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Application of an atmospheric pressure plasma jet in a rat model of ischaemic stroke:Design,optimisation,and characteristics

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High Voltage 2023年第2期8卷 315-325页

作者： Ye Chen Bingyan Yang Yuqing Liu Lixin Xu Zhongfang Shi Yixiao Liu Ruoyu Han Fang Yuan Jiting Ouyang Xu Yan Kostya(Ken)Ostrikov Department of Pathophysiology Beijing Neurosurgical Institute/Beijing Tiantan HospitalCapital Medical UniversityBeijingChina School of Basic Medical Sciences Capital Medical UniversityBeijingChina School of Physics Beijing Institute of TechnologyBeijingChina School of Chemistry and Physics and Centre for Biomedical Technologies Queensland University of TechnologyBrisbaneQueenslandAustralia

Recent studies have shown the in vitro neuro-protective functions of atmospheric pressure plasma(APP)against multiple pathological injuries during ischaemic stroke(IS).However,whether APP treatment exerts a therapeutic effect on a rat IS model remains unclear.Here,on the basis of needle-to-ring dielectric barrier discharge,an atmospheric pressure plasma jet(APPJ)was designed,with the Helium as the working gas which was driven by a sinusoidal voltage.Then,the treatment conditions were optimised for IS rat model treatment and the characteristics of this APPJ were further diagnosed.Subsequently,the rat IS model was established through 90 min middle cerebral artery occlusion(MCAO),and plasma was intermittently inhaled by rats via the nasal cavity for a 2 min period at 60 min of MCAO process.The therapeutic effects of this plasma jet device were then evaluated using biomedical analyses.According to our results,intermittent APP inhalation in the MCAO rats increased the serum NO content,improved the neurological function,enhanced regional cerebral blood flow,lowered brain infarction,and reduced the cell apoptosis in brain tissues of MCAO rats.Collectively,our data provides a novel potential strategy for IS treatment by using atmospheric-pressure plasma inhalation.

关键词： needle cerebral MCAO treatment

Improvement of interleaving Aramid pulp microfibers on compressive strengths of carbon fiber reinforced polymers with and without impact

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维普期刊数据库

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Chinese Journal of Aeronautics 2023年第10期36卷 459-470页

作者： Fei CHENG Guangming yang Yunsen HU bingyan YUAN Xiaozhi HU School of Materials Science and Engineering Southwest University of Science and TechnologyMianyang 621010China Engineering Research Center of Biomass Materials Ministry of EducationSouthwest University of Science and TechnologyMianyang 621010China Department of Mechanical Engineering University of Western AustraliaPerth WA6009Australia

Compressive strengths and elastic moduli of Carbon Fiber Reinforced Polymer(CFRP)composites can be noticeably improved by multiple ultra-thin interlays with non-woven Aramid Pulp(AP)micro/nano-fibers.10-ply CFRP specimens with 0,2,4,6,8 g/m^(2)AP were tested under uniaxial compression.Those flexible AP fibers,filling the resin-rich regions and further constructing the fiber bridging at the ply interfaces,can effectively suppress delamination growth and lead to very good improvements both in the compressive strength and the elastic modulus.The CFRP specimen with an optimum interlay thickness has a distinct shear failure mode instead of the typical delamination cracking along the direction of continuous carbon fibers.Compressive Strengths After Impacts(CAI)of 12.35 J were also measured,up to 90%improvement in CAI has been observed.It is concluded those ultra-thin interlays of non-woven AP micro/nano-fibers are beneficial to design and manufacture“high strength”CFRP composites.

关键词： Compressive strength Carbon Fiber Reinforced Polymer(CFRP) Aramid pulp Interleaving Interfacial reinforcing

Hierarchical Cu_(3)P-based nanoarrays on nickel foam as efficient electrocatalysts for overall water splitting

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Green Energy & Environment 2022年第2期7卷 236-245页

作者： Zhuojun yang Yongxiao Tuo Qing Lu Chen Chen Mengshan Liu bingyan Liu Xuezhi Duan Yan Zhou Jun Zhang School of Materials Science and Engineering China University of Petroleum(East China)66 West Changjiang RoadQingdaoShandong266580China State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)66 West Changjiang RoadQingdaoShandong266580China State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai200237China

Exploring the efficient bifunctional catalysts and binder-free electrode materials for both oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is receiving continuous interest.Herein,we report the fabrication of hierarchical copper phosphide nanoarrays(Cu_(3)P)on three-dimensional(3D)nickel foam(NF)through a template-directed synthetic strategy as electrocatalysts for overall water splitting.Specifically,the Cu_(3)P/NF electrode demonstrates a remarkably low overpotential of~331 m V to approach the current density of 50 m A cm^(-2)in the OER,and an overpotential of~115 m V to achieve-10 m A cm^(-2)current density in the HER.Meanwhile the Cu_(3)P/NF catalyst could hold a great stability for both reactions in alkaline condition,reflected in 37 h for OER and 24 h for HER of consistent galvanostatic electrolysis.As revealed by TEM,STEM and XPS characterizations,the high catalytic OER activity can be ascribed to the 3D open structure of Cu_(3)P/NF and the abundant Cu O active sites in hierarchical Cu O/Cu_(3)P/NF structure after in-situ activation.Furthermore,the overall water splitting is conducted in a two-electrode cell,which requires only a cell voltage of 1.63 V to approach 10 m A cm^(-2)with a good stability of 20 h.This protocol of Cu_(3)P/NF electrode affords a general strategy to construct hierarchically structured metal phosphides for clean energy-related application.

关键词： nickel splitting electrode

Artificial intelligence in bladder cancer:current trends and future possibilities

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Chinese Medical Journal 2022年第7期135卷 881-882页

作者： Jun Ma Deep K.Vaishnani Rixu Lin Jiayu Lyu bingyan Ni yang Zhang Mengjun Hu Guorong Chen Department of Pathology First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China School of International Studies Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Psychiatry The Affiliated Kangning Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China School of Clinical Medicine Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Pathology Zhuji People’s HospitalShaoxingZhejiang 311800China

To the Editor:Bladder cancer is the most common malignant tumor of the urinary system in the Asian population.In China,it is reported 80,000 new cases each year with an increasing incidence every year.Among these cases,75%are of non-muscle invasive bladder cancer(NMIBC).In muscular invasive bladder cancer(MIBC)and NMIBC patients,radical cystectomy is considered as a primary approach of treatment due to the higher risk of tumor progression.Furthermore.

关键词： bladder cancer urinary

Synthesis of arylsulfonyl-substituted indolo[2,1-a]isoquinolin-6(5H)-one derivatives via a TBAI-catalyzed radical cascade cyclization

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Chinese Chemical Letters 2022年第1期33卷 276-279页

作者： Shengxian Zhai Shuxian Qiu Shuai yang bingyan Hua Yongsheng Niu Chuchu Han Youzhu Yu Yuchao Li Hongbin Zhai College of Chemistry&Environmental Engineering Anyang Institute of TechnologyAnyang 455000China Department of Chemistry Guangdong University of EducationGuangzhou 510303China State Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics Shenzhen Engineering Laboratory of Nano Drug Slow-ReleaseShenzhen Graduate School of Peking UniversityShenzhen 518055China

We have developed a metal-free radical cascade reaction of N-substituted 2-aryl indoles with readily available sulfonyl hydrazides for the rapid construction of arylsulfonyl-substituted indolo[2,1-a]isoquinolin-6(5H)-one derivatives.With the TBAI–TBHP catalytic system,a broad series of structurally diverse indolo[2,1-a]isoquinolin-6(5H)-one derivatives were obtained in moderate to excellent yields.The reaction features mild reaction conditions,operationally easiness,scaled-up feasibility,and high functional-group-tolerance.

关键词： TBAI-catalyzed Metal-free Radical cascade Cyclization Nitrogen-containing heterocycles Fused-indole derivatives

Chemical Intervention of ClpP:from antibiotic to antivirulence

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Chemical Intervention of ClpP:from antibiotic to antivirulen...

早产儿NEC并胆汁淤积相关因素及对骨代谢的影响

第十一届全国化学生物学学术会议

作者： bingyan Wei Cai-Guang yang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences

Antibiotics has added an average of 20 years to our life.Unfortunately,bacteria are resistant to almost all antibiotics.To make matters worse,the drug-discovery pipeline of new antibacterial is almost empty.All antibiotics in therapeutic application or development pipelines to date inhibit bacterial growth via the principle of target inhibition.Very interestingly,a new class of antibiotics ADEPs have been identified to activate bacterial ClpP in dysfunctional state. ADEP in combination with rifampicin eradicates a deep-seated persister,which indicates a general principle for killing dormant cells—activation and corruption of a target,rather than conventional inhibition.As an alternative treatment to antibiotics,virulence suppression could effectively reduce pathogenic potential and render the pathogen harmless. Small-molecule inhibitors of ClpP also function to trigger bacterial virulence rather than bactericidal effects. We focuses on the development of both small-molecule activators and inhibitors targeting ClpP in order to treat AMR infection.

关键词： SaClpP activator inhibitor antivirulence antibiotic

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cnki会议

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武汉大学学报（医学版） 2023年第5期44卷 571-575页

作者：杨霄何秉燕武汉大学中南医院儿科湖北武汉430071

目的:探讨早产儿新生儿坏死性小肠结肠炎(NEC)并胆汁淤积(CHO)的相关因素及对骨代谢的影响。方法:回顾性分析145例NECⅡ期或NECⅢ期患儿及母亲临床资料,其中NEC合并CHO为观察组(56例),非CHO为对照组(89例),分析两组患儿临床特点、骨代... 详细信息

目的:探讨早产儿新生儿坏死性小肠结肠炎(NEC)并胆汁淤积(CHO)的相关因素及对骨代谢的影响。方法:回顾性分析145例NECⅡ期或NECⅢ期患儿及母亲临床资料,其中NEC合并CHO为观察组(56例),非CHO为对照组(89例),分析两组患儿临床特点、骨代谢生化指标及长骨X线表现。结果:NECⅢ期(OR=3.083,95%CI:1.125~8.446)是NEC并CHO的危险因素,全胃肠内营养前时间长(OR=1.090,95%CI:1.039~1.143)也是危险因素,即全胃肠内营养是保护因素;观察组血磷及25-羟维生素D3均较对照组低,而碱性磷酸酶(ALP)较对照组高;观察组长骨X线更易出现骨质稀疏、骨皮质变薄,甚至骨折等异常改变,均有统计学意义。结论:NECⅢ期是NEC并CHO的危险因素,全胃肠内营养是保护因素。早产儿NEC并CHO容易骨代谢紊乱,应加强骨营养的管理。

关键词：早产儿新生儿坏死性小肠结肠炎胆汁淤积骨代谢

基于PointNet++的煤场点云分割与识别方法

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中国工程机械学报 2023年第3期21卷 199-203页

作者：乐英杨冰雁华北电力大学能源动力与机械工程学院河北保定071000

为了实现煤场环境下的实时监控与安全监测,对煤场环境应用了一种基于PointNet++的目标分割与识别的方法。利用二维激光扫描仪做直线运动的装置采集三维点云数据,通过设置目标安全距离,采用基于欧氏距离的点云分割算法对原始点云进行分割... 详细信息

为了实现煤场环境下的实时监控与安全监测,对煤场环境应用了一种基于PointNet++的目标分割与识别的方法。利用二维激光扫描仪做直线运动的装置采集三维点云数据,通过设置目标安全距离,采用基于欧氏距离的点云分割算法对原始点云进行分割,调用训练好的PointNet++网络对分割后的目标点云进行识别,对识别结果进行判断,并分析目标物体的工作状态是否安全。实验结果表明:煤场环境典型物体点云的分割精确率与召回率均大于90%,目标识别准确率达到98%,验证了基于PointNet++点云分割与识别方法的可行性。

关键词：三维点云 PointNet++ 分割与识别

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全国统一大市场构建的突出问题与破解思路

社会科学辑刊 2022年第6期 119-127页

作者：刘瑞明杨冰岩中国人民大学国家发展与战略研究院、国有经济研究院中国人民大学全国中国特色社会主义政治经济学研究中心中国人民大学经济学院

构建全国统一大市场既是完善现代化经济体系的前提,又是高质量发展的基础,对我国实现长期经济增长和建设社会主义现代化强国具有重要意义。在统一大市场构建过程中存在一些突出问题:进入退出有壁垒、主体地位有层级、规则标准有差异、... 详细信息

构建全国统一大市场既是完善现代化经济体系的前提,又是高质量发展的基础,对我国实现长期经济增长和建设社会主义现代化强国具有重要意义。在统一大市场构建过程中存在一些突出问题:进入退出有壁垒、主体地位有层级、规则标准有差异、市场秩序有紊乱、基础设施有短板、公共配套有区别、监管体系有错位、激励协调有漏洞。造成这些问题的根本原因在于政府与市场职能错位。因此,要破解这些问题,关键在于使政府和市场职能归位。一方面,“做对价格”,让市场在资源配置中发挥决定性作用;另一方面,“做对激励”,让政府提供更加有效的公共服务。

关键词：全国统一大市场市场分割政府市场关系公共服务职能归位