检索结果-南通市图书馆

Journal of Cancer Therapy 2011年第4期2卷 595-600页

作者： Moshe Schaffer Alina Balandin birgit ertl-wagner Pamela Schaffer Luigi Bonavina Alfons Hofstette Ulrike Kulka 不详

Background: The radiosensitizing effect of Photofrin II has been demonstrated in vitro and in animal models, even in tumor models known to be highly radioresistant, such as glioblastoma and bladder carcinoma. Radio-adaptive doses are also known to lead to an augmented cell or tissue reaction. The aim of this study was to investigate potential synergistic or additive effects when combining the two methods in vitro for an improved therapeutic concept in bladder cancer. Material and Methods: RT4 human bladder carcinoma cell line and HCV29 human bladder epithelium cells were seeded and incubated with various concentrations of Photofrin II. The cells were additionally irradiated with ionizing radiation (0.05 Gy/2 Gy/0.05 Gy + 2 Gy). Cells without Photofrin II incubation and irradiation served as controls. The cell survival was evaluated. Results: The survival rate of both cell lines, RT4 and HCV29, did not differ significantly when incubated with a non-toxic concentration of Photofrin II and exposed to a pre-irradiation dose of 0.05 Gy prior to the 2 Gy radiation fraction, compared to cells exposed to Photofrin II plus a 2 Gy ionizing radiation. Conclusion: The combination of both methods did neither demonstrate a synergistic or additive effect nor did it lead to a negative influence of both modulating factors in an in vitro setting.

关键词： Adative Dose Photofrin II Ionising Irradiation Synergistic/Additive Effect

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

前庭性偏头痛和听觉症状的内淋巴积水患者

前庭性偏头痛和听觉症状的内淋巴积水患者

Synthesis of iron（ll） complexes with asymmetric N2O2 coordinating Schiff base-like ligands and their spin crossover properties

中国中西医结合学会眩晕病专业委员会第二次学术大会暨河南省中西医结合学会眩晕病专业委员会第三次学术大会暨眩晕高峰论坛

作者： Robert Grkov Claudia Kantner Michael Strupp W.Flatz Eike Krause birgit ertl-wagner

目前显示前庭偏头痛(VM)和梅尼病(MD)特征的眩晕患者对临床医师的诊断提出了难题。本研究的目的是调查VM和听觉症状患者内淋巴积水的发生这是一个天文台的诊断研究。在一个学术上跨学科的眩晕中心,通过局部增强的内耳MR成像检查了连续...

目前显示前庭偏头痛(VM)和梅尼病(MD)特征的眩晕患者对临床医师的诊断提出了难题。本研究的目的是调查VM和听觉症状患者内淋巴积水的发生这是一个天文台的诊断研究。在一个学术上跨学科的眩晕中心,通过局部增强的内耳MR成像检查了连续十九位患有明确或可能的VM和听觉症状的患者。评估MR图像是否存在内淋巴积水。在19例患者中,4例(21%)证实了局部增强型内耳MR成像(三个具有"确定的VM"),一个具有"可能的VM"的耳蜗和前庭内淋巴积水。局部增强的内耳MR成像可用于对VM和听觉症状患者的诊断评估,因为其中一些患者具有内淋巴积水的迹象。这些患者是否仅患有MD,并被误诊为VM或患有VM或MD,或VM是否是内淋巴水肿是由于VM引起的内耳损伤的结果,这是临床上可以通过应用该技术进行评估的问题。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2018年第3期12卷 400-408页

作者： Wolfgang Bauer Tanja Ossiander birgit Weber Department of Chemistry University of Bayreuth 95440 Bayreuth Germany

The synthesis of new Schiff base-like ligands with asymmetric substituents pattern and their iron complexes with pyridine as axial ligand is described. Two of the ligands and one of the iron（II） complexes were characterized by single crystal X-ray structure analysis. One of the the iron（II） complexes shows spin crossover behavior while the others remain in the high spin state. The influence of the reduced symmetry of the ligand on the properties of the complexes is discussed.

关键词： iron Schiffbase-like ligands magnetism spin crossover X-ray structures

Product Variability of the ‘Cineole Cassette＇ Monoterpene Synthases of Related Nicotiana Species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2011年第6期4卷 965-984页

作者： Anke Fahnrich Katrin Krause birgit Piechulla University of Rostock Institute for Biological Sciences Albert-Einstein-Str. 3 18059 Rostock Germany

Nicotiana species of the section Alatae characteristically emit the floral scent compounds of the ＇cineole cassette＇ comprising 1,8-cineole, limonene, myrcene, α-pinene, β-pinene, sabinene, and α-terpineol. We successfully isolated genes of Nicotiana alata and Nicotiana langsdorfii that encoded enzymes, which produced the characteristic monoter- penes of this ＇cineole cassette＇ with α-terpineol being most abundant in the volatile spectra. The amino acid sequences of both terpineol synthases were 99% identical. The enzymes cluster in a monophyletic branch together with the closely related cineole synthase of Nicotiana suaveolens and monoterpene synthase 1 of Solanum lycopersicum. The cyclization reactions （α-terpineol to 1,8-cineole） of the terpineol synthases of N. alata and N. langsdorfii were less efficient compared to the ＇cineole cassette＇ monoterpene synthases of Arabidopsis thaliana, N. suaveolens, Salvia fruticosa, Salvia officinalis, and Citrus unshiu. The terpineol synthases of IV. alata and N. langsdorfii were localized in pistils and in the adaxial and abaxial epidermis of the petals. The enzyme activities reached their maxima at the second day after anthesis when flowers were fully opened and the enzyme activity in N. alata was highest at the transition from day to night （diurnal rhythm）.

关键词： Nicotiana alata Nicotiana langsdorfii cineole cassette terpineol synthase multiproduct enzyme monoterpene synthase 1,8-cineole, α-terpineol.

IRF1 and BATF—transcription factors that set the epigenetic landscape for Tr1 cell differentiation?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2017年第9期14卷 727-729页

作者： Katarina Stanko birgit Sawitzki Charité-Universitaetsmedizin Berlin Corporate Member of Freie Universitaet BerlinHumboldt-Universitaet zu Berlinand Berlin Institute of HealthInstitute of Medical ImmunologyAugustenburger Platz 113353 BerlinGermany

Type 1 regulatory T(Tr1)cells are Foxp3-negative regulatory CD4+T cells that develop outside of the thymus and mediate regulatory functions in large part by producing the immunosuppressive cytokine IL-10.

关键词： Foxp3 Tr1 landscape

Do concentrations in eggs and liver tissue tell the same story of temporal trends of mercury in high Arctic seabirds?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第6期30卷 65-72页

作者： Mark L.Mallory birgit M.Braune Biology Department Acadia University Environment and Climate Change Canada National Wildlife Research Centre Carleton University

Mercury（Hg） remains a key contaminant of concern in Arctic biota, and monitoring of Hg concentrations in seabird tissues will be an effective approach to track the effects of implementing the Minamata Convention. We examined trends in total Hg（THg） in liver and egg tissues of two Arctic seabirds, thick-billed murres（Uria lomvia） and northern fulmars（Fulmarus glacialis）, between 1976 and 2013 to assess whether both tissues showed similar patterns of Hg change. Hepatic THg was consistently higher than egg THg, and both species had similar egg THg concentrations, but fulmars had higher hepatic THg than *** THg concentrations showed more relative variation through time than *** suggest that egg THg better reflects exposure of birds to THg in local, Arctic prey,whereas liver THg may incorporate longer term, year-round THg exposure. Additional analysis of THg distribution in Arctic seabirds post-laying would help inform interpretation of long-term trends.

关键词： Canada Fulmarus glacialis Northern fulmar Thick-billed murre Uria lomvia

The Monumentenwacht model for preventive conservation of built heritage:A case study of Monumentenwacht Vlaanderen in Belgium

在线全文

学校读者我要写书评

暂无评论

Frontiers of Architectural Research 2021年第1期10卷 92-107页

作者： Meiping Wu birgit van Laar Department of Architecture Built Environment and Construction EngineerinsPolytechnic University of MilanMilan20133Italy Key Laboratory of Urban and Architectural Heritage Conservation Southeast UniversityNanjing210096China

Monumentenwacht(Monument Watch)is an organization that specializes in the periodic inspection of built heritage to raise awareness among owners and caretakers of the importance of proper maintenance and preventive *** originated in the Netherlands in *** was later established in Belgium,Germany,the UK,Denmark,Hungary,Italy,Slovak,Spain,France,and Portugal in the form of similar organizations and projects with similar *** organization promotes the idea of,fprevention is better than cureM by offering periodic inspection,monitoring,and minor urgent repair and writing independent professional inspection reports as a reference for owners and users for further maintenance and conservation *** study explores the working mode of Monumentenwacht in Flanders,Belgium,including its historical development,organizational structure,inspection team configuration,professional inspection report,database,reporting system,and technical manuals.A brief analysis of other similar organizations and projects in various European countries is included to reveal efficient ways to promote this model while respecting different cultural,economic,social,legal,and political contexts.

关键词： Monum entenwacht Preventive conservation Maintenance Periodic inspection Built heritage

Proteomic and metabolic prediction of response to therapy in gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第38期20卷 13648-13657页

作者： Michaela Aichler birgit Luber Florian Lordick Axel Walch Research Unit Analytical Pathology Institute of Pathology Helmholtz Zentrum MünchenInstitute of Pathology Technische Universit t MünchenUniversity Cancer Center Leipzig University of LeipzigResearch Unit Analytical Pathology Institute of Pathology Helmholtz Zentrum München German Research Centre for Environmental Health

Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer,the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general,but not all patients are responders. The application of targeted therapies and multimodal treatment has improved prognosis for those with advanced ***,these new therapeutic strategies do not uniformly benefit all *** whether patients will respond to specific therapies would be of particular value and would allow for stratifying patients for personalized treatment *** imaging by positron emission tomography was the first technique with the potential to predict the response of esophagogastric cancer to neoadjuvant *** and validating tissue-based biomarkers are ongoing *** this review,we discuss the status of several targeted therapies for gastric cancer,as well as proteomic and metabolic methods for investigating biomarkers for therapy response prediction in gastric cancer.

关键词： Gastric cancer Therapy Response prediction Positron emission tomography Matrix-assisted laser desorption-ionization

Evolution of particle number size distribution in an urban atmosphere during episodes of heavy pollution and new particle formation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2011年第11期54卷 1772-1778页

作者： WU ZhiJun, HU Min YUE DingLi birgit WEHNER Alfred WIEDENSOHLER State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering Peking University Beijing 100871 China Leibniz-lnstitutefor Tropospheric Research 04318 Leipzig Germany

This study discusses the evolution of particle number size distribution during episodes of heavy pollution and new particle formation in the urban atmosphere of Beijing to quantify the effects of dynamic processes (coagulation and condensation) on the particle number size *** a heavy-pollution event,an extremely low number concentration of 3-10 nm particles (on average 46 cm-3) was *** is because nucleation-mode particles were easily removed by strong coagulational scavenging of larger particles under this *** addition,a large condensation sink (on average 0.13 s-1) restrained nucleation,which is one of the major sources of nucleation-mode ***,during a new-particle formation event,the small condensation sink (0.01 s-1) of precursor facilitated *** the same time,preexisting particles had little ability to scavenge newly formed particles (around 1 nm) and allowed them to grow to a detectable size (larger than 3 nm currently).We suggest that the effects of dynamic processes (coagulation and condensation) on particle size distribution should be stressed under some extreme conditions of the relatively polluted urban atmosphere in addition to traffic and meteorological factors.

关键词： particle number size distribution new particle formation coagulation and condensation sinks

Catchment soils as a factor of trace metal accumulation in sediments of the reservoir Klingenberg(eastern Ore Mountains, Germany)

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2019年第12期31卷 1-14页

作者： Jens Hahn Christian Opp Raphael Ganzenmuller Anntke Ewert birgit Schneider Nina Zitzer Gabriela Laufenberg Philipps-University of Marburg Working Group for Hydro-and Soil GeographyDeutschhausstr.1035037 MarburgGermany University of Leipzig Institute of GeographyPhysical GeographyJohannisallee 19a04103 LeipzigGermany Philipps-Uniuersity o/Marbitrg Mass SpectrometryMarbacher Weg 6-1035037 MarburgGermany

The release and accumulation dynamics of trace metals in soils and aquatic sediments were exemplarily investigated in the catchment area of the Reservoir Klingenberg(Germany).Catchment soils were examined for mobilizable and total concentrations of arsenic(As),cadmium(Cd),chrome(Cr),iron(Fe),manganese(Mn),nickel(Ni),lead(Pb),and zinc(Zn)and compared with trace metal quantities accumulated in riverbed and reservoir *** comparison of all samples showed relatively small variations of Cr(7.96–46.0 mg/kg),Fe(7.79–40.4 g/kg),and Ni(6.06–56.5 mg/kg),while stronger differences were found for As(11.2–164 mg/kg),Cd(0.14–30.5 mg/kg),Mn(0.08–1.84 g/kg),Pb(20.7–183 mg/kg),and Zn(69.1–916 mg/kg).The catchment soils were slightly enriched by Cd,Pb,and *** Cd and Zn were characterized by large mobilizable *** mean trace metal concentrations in riverbed sediments were higher than in catchment soils,while reservoir sediments accumulated the highest amounts of the analyzed *** enrichment of trace metals in reservoir sediments was generally determined by the sedimentation of fine particles,while the distribution of As,Fe,and Mn was additionally impacted by redox *** Cd and Zn,which in comparison were most enriched in riverbed and reservoir sediments,a significant release from soils by leaching processes was *** accumulation of As and Pb in reservoir sediments was influenced to a greater extent by soil erosion and by anthropogenic or chalcogen sources in the catchment.

关键词： Trace metals Exchangeable forms Soil Sediment Catchment Sources