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Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

Research 2024年第1期2023卷 281-299页

作者： bitao Lu Enling Hu Weiwei Ding Wenyi Wang Ruiqi Xie Kun Yu Fei Lu Guangqian Lan Fangyin dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China Division of Trauma and Surgical Intensive Care Unit Research Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital settings.Thus,multiple hemostatic strategies are critical for treating large bleeding wounds.In this study,inspired by bombardier beetles to eject toxic spray for defense,a shape-memory aerogel with an aligned microchannel structure was proposed,employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug permeation.Bioinspired aerogels,after contact with blood,can rapidly expand inside the wound,offering robust physical barrier blocking,sealing the bleeding wound,and generating a spontaneous local chemical reaction causing an explosivelike generation of CO_(2) microbubbles,which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug diffusion.The ejection behavior,drug release kinetics,and permeation capacity were evaluated using a theoretical model and experimentally demonstrated.This novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility,displaying great potential for clinical application in humans.

关键词： wound sealing offering

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Microcluster colloidosomes for hemostat delivery into complex wounds:A platform inspired by the attack action of torpedoes

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Bioactive Materials 2022年第10期7卷 372-387页

作者： bitao Lu Enling Hu Ruiqi Xie Kun Yu Fei Lu Rong Bao Chenhui Wang Guangqian Lan Fangyin dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China The Ninth People’s Hospital of Chongqing No.69 Jialing Village BeiBei DistrictChongqing400715China Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing University55 South Daxuecheng RoadChongqing401331China

Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature,thereby causing massive blood loss and significantly increased mortality.Inspired by the attack action of torpedoes,we synthesized microcluster(MC)colloidosomes equipped with magnetic-mediated navigation and“blast”systems to deliver hemostats into the cavity of vase-type wounds.CaCO_(3)/Fe_(2)O_(3)(CF)microparticles functionalized with Arg-Gly-Asp(RGD)modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots(CDs)to form MC colloidosomes,which were loaded with thrombin and protonated tranexamic acid(TXA-NH_(3)^(+)).The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH_(3)^(+).The CO_(2) bubbles generated during disassembly produced a“blast”that propelled thrombin into the wound cavity.Severe bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within~60 s.Furthermore,in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC colloidosomes.This study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis,creating a new paradigm for combating trauma treatment.

关键词： Torpedoes-inspired Microcluster colloidosomes Magnetic guidance Disintegration Hemostasis

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Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

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Bioactive Materials 2021年第9期6卷 2956-2968页

作者： Luoxiao Ran bitao Lu Haoyu Qiu Guofang Zhou Jing Jiang Enling Hu Fangyin dai Guangqian Lan State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China Chongqing General Hospital University of Chinese Academy of Sciences No.118Xingguang AvenueLiangjiang New AreaChongqingChina

The increase in the number of resistant bacteria caused by the abuse of antibiotics and the emergence of biofilms significantly reduce the effectiveness of antibiotics.Bacterial infections are detrimental to our life and health.To reduce the abuse of antibiotics and treat biofilm-related bacterial infections,a biomimetic nano-antibacterial system,RBCM-NW-G namely,that controls the release of antibiotics through near infrared was prepared.The hollow porous structure and the high surface activity of nanoworms are used to realize antibiotic loading,and then,biomimetics are applied with red blood cell membranes(RBCM).RBCM-NW-G,which retains the performance of RBCM,shows enhanced permeability and retention effects.Fluorescence imaging in mice showed the effective accumulation of RBCM-NW-G at the site of infection.In addition,the biomimetic nanoparticles showed a longer blood circulation time and good biocompatibility.Anti-biofilm test results showed damage to biofilms due to a photothermal effect and a highly efficient antibacterial performance under the synergy of the photothermal effect,silver iron,and antibiotics.Finally,by constructing a mouse infection model,the great potential of RBCM-NW-G in the treatment of in vivo infections was confirmed.

关键词： Red blood cell membrane Nanoworms Antibiotics release Bacterial infection

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Mobility in China, 2020: a tale of four phases

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National Science Review 2021年第11期8卷 110-120页

作者： Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu School of Business Central South University Institute of Big Data and Internet Innovations Hunan University of Technology and Business College of Systems Engineering National University of Defense Technology WorldPop School of Geography and Environmental ScienceUniversity of Southampton School of Mathematics and Big Data Foshan University State Key Laboratory on Blind Signal Processing State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences Chinese Evidence-Based Medicine Center National Clinical Research Center for Geriatrics West China Hospital Sichuan University Big Data Research Center University of Electronic Science and Technology of China West China Biomedical Big Data Center West China Hospital Sichuan University Tokyo Tech World Hub Research Initiative Institute of Innovative Research Tokyo Institute of Technology

2020 was an unprecedented year,with rapid and drastic changes in human mobility due to the COVID-19 pandemic.To understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun), to the exceptional calm of COVID-19 lockdown,and then to the recovery period.We observed that cross-city movements,which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of cities.Following the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large cities.Mobility network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in China.While the mass migration back to large cities was delayed,smaller cities connected more densely to form new clusters.During the recovery period after travel restrictions were lifted,the netflows of over 55% city pairs reversed in direction compared to before the lockdown.These findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others.

关键词： human mobility travel restrictions COVID-19 mobile phone data behavioral response

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In situ assembly of Ag nanoparticles（AgNPs） on porous silkworm cocoon-based would film:enhanced antimicrobial and wound healing activity

In situ assembly of Ag nanoparticles（AgNPs） on porous silk...

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中国蚕学会第九届青年学术研讨会

作者： Kun Yu Fei Lu Qing Li Honglei Chen bitao Lu Jiawei Liu Zhiquan Li Fangying dai Dayang Wu Guangqian Lan College of Textile and Garments Southwest University Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile The Ninth People’s Hospital of Chongqing

Preventing wound infection and retaining an appropriate level of moisture around wounds represent the most critical issues in wound treatment.Towards these ends,special focus has been placed on Bombyx mori cocoons because the protective function of the silkworm cocoon resembles the manner in which the skin protects the human body.We have designed a facile technique to develop a novel silkworm cocoon-based wound film（SCWF） wound dressing utilizing a CaCl2-ethanol-H2 O solution.To improve the anti-bacterial performance of SCWF,we have incorporated the ability of silk sericin to act as a reducing agent for the conversion of Ag+ to Ag,yielding nanoparticles（AgNPs） linked together by peptide bonds of silkworm cocoon wound film（SCWF-AgNPs）.SCWF-AgNP dressing exhibited excellent biocompatibility,anti-bacterial performance,and good extensibility.Furthermore,in vivo experiments indicated that SCWF-AgNP dressing was able to significantly accelerate the healing rate of infected wounds in New Zealand White rabbits and histological examination revealed that it aided in the successful reconstruction of intact and thickened epidermis during 14 days of healing of impaired wound tissue.These results demonstrate that the present approach might shed new light on the design of anti-bacterial materials such as SCWF-AgNPs with promising applications in wound dressing.

关键词： Silkworm cocoon Silver nanoparticles Infected wound healing Silk fibroin Antibacterial performance

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Unsupervised hyperspectral unmixing based on robust nonnegative dictionary learning

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Journal of Systems Engineering and Electronics 2022年第2期33卷 294-304页

作者： LI Yang JIANG bitao LI Xiaobin TIAN Jing SONG Xiaorui Department of Space Information Space Engineering UniversityBeijing 101400China Beijing Institute of Remote Sensing Information Beijing 100192China

Considering the sparsity of hyperspectral images(HSIs),dictionary learning frameworks have been widely used in the field of unsupervised spectral unmixing.However,it is worth mentioning here that existing dictionary learning method-based unmixing methods are found to be short of robustness in noisy contexts.To improve the performance,this study specifically puts forward a new unsupervised spectral unmixing solution.For the reason that the solution only functions in a condition that both endmembers and the abundances meet non-negative con-straints,a model is built to solve the unsupervised spectral un-mixing problem on the account of the dictionary learning me-thod.To raise the screening accuracy of final members,a new form of the target function is introduced into dictionary learning practice,which is conducive to the growing robustness of noisy HSI statistics.Then,by introducing the total variation(TV)terms into the proposed spectral unmixing based on robust nonnega-tive dictionary learning(RNDLSU),the context information under HSI space is to be cited as prior knowledge to compute the abundances when performing sparse unmixing operations.Ac-cording to the final results of the experiment,this method makes favorable performance under varying noise conditions,which is especially true under low signal to noise conditions.

关键词： hyperspectral image(HSI) nonnegative dictionary learning norm loss function unsupervised unmixing

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A design method for high fabrication tolerance integrated optical mode multiplexer

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Science China(Information Sciences) 2020年第6期63卷 184-194页

作者： bitao SHEN Haowen SHU Linjie ZHOU Xingjun WANG State Key Laboratory on Advanced Optical Communication Systems and Networks Department of ElectronicsSchool of Electronics Engineering and Computer Science Peking University State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic Engineering Shanghai Jiao Tong University Nano-optoelectronics Frontier Center of Ministry of Education Peking University

The tapered asymmetric directional coupler has the potential to realize high fabrication tolerance and high transmission efficiency on-chip mode multiplexer. However, the geometry parameter selection of tapered structure remains empirical. In this paper, we propose a design method for the tapered structure based on genetic algorithm. Combined with the adjusted coupling equations and interpolation method, lowtime-cost optimization can be realized. Three mode multiplexers(TE0&TE1, TE0&TE2 and TE0&TE5)are designed by our method. According to simulation results, the insertion loss of the designed devices is lower than 1.8 dB and the crosstalk is lower than-15 dB when the fabrication error is within required range(±10 nm for TE0&TE2 and TE0&TE5, and ±20 nm for TE0&TE1) in the bandwidth of 1.5–1.6 μm. In addition, the entire optimization process takes only 2 h for each device, which is around the time cost of a single 3 D simulation.

关键词： mode multiplexer directional coupler taper structure coupled-mode theory genetic algorithm

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孕晚期妇女B族链球菌携带情况与血清维生素D水平的关系

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实用医技杂志 2022年第6期29卷 569-572页

作者：安娜吴碧涛代春梅刘亚荣电子科技大学医学院附属绵阳市中心医院医学检验科 621000

目的探讨绵阳地区孕晚期妇女B族链球菌(GBS)携带状况及其与血清维生素D水平的关系。方法2020年1月至12月绵阳市中心医院妇产科就诊的2055例孕妇参与该研究,取阴道直肠拭子进行GBS培养,高效液相色谱串联质谱法检测血清25羟基维生素D2[25-... 详细信息

目的探讨绵阳地区孕晚期妇女B族链球菌(GBS)携带状况及其与血清维生素D水平的关系。方法2020年1月至12月绵阳市中心医院妇产科就诊的2055例孕妇参与该研究,取阴道直肠拭子进行GBS培养,高效液相色谱串联质谱法检测血清25羟基维生素D2[25-(OH)VD2]、25羟基维生素D3[25-(OH)VD3]水平。结果2055例孕妇中,有生殖道GBS携带者209例(11.32%)。携带GBS孕妇的血清25-(OH)VD2水平[(2.0±2.4)ng/ml]低于对照组[(3.2±4.5)ng/ml],差异有统计学意义(t=-2.261,P=0.025);血清25-(OH)VD3水平[(26±10)ng/ml]、高于对照组[(24±10)ng/ml],差异无统计学意义(t=0.986,P=0.326);血清25-(OH)VD2+25-(OH)VD3水平[(28±10)ng/ml]高于对照组[(27±10)ng/ml],差异无统计学意义(t=0.162,P=0.871)。血清25-(OH)VD2水平减低与孕妇携带GBS之间具有一定相关性(r=-0.167,P=0.026)。结论绵阳地区孕晚期妇女GBS的携带情况仍需重视,孕晚期妇女GBS携带情况与血清25-(OH)VD2水平有一定相关性,同时还需监测孕晚期妇女血清维生素D组分水平。

关键词：链球菌属维生素D 孕妇

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我国空间对地观测技术的发展与展望

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测绘学报 2022年第7期51卷 1153-1159页

作者：江碧涛 61646部队北京100192

经过50余年发展,我国空间对地观测技术实现了从无到有、由弱到强等巨大跨域,已在经济建设和国防安全等领域取得了广泛应用。当前,物联网、大数据、云计算、人工智能等飞速发展,空间对地观测技术正在发生深刻变革。为把握技术发展脉络,... 详细信息

经过50余年发展,我国空间对地观测技术实现了从无到有、由弱到强等巨大跨域,已在经济建设和国防安全等领域取得了广泛应用。当前,物联网、大数据、云计算、人工智能等飞速发展,空间对地观测技术正在发生深刻变革。为把握技术发展脉络,推动“十四五”我国空间对地观测领域高质量发展,本文系统梳理了我国空间对地观测技术的发展历程,从国际竞争、国内需求和技术革新等方面分析了面临的机遇和挑战,展望了巨型星座建设、海量数据处理、智能融合应用等技术发展方向。

关键词：对地观测发展历程展望

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重庆市生态文明建设发展评价

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生态经济 2018年第5期34卷 212-217页

作者：孙顺强戴碧涛刘新元王恺西南大学经济管理学院

生态文明建设是协调资源、环境与经济矛盾的重要举措。文章根据党的十九大的新要求及重庆市生态文明“十三五”规划要求,基于《重庆统计年鉴》2004—2015年的数据,采用熵值法确立指标权重,从国土资源优化、产业结构优化、生态制度建设... 详细信息

生态文明建设是协调资源、环境与经济矛盾的重要举措。文章根据党的十九大的新要求及重庆市生态文明“十三五”规划要求,基于《重庆统计年鉴》2004—2015年的数据,采用熵值法确立指标权重,从国土资源优化、产业结构优化、生态制度建设、生态文化宣传四个方面,选择了37项指标构建了重庆市生态文明发展评价指标体系。研究结果表明,重庆市生态文明建设综合发展水平总体呈上升的态势,但系统的协整性仍存在问题;在生态文明建设指标中,权重前五位的指标是：环境保护产业占工业产值比重、绿色出行率、化肥使用强度、城市人口密度、交通运输用地面积比重。指出重庆市生态文明建设的对策措施,以期为重庆市及其他省份的生态文明建设提供参考。

关键词：生态文明熵值法重庆市

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