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Utilization of Smoking Cessation Support Among Adults-18 PLADs,China,2020

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China CDC weekly 2023年第21期5卷 459-463,I0001-I0003页

作者： Yongfu Yan bingliang lin Qingqing Xu Huiyu Xie Xinying Zeng Xinbo Di Zida Meng lin Xiao Shiwei Liu Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?In 2018,unassisted smoking cessation(USC)was the predominant method for quitting smoking among Chinese adult smokers,accounting for 90.1%of *** utilization of professional smoking cessation support was comparatively low in this *** was added by this report?In 2020,the prevalence of USC methods increased to 93.1%.Concurrently,there was a slight increase in the utilization of pharmaceuticals(from 4.6%in 2018 to 5.5%in 2020)and counseling and quit line services(from 3.2%in 2018 to 7.5%in 2020).On the other hand,the use of e-cigarettes as a cessation aid decreased from 14.9%in 2018 to 9.8%in *** aged 15–24 years old were more likely to rely on pharmaceutical interventions(7.9%),and less likely to choose USC methods(79.0%).What are the implications for public health practice?The promotion of professional cessation support is essential for enhancing smoking cessation rates.

关键词： services likely smoke

Assessing the Effectiveness of a Community-Based Smoking Cessation Intervention-Shenzhen City,Guangdong Province,China,2022

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China CDC weekly 2023年第28期5卷 619-624页

作者： bingliang lin Yi Nan Xiaoyun Xie Yan Yang Huiyu Xie Yongfu Yan Luge Zhang lin Xiao Jingfan Xiong Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina Shenzhen Center for Chronic Disease Control Shenzhen CityGuangdong ProvinceChina

Summary What is already known about this topic?Research on community-based smoking cessation interventions in China is still in its early *** existing studies have focused on a limited number of communities and have p... 详细信息

关键词： primarily Guangdong communities

Single-cell Technologies Provide Novel Insights into Liver Physiology and Pathology

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 79-90页

作者： Guanzi Chen Wenli Xu Zhicong Long Yutian Chong bingliang lin Yusheng Jie Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

The liver is the largest glandular organ in the body and has a unique distribution of cells and ***,the treatment outcome of end-stage liver disease is extremely ***-cell sequencing is a new advanced and powerful technique for identifying rare cell populations and biomolecules by analyzing the characteristics of gene expression between individual *** cells and biomolecules might be used as potential targets for immunotherapy of liver diseases and contribute to the development of precise individualized *** to whole-tissue RNA sequencing,single-cell RNA sequencing(scRNA-seq)or other single-cell histological techniques have solved the problem of cell population heterogeneity and characterize molecular changes associated with liver diseases with higher accuracy and *** this review,we comprehensively summarized single-cell approaches including transcriptomic,spatial transcriptomic,immunomic,proteomic,epigenomic,and multiomic technologies,and described their application in liver physiology and *** also discussed advanced techniques and recent studies in the field of single-cell;our review might provide new insights into the pathophysiological mechanisms of the liver to achieve precise and individualized treatment of liver diseases.

关键词： Single-cell technology Normal liver Chronic liver disease Hepatocellular carcinoma Acute-on-chronic liver failure

血清ALT不能作为慢性HBV感染者启动抗病毒治疗的必备条件

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中华肝脏病杂志 2021年第12期29卷 1209-1210页

作者：林炳亮中山大学附属第三医院感染科广州510630

1.我国血清丙氨酸转氨酶(ALT)阈值可能高估:血清ALT是反映肝细胞损伤的最敏感的指标,肝细胞轻微损伤就会引起血清ALT升高。ALT水平受到多种因素的影响,包括性别、年龄、种族、地域等人口学特征,合并症和并发症的存在、实验条件和检测方... 详细信息

1.我国血清丙氨酸转氨酶(ALT)阈值可能高估:血清ALT是反映肝细胞损伤的最敏感的指标,肝细胞轻微损伤就会引起血清ALT升高。ALT水平受到多种因素的影响,包括性别、年龄、种族、地域等人口学特征,合并症和并发症的存在、实验条件和检测方法等等。血清ALT的阈值如何界定,没有一个统一的标准。目前ALT正常值界定多来源于供血员的资料,并没有完全考虑以上各种因素,纵观国内外指南,男性30~50 U/L,女性19~40 U/L不等。我国不同地方采取的正常值上限也不完全一致,国家卫生健康委员会建议男性50 U/L,女性40 U/L为ALT正常值上限,但是并没有肝组织学的验证,也没有考虑到是否存在病毒感染、代谢性疾病等因素,所以其是否能真实反映肝脏存在炎症,需要更多证据确证。

关键词：慢性乙型肝炎乙型肝炎病毒丙氨酸转氨酶治疗阈值

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The Association between Expression of NK Cells and Prognosis of Patients with HBV Acute-on-Chronic Liver Failure in Advanced Phase

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Advances in Infectious Diseases 2017年第4期7卷 118-125页

作者： Weizhen Weng Yiming Shi Xiaohua Peng Jing Xiong Huijuan Cao bingliang lin Department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-Sen University Guangzhou China Department of Intensive Care Unit the Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou China Department of Gastroenterology the Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen China

Acute-on-chronic liver failure (Acute-on-chronic liver failure, ACLF) is acute liver function decompensation on the basis of chronic liver disease. The progression of ACLF develops from advanced phase, plateau phase to remission phase. The pathophysiological basis of ACLF in different phases is various. In advanced phase, immune imbalance and systemic inflammatory reaction plays key roles. In this study, we try to assess the association between expression of NK cells and its receptors and prognosis of patients with ACLF in advanced phase. A total of 35 inpatients with HBV acute-on-chronic liver failure in advanced phase were recruited. They were divided into case group (n = 18) and control group (n = 17) according to whether the patients was dead in the 12 weeks. PBMC were detected for the frequency and expression of NK cell receptors by flow cytometric analysis. Our results demonstrated that patients who died had lower expression of NK cells and inhibitory receptor KIR3DL1, higher levels of FASL. During 12-week follow-up in those case alive, we found that NK cells increased, while expression of FASL decreased. High short-term mortality of ALCF was associated with NK cell, especially related to KIR3DL1 and FASL (PNK = 0.036, PKIR3DL1 = 0.0265, PFasL = 0.0008).

关键词： HBV ACLF NK Cell Flow Cytometry

HBV感染免疫耐受期患者应进行抗病毒治疗降低病毒量

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临床肝胆病杂志 2021年第4期37卷 778-780页

作者：林炳亮中山大学附属第三医院感染科广州510630

传统观念认为免疫耐受期患者的病情是良性的,不会导致不良预后,不推荐抗病毒治疗。但是随着研究的深入以及防控理念的改变,这种观念面临极大的挑战。1免疫耐受期的概念慢性HBV感染的自然史很复杂,根据患者感染病毒与宿主免疫状态及其相... 详细信息

传统观念认为免疫耐受期患者的病情是良性的,不会导致不良预后,不推荐抗病毒治疗。但是随着研究的深入以及防控理念的改变,这种观念面临极大的挑战。1免疫耐受期的概念慢性HBV感染的自然史很复杂,根据患者感染病毒与宿主免疫状态及其相互作用对肝脏的影响,传统上分为4个期,即免疫耐受期(慢性HBV携带状态)、免疫清除期(HBeAg阳性慢性乙型肝炎)、免疫控制期(非活动性HBsAg携带状态)和再活动期(HBeAg阴性慢性乙型肝炎)。

关键词：乙型肝炎病毒乙型肝炎,慢性免疫耐受治疗学

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社区戒烟干预理论概述

中华流行病学杂志 2022年第10期43卷 1677-1680页

作者：林炳亮谢晓芸肖琳中国疾病预防控制中心控烟办公室北京100050

通过对近几十年国内外以社区为基础开展戒烟干预研究的文献进行分析汇总,介绍根据不同理论框架开发的戒烟措施在社区应用的效果。针对中国严峻的烟草流行形势和现有戒烟服务的不足,探讨其在降低中国人群吸烟率中的应用前景,以期为国内... 详细信息

通过对近几十年国内外以社区为基础开展戒烟干预研究的文献进行分析汇总,介绍根据不同理论框架开发的戒烟措施在社区应用的效果。针对中国严峻的烟草流行形势和现有戒烟服务的不足,探讨其在降低中国人群吸烟率中的应用前景,以期为国内开展社区戒烟干预研究的理论框架和实践应用提供参考。

关键词：社区戒烟干预理论框架

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Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19

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Synthetic and Systems Biotechnology 2021年第3期6卷 135-143页

作者： Jing Liu Sheng Liu Zhao Zhang Xuejun Lee Wenxuan Wu Zhanlian Huang Ziying Lei Wenxiong Xu Dabiao Chen Xing Wu Yang Guo Liang Peng bingliang lin Yutian Chong Xiangyu Mou Mang Shi Ping Lan Tao Chen Wenjing Zhao Zhiliang Gao Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong510630China The Center for Infection and Immunity Study(CIIS) School of MedicineSun Yat-sen UniversityShenzhenChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSchool of MedicineSun Yat-sen UniversityGuangzhouChina South China Institute of Biomedicine GuangzhouGuangdong510535China

SARS-CoV-2,the causative agent for COVID-19,infect human mainly via respiratory tract,which is heavily inhabited by local ***,the interaction between SARS-CoV-2 and nasopharyngeal microbiota,and the association with metabolome has not been well ***,metabolomic analysis of blood,urine,and nasopharyngeal swabs from a group of COVID-19 and non-COVID-19 patients,and metagenomic analysis of pharyngeal samples were used to identify the key features of *** showed lactic acid,L-proline,and chlorogenic acid methyl ester(CME)were significantly reduced in the sera of COVID-19 patients compared with non-COVID-19 *** commensal bacteria including Gemella morbillorum,Gemella haemolysans and Leptotrichia hofstadii were notably depleted in the pharynges of COVID-19 patients,while Prevotella histicola,Streptococcus sanguinis,and Veillonella dispar were relatively *** abundance of *** and *** were significantly positively associated with serum CME,which might be an anti-SARS-CoV-2 bacterial *** study provides important information to explore the linkage between nasopharyngeal microbiota and disease *** findings were based on a very limited number of patients enrolled in this study;a larger size of cohort will be appreciated for further investigation.

关键词： Metabolome Nasopharyngeal microbiome COVID-19 SARS-CoV-2 Susceptibility

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间充质干细胞治疗终末期肝病的临床研究进展

临床肝胆病杂志 2023年第5期39卷 1010-1018页

作者：冯宇陈俊峰林炳亮中山大学附属第三医院感染性疾病科广州510630

终末期肝病(ESLD)包括失代偿期肝硬化和肝衰竭,其病情凶险,预后不佳。肝移植是唯一可以治愈ESLD的方法,但因肝源短缺、免疫排斥和费用昂贵等问题,其在临床中的应用受到很大限制。间充质干细胞(MSC)可分化为肝细胞样细胞,并可通过旁分泌... 详细信息

终末期肝病(ESLD)包括失代偿期肝硬化和肝衰竭,其病情凶险,预后不佳。肝移植是唯一可以治愈ESLD的方法,但因肝源短缺、免疫排斥和费用昂贵等问题,其在临床中的应用受到很大限制。间充质干细胞(MSC)可分化为肝细胞样细胞,并可通过旁分泌调节机体免疫功能,改善肝纤维化,在治疗ESLD领域具有极广的应用前景。很多临床研究已经证明输注MSC治疗ESLD在短期内是安全有效的,其长期应用的安全性和有效性也有一定的临床证据支持。MSC分泌的外泌体没有完整的细胞结构,可通过多种机制促进肝细胞再生,其临床应用价值日益受到重视,但与之相关的临床研究仍寥寥可数。干细胞治疗ESLD的核心机制、制备干细胞的标准化流程等是当下亟待解决的问题。

关键词：终末期肝病干细胞间质干细胞治疗学

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