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Effect of Kang Ai injection + conventional chemotherapy on tumor markers, apoptotic molecules and immune response in patients with advanced NSCLC

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Journal of Hainan Medical University 2018年第22期24卷 67-70页

作者： Shun-Ping Yuan bing-Long huang Wei-Ping huang qiao-Li Mo Qiang huang Pharmacy Affiliated XiaoLan Hospital of Southern Medical UniversityZhongshanGuangdong528415China

Objective: To study the effects of Kang Ai injection + conventional chemotherapy on tumor markers, apoptotic molecules and immune response in patients with advanced non-small cell lung cancer (NSCLC). Methods: Patients diagnosed as advanced NSCLC in our hospital during March 2015 - October 2017 were randomly divided into the experimental group receiving Kang Ai injection + conventional chemotherapy and the control group receiving conventional chemotherapy. The contents of tumor markers, apoptotic molecules and immunologic cytokines in serum and the contents of immune cells in peripheral blood were determined before and after chemotherapy. Results: after chemotherapy, the content of CEA, CYFRA21-1, SCC-Ag, GDF15 and Livin in the serum of the two groups decreased significantly, and the content of PDCD5, P53 and Bax increased significantly, and the content of CEA, CYFRA21-1, SCC-Ag, GDF15, Livin in the serum of the experimental group were lower than those of the control group, and the content of PDCD5, P53 and Bax were higher than those of the control group;the content of CD3+ and CD4+ cells in peripheral blood and the content of IFN-γ, IL-2 in serum of control group significantly decreased, whereas the content of CD8+ cells in peripheral blood and the content of IL-4, IL-5 in serum significantly increased after chemotherapy;while the content of CD3+ and CD4+ cells in peripheral blood and the content of IFN-γ, IL-2 in serum of experimental group significantly increased, whereas the content of CD8+ cells in peripheral blood and the content of IL-4, IL-5 in serum significantly decreased after chemotherapy. Conclusion: Kang Ai injection + conventional chemotherapy in the treatment of advanced NSCLC can more significantly decrease the serum tumor markers, regulate the secretion of apoptotic molecules and anti-tumor immune response than conventional chemotherapy.

关键词： Non-small cell lung cancer Kang Ai injection Tumor markers Apoptotic molecules Immune response

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疲劳荷载作用下栓钉连接件的抗剪承载力退化规律

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哈尔滨工业大学学报 2016年第9期48卷 76-82页

作者：汪炳黄侨刘小玲东南大学交通学院南京210096

为了解钢-混凝土组合结构中栓钉连接件在疲劳荷载后的力学特性,针对栓钉推出试件进行静载破坏试验、完全疲劳试验以及非完全疲劳破坏试验.在此基础上归纳了已有栓钉连接件的非完全疲劳破坏的相关试验数据,将疲劳循环次数和剩余抗剪承载... 详细信息

为了解钢-混凝土组合结构中栓钉连接件在疲劳荷载后的力学特性,针对栓钉推出试件进行静载破坏试验、完全疲劳试验以及非完全疲劳破坏试验.在此基础上归纳了已有栓钉连接件的非完全疲劳破坏的相关试验数据,将疲劳循环次数和剩余抗剪承载力这两个参数作归一化处理,使得所有试验数据具备可比性;同时基于剩余强度理论,推导出适用于栓钉连接件的剩余承载力计算模型,并通过试验数据拟合确定其参数;最后通过若干文献的试验数据进行验证分析.结果表明:在疲劳荷载作用下,栓钉连接件的剩余承载能力呈现先慢后快的非线性退化趋势.所提出的栓钉连接件承载力幂指数退化模型可以较好地描述栓钉连接件的剩余承载力随疲劳循环次数的变化规律.

关键词：钢-混凝土组合结构栓钉连接件疲劳剩余强度桥梁

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Sparse polynomial interpolation based on diversification

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Science China Mathematics 2022年第6期65卷 1147-1162页

作者： qiao-Long huang Research Center for Mathematics and Interdisciplinary Sciences Shandong UniversityJinan 266237China

We consider the problem of interpolating a sparse multivariate polynomial over a finite field,represented with a black box.Building on the algorithm of Ben-Or and Tiwari(1988)for interpolating polynomials over fields with the characteristic 0,we develop a new Monte Carlo algorithm over finite fields by doing additional probes.To interpolate a polynomial f∈Fq[x1,...,xn]with a partial degree bound D and a term bound T,our new algorithm costs O~(nTlog^(2)q+nT√Dlogq)bit operations and uses 2(n+1)T probes to the black box.If q O(n T^(2)D),it has a constant success rate to return the correct polynomial.Compared with the previous algorithms over a general finite field,our algorithm has better complexity in the parameters n,T and D,and is the first one to achieve the complexity of the fractional power about D,while keeping linear in n and T.A key technique is a randomization which makes all the coefficients of the unknown polynomial distinguishable,producing a diverse polynomial.This approach,called diversification,was proposed by Giesbrecht and Roche(2011).Our algorithm interpolates each variable independently by using O(T)probes,and then uses the diversification to correlate terms in different images.At last,we get the exponents by solving the discrete logarithms and obtain the coefficients by solving a linear system.We have implemented our algorithm in Maple.Experimental results show that our algorithm can be applied to the sparse polynomials with large degree within a few minutes.We also analyze the success rate of the algorithm.

关键词： interpolation finite field diversification

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Effect of salvianolic acid B on TNF-α induced cerebral microcirculatory changes in a micro-invasive mouse model

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中华创伤杂志(英文版) 2016年第2期19卷 85-93页

作者： Chen Bo Sun Kai Liu Yu-Ying Xu Xiang-Shun Wang Chuan-She Zhao Ke-Seng huang qiao-bing Han Jing-Yan Department of Pathophysiology Key Laborotory for Shock and Microcirculation Research School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China Tasly Microcirculation Research Center Health Science Center Peking University Beijing China Department of Integration of Chinese and Western Medicine School of Basic Medical Sciences Peking University Beijing 100083 China

Purpose: To investigate the effects of salvianolic acid B (SAB) on tumor necrosis factor α (TNF-α) induced alterations of cerebral microcirculation with a bone-abrading model. Methods: The influences of craniotomy model and bone-abrading model on cerebral microcirculation were compared. The bone-abrading method was used to detect the effects of intracerebroventricular application of 40 μg/kg·bw TNF-α on cerebral venular leakage of fluorescein isothiocyanate (FITC)albulmin and the rolling and adhesion of leukocytes on venules with fluorescence tracer rhodamine 6G. The therapeutical effects of SAB on TNF-α induced microcirculatory alteration were observed, with continuous intravenous injection of 5 mg/kg·h SAB starting at 20 min before or 20 min after TNF-α administration, respectively. The expressions of CD11b/CD18 and CD62L in leukocytes were measured with flow cytometry. Immunohistochemical staining was also used to detect E-selectin and ICAM-1 expression in endothelial cells. Results: Compared with craniotomy method, the bone-abrading method preserved a higher erythrocyte velocity in cerebral venules and more opening capillaries. TNF-α intervention only caused responses of vascular hyperpermeability and leukocyte rolling on venular walls, without leukocyte adhesion and other hemodynamic changes. Preor post-SAB treatment attenuated those responses and suppressed the enhanced expressions of CD11b/CD18 and CD62L in leukocytes and E-selectin and ICAM-1 in endothelial cells induced by TNF-α. Conclusions: The pre- and post-applications of SAB during TNF-α stimulation could suppress adhesive molecular expression and subsequently attenuate the increase of cerebral vascular permeability and leukocyte rolling.

关键词： Microcirculation Tumor necrosis factor-alpha Salvianolic acid B

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Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 342-347页

作者： Qi YU En-qi LIU Si-hai ZHAO Ya-feng LI Yan-li WANG Yu-long CHEN Ke-na WEI Bing-qiao HUANG Jian-lin FAN Peng-hui YANG Research Institute of A therosclerotic Disease Xi'an Jiaotong University School of MedicineShaanxi 710061China Laboratory Animal Center Xi'an Jiaotong University School of MedicineShaanxi 710061China Department of Molecular Pathology Interdisciplinary Graduate School of Medicine and EngineeringUniversity of YamanashL Yamanashi 409-3898Japan

Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The lit- erature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB poly- morphism of CETP was found to be associated with CAD in the Chinese population.

关键词： Cholesteryl ester transfer protein Coronary artery disease Polymorphism Chinese population

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基于证据推理框架的斜拉桥状态评估模型

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华南理工大学学报（自然科学版） 2020年第6期48卷 69-76页

作者：刘小玲汪炳黄侨任远宁波大学海运学院浙江宁波315211 宁波大学土木与环境工程学院浙江宁波315211 东南大学交通学院江苏南京210096

为更加准确、可靠地掌握斜拉桥的整体技术状况,提出了一个基于层次证据推理框架的桥梁状态评估方法。首先将斜拉桥指标体系分为3个层次,第1层为桥梁总体状态,第2层分为一级、二级、三级和交通安全部件,底层为实际检测指标;接着将底层指... 详细信息

为更加准确、可靠地掌握斜拉桥的整体技术状况,提出了一个基于层次证据推理框架的桥梁状态评估方法。首先将斜拉桥指标体系分为3个层次,第1层为桥梁总体状态,第2层分为一级、二级、三级和交通安全部件,底层为实际检测指标;接着将底层指标信息转换为证据,且指标证据的可信度考虑了桥梁要素的重要性和采集数据的可靠性;然后通过Dempster-Shafer组合规则进行融合,以传递整个模型中偶然和认知的不确定性,并得出一级、二级、三级和交通安全部件指标以及桥梁整体状态指标;最后以一座独塔斜拉桥为例,验证所提证据推理框架的合理性。结果表明:基于Dempster-Shafer规则的组合在归一化过程中丢失的数据较少,更具应用价值;指标可靠性系数修正了桥梁评估中的主观判断误差,使评估结果更偏于保守且客观;所建立的桥梁评估方法提供了更准确、详细的桥梁子部件状况,也可用于桥梁群的状态等级排序。

关键词：桥梁工程斜拉桥状态评估证据推理组合规则可靠性

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考虑界面滑移与剪切变形的钢-混凝土组合梁解析方法

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南京航空航天大学学报 2018年第1期50卷 131-137页

作者：黄侨李文贤汪炳东南大学交通学院南京210096

为求解钢-混凝土组合梁在界面滑移与剪切变形双重影响下的变形与应力,本文引入Timoshenko梁双广义位移假定,建立了钢-混凝土简支组合梁弹性状态下的计算模型,并以跨中作用集中荷载为例,得到其全梁挠度与截面应力的解析解。同时对4根不... 详细信息

为求解钢-混凝土组合梁在界面滑移与剪切变形双重影响下的变形与应力,本文引入Timoshenko梁双广义位移假定,建立了钢-混凝土简支组合梁弹性状态下的计算模型,并以跨中作用集中荷载为例,得到其全梁挠度与截面应力的解析解。同时对4根不同抗剪连接程度的钢-混凝土组合梁试验结果进行分析,与解析计算结果进行对比验证,并讨论了界面剪切刚度的取值对组合梁挠度的影响。结果表明理论计算所得挠度、应力均与试验值吻合良好;界面滑移将增大组合梁挠度,界面剪切刚度对这种增大效应有重要影响;在计算组合梁挠度时,忽略剪切变形在一定程度上不安全。

关键词：钢-混凝土组合梁滑移效应剪切变形解析计算界面剪切刚度

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内皮细胞屏障与烧伤后血管通透性的关系及机制

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中华烧伤杂志 2007年第5期23卷 324-326页

作者：黄巧冰南方医科大学病理生理学教研室(广东省医学休克微循环重点实验室) 广州510515

正常血管通透性的维持有赖于血管内皮细胞屏障的完整性，内皮细胞与内皮细胞间、细胞与基底膜间的连接以及胞内骨架蛋白收缩这3种力量，经蛋白质相互作用，在功能和调节上互相关联。烧伤休克的主要临床特点是低血容量性休克，其主要原... 详细信息

正常血管通透性的维持有赖于血管内皮细胞屏障的完整性，内皮细胞与内皮细胞间、细胞与基底膜间的连接以及胞内骨架蛋白收缩这3种力量，经蛋白质相互作用，在功能和调节上互相关联。烧伤休克的主要临床特点是低血容量性休克，其主要原因之一是毛细血管扩张，血管通透性增加，毛细血管静水压增加，促进了血浆样液体的渗出，导致血容量锐减。关于内皮细胞屏障功能在烧伤后血管通透性变化中的作用，我们近年来做了一些研究工作。

关键词：烧伤内皮细胞通透性细胞骨架紧密连接部肌动蛋白类

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熔盐电解法制备Y-Ni合金工艺研究

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稀土 2024年第2期45卷 105-112页

作者：邱小英蓝桥发邱小兵黄金江西离子型稀土工程技术研究有限公司江西赣州341000 国家离子型稀土资源高效开发利用工程技术研究中心江西赣州341000

以Y_(2)O_(3)为原料、YF_(3)-LiF为熔盐,研究自耗阴极熔盐电解法制备Y-Ni合金,分析电解电压、电解电流对合金成分、电解温度、电解效率和金属收率的影响。在61.5%YF_(3)-38.5%LiF(原子分数)的熔盐体系下,电解电压、电解电流对电解温度... 详细信息

以Y_(2)O_(3)为原料、YF_(3)-LiF为熔盐,研究自耗阴极熔盐电解法制备Y-Ni合金,分析电解电压、电解电流对合金成分、电解温度、电解效率和金属收率的影响。在61.5%YF_(3)-38.5%LiF(原子分数)的熔盐体系下,电解电压、电解电流对电解温度影响显著,电解温度过高,稀土金属在熔体中溶解加快,稀土金属氧化、二次反应加剧,合金中钇成分含量、电解效率以及钇金属收率随着电解温度的增加逐渐降低,实验获得的最佳电解条件为:电解电压为7.2 V±0.2 V,电解电流为555 A±5 A,电解温度为1080℃±20℃。通过对Y-Ni合金的表征分析,制备的Y-Ni合金成分较为均匀,无明显偏析现象,合金中Y∶Ni=1∶1(质量比),主要由NiY相和Ni_(2)Y相组成,其中YNi相占比为42.11%,YNi_(2)相占比为57.89%。

关键词：熔盐电解钇镍合金 YF_(3)-LiF 自耗阴极

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Attributable Causes of Cancer in China:Fruit and Vegetable

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Chinese Journal of Cancer Research 2011年第3期23卷 171-176页

作者： Hui-juan Xiao Hao Liang Jian-bing Wang Cheng-Yu huang Wen-qiang Wei Mathieu Boniol You-lin qiao Paolo Boffetta Department of Nutrition and Food Hygiene West China School of Public Health Sichuan University Chengdu 610041 China Departments of Cancer Epidemiolo gy Cancer Institute Chinese Academy of Medical Sciences Beijing 100021 China Department of Epidemiology and Statistics Institute of Basic Medical Sciences Chinese Academy of Medical Sciences ＆School of Basic Medicine Peking Union Medical College Beijing 100005 China International Prevention Research Institute Lyon 69008 France The Tisch Cancer Institute Mount Sinai School of Medicine New York NY 10029 USA Nutrition Department Tianjin Third Central Hospital Tianjin 300170 China

Objective：To provide an evidence-based and consistent assessment of the burden of cancer attributable to inadequate fruit and vegetable intake in China in 2005.Methods：The proportions of cancers attributable to low consumption of vegetable and fruit were calculated separately to estimate the burden of related cancers for the year 2005 in China.Data on the prevalence of exposure were derived from a Chinese nutrition and health survey.Data on relative risks were mainly derived from meta-analysis.Attributable fractions were calculated based on the counterfactual scenario which was a shift in the exposure distribution.Results：The total cancer burden attributable to inadequate consumption of fruit was up to 233,000 deaths （13.0% of all cancers） and 300,000 cases （11.6% of all cancers） in 2005.Increasing consumption of vegetable to the highest quintile could avoid total cancer deaths and cases by 3.6% （64,000 persons） and 3.4% （88,000 persons）.The contributions to cancer burden were higher in rural areas than in urban areas.They have greater influence on men than on women.The largest proportions of cancer burden attributable to low fruit and vegetable intake were for oral and pharyngeal cancers.Conclusion：This study showed that inadequate intake of fruit and vegetable makes a significant contribution to the cancer burden.Increasing consumption of fruit and vegetable could prevent many cancer deaths and save many lives.Promoting the consumption of fruit and vegetable is an important component in diet-based strategies for preventing cancer.

关键词： Fruit Vegetable Cancer Population attributable fraction China

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