MedicineChangchun 130117China Department of Dirty Tuina the affiliated Hospital to Changchun University of Chinese MedicineChangchun 130117China Department of Acupuncture the affiliated Hospital to Changchun University of Chinese MedicineChangchun 130117China Department of Rehabilitation Medicine the 924th Hospital of the PLA Joint Logistic Support ForceFoshan 528226China Department of College of Acupuncture and Massage Changchun University of Chinese MedicineChangchun 130117China

Worldwide,as the population age,osteoporosis is becoming increasingly common,and osteoporotic fractures have a significant economic burden.Postmenopausal women are the most susceptible to developing osteoporosis and the most critical time to prevent it is during the perimenopausal and early menopausal years.In this regard,we hypothesize rational combination of acupuncture and Traditional Chinese Medicine(TCM)in the form of herbal extract could prevent osteoporosis in women.Estrogen deficiency during menopause causes low-level inflammation that stimulates the formation of osteoclasts,the boneresorbing cells,and simultaneously inhibits the viability and function of osteoblasts,the bone-forming cells.The most potent inflammatory cytokine in skeletal homeostasis is the receptor activator of nuclear factor kappa B ligand(RANKL)that stimulates osteoclast function.Conversely,the canonical Wnt pathway is essential for osteoblastogenesis and bone formation,and estrogen deficiency leads to diminished functioning of this pathway.TCM and acupuncture could target the RANKL and the Wnt pathway in favorable ways to prevent the accelerated bone loss experienced during the early menopausal stage and promote the gain in bone mass in postmenopausal women.In this review,we propose a rational combination of specific TCM and acupuncture targeting those signaling molecules/pathways by the drugs that are in clinical use for the treatment of postmenopausal osteoporosis.Our rational approach revealed that Danshen(Radix Salviae Miltiorrhizae)could exert a synergistic effect with acupuncture.We then propose a translational path for developing the putative combination in women with postmenopausal osteoporosis to curtail the risk of osteoporotic fractures.

关键词： medicine traditional osteogenic anti-resorptive review

Mechanical Janus lattice with plug-switch orientation

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 23-26页

作者： Yupei Zhang Jiawei Zhong Zhengcai Zhao Ruiyu bai Yanqi Yin Yang Yu bo Li State Key Laboratory for Manufacturing System EngineeringShaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Qian Xuesen Honors College Xi’an Jiaotong UniversityXi’an 710049China

In recent years,materials with asymmetric mechanical response properties(mechanical Janus materials)have been found possess numerous potential applications,i.***.shock absorption and vibration isolation.In this study,we propose a novel mechanical Janus lattice whose asymmetric mechanical response can be switched in orientation by a plug.Through finite element analysis and experimental verification,this lattice exhibits asymmetric displacement responses to symmetric forces.Furthermore,with such a plug structure inside,individual lattices can switch the orientation of asymmetry and thus achieve reprogrammable design of a mechanical structure with chained lattices.The reprogrammable asymmetry of this material will offer multiple functions in design of mechanical metamaterials.

关键词： Janus Non-reciprocity Programmability Mechanical metamaterial

Construction of shallow buried large-span metro stations using the small pipe roof-beam method

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Frontiers of Structural and Civil Engineering 2024年第1期18卷 122-136页

作者： Qian bai Wen ZHAO Yingda ZHANG Pengjiao JIA Xiangrui MENG bo LU Xin WANG Dazeng SUN School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China Centre for Infrastructure Engineering and Safety School of Civil and Environmental EngineeringThe University of New South WalesNSW 2052Australia School of Rail Transportation Soochow UniversitySuzhou 215131China China Northeast Architectural Design and Research Institute Co. Ltd.Shenyang 110006China

In relation to the Shifu Road Station project on Line 4 of the Shenyang Metro in China,a small-pipe roof-beam method for constructing subway stations is presented.First,a numerical simulation was performed to optimize the supporting parameters of the proposed method and determine the design scheme.Subsequently,the deformation of the pipe roof and surface settlement during the construction process were investigated.Finally,the surface settlement attributed to the excavation was studied through field monitoring,and the proposed method was compared with other methods.The results show that an increase in the pipe-roof spacing has little effect on the surface settlement and piperoof deformation.The bearing capacity of the pipe roof can be efficiently utilized once the flexural stiffness reaches 2EI,and the flexural stiffness is not the dominant factor controlling the deformation.The essential stages in controlling surface settlement are the excavations of the transverse pilot tunnels and the soil between them.The final settlement value of the ground was 24.1 mm,resulting in a reduction in the construction period by at least five months while satisfying the control requirements.

关键词： subway station pipe-roof method surface settlement simulation on-site monitoring

Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system

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World Journal of Gastroenterology 2024年第6期30卷 607-609页

作者： bai-Wei Zhao Ying-Jia Chen Ruo-Peng Zhang Yong-Ming Chen bo-Wen Huang Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina Health Science Center Peking UniversityBeijing 100191China

The present letter to the editor is related to the study titled‘Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells’.Angiotensin-converting enzyme 2 can alleviate liver fibrosis by regulating autophagy of hepatic stellate cells and affecting the renin-angiotensin system.

关键词： Angiotensin-converting enzyme 2 Hepatic stellate cells Liver fibrosis Angiotensin II Angiotensin 1-7 Renin-angiotensin system

The root microbiome:Community assembly and its contributions to plant fitness

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Journal of Integrative Plant Biology 2022年第2期64卷 230-243页

作者： bo bai Weidong Liu Xingyu Qiu Jie Zhang Jingying Zhang Yang bai State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing100101 China Institute of Crop Germplasm Resources Shandong Provincial Key Laboratory of Crop Genetic ImprovementEcology and PhysiologyShandong Academy of Agricultural SciencesJi'nan250100 China CAS Center for Excellence in Biotic Interactions College of Advanced Agricultural SciencesUniversity of Chinese Academy of SciencesBeijing100049 China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100101 China Center for life science Yunnan UniversityYunnan650091 China State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing100101 China

The root microbiome refers to the community of microbes living in association with a plant's roots,and includes mutualists,pathogens,and commensals.Here we focus on recent advances in the study of root commensal community which is the major research object of microbiomerelated researches.With the rapid development of new technologies,plant-commensal interactions can be explored with unprecedented breadth and depth.both the soil environment and the host plant drive commensal community assembly.The bulk soil is the seed bank of potential commensals,and plants use root exudates and immune responses to build healthy microbial communities from the available microbes.The plant microbiome extends the functional system of plants by participating in a variety of processes,including nutrient absorption,growth promotion,and resistance to biotic and abiotic stresses.Plants and their microbiomes have evolved adaptation strategies over time.However,there is still a huge gap in our understanding of the regulatory mechanisms of plant-commensal interactions.In this review,we summarize recent research on the assembly of root microbial communities and the effects of these communities on plant growth and development,and look at the prospects for promoting sustainable agricultural development through the study of the root microbiome.

关键词： commensal microbiome assembly plant fitness plant-microbe interaction root microbiome

Surficial modification enabling planar Al growth toward dendrite-free metal anodes for rechargeable aluminum batteries

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Science China Chemistry 2024年第4期67卷 1341-1351页

作者： Wenhao Liu Yu Li bo Long Haoyi Yang Lumin Zheng Ying bai Feng Wu Chuan Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019China

Al metal possesses ultrahigh theoretical volumetric capacity of 8,040 m Ah cm^(-3),and gravimetric capacity of 2,980 m Ah g^(-1),and thus is highly attractive for electrochemical energy storage.However,it suffers from several issues,such as the dendrite formation,during Al stripping-deposition cycling,which has been verified to account for the short circuit and limited cyclic performance.Herein,we use a facile and applicable method to in-situ reconstruct the Al anode surface with F-Al-O chemical bonds,which could preferentially induce the planar growth of Al along the interface plane,thus leading to the dendrite-free morphology evolution during the cycling.Benefiting from F-Al-O chemical bonds on the surface of Al anodes,long lifespan of symmetric cells can be realized even under 1 m A cm^(-2)and 1 m Ah cm^(-2).Coupling the F-Al anode with graphite-based cathodes,high-voltage dual-ion Al metal batteries can be achieved with long-term cycle stability up to 1,200 cycles(at 0.5 m A cm^(-2)),surpassing the counterparts using pristine Al metal anode.Furthermore,the effectiveness of this surficial modification strategy is also elucidated with the aid of theoretical calculation.This work provides novel insights on low-cost and facile strategies against the Al dendrite growth in aluminum batteries.

关键词： rechargeable aluminum batteries Al metal anode Al dendrite dual-ion batteries surficial modification

No Incidence of Liver Cancer Was Observed in A Retrospective Studyof Patients with Aristolochic Acid Nephropathy

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Chinese Journal of Integrative Medicine 2024年第2期30卷 99-106页

作者： SU Tao FANG Zhi-e GUO Yu-ming WANG Chun-yu WANG Jia-bo JI Dong bai Zhao-fang YANG Li XiAO Xiao-he Renal Division Department of MedicinePeking University First HospitalBeijing(100034)China Department of Pharmacy Chongqing Hospital of Traditional Chinese MedicineChongqing(400021)China Department of Hepatology Fifth Medical Center of Chinese PLA General HospitalBeijing(100039)China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing(100039)China Phase I Clinical Trials Unit Department of Medicine for Infectious DiseasesFifth Medical Center of Chinese PLA General HospitalBeijing(100039)China Department of Pharmacy Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan(250000)China National Key Laboratory of Kidney Diseases Beijing(100039)China

Objective:To assess the risk of aristolochic acid(AA)-associated cancer in patients with AA nephropathy(AAN).Methods:A retrospective study was conducted on patients diagnosed with AAN at Peking University First Hospital from January 1997 to December 2014.Long-term surveillance and follow-up data were analyzed to investigate the influence of different factors on the prevalence of cancer.The primary endpoint was the incidence of liver cancer,and the secondary endpoint was the incidence of urinary cancer during 1 year after taking AA-containing medication to 2014.Results:A total of 337 patients diagnosed with AAN were included in this study.From the initiation of taking AA to the termination of follow-up,39 patients were diagnosed with cancer.No cases of liver cancer were observed throughout the entire follow-up period,with urinary cancer being the predominant type(34/39,87.17%).Logistic regression analysis showed that age,follow-up period,and diabetes were potential risk factors,however,the dosage of the drug was not significantly associated with urinary cancer.Conclusions:No cases of liver cancer were observed at the end of follow-up.However,a high prevalence of urinary cancer was observed in AAN patients.Establishing a direct causality between AA and HCC is challenging.

关键词： aristolochic acid hepatocellular carcinoma urinary cancer drug safety retrospective study

Pharmacological interventions targeting the microcirculation following traumatic spinal cord injury

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Neural Regeneration Research 2024年第1期19卷 35-42页

作者： Rongrong Wang Jinzhu bai Department of Spine and Spinal Cord Surgery Beijing Bo’ai HospitalChina Rehabilitation Research CenterBeijingChina School of Rehabilitation Medicine Capital Medical UniversityBeijingChina

Traumatic spinal cord injury is a devastating disorder chara cterized by sensory,motor,and autonomic dysfunction that seve rely compromises an individual's ability to perform activities of daily living.These adve rse outcomes are closely related to the complex mechanism of spinal cord injury,the limited regenerative capacity of central neurons,and the inhibitory environment fo rmed by traumatic injury.Disruption to the microcirculation is an important pathophysiological mechanism of spinal cord injury.A number of therapeutic agents have been shown to improve the injury environment,mitigate secondary damage,and/or promote regeneration and repair.Among them,the spinal cord microcirculation has become an important target for the treatment of spinal cord injury.Drug inte rventions targeting the microcirculation can improve the microenvironment and promote recovery following spinal cord injury.These drugs target the structure and function of the spinal cord microcirculation and are essential for maintaining the normal function of spinal neuro ns,axons,and glial cells.This review discusses the pathophysiological role of spinal cord microcirculation in spinal cord injury,including its structure and histopathological changes.Further,it summarizes the progress of drug therapies targeting the spinal cord mic rocirc ulation after spinal cord injury.

关键词： blood-spinal cord barrier drug therapy microcirculation microvascular blood flow neuroprotection pharmacological intervention pharmacotherapy spinal cord injury trauma