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Differential roles of C-3 and C-6 phosphate monoesters in affecting potato starch properties

Grain & Oil Science and Technology 2024年第2期7卷 79-86页

作者： Li Ding Andreas blennow Yuyue Zhong Department of Plant and Environmental Sciences Faculty of ScienceUniversity of CopenhagenDenmark Department of Sustainable and Bio-inspired Materials Max-Planck Institute of Colloids and InterfacesPotsdamGermany

The effects of starch phosphate monoester content(SPC),namely C-3(C3P)and C-6 phosphate monoesters(C6P),on the starch properties were investigated using four potato starches with varied SPC/C3P/C6P and two nonphosphorylated maize starches with a similar range of amylose content(AC)as *** starch property results showed that a higher SPC is associated with lower turbidity,storage and loss modulus after storage,and water solubility,but higher swelling power(SP)and pasting *** findings suggested that SPC inhibited molecular rearrangement during storage and starch leaching during heating,and enhanced swelling and viscosities due to increased hydration and water uptak. caused by the repulsion effect of phosphate groups and a less ordered crystalline *** SPC also resulted in lower resistant starch(RS)content in a native granular state but higher RS after *** correlations further indicated that SPC/C3P/C6P were positively correlated with peak.r^(2)=0.925,0.873 and 0.930,respectively),trough(r^(2)=0.994,0.968 and 0.988,respectively),and final viscosities(r^(2)=0.981,0.968 and 0.971,respectively).Notably,SPC,mainly C3P,exhibited a significantly positive correlation with SP(r^(2)=0.859)and setback.viscosity(r^(2)=0.867),whereas SPC,mainly C6P,showed a weak.positive correlation with RS after retrogradation(r^(2)=0.746).However,SPC had no significant correlations with water solubility,turbidity and rheology properties,which were more correlated with *** findings are helpful for the food industry to select potato starches with desired properties based on their contents of SPC,C3P,or C6P.

关键词： Starch phosphate monoesters C-3 phosphate monoesters C-6 phosphate monoesters Physicochemical properties In vitro digestibility

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CSF淀粉样蛋白β42和tau水平与AIDS痴呆综合征有关

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 32-32页

作者： Brew B.J. Pemberton L. blennow k. 陈海 Department of Neurology Xavier Building Victoria St Sydney NSW 2010 Australia

There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk.are related to CSF β-amyloid(1-42) (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF Aβ42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-lik. process.

关键词：淀粉样蛋白 CSF tau 痴呆综合征阿尔茨海默病

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额颞型痴呆患者鞘内炎性反应增强的病理生理意义

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 17-17页

作者： Sjgren M. Folk.sson S. blennow k. Tark.wsk. E. 李锐 Department of Neuropsycniatry Sahlgrenska Univ. Hosp./Mlndal SE431 80Mal Sweden Dr

Objective: Immunological mechanisms may be part of the pathophysiological mechanisms in frontotemporal dementia (FTD), but hitherto only vague evidence of such me chanisms has been presented. The aim of this study was to compare the cerebrospinal fluid (CSF) levels of the pro inflammatory cytok.nes interleuk.n (IL) 1β and tumour necrosis factor (TNF) α , and the anti inflammatory cytok.ne transforming growth factor (TGF) β in patients with FTD and normal controls. Furthermore, serum levels of TNF α , TGF β , and IL 1β were measured in FTD patients. Methods: The CSF levels of IL 1β , TNFα , and TGF β were measured using ELISA in 19 patients with FTD and 24 sex and age matched healthy controls. Results: The CSF levels of TNF α (FTD 0.6 pg/mL (median: lower, upper quartile 0.3, 0.7); controls: 0.0 pg/mL (0.0, 0.0); p = 0.008) and TGF β (FTD 266 pg/mL (157, 371), controls: 147 pg/mL (119, 156); p = 0.0001)were significantly increased in FTD patients compared with controls. No correlations were found between CSF and serum levels of the cytok.nes. In the controls, but not in the FTD patients, a positive correlation was found between the CSF levels of TGF β and age (r = 0.42, p k.nes and degree of brain atrophy or white matter changes. No differences between the groups were found for age, gender, or CSF/serum albumin ratio. Conclusions: The results suggest an increased intrathecal production of both pro and anti inflammatory cytok.nes in FTD. As no correlations were found with the albumin ratio, and no correlations between CSF and serum levels of the cytok.nes were found, these changes in the CSF cannot be explained by a systemic overproduction of cytok.nes.

关键词：病理生理意义炎性反应细胞因子水平血浆白蛋白脑萎缩转化生长因子前炎症细胞因子肿瘤坏死因子抗炎因子四分位数

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GTR-Mediated Radial Import Directs Accumulation of Defensive Glucosinolates to Sulfur-Rich Cells in the Phloem Cap of Arabidopsis Inflorescence Stem

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Molecular Plant 2019年第11期12卷 1474-1484页

作者： Deyang Xu Pascal Hunzik.r Olga k.roleva Andreas blennow Christoph Crocoll Alexander Schulz Hussam Hassan Nour-Eldin Barbara Ann Halk.er DynaMo Center Department of Plant and Environmental SciencesFaculty of ScienceUniversity of Copenhagen1871 Frederiksberg CDenmark Lonza Biologies Pic 228 Bath RoadSlough SL14DXUK Section for Plant Glycobiology Department of Plant and Environmental SciencesFaculty of ScienceUniversity of Copenhagen1871 Frederiksberg CDenmark

In the phloem cap region o i Arabidopsis plants,sulfur-rich cells(S-cells)accumulate>100 mM glucosinolates(GLS),but are biosynthetically *** source and route of S-cell-bound GLS remain *** this study,using single-cell sampling and scanning electron microscopy with energy-dispersive X-ray analysis we show that two GLS importers,NPF2.10/GTR1 and NPF2.11/GTR2,are critical for GLS accumulation in S-cells,although they are not localized in the *** of GLS levels in S-cells in multiple combinations of homo-and heterografts o lg t r l gtr2,biosynthetic null mutant and wild-type plants indicate that S-cells accumulate GLS via symplasmic connections either directly from neighboring biosynthetic cells or indirectly to non-neighboring cells expressing GTR1/*** sources and transport routes exist for different types of GLS,and vary depending on the position of S-cells in the inflorescence *** on these findings,we propose a model illustrating the GLS transport routes either directly from biosynthetic cells or via GTR-mediated import from apoplastic space radially into a symplasmic domain,wherein the S-cells are the ultimate ***,we observed accumulation of the cyanogenic glucoside defensive compounds in high-turgor cells in the phloem cap of Lotus japonicus,suggesting that storage of defensive compounds in high-turgor cells may be a general mechanism for chemical protection of the phloem cap.

关键词： Arabidopsis glucosinolate S-cell phloem cap xylem symplasmic transport

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Combined nasal CPAP(nCPAP)and inhaled nitric oxide(iNO)for moderate RDS of the newborn: effects from 30-min exposure

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Acta Pharmacologica Sinica 2003年第12期 171-172页

作者： R LINDWALL,E BERGGREN,M blennow,M FLANBY,C FROSTELL,B JONSSON,P-A LONNQVIST,M NORMAN,M SVENSSON Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden Department of Anesthesia and Intensive Care k.rolinsk. Institutet Danderyd Hospital Stock.olm Sweden

Treatment with iNO has so far mainly been described and approved for delivery during endotracheal intubation and mechanical ventilation. We have recently validated a modified nasal CPAP(nCPAP) svstem for the concomita... 详细信息

关键词： Combined nasal CPAP effects from 30-min exposure iNO)for moderate RDS of the newborn nCPAP)and inhaled nitric oxide from for of RDS

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Increased plasma TACE activity in subjects with mild cognitive impairment and patients with Alzheimer's disease

Increased plasma TACE activity in subjects with mild cogniti...

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中国神经科学学会第十届全国学术会议

作者： Qi-Ying SUN Harald Hampel k.j blennow Simone Lista Allan Levey Bei-Sha TANG Rena LI Yong SHEN Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute Department of Neurology Xiangya HospitalCentral south university Department of Psychiatry Alzheimer Memorial CenterUniversity of Munich Department of Neurology University of Belgrade Clinical Neurochemistry Lab Department of Neuroscience and Physiology University of GothenburgSahlgren's University Hospital

Objective Evidence suggests that the tumor necrosis factor receptor(TNFR)-signaling pathway contributes to the pathogenesis of Alzheimer’s disease(AD).TNF-α converting enzyme(TACE/AD AM-17) can cleave both pro-TNF-α and TNF ***,we have shown that TACE activity in the cerebrospinal fluid(CSF) from subjects with mild cognitive impairment(MCI) and AD patients is significantly higher than that from cognitively healthy controls(HC).However,it is not clear whether TACE activity could be detected and whether TACE activity is higher than that in HC *** We examined TACE expression and ist enzamatic activity in the frontal cortex of postmortem AD cases and control ***,we also analyzed a large set of clinical sample of 64patients with AD,88 subjects with MCI,and 50 age-matched HC recruited from three distinct academic *** In the frontal cortex of AD patients,TACE protein levels and enzymatic activity tended to be higher than in HC,although the difference was not statistically *** TACE protein levels did not differ significantly in the three study groups(AD,MCI,and HC).However,plasma TACE activity was significantly higher in subjects with MCI and AD patients than in ***,in MCI and AD groups we found a significant correlation between plasma TACE activity and CSF T-tau and Aβ *** AD patients,the levels of plasma TACE activity correlated significantly and negatively with *** These findings further support the role of the TNF-α receptor complex in AD-related neuroinflammation and propose TACE plasma activity as a promising hypothesis-driven biomark.r candidate for detection,diagnosis,and prognosis of prodromal and clinical AD.

关键词： mild cognitive impairment Alzheimer’s disease tumor necrosis factor converting enzyme plasma biomark.r

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A phase 1b randomized clinical trial of CT1812 to measure Aβoligomer displacement in Alzheimer’s disease using an indwelling CSF catheter

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Translational Neurodegeneration 2023年第1期12卷 568-571页

作者： k.lsie M.LaBarbera Yvette I.Sheline Nicholas J.Izzo Carla M.Yuede Lora Waybright Raymond Yurk. Hannah M.Edwards Woodrow D.Gardiner k.j blennow Henrik.Zetterberg Anne Börjesson-Hanson Roger Morgan Charles S.Davis Robert J.Guttendorf Lon S.Schneider Steven Dek.sk. Harry LeVine III Michael Grundman Anthony O.Caggiano John R.Cirrito Susan M.Catalano Mary E.Hamby Cognition Therapeutics Inc. PittsburghPAUSA University of Pennsylvania PhiladelphiaUSA Washington University St.LouisUSA University of Gothenburg MölndalSweden Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden Clinical Neurochemistry Laboratory Sahlgrenska University HospitalMölndalSweden Department of Neurodegenerative Disease UCL Institute of NeurologyQueen SquareLondonUK Uk.Dementia Research Institute at UCL LondonUK Hong k.ng Center for Neurodegenerative Diseases Clear Water BayHong KongChina Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWIUSA k.rolinsk. University Hospital StockholmSweden MedSurgPI LLCRaleighNCUSA CSD Biostatistics Inc.Oro ValleyAZUSA Aclairo Pharmaceutical Development Group IncViennaVAUSA k.ck.School of Medicine of USC Los AngelesCAUSA Mck.ight Brain Institute University of FloridaGainesvilleFLUSA Sanders-Brown Center on Aging University of KentuckyLexingtonKYUSA Global R&D Partners LLCSan DiegoCAUSA Department of Neurosciences University of CaliforniaSan DiegoUSA

Trial Registration:May 11th,2018 *** Identifier:NCT03522129 https://clini caltr ***/ct2/show/*** therapies for Alzheimer’s disease(AD)target a wide range of mechanisms,yet promising dis-ease-modifying therapies remain a huge unmet *** evidence indicates that the oligomeric form of amyloid-beta(Aβ)is a toxic species contributing to AD through synaptic damage and neuronal toxicity[1].

关键词： Alzheimer Aβ damage

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最新AD研究用诊断标准:IWG-2标准

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神经病学与神经康复学杂志 2014年第3期11卷 133-143页

作者：陈刚曹雯炜俞羚糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL blennow k.Dek.osk. ST Gauthier S Selk.e D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galask. D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL 上海交通大学医学院附属仁济医院神经内科上海200127

在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点... 详细信息

在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。

关键词：阿尔茨海默病生物标志物研究用诊断标准临床表型淀粉样蛋白诊断流程 AD IWG-2 病理生理

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