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Microcluster colloidosomes for hemostat delivery into complex wounds:A platform inspired by the attack action of torpedoes

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Bioactive Materials 2022年第10期7卷 372-387页

作者： bitao lu Enling Hu Ruiqi Xie Kun Yu Fei lu Rong Bao Chenhui Wang Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China The Ninth People’s Hospital of Chongqing No.69 Jialing Village BeiBei DistrictChongqing400715China Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing University55 South Daxuecheng RoadChongqing401331China

Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature,thereby causing massive blood loss and significantly increased *** by the attack action of torpedoes,we synthesized microcluster(MC)colloidosomes equipped with magnetic-mediated navigation and“blast”systems to deliver hemostats into the cavity of vase-type ***_(3)/Fe_(2)O_(3)(CF)microparticles functionalized with Arg-Gly-Asp(RGD)modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots(CDs)to form MC colloidosomes,which were loaded with thrombin and protonated tranexamic acid(TXA-NH_(3)^(+)).The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH_(3)^(+).The CO_(2) bubbles generated during disassembly produced a“blast”that propelled thrombin into the wound *** bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within~60 ***,in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC *** study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis,creating a new paradigm for combating trauma treatment.

关键词： Torpedoes-inspired Microcluster colloidosomes Magnetic guidance Disintegration Hemostasis

Magnetic field-mediated Janus particles with sustained driving capability for severe bleeding control in perforating and inflected wounds

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Bioactive Materials 2021年第12期6卷 4625-4639页

作者： Qing Li Enling Hu Kun Yu Mengxing lu Ruiqi Xie Fei lu bitao lu Rong Bao Guangqian Lan State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China The Ninth People’s Hospital of Chongqing No.69 Jialing VillageBeiBei DistrictChongqing400715China

Severe bleeding in perforating and inflected wounds with forky cavities or fine voids encountered during prehospital treatments and surgical procedures is a complex ***,we present a novel hemostatic strategy based on magnetic field-mediated *** biphasic Janus magnetic particle(MSS@Fe2O3-T)comprised aggregates ofα-Fe2O3 nanoparticles(Fe_(2)O_(3) NPs)as the motion actuator,negatively modified microporous starch(MSS)as the base hemostatic substrate,and thrombin as the loaded hemostatic *** application,the particles were first wrapped using NaHCO_(3) and then doped with protonated tranexamic acid(TXA-NH_(3)^(+)),which ensured their high self-dispersibility in *** application,the particles promptly self-diffused in blood by bubble propulsion and travelled to deep bleeding sites against reverse rushing blood flow under magnetic *** vivo tests confirmed the superior hemostatic performance of the particles in perforating and inflected wounds(“V”-shaped femoral artery and“J”-shaped liver bleeding models).The present strategy,for the first time,extends the range of magnetically guided drug carriers to address the challenges in the hemorrhage control of perforating and inflected wounds.

关键词： Janus particle Sustained driving Magnetic guidance Hemostasis Complex wound

Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

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Bioactive Materials 2021年第9期6卷 2956-2968页

作者： luoxiao Ran bitao lu Haoyu Qiu Guofang Zhou Jing Jiang Enling Hu Fangyin Dai Guangqian Lan State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China Chongqing General Hospital University of Chinese Academy of Sciences No.118Xingguang AvenueLiangjiang New AreaChongqingChina

The increase in the number of resistant bacteria caused by the abuse of antibiotics and the emergence of biofilms significantly reduce the effectiveness of *** infections are detrimental to our life and *** reduce the abuse of antibiotics and treat biofilm-related bacterial infections,a biomimetic nano-antibacterial system,RBCM-NW-G namely,that controls the release of antibiotics through near infrared was *** hollow porous structure and the high surface activity of nanoworms are used to realize antibiotic loading,and then,biomimetics are applied with red blood cell membranes(RBCM).RBCM-NW-G,which retains the performance of RBCM,shows enhanced permeability and retention *** imaging in mice showed the effective accumulation of RBCM-NW-G at the site of *** addition,the biomimetic nanoparticles showed a longer blood circulation time and good ***-biofilm test results showed damage to biofilms due to a photothermal effect and a highly efficient antibacterial performance under the synergy of the photothermal effect,silver iron,and ***,by constructing a mouse infection model,the great potential of RBCM-NW-G in the treatment of in vivo infections was confirmed.

关键词： Red blood cell membrane Nanoworms Antibiotics release Bacterial infection

In situ assembly of Ag nanoparticles（AgNPs） on porous silkworm cocoon-based would film:enhanced antimicrobial and wound healing activity

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In situ assembly of Ag nanoparticles（AgNPs） on porous silk...

面向波动可再生能源的质子交换膜电制氢系统最优压强运行

中国蚕学会第九届青年学术研讨会

作者： Kun Yu Fei lu Qing Li Honglei Chen bitao lu Jiawei Liu Zhiquan Li Fangying Dai Dayang Wu Guangqian Lan College of Textile and Garments Southwest University Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile The Ninth People’s Hospital of Chongqing

Preventing wound infection and retaining an appropriate level of moisture around wounds represent the most critical issues in wound *** these ends,special focus has been placed on Bombyx mori cocoons because the protective function of the silkworm cocoon resembles the manner in which the skin protects the human *** have designed a facile technique to develop a novel silkworm cocoon-based wound film（SCWF） wound dressing utilizing a CaCl2-ethanol-H2 O *** improve the anti-bacterial performance of SCWF,we have incorporated the ability of silk sericin to act as a reducing agent for the conversion of Ag+ to Ag,yielding nanoparticles（AgNPs） linked together by peptide bonds of silkworm cocoon wound film（SCWF-AgNPs）.SCWF-AgNP dressing exhibited excellent biocompatibility,anti-bacterial performance,and good ***,in vivo experiments indicated that SCWF-AgNP dressing was able to significantly accelerate the healing rate of infected wounds in New Zealand White rabbits and histological examination revealed that it aided in the successful reconstruction of intact and thickened epidermis during 14 days of healing of impaired wound *** results demonstrate that the present approach might shed new light on the design of anti-bacterial materials such as SCWF-AgNPs with promising applications in wound dressing.

关键词： Silkworm cocoon Silver nanoparticles Infected wound healing Silk fibroin Antibacterial performance

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电力自动化设备 2024年第8期44卷 210-217页

作者：刘元肖碧涛卢昂刘文昕钟治垚方家琨王辉黄蕾国电南京自动化股份有限公司江苏南京210032 华中科技大学强电磁技术全国重点实验室湖北武汉430074

为提升质子交换膜电制氢系统在波动可再生能源输入下的制氢效率,提出面向最大效率的质子交换膜电制氢系统最优压强运行模式。介绍质子交换膜电制氢系统,提出基于压强控制的协调运行原理;对质子交换膜电制氢系统的压强特性和功率特性进... 详细信息

为提升质子交换膜电制氢系统在波动可再生能源输入下的制氢效率,提出面向最大效率的质子交换膜电制氢系统最优压强运行模式。介绍质子交换膜电制氢系统,提出基于压强控制的协调运行原理;对质子交换膜电制氢系统的压强特性和功率特性进行建模,从而建立面向最大效率的压强优化模型。在波动电流输入算例下检验最优压强运行模式的制氢效果,结果表明,相较于恒定压强模式,最优压强运行模式下的质子交换膜电制氢系统平均制氢能耗得到有效降低,系统性能得到明显提升。

关键词：可再生能源质子交换膜电制氢系统压强特性建模最大制氢效率最优压强运行

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苎麻微生物脱胶菌株的最佳脱胶条件

纺织学报 2014年第12期35卷 91-95页

作者：陈景浩卢必涛王天佑蓝广芊西南大学纺织服装学院重庆400715

从保存的苎麻微生物脱胶菌株中筛选出脱胶效果最好的菌株8-1,以培养时间、培养温度、菌液量体积比、转速为因素作正交试验,研究其最佳脱胶条件。结果表明,影响因素最大的是培养时间,其次是培养温度与菌液量体积比,转速影响最小。该菌株... 详细信息

从保存的苎麻微生物脱胶菌株中筛选出脱胶效果最好的菌株8-1,以培养时间、培养温度、菌液量体积比、转速为因素作正交试验,研究其最佳脱胶条件。结果表明,影响因素最大的是培养时间,其次是培养温度与菌液量体积比,转速影响最小。该菌株的最佳脱胶条件为:4 d、39℃、菌液量体积比1∶40、静置培养。该条件下苎麻胶质去除率达到25.94%。对菌株8-1脱胶后的苎麻单纤维进行力学性能测试和表面观察,结果表明,经微生物脱胶得到的苎麻单纤维强力比经化学脱胶后的单纤维提高43.45%,且纤维表面更光滑,损伤更小。

关键词：苎麻微生物脱胶优化工艺单纤维强力

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纤维素改性处理的研究进展

丝绸 2014年第11期51卷 10-16页

作者：王天佑陈景浩卢必涛蓝广芊西南大学纺织服装学院重庆400715

介绍了近年来关于纤维素改性方面的研究和进展。纤维素改性一般从预处理开始,有物理方法预处理和化学方法预处理两种方法。纤维素的改性有物理方法改性,化学方法改性及生物方法改性等。物理方法改性包括机械粉碎、润胀、复合、吸附、放... 详细信息

介绍了近年来关于纤维素改性方面的研究和进展。纤维素改性一般从预处理开始,有物理方法预处理和化学方法预处理两种方法。纤维素的改性有物理方法改性,化学方法改性及生物方法改性等。物理方法改性包括机械粉碎、润胀、复合、吸附、放电、液氨加工、高压蒸汽闪爆、超声波及微波辐照等。纤维素的化学改性处理主要包括纤维素酯化、醚化及接枝共聚等。纤维素的生物改性在造纸行业应用广泛,大多数利用纤维素酶、半纤维素酶等来对纸浆进行处理。最后对改性纤维素在未来的应用进行了展望。

关键词：纤维素改性处理预处理纤维素改性接枝共聚

Effects of the Convex Topography on Railway Environmental Vibrations

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Computer Modeling in Engineering & Sciences 2019年第1期118卷 177-205页

作者： Huaxi lu Zhicheng Gao luyao Xu bitao Wu Department of Civil Engineering East China Jiaotong UniversityNanchang330013China.

The railway environmental vibration caused by high-speed railways is harmful to the human health,the structural safety of adjacent buildings,and the normal use of precision *** the same time,it occurs *** this case,the railway environmental vibration has drawn much attention with the rapid development of highspeed *** in Earthquake Engineering show that a convex topography has a great impact on ground vibrations,however,there is no consideration about the convex topographic effect in the study of the railway environmental vibration when the convex topography is near the *** this paper,the influence of a convex topography on the railway environmental vibration was ***-dimensional(2D)finite element models consist of subgrade-convex topography and subgrade-flat topography are established using the finite element *** length and the height of the analysis model are taken as 200 m and 41.3 m,*** external soil of the calculation model is simulated via the artificial *** comparison with measured results,the 2D finite element models were verified to be *** convex topographic effect is studied by conducting parameter investigations,such as the bottom width,cross-sectional shape,height-width ratio and the foundation soil *** show that the dimension and cross-section shape of the convex topography and the foundation soil properties have significant effect on the convex topographic effect.

关键词： Railway environmental vibration convex topography ground acceleration ground displacement frequency spectra.

小干扰RNA干扰大鼠神经元Nogo受体mRNA表达的实验研究

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脊柱外科杂志 2007年第4期5卷 239-241页

作者：张涛吕碧涛徐盛明徐建广袁文交通大学附属第六人民医院骨科上海200233 第二军医大学附属长征医院骨科

目的观察大鼠Nogo受体(NgR)特异性小干扰RNA(small interfering RNA,siRNA)在原代神经元干扰其mRNA表达的效果。方法体外培养大鼠原代皮层和海马细胞,应用阳离子脂质体转染试剂转染4对化学合成的大鼠NgR特异性siRNA,72h后提取细胞总RNA... 详细信息

目的观察大鼠Nogo受体(NgR)特异性小干扰RNA(small interfering RNA,siRNA)在原代神经元干扰其mRNA表达的效果。方法体外培养大鼠原代皮层和海马细胞,应用阳离子脂质体转染试剂转染4对化学合成的大鼠NgR特异性siRNA,72h后提取细胞总RNA,实时荧光定量RT-PCR检测NgR mRNA表达情况。结果4对siRNA均能够下调靶基因NgR的mRNA表达水平,siNgR199、siNgR562、siNgR772和siNgR964等干扰后,NgR mRNA的表达分别为对照siRNA干扰组的6.5%、62.4%、15.2%和6.86%,与对照siRNA干扰组比较有统计学意义(P<0.05)。结论化学合成的NgR特异性siRNA能够有效的干扰大鼠原代皮层和海马细胞内NgR基因mRNA的表达水平。

关键词：大鼠脊髓损伤生长抑制物髓磷脂蛋白质类细胞表面受体逆转录聚合酶链反应