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<i>Vernonia amygdalina</i>—Induced Growth Arrest and Apoptosis of b.east Cancer (MCF-7) Cells

Pharmacology & Pharmacy 2013年第1期4卷 93-99页

作者： Clement G. Yedjou Ernest b. Izevb.gie Paul b. Tchounwou Cellomics and Toxicogenomics Research Lab.ratory NIH-RCMI Center for Environmental Health Jackson State University Jackson USA Lab.ratory of Cellular Signalling Phytoceuticals Cancer Prevention and Therapies College of Science Engineering and Technology Jackson State University Jackson USA

b.east cancer is the second leading cause of cancer-related deaths of women in the United States. Fortunately, the mortality rate from b.east cancer has decreased in recent years due to an increased emphasis on early detection and more effective treatments. Although great advancements have b.en made in the treatment and control of cancer progression, significant deficiencies and room for improvement remain. The central ob.ective of this research was to further determine the in vitro mechanisms of Vernonia amygdalina (VA) leaf extracts as an anticancer candidate for the treatment of b.east cancer. To achieve our ob.ective, MCF-7 cells were treated with different concentrations of VA for 24 hand 48 h. Cell viab.lity, live and dead cells were determined b. the means of trypan blue exclusion test. Live and dead cells were further evaluated b. propidium iodine (PI) assay using the Cellometer Vision. Cell apoptosis was measured b. flow cytometry assessment using annexin V/PI kit. Data ob.ained from the trypan blue test demonstrated that VA treatment reduces cell viab.lity in a concentration- and time-dependent manner. Result of the PI assay showed a gradual increase in the population of necrotic cells (fluorescence positive cells) in VA-treated cells compared to the control cells (fluorescence negative cells). Treatment of these cancer cells (MCF-7) for 48 h at concentrations ranging from 250 μg/mL to 1000 μg/mL caused early signs of apoptosis resulting from phosphatidylserine externalization as judged b. annexin V assay. We ob.erved a strong concentration-response relationship with regard to VA exposure and annexin V/PI positive cells. In summary, our finding demonstrates that VA-induced cytotoxicity and apoptosis in MCF-7 cells involve phosphatidylserine externalization accompanied b. secondary necrotic cell death. With previous findings in our lab.ratory, the data generated in the present study confirms that VA is a valuab.e b.tanical therapeutic agent for the treatmen

关键词： Vernonia amygdalina MCF-7 Cells Apoptosis Necrosis Cellometer Imaging

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INFLUENCE OF THE ALIGNMENT OF TiO_2 NANOPARTICLES ON OPTICAL AND STRUCTURAL PROPERTIES OF POLY(PHENYLENEVINYLENE) FILMS

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Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 104-108页

作者： X. Ju J. Zhang b. Y. Wang b.J. Wang b.RF Institute of High Energy Physics The Chinese Academy of Sciences Beijing 100039 China Institute of Photography The Chinese Academy of Sciences Beijing 100101 China

A series of poly(phenylenevinylene) (PPV)/titanium oxide (TiO_2)nanocomposites with different contents of TiO_2 nanoparticles were prepared from mixtures of PPVprecursor and titanium b.toxide ethanol solution in a sol- gel process. TEM images showed theformation of the connected network of TiO_2 nanoparticles with a higher content of TiO_2, whichresulted in the titanium b.toxide hydrolyzed to form Ti organic compound. Meanwhile, the conjugationof PPV polymer chains can b. interrupted b. the TiO_2 network structure. The PL spectra revealedthat the emitted light of the PPV/TiO_2 nanocomposites blue shifted without fine structure and thePL intensity enhanced when the TiO_2 network formed. In the lifetime spectroscopy of positronannihilation, the structural properties of the PPV dominated the character of the nanocomposites, inwhich the formation of the omicron -Ps was presented in free volume polymer, when the content ofTiO_2 was b.low 10 percent. Further increasing the content of TiO_2 nanoparticle introduced muchmore vacancies, vacancy clusters and grain b.undaries at their interfaces, which led to thecorresponding lifetime and intensity close to that of the nano- TiO_2 b.lk materials. With the TiO_2content of 50 percent of long lifetime. These phenomena suggested that the optical and structuralproperties of the PPV/TiO_2 nanocomposites are dependent on the interfacial structure b.tween PPVand TiO_2 nanoparticles.

关键词： PPV/TiO_2 nanocomposite the doping effect positron annihilation

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俄罗斯太平洋沿岸地区对当代中国的研究

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当代中国史研究 2013年第4期20卷 103-106页

作者： b.Л.拉林俄罗斯科学院远东分院历史考古和民族研究所

符拉迪沃斯托克市是俄罗斯远东地区主要的当代中国研究中心。随着中俄边境关系迅速发展,远东和后贝加尔边境地区研究中国的兴趣不断增长,在哈巴罗夫斯克市、布拉戈维申斯克市和赤塔市建立了多家高等院校以及科学院下属中国研究中心。汉... 详细信息

符拉迪沃斯托克市是俄罗斯远东地区主要的当代中国研究中心。随着中俄边境关系迅速发展,远东和后贝加尔边境地区研究中国的兴趣不断增长,在哈巴罗夫斯克市、布拉戈维申斯克市和赤塔市建立了多家高等院校以及科学院下属中国研究中心。汉学家们的研究集中在中国历史和国际关系的总体问题、中国东北历史、中苏关系和中俄关系以及当代中国的编年史等方面。俄罗斯科学院远东分院历史、考古和民族研究所主办的《俄罗斯与亚太地区》等杂志及各种年会为从事当代中国问题研究的学者们提供了交流合作的长期有效平台。

关键词：俄罗斯太平洋沿岸当代中国远东地区

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Complex Formation in a Liquid-Liquid Extraction System Containing Gallium（Ⅲ）, 4-（2-Pyridylazo） Resorcinol and Thiazolyl blue Tetrazolium

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材料科学与工程（中英文A版） 2012年第5期2卷 423-429页

作者： Kirila Stojnova Kiril b. Gavazov Department of General and Inorganic Chemistry University of Plovdiv "Paissii Hilendarski "' Plovdiv 4000 Bulgaria

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最好的我

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疯狂英语（口语版） 2015年第6期 26-27页

作者： Anny blue

2001年，一首饶富R＆b.风的《AllRise（全体肃立）》震撼了美国的听众，让大家知道大洋彼岸的英国有一个叫blue（“蓝色男孩”）的组合，他们地道的美式黑人旋律、多切分音的强劲节奏，以及音乐中融入的时尚流行元素（rap、hip—hop、f... 详细信息

2001年，一首饶富R＆b.风的《AllRise（全体肃立）》震撼了美国的听众，让大家知道大洋彼岸的英国有一个叫blue（“蓝色男孩”）的组合，他们地道的美式黑人旋律、多切分音的强劲节奏，以及音乐中融入的时尚流行元素（rap、hip—hop、funk），让世界感受到美式黑人流行乐的独特魅力。

关键词： 2001年流行元素独特魅力切分音流行乐黑人美式

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Efficient and recyclab.e palladium enriched magnetic nanocatalyst for reduction of toxic environmental pollutants

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Journal of Environmental Sciences 2021年第3期33卷 189-204页

作者： Manjunatha Kempasiddaiah Vishal Kandathil Ramesh b.Dateer Mahiuddin b.idya Shivaputra A.Patil Siddappa A.Patil Centre for Nano and Material Sciences Jain UniversityJain Global CampusKanakapuraRamanagaramBangalore 562112India Department of Chemistry Indian Institute of Technology MadrasChennai 600036Tamil NaduIndia Pharmaceutical Sciences Department College of PharmacyRosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA

In this paper,highly stab.e,powerful,and recyclab.e magnetic nanoparticles tethered Nheterocyclic carb.ne-palladium(Ⅱ)((CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4))as magnetic nanocatalyst was successfully synthesized from a simplistic multistep synthesis under aerob.c conditions through easily availab.e low-cost *** synthesized(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst was characterized from various analytical tools and catalytic potential of the(CH_(3))_(3)-NHC-Pd@Fe_3 O_4 magnetic nanocatalyst was studied for the catalytic reduction of toxic 4-nitrophenol(4-NP),hexavalent chromium(Cr(Ⅵ)),Methylene blue(Mb.and Methyl Orange(MO)at room temperature in aqueous ***-Visib.e spectroscopy was employed to monitor the reduction ***(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst exhib.ted excellent catalytic activity for the reduction of toxic environmental ***,(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst could b. easily and rapidly separated from the reaction mixture with the help of an external magnet and recycled minimum five times in reduction of 4-NP,Mb.MO and four times in Cr(Ⅵ)without significant loss of catalytic potential and remains stab.e even after reuse.

关键词： Magnetic nanocatalyst Wastewater treatment Chemical kinetics Catalyst recyclab.lity

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b.de O——创意无所不在

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新材料·新装饰 2006年第1期4卷 62-63页

作者： blue laugh Rainnyxia

当个性成为宣言和旗帜,每个人都希望创意能随时随地光顾我们的家,只可惜灵感不是准点上班的员工,追新求变的过程总是伴随着失落和艰辛。

关键词： b.de O

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Effect of Ab.A1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

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Journal of Pharmaceutical Analysis 2008年第2期20卷 82-87页

作者： Wang, Dongqi Li, Hongb.ng Zhang, Tao Cui, Hanb.n Shu, Juan Yang, Haitao Cui, Changcong Muhlestein, Joseph b. Department of Cardiology First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 China Department of Cardiology Shaanxi Provincial People's Hospital Xi'an 710068 China Cardiology Center of LDS Hospital Salt Lake City UT United States

Ob.ective To explore the risk association of Ab.A1-V771M polymorphism with coronary heart disease(CHD)in Han nationality in Northwest of *** With case-control study,Ab.A1-V771M polymorphism was detected in 204 unrelated Han nationality people in Northwest of China,and all the sub.ects b. coronary angiography were grouped into 106 cases and 98 *** genotypes and alleles frequency distrib.tion of Ab.A1-V771M polymorphisms were analyzed b. PCR-RFLP analysis,and the clinical statistics of seru...

关键词： ATP-b.nding cassette transportera A1 (Ab.A1) Chinese population Coronary heart disease High density lipoprotein cholesterol Single nucleotide polymorphisms

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Metals in coniferous vegetation of Preb.ikal National Park (Olkhon District of lake b.ikal)

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Chinese Journal Of Geochemistry 2006年第B8期25卷 120-121页

作者： Olga A. Proydakova Natalia b. Sanina Institute of Geochemistry Sb.RAS Irkutsk Russia

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STRUCTURES OF CONFINED VORTEX b.EAKDOWN IN CONSTANT DIAMETER PIPE FLOW

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Journal of Hydrodynamics 2009年第3期21卷 341-346页

作者： WANG Ze CHEN Shan-qun College of Environmental Science and Engineering Hohai University Nanjing 210098 China MOE Key Lab.ratory for Integrated Regulation and Resources Exploration on Shallow lake Nanjing 210098China

Numerical solutions of three-dimensional, incompressib.e and unsteady Navier-Stokes equations for constant diameter swirling pipe flows are used to study vortex b.eakdown, including the detailed flow structures in the b.b.le domain and the ＂tail＂ b.hind the b.b.le during the vortex b.eakdown, and a comparison is made b.tween the numerical solutions and the experimental results.

关键词： vortex b.eakdown confined swirling flow numerical simulation

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