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Latest developments in early diagnosis and specific treatment of severe influenza infection

Journal of Intensive Medicine 2024年第2期4卷 160-174页

作者： Francisco Valenzuela-Sánchez blanca Valenzuela-Méndez Juan Francisco Rodríguez-Gutiérrez Ángel Estella Intensive Care Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Centro de Investigación Biomédica en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Oncological Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of Medicine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigación e Innovación Biomédica de Cádiz(INIBiCA) Avenida Ana de Viya 21CádizSpain

Influenza pandemics are unpredictable recurrent events with global health,economic,and social *** objective of this review is to provide an update on the latest developments in early diagnosis and specific treatment of the disease and its complications,particularly with regard to respiratory organ *** advances in treatment,the rate of mortality in the intensive care unit remains approximately 30%.Therefore,early identification of potentially severe viral pneumonia is extremely important to optimize treatment in these *** pathogenesis of influenza virus infection depends on viral virulence and host ***,in some patients,it is associated with an excessive systemic response mediated by an authentic cytokine *** process leads to severe primary pneumonia and acute respiratory distress *** prognostication in the emergency department based on comorbidities,vital signs,and biomarkers(e.g.,procalcitonin,ferritin,human leukocyte antigen-DR,mid-regional proadrenomedullin,and lactate)is *** of these biomarkers on admission may facilitate clinical decision-making to determine early admission to the hospital or the intensive care *** decisions are reached considering pathophysiological circumstances that are associated with a poor prognosis(e.g.,bacterial co-infection,hyperinflammation,immune paralysis,severe endothelial damage,organ dysfunction,and septic shock).Moreover,early implementation is important to increase treatment *** on a limited level of evidence,all current guidelines recommend using oseltamivir in this *** possibility of drug resistance should also be *** options include other antiviral drugs and combination therapies with monoclonal ***,it is not recommended to use corticosteroids in the initial treatment of these ***,the implementation of supportive measures for respiratory failure is ***

关键词： Influenza Pandemic Respiratory failure Acute respiratory distress syndrome Intensive care unit admission

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恋上萨里的阳光

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现代装饰（家居） 2013年第9期 112-119页

作者： blanca Sanchez Robert Sanderson 肖俊英国Halo Design Interiors

本案是一栋建于2003年的房子,根据目前的房屋状况,急需对其进行个性化和现代化改造。业主是一对年轻夫妇和他们的两个小男孩。业主对本次改造的要求是对房屋进行全面更新的同时,着眼于对主卧套房的改造,使其纳入一个全新的卫浴间和更衣... 详细信息

本案是一栋建于2003年的房子,根据目前的房屋状况,急需对其进行个性化和现代化改造。业主是一对年轻夫妇和他们的两个小男孩。业主对本次改造的要求是对房屋进行全面更新的同时,着眼于对主卧套房的改造,使其纳入一个全新的卫浴间和更衣室。此外。

关键词：卫浴间主卧现代化改造萨里儿童房 patio kitchen 室内设计 floor 两层楼

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萨里初印象

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现代装饰（家居） 2014年第3期 96-101页

作者： blanca Sanchez Roxanne Holland 肖俊英国Halo Design Interiors

本案是受乔治王时期艺术风格的启发而新建的一栋位于英国萨甩琊的宅邸。建筑的中央是一个全高的八角形中庭，源源不断的自然光线从中庭上方的灯笼窗口倾泻而下。

关键词：印象艺术风格自然光线中庭建筑

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Triage and Risk Concept: Application Proposal for Pre-Hospital Emergencies in a Psychiatric Ambulance in the City of Buenos Aires

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Open Journal of Emergency Medicine 2023年第1期11卷 21-31页

作者： Mazzoglio Y. Nabar Martín Javier Rubén Daniel Algieri Gabriel Schraier blanca Lopez Sergio Giordano Department of Psychiatric Emergencies “Torcuato de Alvear” Psychiatric Emergency Hospital Buenos Aires Argentina

The heterogeneity of clinical presentations in psychiatric emergencies creates difficulties in the response by interdisciplinary Mental Health teams. This is aggravated and difficult when the care is carried out on public roads or the patient’s home, that is, it is a pre-hospital context. Our Psychiatric Emergency Hospital, located in the City of Buenos Aires, provides pre-hospital care with a psychiatric ambulance, which is then referred to general hospitals or other health system providers. Not all effectors in the network have the same resources and, at the time of the emergency, the reasons for consultation such as the patient’s clinic are heterogeneous and require the greatest effectiveness in the intervention that is taken. The triage system is a resource that allows the systematization of approaches against the multiplicity of reasons for consultation and presentation of mental pathologies in the emergency room, in addition to providing greater effectiveness in interventions, homogeneity for the health system and consensus among the health effectors. Framed in the Mental Health Law, and especially in the concept of risk, a triage proposal was designed for pre-hospital interventions by the psychiatric ambulance dependent on Hospital Alvear and under current legal regulations with the aim of homogenizing care and referrals with the highest rate of effectiveness to provide quality interdisciplinary medicine.

关键词： Psychiatry Ambulance Emergencies Triage

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馨雅时刻

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现代装饰（家居） 2016年第8期 84-93页

作者： blanca Sanchez 范嘉苑英国Halo Design Interiors

项目地址英国设计单位Halo Design InteriorsHalo Design Interiors在近期翻新了一座建于80年代的独栋住屋。由于房子原来的厨房采用了封闭式的布局,看上去昏暗老旧,且对其它空间的布局也造成了影响,所以厨房成为了设计团队首先改造的... 详细信息

项目地址英国设计单位Halo Design InteriorsHalo Design Interiors在近期翻新了一座建于80年代的独栋住屋。由于房子原来的厨房采用了封闭式的布局,看上去昏暗老旧,且对其它空间的布局也造成了影响,所以厨房成为了设计团队首先改造的区域。通过移除厨房原先的两面墙体,使之拥有了开放式的格局,并与餐区及家庭活动室相连。厨房色调以白色及金色为主调,橱柜采用了哑光白及抛光金的质感与色调,并配备了纯白的光面操作台。经过改造后的厨房看起来更加干净明亮,营造出一种平和宁静的空间调性。

关键词：项目地址纯白英国设计过渡区主卧 kitchen interior bases bronze 觉木

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Whole-genome resequencing of Cucurbita pepo morphotypes to discover genomic variants associated with morphology and horticulturally valuable traits

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Horticulture Research 2019年第1期6卷 568-584页

作者： Aliki Xanthopoulou Javier Montero-Pau Ifigeneia Mellidou Christos Kissoudis Joséblanca Belén Picó Aphrodite Tsaballa Eleni Tsaliki Athanasios Dalakouras Harry S.Paris Maria Ganopoulou Theodoros Moysiadis Maslin Osathanunkul Athanasios Tsaftaris Panagiotis Madesis Apostolos Kalivas Ioannis Ganopoulos Department of Genetics and Plant Breeding Aristotle University of ThessalonikiThessaloniki 54124Greece Department of Biochemistry and Molecular Biology Universitat de València46022 ValenciaSpain Institute of Plant Breeding and Genetic Resources Hellenic Agricultural Organization DEMETER(ex NAGREF)ThermiMacedonia 57001Greece Perrotis College American Farm SchoolThessaloniki 57001Greece Institute for the Conservation and Breeding of Agricultural Biodiversity(COMAV-UPV) Universitat Politècnica de ValènciaCamino de Vera s/n46022 ValenciaSpain Department of Vegetable Crops and Plant Genetics Agricultural Research OrganizationNewe Ya’ar Research CenterRamat YishayIsrael Institute of Applied Biosciences(INAB) CERTHThermi-Thessaloniki 57001Greece Department of Biology Faculty of Science Chiang Mai UniversityChiang MaiThailand Center of Excellence in Bioresources for Agriculture Industry and MedicineChiang Mai UniversityChiang MaiThailand

Cucurbita pepo contains two cultivated subspecies,each of which encompasses four fruit-shape morphotypes(cultivar groups).The Pumpkin,Vegetable Marrow,Cocozelle,and Zucchini Groups are of *** and the Acorn,Crookneck,Scallop,and Straightneck Groups are of ***,a de novo assembly of the *** *** Zucchini genome was published,providing insights into its *** expand our knowledge of evolutionary processes within *** and to identify variants associated with particular morphotypes,we performed wholegenome resequencing of seven of these eight *** *** report for the first time whole-genome resequencing of the four ***(Pumpkin,Vegetable Marrow,Cocozelle,green Zucchini,and yellow Zucchini)morphotypes and three of the ***(Acorn,Crookneck,and Scallop)morphotypes.A high-depth resequencing approach was followed,using the BGISEQ-500 platform that enables the identification of rare variants,with an average of *** 94.5%of the clean reads were mapped against the reference Zucchini *** total,3,823,977 high confidence single-nucleotide polymorphisms(SNPs)were *** each accession,SNPs varied from 636,918 in green Zucchini to 2,656,513 in Crookneck,and were distributed homogeneously along the *** differences between subspecies pepo and ovifera in genetic variation and linkage disequilibrium are *** fact,comparison between subspecies pepo and ovifera indicated 5710 genes(22.5%)with Fst>0.80 and 1059 genes(4.1%)with Fst=1.00 as potential candidate genes that were fixed during the independent evolution and domestication of the two *** disequilibrium was greater in *** than in ***,perhaps reflective of the earlier differentiation of morphotypes within *** morphotype-specific genes have been *** results offer new clues that may provide an improved understanding of the underlying genomic regions involved

关键词： cultivar traits Whole

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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Organ Abscission in Plants: With Special Emphasis on Bell Pepper

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1467-1484页

作者： Ramiro Reyes-Castro Héctor G.Núñez-Palenius Juan I.Valiente-Banuet María E.Sosa-Morales blanca E.Orosco-Alcalá Rafael Guzmán-Mendoza Graciela M.L.Ruiz-Aguilar Rogelio Costilla-Salazar Life Sciences Division Universidad de GuanajuatoIrapuato36500México School of Engineering and Sciences Tecnologico de MonterreyQuerétaro76130México

Bell pepper(Capsicum annuum L.),along with potato and tomato,is one of the three most cultivated vegetables in the *** pepper is worldwide accepted due to its characteristics of color,smell,ﬂavor,and *** pepper is also considered a nutritious food due to its vitamin and antioxidant *** Mexico,bell pepper production has a high value because it is grown for the international markets,particularly the United States of ***,the abscission ofﬂowers and fruits is a factor that limits the yield,hinders the planning of activities,and causes a variation in the prices of *** to the importance of this process,in this work we did a bibliometric analysis and literature review of scientiﬁc advances for the understanding of the abscission pro-cess in plants,and in particular for the bell ***,we introduce new perspectives that would help direct future research about organ abscission in ***,the lack of research that would further clarify abscis-sion process in the bell pepper plant is discussed.

关键词： Capsicum annuum abscission zone plant growth regulators environmental factors

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Comparison of Locomotion Problems and Its Economic Impact on Cobb and Ross Broiler Strains

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Veterinary Science Research 2021年第2期3卷 40-46页

作者： blanca Leydi Guevara-Torres Luis Antonio Landin-Grandvallet Alberto Tirado-Madrid JoséAlfredo Villagómez-Cortés Facultad de Medicina Veterinaria y Zootecnia Universidad VeracruzanaVeracruzMexico Productos Agrícolas y Pecuarios de Neria Super PolloFortínMexico

The rapid weight gain and fast muscle growth due to intense genetic selection and improved nutrition for additional breast muscle in broiler commercial strains affect chickens *** order to compare the main locomotive problems in broilers of Cobb and Ross strains,two pens from a commercial farm in Veracruz,Mexico were *** first pen housed 16,500 males and 16,500 females of Cobb strain and the second one 16,500 males and 16,500 females of Ross *** were checked for locomotion problems from day one until their *** with problems were recorded and necropsies were performed to identify the *** of 1406 animals with locomotive problems(2.13%of the total),58.9%were Cobb and 41.1%Ross(P<0.05).The frequency of locomotive problems was 2.51%for Cobb and 1.75%for *** common individual lesions were osteochondrosis(38.61%),inflamed joints with purulent contents(37.13%),and valgus(19.65%).Locomotive problems appeared since the first week,but its number increased as birds gained weight,particularly from the fourth week *** occurred more in males than in females and in Cobb birds than in the Ross *** loss due to locomotion problems was higher for the Cobb strain.

关键词： Animal welfare Bone symmetry Cost of disease Femoral degeneration Genetics Poultry health

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1.3 μm emitting SrF2：Nd^3＋ nanoparticles for high contrast in vivo imaging in the second biological window

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Nano Research 2015年第2期8卷 649-665页

作者： Irene Villa Anna Vedda Irene Xochilt Cantarelli Marco Pedroni Fabio Piccinelli Marco Bettinelli Adolfo Speghini Marta Quintanilla Fiorenzo Vetrone Ueslen Rocha Carlos Jacinto Elisa Carrasco Francisco Sanz Rodrfguez Angeles Juarranz blanca del Rosal Dirk H. Ortgies Patricia Haro Gonzalez Jose Garcia Sole Daniel Jaque Garcia Department of Materials Science University of Milano-Bicocca Via R. Cozzi 55 20125 Milano Italy Dipartimento di Biotecnologie Universita di Verona and INSTM UdR Verona Strada le Grazie 15 37134 Verona Italy Institut National de la Recherche Scientifique-Energie Materiaux et Telecommunications Universitd du Quebec Varennes QC PQ J3X 1S2 Canada Grupo de Fotonica e Fluidos Complexos Instituto de Fisica Universidade Federal de Alagoas 57072-970 Maceio Alagoas Brazil Departamento de Biologia Facultad de Ciencias Campus de Cantoblanco Universidad Autdnoma de Madrid Madrid 28049 Spain Fluorescence Imaging Group Departamento de Fisica de Maferiales Facultad de Ciencias Campus de Cantoblanco Universidad Aut6noma de Madrid Madrid 28049 Spain

Novel approaches for high contrast, deep tissue, in vivo fluorescence biomedical imaging are based on infrared-emitting nanoparticles working in the so-called second biological window （1,000-1,400 nm）. This allows for the acquisition of high resolution, deep tissue images due to the partial transparency of tissues in this particular spectral range. In addition, the optical excitation with low energy （infrared） photons also leads to a drastic reduction in the contribution of autofluorescence to the in vivo image. Nevertheless, as is demonstrated here, working solely in this biological window does not ensure a complete removal of autofluorescence as the specimens diet shows a remarkable infrared fluorescence that extends up to 1,100 nm. In this work, we show how the 1,340 nm emission band of Nd3. ions embedded in SrF2 nanoparticles can be used to produce autofluorescence free, high contrast in vivo fluorescence images. It is also dem- onstrated that the complete removal of the food-related infrared autofluorescence is imperative for the development of reliable biodistribution studies.

关键词： fluorescence imaging rare earth dopednanoparticles nanomedicine

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