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Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-Fu Wang Jie Zheng Yi-Ming Lei Zhong-Yuan Chen Yi guo Ya-Jie guo bing-qian guo Yu-Fang Lv Hong-Hong Wang Juan-Juan Xie Yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

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Localizing vitamin-C through nanoconfinement enables high-rate CO_(2) electrolysis to ethylene

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Science China Materials 2024年第3期67卷 1006-1008页

作者： Zhengyi qian Shaojun guo School of Materials Science and Engineering Peking UniversityBeijing 100871China

The electrosynthesis of value-added fuels and chemicals from carbon dioxide reduction reaction(CO_(2)RR)is a promising approach for realizing the objectives of carbon neutrality[1].Nevertheless,the current production of desirable multicarbon(C_(2+))chemicals,such as ethylene(C_(2)H_(4)),still encounters challenges related to low selectivity,low current density,and the requirement for high-purity feeding gas[2].

关键词： enable purity dioxide

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Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： bing-bing Liu Yi-Hui Liu You-Bin Zhang Zhen-guo Qi guo-Hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

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For Mega-Constellations: Edge Computing and Safety Management Based on Blockchain Technology

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China Communications 2024年第2期21卷 59-73页

作者： Zhen Zhang bing guo Chengjie Li College of Computer Science Sichuan UniversityChengdu 610064China The Key Laboratory for Computer Systems of State Ethnic Affairs Commission School of Computer Science and TechnologySouthwest Minzu UniversityChengdu 610225China National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In mega-constellation Communication Systems, efficient routing algorithms and data transmission technologies are employed to ensure fast and reliable data transfer. However, the limited computational resources of satellites necessitate the use of edge computing to enhance secure *** edge computing reduces the burden on cloud computing, it introduces security and reliability challenges in open satellite communication channels. To address these challenges, we propose a blockchain architecture specifically designed for edge computing in mega-constellation communication systems. This architecture narrows down the consensus scope of the blockchain to meet the requirements of edge computing while ensuring comprehensive log storage across the network. Additionally, we introduce a reputation management mechanism for nodes within the blockchain, evaluating their trustworthiness, workload, and efficiency. Nodes with higher reputation scores are selected to participate in tasks and are appropriately incentivized. Simulation results demonstrate that our approach achieves a task result reliability of 95% while improving computational speed.

关键词： blockchain consensus mechanism edge computing mega-constellation reputation management

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Sodium Sulfite as a Novel Hypoxia Revulsant Involved in Hypoxic Regulation in Escherichia coli

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Biomedical and Environmental Sciences 2024年第2期37卷 228-232页

作者： YE Qiao HUO Jia Nan LUO Yuan MEI Zhu Song FANG Long Mei guo bing qian WANG Guang Yun Laboratory of clinical medicine Air Force Medical CenterAir Force Medical UniversityBeijing 100142China

As a reducing salt,sodium sulfite could deprive oxygen in solution,which could mimic hypoxic stress in Caenorhabditis *** this study,the wildtype Escherichia coli strain MG1655 was used to examine the inhibition of so... 详细信息

关键词： hypoxic Sodium observing

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A Practical Approach for Missing Wireless Sensor Networks Data Recovery

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China Communications 2024年第5期21卷 202-217页

作者： Song Xiaoxiang guo Yan Li Ning Ren bing The College of Communications Engineering Army Engineering University of PLANanjing 210007China The 63891 Unit of PLA Luoyang 471000China

In wireless sensor networks(WSNs),the performance of related applications is highly dependent on the quality of data ***,missing data is almost inevitable in the process of data acquisition and *** methods often rely on prior information such as low-rank characteristics or spatiotemporal correlation when recovering missing WSNs ***,in realistic application scenarios,it is very difficult to obtain these prior information from incomplete data ***,we aim to recover the missing WSNs data effectively while getting rid of the perplexity of prior *** designing the corresponding measurement matrix that can capture the position of missing data and sparse representation matrix,a compressive sensing(CS)based missing data recovery model is ***,we design a comparison standard to select the best sparse representation basis and introduce average cross-correlation to examine the rationality of the established ***,an improved fast matching pursuit algorithm is proposed to solve the *** results show that the proposed method can effectively recover the missing WSNs data.

关键词： average cross correlation matching pursuit missing data wireless sensor networks

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Development of a novel Eu^(3+)-doped tantalate red-emitting phosphor for w-LEDs application

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Journal of Rare Earths 2024年第8期42卷 1479-1488,I0003页

作者： Fan Zeng Jingjing Ru bing Zhao Feiyun guo Jianzhong Chen College of Chemistry and Materials Fujian Province University Key Laboratory of Green Energy and Environment CatalysisNingde Normal University.Ningde352100China School of Environment and Resources School of Carbon Neutral and Modern IndustryFujian Normal UniversityFuzhou350007China College of Information and Mechanical&Electrical Engineering Ningde Normal UniversityNingde352100China College of Chemistry Fuzhou UniversityFuzhou350108China

Two novel phosphors LiBa_(4(1-x))Eu_(4x)Ta_(3)O_(12)(H-LBTO:xEu^(3+)) and Li_(0.25)Ba_(1-x)Eu_(x)Ta_(0.75)O_(3)(C-LBTO:xEu^(3+))were prepared successfully by a molten salt *** transformation between these two structures was realized by changing the sintering temperature or changing the Eu^(3+) ions concentration,which was also demonstrated by the X-ray diffraction(XRD),scanning electron microscopy(SEM),diffuse reflectance spectra(DRS),and photoluminescence excitation(PLE) analyses,Both the sintering temperature and the Eu^(3+)ions doping concentration have significant impact on the formation of the crystal *** these phosphors sintered at 1023 K exhibit two major luminescence lines at 594 and 614 nm under nearUV light of 395 nm excitation,corresponding to Eu^(3+)ions typical transitions of ^(5)D_(0)→^(7)F_(1) and ^(5)D_(0)→^(7)F_(2).The optimum concentration of Eu^(3+) ions is 9 mol% for C-LBTO:xEu^(3+) samples and the quenching interaction type is the nearest-neighbor ion *** thermal stability of the C-LBTO:0.09Eu^(3+)sample was investigated in detail and the device application further suggests that C-LBTO:0.09Eu^(3+) can be used as a red phosphor for near-UV excited w-LEDs in lighting.

关键词： Phosphor Tantalate LED device Rare earths

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Ramsey Numbers of Trees Versus Multiple Copies of Books

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 600-612页

作者： Xiao-bing guo Si-nan HU Yue-jian PENG School of Mathematical Sciences Luoyang Normal UniversityLuoyang 471934China School of Mathematics Hunan UniversityChangsha 410082China

Given two graphs G and H,the Ramsey number R(G,H) is the minimum integer N such that any two-coloring of the edges of K_(N) in red or blue yields a red G or a blue *** v(G) be the number of vertices of G and χ(G) be the chromatic number of *** s(G) denote the chromatic surplus of G,the number of vertices in a minimum color class among all proper χ(G)-colorings of *** showed that R(G,H)≥(v(G)-1)(χ(H)-1)+s(H) if G is connected and v(G)≥s(H).A connected graph G is H-good if R(G,H)=(v(G)-1)(χ(H)-1)+s(H).Let tH denote the disjoint union of t copies of graph H,and let G∨H denote the join of G and *** a complete graph on n vertices by K_(n),and a tree on n vertices by T_(n).Denote a book with n pages by B_(n),i.e.,the join K_(2) ∨■.Erd?s,Faudree,Rousseau and Schelp proved that T_(n) is B_(m)-good if n≥*** this paper,we obtain the exact Ramsey number of T_(n) versus 2B_(2).Our result implies that T_(n) is 2B_(2)-good if n≥5.

关键词： ramsey number ramsey goodness tree book

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Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-bing qian Jun-Feng Li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

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Joined AZ31B Magnesium Alloys with Ag Interlayer by Ultrasonic-Induced Transient Liquid Phase Bonding in Air

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1177-1185页

作者： qian Wang Peng Yu Haoran Lin Chongzhi guo Xiaoqiang Hu Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China School of Rare Earths University of Science and Technology of ChinaHefei230026China Shenyang 7D New Materials Equipment Co.LTD. Shenyang110076China Shenyang National Laboratory of Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

AZ31B magnesium alloys are commonly used in lightweight structures of automobile and aerospace *** this work,the ultrasonic-induced transient liquid phase bonding technique is deployed to joint AZ31B magnesium alloys at 490℃ with Ag interlayer in the *** effect of ultrasonic vibration on microstructure and mechanical properties of welding seam is *** vibration duration increases,the width of the welding seam increases firstly and then *** the ultrasound vibration sustained for one second,the eutectic reaction occurred in the contacting interface between Ag interlayer and the base metal AZ31B,resulting in formation of liquid phase and metallurgical *** the ultrasound vibration sustained for seven second,the width of the welding seam increased to a maximum of about 303.1μm and the average shear bond strength of the welding joint attained the peak value of about 66.87 *** the ultrasound vibration sustained over seven seconds,the liquid phase is gradually squeezed out and the width of the welding seam decreases.α-Mg and AgMg_(3) can be observed in the welding *** analysis shows thatα-Mg has a certain strengthening *** whole process of appearance,growth and integration ofα-Mg is analyzed.

关键词： Ultrasonic bonding Magnesium alloy Silver Microstructure Intermetallic compound

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