额颞型痴呆患者鞘内炎性反应增强的病理生理意义

作     者：Sjgren M. Folkesson S. Blennow K. Tarkowski E. 李锐 

作者机构：Department of NeuropsycniatrySahlgrenska Univ. Hosp./Mlndal SE431 80Mal Sweden Dr 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第1期

页      面：17-17页

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

主　　题：病理生理意义 炎性反应 细胞因子水平 血浆白蛋白 脑萎缩 转化生长因子 前炎症细胞因子 肿瘤坏死因子 抗炎因子 四分位数 

摘      要：Objective: Immunological mechanisms may be part of the pathophysiological mechanisms in frontotemporal dementia (FTD), but hitherto only vague evidence of such me chanisms has been presented. The aim of this study was to compare the cerebrospinal fluid (CSF) levels of the pro inflammatory cytokines interleukin (IL) 1β and tumour necrosis factor (TNF) α , and the anti inflammatory cytokine transforming growth factor (TGF) β in patients with FTD and normal controls. Furthermore, serum levels of TNF α , TGF β , and IL 1β were measured in FTD patients. Methods: The CSF levels of IL 1β , TNFα , and TGF β were measured using ELISA in 19 patients with FTD and 24 sex and age matched healthy controls. Results: The CSF levels of TNF α (FTD 0.6 pg/mL (median: lower, upper quartile 0.3, 0.7); controls: 0.0 pg/mL (0.0, 0.0); p = 0.008) and TGF β (FTD 266 pg/mL (157, 371), controls: 147 pg/mL (119, 156); p = 0.0001)were significantly increased in FTD patients compared with controls. No correlations were found between CSF and serum levels of the cytokines. In the controls, but not in the FTD patients, a positive correlation was found between the CSF levels of TGF β and age (r = 0.42, p 0.05). No correlation was found between any of the cytokines and degree of brain atrophy or white matter changes. No differences between the groups were found for age, gender, or CSF/serum albumin ratio. Conclusions: The results suggest an increased intrathecal production of both pro and anti inflammatory cytokines in FTD. As no correlations were found with the albumin ratio, and no correlations between CSF and serum levels of the cytokines were found, these changes in the CSF cannot be explained by a systemic overproduction of cytokines.