Single-cell Technologies Provide Novel Insights into Liver Physiology and Pathology
作者机构：Department of Infectious DiseasesThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2024年第12卷第1期
页 面：79-90页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported in part by the National Natural Science Foundation of China(32000892) the Guangdong Basic and Applied Basic Research Foundation(2023A1515010143) Science and Technology Program of Guangzhou,China(202102010155)
主 题：Single-cell technology Normal liver Chronic liver disease Hepatocellular carcinoma Acute-on-chronic liver failure
摘 要：The liver is the largest glandular organ in the body and has a unique distribution of cells and ***,the treatment outcome of end-stage liver disease is extremely ***-cell sequencing is a new advanced and powerful technique for identifying rare cell populations and biomolecules by analyzing the characteristics of gene expression between individual *** cells and biomolecules might be used as potential targets for immunotherapy of liver diseases and contribute to the development of precise individualized *** to whole-tissue RNA sequencing,single-cell RNA sequencing(scRNA-seq)or other single-cell histological techniques have solved the problem of cell population heterogeneity and characterize molecular changes associated with liver diseases with higher accuracy and *** this review,we comprehensively summarized single-cell approaches including transcriptomic,spatial transcriptomic,immunomic,proteomic,epigenomic,and multiomic technologies,and described their application in liver physiology and *** also discussed advanced techniques and recent studies in the field of single-cell;our review might provide new insights into the pathophysiological mechanisms of the liver to achieve precise and individualized treatment of liver diseases.
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