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Latest developments in early.diagnosis and specific treatment of severe influenza infection

Journal of Intensive Medicine 2024年第2期4卷 160-174页

作者： Francisco Valenzuela-s.nchez blanca Valenzuela-Méndez Juan Francisco Rodríguez-Gutiérrez Ángel Estella Intensive Care Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology.Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Centro de Investigación Biomédica en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Oncological surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of Medicine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigación e Innovación Biomédica de Cádiz(INIBiCA) Avenida Ana de Viya 21CádizSpain

Influenza pandemics are unpredictable recurrent events with global health,economic,and social *** objective of this review is to provide an update on the latest developments in early.diagnosis and specific treatment of the disease and its complications,particularly.with regard to respiratory.organ *** advances in treatment,the rate of mortality.in the intensive care unit remains approximately.30%.Therefore,early.identification of potentially.severe viral pneumonia is extremely.important to optimize treatment in these *** pathogenesis of influenza virus infection depends on viral virulence and host ***,in some patients,it is associated with an excessive sy.temic response mediated by.an authentic cy.okine *** process leads to severe primary.pneumonia and acute respiratory.distress *** prognostication in the emergency.department based on comorbidities,vital signs,and biomarkers(e.g.,procalcitonin,ferritin,human leukocy.e antigen-DR,mid-regional proadrenomedullin,and lactate)is *** of these biomarkers on admission may.facilitate clinical decision-making to determine early.admission to the hospital or the intensive care *** decisions are reached considering pathophy.iological circumstances that are associated with a poor prognosis(e.g.,bacterial co-infection,hy.erinflammation,immune paraly.is,severe endothelial damage,organ dy.function,and septic shock).Moreover,early.implementation is important to increase treatment *** on a limited level of evidence,all current guidelines recommend using oseltamivir in this *** possibility.of drug resistance should also be *** options include other antiviral drugs and combination therapies with monoclonal ***,it is not recommended to use corticosteroids in the initial treatment of these ***,the implementation of supportive measures for respiratory.failure is ***

关键词： Influenza Pandemic Respiratory.failure Acute respiratory.distress sy.drome Intensive care unit admission

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Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

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Neural Regeneration Research 2024年第12期19卷 2626-2636页

作者： blanca Molins Andrea Rodríguez Víctor Llorenç Alfredo Adán Group of Ocular Inflammation:Clinical and Experimental studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain Institut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degeneration,a multifactorial inflammatory.degenerative retinal disease,ranks as the leading cause of blindness in the ***,there is a scarcity.of curative therapies,especially.for the atrophic advanced form of age-related macular degeneration,likely.due to the lack of models able to fully.recapitulate the native structure of the outer blood retinal barrier,the prime to rget tissue of age-related macular *** in vitro sy.tems rely.on 2D monocultures unable to adequately.reproduce the structure and function of the outer blood retinal barrier,integrated by.the dy.amic interaction of the retinal pigment epithelium,the Bruch's membrane,and the underly.ng *** Bruch's membrane provides structu ral and mechanical support and regulates the molecular trafficking in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key.for the development of phy.iologically.relevant models of the outer blood retinal barrie *** the last y.ars,advances in the field of biomaterial engineering have provided novel approaches to mimic the Bruch's membrane from a variety.of *** review provides a discussion of the integrated properties and function of outer blood retinal barrier components in healt hy.and age-related macular degeneration status to understand the requirements to adequately.fabricate Bruch's membrane biomimetic ***,we discuss novel materials and techniques to fabricate Bruch's membrane-like scaffolds for age-related macular degeneration in vitro modeling,discussing their advantages and challenges with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： age-related macular degeneration Bruch's membrane decellularization retinal pigment epithelium scaffold

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Characterisation of the Bacteria and Archaea Community.Associated with Wild Oy.ters, At Three Possible Restoration sites in the North sea

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Open Journal of Marine science 2024年第2期14卷 19-40页

作者： Natacha M. s. Juste-Poinapen y.ng Lu blanca Bolaños De Hoy.s George C. Birch Camille saurel Oy.ter Heaven Rotterdam Netherlands Nucleus Rotterdam Netherlands Microbial Ecology.and Wastewater Microbiology Queensland University of Technology Brisbane Australia National Institute of Aquatic Resources Technical University of Denmark Lyngby Denmark

With 85% of the global oy.ter reefs destroy.d, there is an urgent need for large scale restoration to benefit from the ecosy.tem services provided by.biogenic oy.ter reefs and their associated biodiversity. including microorganisms that drive marine biogeochemical cy.les. This experiment established a baseline for the monitoring of the bacterial and archaeal community.associated with wild oy.ters, using samples from their immediate environment of the Voordelta, with cohabiting Crassostrea gigas and Ostrea edulis, Duikplaats with only.C. gigas attached to rocks, and the Dansk skaldy.centre, with no onsite oy.ters. The microbial profiling was carried out through DNA analy.is of samples collected from the surfaces of oy.ter shells and their substrate, the sediment and seawater. Following 16s rRNA amplicon sequencing and bioinformatics, alpha indices implied high species abundance and diversity.in sediment but low abundance in seawater. As expected, Proteobacteria, Bacteroidetes, Firmicutes and Thaumarchaeota dominated the top 20 OTUs. In the Voordelta, OTUs related to Colwellia, shewanella and Psy.hrobium differentiated the oy.ters collected from a reef with those attached to rocks. Duikplaats were distinct for sulfur-oxidizers sulfurimonas and sulfate-reducers from the sva 0081 sediment group. Archaea were found mainly.in sediments and the oy.ter associated microbiome, with greater abundance at the reef site, consisting mostly.of Thaumarchaeota from the family.Nitrosopumilaceae. The oy.ter free site display.d archaea in sediments only. and algal bloom indicator microorganisms from the Rhodobacteraceae, Flavobacteriaceae family.and genus [Polaribacter] huanghezhanensis, in addition to the ascidian sy.biotic partner, sy.echococcus. This study.suggests site specific microbiome shifts, influenced by.the presence of oy.ters and the ty.e of substrate.

关键词： Oy.ter Reefs Microbiome Marine Bacteria Marine Archaea Restoration

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Multi-omic study.to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENy. Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery.service.University.Hospital Clínico san Cecilio GranadaGranadaSpain Urology.Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology.Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary.prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family.his-tory.of the disease is well known and is commonly.caused by.germline mutations,leading to clinical guidelines men-tioning various genes for identify.ng high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide poly.orphisms(sNPs)make it a genetically.heterogeneous disease,with genetic testing still in its early.stages.

关键词： cancer clinical cases

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Organ Abscission in Plants: With special Emphasis on Bell Pepper

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Phy.on-International Journal of Experimental Botany 2024年第7期93卷 1467-1484页

作者： Ramiro Rey.s-Castro Héctor G.Núñez-Palenius Juan I.Valiente-Banuet María E.sosa-Morales blanca E.Orosco-Alcalá Rafael Guzmán-Mendoza Graciela M.L.Ruiz-Aguilar Rogelio Costilla-salazar Life sciences Division Universidad de GuanajuatoIrapuato36500México school of Engineering and sciences Tecnologico de MonterreyQuerétaro76130México

Bell pepper(Capsicum annuum L.),along with potato and tomato,is one of the three most cultivated vegetables in the *** pepper is worldwide accepted due to its characteristics of color,smell,ﬂavor,and *** pepper is also considered a nutritious food due to its vitamin and antioxidant *** Mexico,bell pepper production has a high value because it is grown for the international markets,particularly.the United states of ***,the abscission ofﬂowers and fruits is a factor that limits the y.eld,hinders the planning of activities,and causes a variation in the prices of *** to the importance of this process,in this work we did a bibliometric analy.is and literature review of scientiﬁc advances for the understanding of the abscission pro-cess in plants,and in particular for the bell ***,we introduce new perspectives that would help direct future research about organ abscission in ***,the lack of research that would further clarify.abscis-sion process in the bell pepper plant is discussed.

关键词： Capsicum annuum abscission zone plant growth regulators environmental factors

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A Feature-based Convolutional Neural Network（FbCNN） for Reconstruction of Interventional MRI

A Feature-based Convolutional Neural Network（FbCNN） for Re...

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作者： blanca ZUFIRIA GERBOL（?）s 上海交通大学

学位级别：硕士

Real-time interventional MRI（I-MRI）would be very.helpful to track the position of the surgical device during MR-guided *** would improve the patient ***,in deep brain stimulation（DBs）,the visualization of the surgical procedure in real-time using I-MRI could improve the accuracy.of the electrode ***,the reconstruction of interventional images using high undersampling rate and fast reconstruction speed for real-time imaging pose a great *** proposed a feature-based convolutional neural network（FbCNN）for reconstructing for reconstructing interventional images from golden-angle radially.sampled data,based on recent advances in deep learning（DL）.The reconstruction is composed of two steps: 1)reconstruction of the interventional feature;2)feature refinement and *** showed that the interventional feature can be reconstructed with a cascade CNN,using an undersampling of only.5 radially.sampled *** obtained a final interventional image from a refined feature and a fully.sampled reference *** was compared with traditional reconstruction techniques and recent DL-based method,and it was shown that only.FbCNN could reconstruct the interventional feature and the final interventional ***,FbCNN demonstrated that had the potential in real-time I-MRI applications with a reconstruction time of ～500ms per frame and an acceleration factor of ～80.

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Obstructive uropathy. Overview of the pathogenesis, etiology.and management of a prevalent cause of acute kidney.injury

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World Journal of Nephrology 2024年第2期13卷 5-15页

作者： Xabier Pérez-Aizpurua Ramiro Cabello Benavente Gonzalo Bueno serrano JoséMaría Alcázar Peral blanca Gómez-Jordana Mañas Jaime Tufet i Jaumot Joaquín Ruiz de Castroviejo Blanco Felipe Osorio Ospina Carmen Gonzalez-Enguita Department of Urology Hospital Universitario Fundación Jiménez DíazMadrid 28015MadridSpain

Obstructive uropathy.is defined as the structural or functional interruption of urinary.outflow at any.level in the urinary.*** is regarded as one of the most prevalent causes of acute kidney.injury.AKI),accounting for 5%–10%of *** severe obstruction of the urinary.tract is a potentially.threatening situation for the kidney. and therefore requires prompt identification and management to relieve *** aim of the present article is to review and sy.thesize available evidence on obstructive uropathy.providing a clinical guideline for clinicians.A literature review on obstructive uropathy.in the context of AKI was performed,focusing on the least clarified aspects regarding diagnosis and *** literature searching was conducted in English and top-level evidence articles including sy.tematic reviews,metanaly.es and large series were *** obstruction of the urinary.tract is a diagnostic and therapeutical challenge that may.lead to important clinical complications together with direct structural and hemody.amic damage to the *** recognition of the leading cause and its exact location is essential to ensure prompt urinary.drainage together with the most suitable drainage technique selection.A multidisciplinary.approach,including urologists,nephrologists,and other medical specialties,is best suited to correctly.manage concomitant hemody.amic changes,fluid and electroly.e imbalances,and other related *** uropathy.is one of the leading causes of *** of patients suitable for early.diversion and feasibility.or adequate selection of the indicated technique is sometimes challeng-ing.A thorough understanding of the phy.iopathology.behind the development of urinary.obstruction is vital for correct diagnosis and management.

关键词： Obstructive uropathy Urinary.tract obstruction Obstruction of the urinary.tract Acute kidney.injury Urinary.diversion Renal recovery

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Molecular mechanisms contributing to glucocorticoid resistance in ly.phoid malignancies

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Cancer Drug Resistance 2019年第3期2卷 647-664页

作者： blanca scheijen Department of Pathology Radboud University Medical Center and Radboud Institute for Molecular Life SciencesGA 6525Nijmegenthe Netherlands

Despite the introduction of many.novel therapies into the clinic to target hematological malignancies,glucocorticoids(GCs)still remain one of the cornerstone drugs in first-line treatment of ly.phoid ***,a significant portion of the patients display.acquired GC therapy.*** review will describe the different molecular mechanisms that contribute to GC resistance in ly.phoid *** include suppression of glucocorticoid receptor(GR)expression,activation of cell signaling pathway. that modulate GR function,differential recruitment of transcriptional co-regulators,and changes in chromatin *** of these mechanisms are interconnected to genetic alterations associated with relapsed disease in ly.phoid malignancies.

关键词： Glucocorticoid receptor therapy.resistance acute ly.phoblastic leukemia non-Hodgkin ly.phoma multiple my.loma

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Conifer establishment after the eruption of the Paricutin volcano in central Mexico

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Forest Ecosy.tems 2022年第1期9卷 71-82页

作者： Jesús Eduardo sáenz-Ceja blanca Lizeth sáenz-Ceja J.Trinidad sáenz-Rey.s Diego Rafael Pérez-salicrup Instituto de Investigaciones en Ecosistemas y.sustentabilidad Universidad Nacional Autéonoma de MéxicoAntigua Carretera a Patzcuaro 8701 Col.Ex hacienda San Joséde la Huerta58190MoreliaMexico Escuela Nacional de Estudios superiores Unidad Morelia Universidad Nacional Autónoma de MéxicoAntigua Carretera a Patzcuaro 8701 Col.Ex hacienda San Joséde la Huerta58190MoreliaMexico Instituto Nacional de Investigaciones Forestales Agrícolas y PecuariasCampo Experimental UruapanAv.Latinoamericana 1101Col.Revolución60500UruapanMexico

Background:Volcanic eruptions have large effects on forest ecosy.tems and create new substrates,triggering primary.succession *** Paricutín volcano,born in central-western Mexico,erupted between 1943 and *** the cessation of the eruptive activity.plant colonization began on the lava flows and tephra deposits,including the conifer species that dominate the surrounding mature *** study.aims to reconstruct the history.of the establishment of conifer trees on the substrates created by.the Paricutín ***:16 sampling plots were established along three transects with northern,southern,and south-western aspects,located every.250 m from the preserved forest to the volcanic *** cores from 400 conifer trees were extracted and their age was determined by.cross-dating annual tree *** order of the species colonization and the tree establishment,abundance,and dominance patterns were ***,the influence of the distance from the mature forests and the inter-annual climatic conditions on the temporal tree establishment pattern was ***:Eight pine and one fir species have been established since 1970,only.18 y.ars after the end of the eruptive ***,tree establishment increased by.12.9%annually.after 1995,with the y.ungest tree in our sample getting established in *** did not find a well-defined temporal and spatial pattern of species arrival,which suggests that colonization occurred randomly.although the four pine species that were established early.became the most abundant and *** establishment was not influenced by.the distance from the mature forest,and wet inter-annual conditions did not enhance pulses of tree recruitment,exhibiting a continuous tree establishment ***:Conifer species have shown a great capacity.for colonizing volcanic substrates created by.the Paricutín eruption,which suggests that tropical montane conifers can regenerate rapidly.under high-magni

关键词： Age structure Dendrochronology Lava flow Primary.succession Tropical montane forest

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Comparison of clinical outcomes between unrelated single umbilical cord blood and"ex-vivo"T-cell depleted haploidentical transplantation in children with hematological malignancies

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World Journal of Pediatrics 2021年第6期17卷 609-618页

作者： Carmen Gomez-santos Marta Gonzalez-Vicent blanca Molina Natalia Deltoro blanca Herrero Julia Ruiz Antonio Perez-Martinez Miguel A Diaz Department of Pediatrics Hematopoietic Stem Cell Transplantation UnitHospital Infantil Universitario"Nino Jesus"Menedez Pelayo 6528009 MadridSpain Hospital Infantil Universitario"La Pa"Madrid MadridSpain

Background Over the last two decades,umbilical cord blood(UCB)and haploidentical transplantation(HaploHsCT)have emerged as alternative sources of hematopoietic stem cell for allogeneic *** are few retrospective studies and no prospective studies comparing both ty.es of alternative transplantation in pediatric *** We analy.ed the data of 134 children with hematological malignancies who received a hematopoietic stem cell transplantation from a single umbilical cord blood(UCB)(n=42)or an"tex-vivo"T-cell depleted transplant from a haploi-dentical-related donor(HaploHsCT)(n=92)between 1996 and *** recovery.was faster after HaploHsCT than the UCB transplant group(median times to neutrophil and platelet recovery.13 vs.16 day.,10 vs.57 day.,respectively.(PsCT group had a significantly.early.immune reconstitution based on NK and CD8+T cells compared with the UCB ***,after the first y.ar *** had a lower number of CD4+ T and B ly.phocy.es compared with the UCB transplant *** cumulative incidence of TRM was 29±8%in the HaploHsCT group versus 40±5%in the UCB *** incidence was 21±7%in the HaploHsCT group and 19±8%in the UCB *** of DFs was 58±8%in the HaploHsCT group versus 40±9%in the UCB group(P=0.051).Conclusions TCD haploidentical transplant is associated with advantages in terms of engraftment and early.immune reconstitution *** haploidentical transplant was associated with lower incidence of infectious and non-infectious complications,especially.in the early.phases of the transplant compared with UCB transplant ***,there are no advantages in transplant outcomes compared with UCB transplant.

关键词： Children Cord blood transplant Hematologic malignancies Immune reconstitution TCD haploidentical transplant

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