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The pathogenesis and diagnosis of sepsis post burn injury

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Burns & Trauma 2021年第1期9卷 678-693页

作者： Pengju Zhang Bingwen Zou Yih-Cherng Liou Canhua Huang State Key Laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyNo.17 People’s South RoadChengdu610041China Department of Thoracic Oncology and Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityNo.37 Guoxue AlleyWuhou DistrictChengdu610041China Department of Biological Sciences Faculty of ScienceNational University of Singapore14 Science Drive 4117543Singapore

Burn is an under-appreciated trauma that is associated with unacceptably high morbidity and mortality.Although the survival rate after devastating burn injuries has continued to increase in previous decades due to medical advances in burn wound care,nutritional and fluid resuscitation and improved infection control practices,there are still large numbers of patients at a high risk of death.One of the most common complications of burn is sepsis,which is defined as“severe organ dysfunction attributed to host’s disordered response to infection”and is the primary cause of death in burn patients.Indeed,burn injuries are accompanied by a series of events that lead to sepsis and multiple organ dysfunction syndrome,such as a hypovolaemic state,immune and inflammatory responses and metabolic changes.Therefore,clear diagnostic criteria and predictive biomarkers are especially important in the prevention and treatment of sepsis and septic shock.In this review,we focus on the pathogenesis of burn wound infection and the post-burn events leading to sepsis.Moreover,the clinical and promising biomarkers of burn sepsis will also be summarized.

关键词： Burn Infection Sepsis Septic shock Multiple organ dysfunction syndrome Immune dysregulation Hypermetabolism Trauma Biomaker Inflammation

Radiotherapy-induced heart disease:a review of the literature

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Precision Clinical Medicine 2019年第4期2卷 270-282页

作者： Bingwen Zou Julius Philipp Schuster Kerun Niu Qianyi Huang Alexander Rühle Peter Ernst Huber Department of Radiation Oncology Heidelberg University HospitalIm Neuenheimer Feld 400Heidelberg 69120Germany Department of Molecular Radiation Oncology German Cancer Research CenterIm Neuenheimer Feld 280Heidelberg 69120Germany Heidelberg Institute for Radiation Oncology(HIRO)and National Center for Radiation Oncology(NCRO) Im Neuenheimer Feld 280Heidelberg 69120Germany

Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the multimodal treatment of thoracic cancers.Due to significant improvements in overall cancer survival,radiotherapy-induced heart disease(RIHD)has become an increasingly recognized adverse reaction which contributes to major radiationassociated toxicities including non-malignant death.This is especially relevant for patients suffering from diseases with excellent prognosis such as breast cancer or Hodgkin’s lymphoma,since RIHD may occur decades after radiotherapy.Preclinical studies have enriched our knowledge of many potential mechanisms by which thoracic radiotherapy induces heart injury.Epidemiological findings in humans reveal that irradiation might increase the risk of cardiac disease at even lower doses than previously assumed.Recent preclinical studies have identified non-invasive methods for evaluation of RIHD.Furthermore,potential options preventing or at least attenuating RIHD have been developed.Ongoing research may enrich our limited knowledge about biological mechanisms of RIHD,identify non-invasive early detection biomarkers and investigate potential treatment options that might attenuate or prevent these unwanted side effects.Here,we present a comprehensive review about the published literature regarding clinical manifestation and pathological alterations in RIHD.Biological mechanisms and treatment options are outlined,and challenges in RIHD treatment are summarized.

关键词： Radiotherapy heart injury thoracic cancer radiation-induced heart injury cancer treatment

NAD+metabolism:pathophysiologic mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2020年第1期5卷 596-632页

作者： Na Xie Lu Zhang Wei Gao Canhua Huang Peter Ernst Huber Xiaobo Zhou Changlong Li Guobo Shen Bingwen Zou State Key Laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China State Key Laboratory of Biotherapy and Cancer Center West China Hospitaland Collaborative Innovation Center for BiotherapyChengdu 610041China School of Basic Medical Sciences Chengdu University of Traditional Chinese MedicineChengduSichuan 611137China CCU Molecular and Radiation Oncology German Cancer Research CenterDepartment of Radiation OncologyHeidelberg University HospitalHeidelbergGermany First Department of Medicine Medical Faculty MannheimUniversity of HeidelbergTheodor-Kutzer-Ufer 1-368167 MannheimGermany West China School of Basic Medical Sciences&Forensic Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Thoracic Oncology and Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Chin

Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbation,genotoxic factors,circadian disorder,infection,inflammation and xenobiotics.These effects are mainly achieved by the driving effect of NAD^(+)on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions.Besides,multiple NAD^(+)-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA,RNA and proteins,or releasing second messenger cyclic ADPribose(cADPR)and NAADP^(+).Prolonged disequilibrium of NAD^(+)metabolism disturbs the physiological functions,resulting in diseases including metabolic diseases,cancer,aging and neurodegeneration disorder.In this review,we summarize recent advances in our understanding of the molecular mechanisms of NAD^(+)-regulated physiological responses to stresses,the contribution of NAD^(+)deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention.

关键词： metabolism therapeutic potential

Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy

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Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 49-60页

作者： Bo Chen Lan Mei Rangrang Fan Di Chuan Yangmei Ren Min Mu Haifeng Chen Bingwen Zou Gang Guo State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China Department of Thoracic Oncology and Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

The combination of photothermal therapywith chemotherapy has gradually developed into promising cancer therapy.Here,a synergistic photothermal-chemotherapy nanoplatform based on polydopamine(PDA)-coated gold nanoparticles(AuNPs)were facilely achieved via the in situ polymerization of dopamine(DA)on the surface of AuNPs.This nanoplatform exhibited augmented photothermal conversion efficiency and enhanced colloidal stability in comparison with uncoated PDA shell AuNPs.The i-motif DNA nanostructure was assembled on PDA-coated AuNPs,which could be transformed into a C-quadruplex structure under an acidic environment,showing a characteristic pH response.The PDA shell served as a linker between the AuNPs and the i-motif DNA nanostructure.To enhance the specific cellular uptake,the AS1411 aptamer was introduced to the DNA nanostructure employed as a targeting ligand.In addition,Dox-loaded NPs(DAu@PDA-AS141)showed the pH/photothermal-responsive release of Dox.The photothermal effect of DAu@PDA-AS141 elicited excellent photothermal performance and efficient cancer cell inhibition under 808 nm near-infrared(NIR)irradiation.Overall,these results demonstrate that the DAu@PDA-AS141 nanoplatform shows great potential in synergistic photothermal-chemotherapy.

关键词： Gold nanoparticles Polydopamine i-motif AS1411 aptamer Photothermal-chemotherapy

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网络粉丝趣缘群体集体行动的动员机制分析

文化创新比较研究 2022年第8期6卷 54-57页

作者：周雪莹何并文邹增丽广西中医药大学广西南宁530001

商业资本对娱乐产业的不断渗透、造星模式的改变使得粉丝社群的组织运作有了明显的变化。粉丝社群作为趣缘群体,在没有强利益关系的牵绊下,粉丝对偶像的情感投射成为了社群集体行动的根基。官方粉丝后援会作为动员主体所带有的权威性色... 详细信息

商业资本对娱乐产业的不断渗透、造星模式的改变使得粉丝社群的组织运作有了明显的变化。粉丝社群作为趣缘群体,在没有强利益关系的牵绊下,粉丝对偶像的情感投射成为了社群集体行动的根基。官方粉丝后援会作为动员主体所带有的权威性色彩促使粉丝接受其领导地位并响应号召,同时通过对成员灌输并强化群体身份认同意识、在社会互动中形成积极反馈以及满足个体物质情感需求的激励方式鼓励群体成员参与集体行动。

关键词：趣缘群体粉丝社群集体行动动员机制

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东北地区水稻扩张的海拔优势区间分析

地理科学进展 2020年第9期39卷 1557-1564页

作者：黄莹泽邱炳文何玉花张珂邹凤丽福州大学空间数据挖掘与信息共享教育部重点实验室福州350116 地理空间信息技术国家地方联合工程研究中心福州350116 数字中国研究院(福建) 福州350116

及时掌握水稻的时空分布信息,对调整和优化农业生产结构至关重要。论文利用综合考虑植被物候和地表水变化的水稻自动制图方法,结合海拔、地表水体因素开展2001—2017年东北地区水稻分布的时空演变研究。通过889个地面调研点位对水稻分... 详细信息

及时掌握水稻的时空分布信息,对调整和优化农业生产结构至关重要。论文利用综合考虑植被物候和地表水变化的水稻自动制图方法,结合海拔、地表水体因素开展2001—2017年东北地区水稻分布的时空演变研究。通过889个地面调研点位对水稻分类结果验证,总体精度达90.66%,Kappa系数为0.8128。研究表明:①21世纪初,东北地区水稻种植面积呈先略减后持续增加的趋势,2017年水稻种植面积达2001年的2.13倍。其中,水稻扩张面积的60%分布在三江平原,30%分布在松嫩平原,下辽河平原仅占不足5%。水稻扩张的海拔优势区间在200 m范围内,随着海拔的上升水稻扩张与地表水关系越来越密切。②三江平原内,水稻扩张幅度在海拔30~70 m范围内逐渐增加,使优势区间从相对高度70 m缩减至40 m内,也使得分布优势逐渐趋向于距地表水体较远的区域。而松嫩平原和下辽河平原水稻种植分布的海拔优势区间始终分别保持在相对高度100 m、40 m内。③三江平原水稻的集中分布和急剧扩张,使水稻分布优势逐渐趋向于距地表水体远的区域,这将对地下水带来更大的压力;而松嫩平原水稻分布受地表水体影响较大,分布优势随着距地表水体距离的增加而减小。研究可为农业部门评估水资源承载力、保障农业可持续发展提供数据支撑及理论参考。

关键词：水稻种植东北地区长时间序列地理因素优势区间

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59例骶尾部脊索瘤术后放疗后的生存分析

肿瘤预防与治疗 2019年第1期32卷 38-42页

作者：路顺邹炳文彭新皓张菡奕郎锦义四川省肿瘤医院.研究所四川省癌症防治中心电子科技大学医学院四川大学华西医院胸部肿瘤科成都614041

目的:明确骶尾部脊索瘤患者是否能从术后的辅助放疗中获益,并且探索恰当的术后放疗模式。方法:回顾性纳入59例无远处转移且病理诊断明确为骶尾部脊索瘤的患者,分析其术后辅助放疗的生存情况。患者分为3组:22例为单纯手术切除组,24例为... 详细信息

目的:明确骶尾部脊索瘤患者是否能从术后的辅助放疗中获益,并且探索恰当的术后放疗模式。方法:回顾性纳入59例无远处转移且病理诊断明确为骶尾部脊索瘤的患者,分析其术后辅助放疗的生存情况。患者分为3组:22例为单纯手术切除组,24例为手术联合术后图像引导下调强放疗(IG-IMRT)治疗组,13例为手术联合伽马刀(GKS)治疗组。结果:所有患者的5年生存率及5年无复发生存率分别为80.1%和44.5%;单纯手术组、IG-IMRT组及GKS组5年生存率分别为90.9%、87.5%及59.3%,5年无复发生存率分别为29.8%、70.9%和35.0%;术后辅助放疗组对比单纯手术组的5年无复发生存率差异具有统计学意义(P=0.029),IG-IMRT组的5年无复发生存率优于GKS组(P=0.023)。结论:术后辅助放疗有助于提升脊索瘤术后患者的5年无复发生存率,且术后辅助IG-IMRT可能是更为恰当的术后放疗模式。

关键词：骶尾部脊索瘤外科手术辅助放疗 IG-IMRT GKS

基于光学表面成像与锥形束CT结合的综合引导模式在头颈部肿瘤精确放疗中的研究

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中国辐射卫生 2019年第3期28卷 346-350页

作者：叶程伟周继丹商强周兆明柏森钟仁明邹炳文四川大学华西医院肿瘤中心放疗科四川成都610041 广东三九脑科医院四川大学华西医院肿瘤中心胸部肿瘤科

目的探讨光学表面成像(OSI)Catalyst^TM系统与锥形束CT(CBCT)相结合用于引导头颈部肿瘤精确放疗的临床价值。方法82名患者均来自四川大学华西医院2015年2月至2018年1月收治的需要进行头颈部肿瘤放射治疗的患者,其中45名患者使用OSI-CBC... 详细信息

目的探讨光学表面成像(OSI)Catalyst^TM系统与锥形束CT(CBCT)相结合用于引导头颈部肿瘤精确放疗的临床价值。方法82名患者均来自四川大学华西医院2015年2月至2018年1月收治的需要进行头颈部肿瘤放射治疗的患者,其中45名患者使用OSI-CBCT综合引导放射治疗,37名患者CBCT独立引导治疗。每组患者在治疗疗程中均获得208次有效分次治疗;对综合引导治疗组与独立引导治疗组CBCT所得到的摆位误差数据进行统计学分析。结果独立引导组CBCT扫描得出的分次间摆位误差平移方向x、y、z和旋转方向rx、ry、rz的结果(均值±标准差)分别为(0.19±1.01)mm、(0.29±1.36)mm、(-0.05±1.23)mm,(-0.05±0.65)°、(0.18±0.83)°、(-0.12±0.59)°;综合引导组OSI-CBCT得出的分次间摆位误差的结果分别为(0±1)mm、(0.01±0.98)mm、(-0.4±1.08)mm,(-0.03±0.72)°、(-0.19±0.82)°、(-0.37±0.85)°。两系统的相关性系数分别为:0.17、0.07、0.03、0.1、-0.06、0.01。两系统进行配对样本t检验,结果分别为(0.19±1.3)mm,P0.05;(0.37±1.2)°,P<0.05、(0.25±1.03)°,P<0.05。结论OSI-CBCT系统综合引导模式在保证放疗精确性的同时可以减少CBCT扫描次数,能有效降低CBCT带来的额外辐射量,在头颈部肿瘤放疗中优于传统的单一的CBCT引导模式。

关键词： OSI OSI-CBCT综合引导模式锥形束CT(CBCT) 头颈部肿瘤放射治疗摆位误差

厄洛替尼挽救治疗吉非替尼治疗失败的晚期非小细胞肺癌疗效观察

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重庆医学 2011年第20期40卷 1997-1999,2002页

作者：罗大先龙建林丘金凤余敏邹炳文周麟卢铀黄媚娟四川大学华西医院肿瘤中心胸部肿瘤科成都610041

目的评价厄洛替尼作为挽救方案治疗吉非替尼治疗失败的晚期非小细胞肺癌的疗效及不良反应。方法回顾性分析2005年12月至2009年11月吉非替尼治疗进展后接受厄洛替尼治疗的晚期非小细胞肺癌患者。观察的主要指标为:客观有效率(RR)、疾病... 详细信息

目的评价厄洛替尼作为挽救方案治疗吉非替尼治疗失败的晚期非小细胞肺癌的疗效及不良反应。方法回顾性分析2005年12月至2009年11月吉非替尼治疗进展后接受厄洛替尼治疗的晚期非小细胞肺癌患者。观察的主要指标为:客观有效率(RR)、疾病控制率(DCR)、疾病无进展生存时间(PFS)、总生存时间(OS)及不良反应。结果随访至2010年6月,共有22例患者符合入组条件。22例患者均可接受疗效及生存评价,其中部分缓解(PR)2例,稳定(SD)12例,进展(PD)8例,RR为9.1%,DCR为63.6%,中位为PFS 3.0个月,OS为5.5个月。4例患者检测了表皮生长因子受体(EGFR)突变,2例有突变,2例无突变,全部患者均得到疾病控制。1例男性吸烟腺癌合并颅内转移患者原发无效给予厄洛替尼治疗后颅内病灶达到CR。亚组分析显示:吉非替尼治疗疗效SD者DCR显著提高(90%vs 58.3%,P=0.031),其RR、PFS及OS分别为20%、3.0个月及5.5个月。Ⅲ/Ⅳ度不良反应主要是皮疹1/22(4.5%)、肝功能损害1/22(4.5%)及肺间质纤维化1/22(4.5%)。结论吉非替尼治疗失败后的晚期非小细胞肺癌给予厄洛替尼挽救治疗具有较好的临床获益率,其中吉非替尼治疗疗效SD患者显著提高疾病控制率。

关键词：癌非小细胞肺厄洛替尼吉非替尼