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Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

Neural Regeneration Research 2024年第12期19卷 2626-2636页

作者： blanca molins.andrea rodríguez Víctor Llorenç Alfredo Adán Group of Ocular Inflammation:Clinical and Experimental Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain Institut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degeneration,a multifactorial inflammatory degenerative retinal disease,ranks as the leading cause of blindness in the ***,there is a scarcity of curative therapies,especially for the atrophic advanced form of age-related macular degeneration,likely due to the lack of models able to fully recapitulate the native structure of the outer blood retinal barrier,the prime to rget tissue of age-related macular *** in vitro systems rely on 2D monocultures unable to adequately reproduce the structure and function of the outer blood retinal barrier,integrated by the dynamic interaction of the retinal pigment epithelium,the Bruch's membrane,and the underlying *** Bruch's membrane provides structu ral and mechanical support and regulates the molecular trafficking in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key for the development of physiologically relevant models of the outer blood retinal barrie *** the last years,advances in the field of biomaterial engineering have provided novel approaches to mimic the Bruch's membrane from a variety of *** review provides a discussion of the integrated properties and function of outer blood retinal barrier components in healt hy and age-related macular degeneration status to understand the requirements to adequately fabricate Bruch's membrane biomimetic ***,we discuss novel materials and techniques to fabricate Bruch's membrane-like scaffolds for age-related macular degeneration in vitro modeling,discussing their advantages and challenges with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： age-related macular degeneration Bruch's membrane decellularization retinal pigment epithelium scaffold

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墨西哥不同地区临床护理服务资源测量指数的研究

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International Journal of Nursing Sciences 2020年第3期7卷 344-348页

作者： Rey Arturo Salcedo-Alvarez blanca Consuelo González-Caamano Sara Huerta-González andrea Del Prado-Vázquez Universidad Nacional Autónoma de México Escuela Nacional de Enfermería y ObstetriciaCamino viejo a Xochimilco S/N y Viaducro TlalpanColonia San Lorenzo Huipulco14370Mexico CityMexico Universidad Veracruzana Región Poza Rica-Tuxpan.Boulevard Lázaro Cárdenas#801Colonia Morelos93240Poza RicaVeracruzMexico

目的本研究旨在以孕产妇死亡率为基础,对相关护理数据和社会背景的因素进行分析,制订临床护理服务资源测量指数。方法采用来源于卫生部、国家统计和地理研究所的数据进行分析,包括:护理覆盖率指数、学士学位及以上护士比例、人类发展指... 详细信息

目的本研究旨在以孕产妇死亡率为基础,对相关护理数据和社会背景的因素进行分析,制订临床护理服务资源测量指数。方法采用来源于卫生部、国家统计和地理研究所的数据进行分析,包括:护理覆盖率指数、学士学位及以上护士比例、人类发展指数和人口密度。通过主成分分析法构建墨西哥护理资质指数(Index of Nursing Qualification in Mexico,INQM)。结果INQM与护理覆盖排序指数(The NursingCover-age PrioritisationIndex,NCPI)(0.849,P<0.01)及人口密度排序指数(The Population Density Prioritization in-dex,PDPI)(0.716,P<0.01)相关性均较高。通过主成成分分析提取3个公因子,INQM主要由模型中3个主要成分组成。INQM与孕产妇死亡率之间没有显示有统计学意义的相关关系。结论研究表明,形成INQM的要素可能会对严重的公共卫生问题产生影响,该结果为应用这些指标提供了参考,有助于确定临床护理服务资源测量指数的贡献。

关键词：产妇死亡率人口密度护理墨西哥

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The Two Perspectives of the Climate Change: Social vs. Scientific

The Two Perspectives of the Climate Change: Social vs. Scien...

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2015 4th International Conference on Environment, Energy and Biotechnology

作者： blanca andrea Ortega-Marín Raúl Vera-Alejandre Pedro Joaquín Gutiérrez-Yurrita National Polytechnic Institute Interdisciplinary Center for Research and Studies on Environment and Development

Climatic conditions become ostensible in human activities altering agricultural production, forestry and civil security, increasing vulnerability risk of socio-environmental disaster. In regions where natural resources proliferate in good condition and therefore are declared protected areas, it is essential to determine whether there is indeed climate changes or, if there are just climate variations because ethnic and peasant communities depend entirely of their natural resources to survival. The aim of this study was to compare local people perception of weather variations respect what was found by scientists to analyze long series of traditional climatic data. To understand social vs. scientific perception of the same phenomenon we rely on a case study in the Sierra Otomí. Examination of both temperature and precipitation showed no significant differences between 1944 and 2010. However, the overall trend in temperature was to decline 0.5℃. When crossing statistical information regarding natural and anthropogenic historical phenomena, there seems no climate change in the region. On the other hand, social perception is that there is a major climate change in the region, increasing trouble scheduling crops because the rain is delayed or comes suddenly and everything floods. It also tells people that the temperature is getting warmer than ever, because the nights are cooler and the days are hotter than some years ago. Although the perception of the population is not supported by scientific data, the feeling is strong, but is due to cultural, economic criteria, and traditional beliefs. This information is important to develop specific programs for management of natural resources in rural places with adjoining protected natural areas.

关键词： landscape management holism conservation biology ethnic communities xajay

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High passage numbers induce resistance to apoptosis in C2C12muscle cells

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BIOCELL 2013年第1期37卷 1-9页

作者： LUCIA PRONSATO ANABELA LA COLLA ANA CAROLINA RONDA LORENA MILANESI RICARDOBOLAND andrea VASCONSUELO Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur.San Juan 6708000 Bahía BlancaArgentina

Cell lines with high passage numbers exhibit alterations in cell morphology and *** thepresent work,C2C12 skeletal muscle cells with either low(60)passage numbers(identified as l-C2C12 or h-C2C12,respectively)were used to investigate the apoptotic response to H2O2 as a function ofculture age *** found that older cultures(h-C2C12 group)were depleted of mitochondrial DNA(mtDNA).When we analyzed the behavior of Bad,Bax,caspase-3 and mitochondrial transmembrane potential,we observed that cells in the h-C2C12 group were resistant to H2O2 induction of *** propose seriallycultured C2C12 cells as a refractory model to H2O2-induced *** addition,the data obtained in thiswork suggest that mtDNA is required for apoptotic cell death in skeletal muscle C2C12 cells.

关键词： over-subculturing changes aged muscle cultures mitochondrial DNA

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Characterization of oral yeasts isolated from healthy individuals attended in different Colombian dental clinics

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The Journal of Biomedical Research 2019年第5期33卷 333-342页

作者： Raul Eduardo Rivera Alejandra Zuluaga Karen Arango Itzjak Kadar Paola andrea Pinillos Luis Fernando Montes Eugenia Catalina Cepeda Ernesto Gonzalez Pedro Antonio Alfonso andrea Alejandra Villalba Luis Fernando Casanova Adolfo Perez Armando Roa Martha Jhoana Arias Jorge Orlando Francisco Cuellar Lorena Pedraza Adiel Alberto Vasquez blanca Lynne Suarez Beatriz LGomez Catalina De Bedout Luz Elena Cano Group of Investigation in Oral Health Faculty of DentistryAntonio Narino UniversityArmeniaQuindio 630001Colombia Medical and Experimental MycologyUnit Corporation for Biological Research(CIB)MedellinAntioquia 050034Colombia School of Medicine and Health Sciences Universidad del RosarioCarreraBogota 111221Colombia School of Microbiology University of AntioquiaMedellinAntioquia 050036Colombia.

The aim of this study was to identify the most frequent yeasts in the oral cavity of adult individuals without immune disorders and to associate the presence of these oral yeasts with different characteristics of each individual. Oral rinse samples were obtained from 96 healthy adults and cultured in Sabouraud dextrose agar media and CHROMagar. Yeasts were identified by sequencing the D1/D2 region of the 28 S rRNA gene. Probable association among the socio-demographic characteristics, body mass index, family and personal medical history,oral hygiene, tobacco and/or alcohol consumption habits and presence of oral fungi was analyzed. Contingency tables and logistic regression were employed to evaluate possible relationships between the presence of oral fungi and mixed colonization with these variables. 57.3% of the healthy individuals had oral yeasts and 21.8% had mixed colonization. The most prevalent yeasts were Candida albicans(52%), C. parapsilosis(17.9%), and ***(7.57%). Yeasts with most frequently mixed colonization were C. albicans and C. parapsilosis. No relationships were found among the variables analyzed. However, the presence of mixed colonization was related to the presence of dental prostheses(P<0.006), dental apparatuses(P=0.016) and O’Leary index(P=0.012). This is the first study that characterized oral yeasts in Colombian healthy individuals, determined the most prevalent oral yeasts C. albicans, C. parapsilosis and C. dublinensis and an association of mixed colonization with the use of dental prostheses and aparatology and poor hygiene.

关键词： oral yeast Candida species microbial epidemiology

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