检索结果-南通市图书馆

A Review of WBG and Si Devices Hybrid Applications

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electrical Engineering 2021年第2期7卷 1-20页

作者： Li Zhang Zhongshu Zheng Xiutao lou College of Energy and Electrical Engineering Hohai UniversityNanjing 211100China

In recent years,next-generation power semiconductor devices,represented by silicon carbide(SiC)and gallium nitride(gan),have gradually *** wide-bandgap(WBG)devices have better electrical characteristics than those of silicon(Si)based devices,they have attracted increased attention both from academic researchers and industrial *** WBG devices will further improve the efficiency and power density of power ***,the current price of WBG devices remains extremely ***,some researches have focused on the hybrid utilization of WBG devices and Si-based devices to achieve a tradeoff between the performance and *** summarize the current research on WBG/Si hybrid applications,the issues mentioned above with representative research approaches,results,and characteristics,are systematically ***,the current research on WBG/Si hybrid applications and their future trends are discussed.

关键词： Silicon carbide(SiC)devices gallium nitride(gan)devices silicon(Si)devices hybrid application

The synthesis and fluorescence of a methoxy-phenyl substituted C_60-pyrrolidine derivative

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1997年第1期15卷 35-41页

作者： ZHOU, De-Jian gan, Liang-bing LUO, Chu-Ping HUANG, Chun-HuiYAO, Guang-QingState Key Laboratory of Rare Earth Materials Chemistry and Applications, Peking University,Beijing 100871, China State Key Laboratory of Rare Earth Materials Chemistry and Applications Peking University Beijing 100871 China

A new 4-methoxyphenyl substituted C60-pyrrolidine derivative, C60(C10H13NO) (1), was prepared and its room-temperature fluorescence was studied. Its fluorescence intensity is three times stronger than that of C60. Its singlet energy was estimated to be 25 kJ/mol lower than that of C60. The fluorescence lifetime was determined to be 2.1+0.3 ns by using the frequency domain method. The fluorescence quenching by concentration and aromatic electron donor: N, N-dimethyl aniline (DMA) was investigated. Data show that its fluorescence could not be quenched by DMA.

关键词： C60-pyrrolidine derivative fluorescence fluorescence quenching

使用带孔阻尼套的座阀液动力试验和数值研究（英文）

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第6期19卷 417-430页

作者： Jun-hui ZHANG Di WANG bing XU Min-yao gan Min PAN Hua-yong YANG State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Shanghai Marine Equipment Research Institute Shanghai 200031China Department of Mechanical Engineering University of BathBath BA2 7A YUK

目的:液压自由活塞发动机性能受燃油喷射系统开关阀性能限制。本文旨在对开关阀内部结构进行优化,降低液动力,从而提高阀的开启速度。创新点:1.提出一种易于安装的带孔阻尼套结构,可以用于改变阀芯表面压力分布和油液射流角,从而降低液... 详细信息

目的:液压自由活塞发动机性能受燃油喷射系统开关阀性能限制。本文旨在对开关阀内部结构进行优化,降低液动力,从而提高阀的开启速度。创新点:1.提出一种易于安装的带孔阻尼套结构,可以用于改变阀芯表面压力分布和油液射流角,从而降低液动力;2.建立数值仿真模型,分析阻尼套不同结构和安装参数对液动力和空化的影响。方法:1.进行数值模拟,分析阀芯表面压力分布和内部流场分布,并通过实验验证方法有效性和模型准确性;2.对不同阻尼孔宽度、深度和相对位置下的阀芯液动力和流量损失情况进行对比和分析;3.对上述不同阻尼孔结构下阀内空化情况进行仿真和对比;4.建立燃油喷射系统试验台,验证阻尼套对提高阀开启速度的作用。结论:1.提出的带孔阻尼套结构可以有效降低阀芯液动力。2.随阻尼孔的减小,其对液动力的改变作用和节流作用逐渐增强;阻尼孔足够小时液动力反向并逐渐加强。3.阻尼套对油液的阻碍作用也会改变流场内的空化情况,但空化强度不一定随节流孔的变大而单调变强,其还受相对安装位置影响。4.带孔阻尼套可以有效降低阀的开启时间。

关键词：座阀阻尼套液动力数值研究

Histone deacetylase 6 mediated NALP3 inflammasome activation contributes to dopaminergic injury in experimental models of Parkinson disease

在线全文

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2018年第9期32卷 686-687页

作者： YAN Shao-qi WEI Xin-bing JIAN Wen-cheng QIN Yue JIANG Fan lou Hai-yan ZHANG Bin Department of Pharmacology School of Basic Medical SciencesShandong University Jinan 250012China Department of Radiology Qilu HospitalShandong University Jinan 250012China Department of Pathophysiology School of Basic Medical SciencesShandong University Jinan 250012China

OBJECTIVE To investigate the mechanisms of histone deacetylase 6(HDAC6)deacetylation activity on NALP3 inflammasome activation and explore the protective effect s of pharmacological inhibition of HDAC6 on dopaminergic *** In vitro and in vivo6-OHDA induced Parkinson disease(PD) model was *** distinguish the effect of deacetylase catalytic domains of HDAC6,we used a specific HDAC6 inhibitor tubastatin A(TBA),siRNAHDAC6,and pcDNA-HDAC6-FLAG ***,the role of pharmacological inhibition or siRNA or overexpression of HDAC6 on NALP3 inflammasome and cell death was explored by using Western blotting,TUNEL,and flow cytometric ***,the acetylation level of peroxiredoxin 2(Prx2) and the production of reactive oxygen species(ROS) in cells under different treatments was examined by using immunoprecipitation and DCFH-DA fluorescence *** effects of TBA on neuroinflammation and nigrostriatal dopaminergic system in vivo was further investigated by using Western blotting,immunohistochemistry and HPLC *** TBA remarkably inhibited 6-OHDA induced NALP3 inflammasome activation,reduced dopaminergic neurodegeneration and neuroinflammation as demonstrated by increased TH-positive neurons,striatal levels of DA and its metabolites,and decreased gliocyte *** recovered acetylation of Prx2,and reduced ROS production,which was associated with decreased NALP3 inflammasome *** HDAC6 may medicate deacetylation of Prx2 contributes to NALP3 inflammasome activation in PD pathology,suggesting that the development of specific pharmacological inhibitors of HDAC6 be required for this kind of disease.

关键词： histone deacetylase 6 NALP3 peroxiredoxin 2 reactive oxygen species

基于共聚焦显微拉曼光谱揭示炭疽病侵染下茶叶细胞壁变化的研究

在线全文

学校读者我要写书评

暂无评论

光谱学与光谱分析 2014年第6期34卷 1571-1576页

作者：李晓丽罗榴彬胡小倩楼兵干何勇浙江大学生物系统工程与食品科学学院浙江杭州310058 浙江大学农业试验站浙江杭州310058 浙江大学生物技术研究所浙江杭州310058

采用共聚焦显微拉曼技术研究了炭疽病感染所致茶叶细胞壁结构和化学成分的变化。对茶叶健康和染病组织细胞进行微米级空间分辨率的显微拉曼光谱扫描,并结合透射电镜观察炭疽病侵染所致的细胞超微结构变化,结果显示染病前后细胞壁的拉曼... 详细信息

采用共聚焦显微拉曼技术研究了炭疽病感染所致茶叶细胞壁结构和化学成分的变化。对茶叶健康和染病组织细胞进行微米级空间分辨率的显微拉曼光谱扫描,并结合透射电镜观察炭疽病侵染所致的细胞超微结构变化,结果显示染病前后细胞壁的拉曼光谱位移和强度都有明显的差异,表明炭疽病侵染导致细胞壁中化学成分发生了较大的变化。其中由纤维素,果胶,酯类化合物产生的拉曼峰强度都有明显下降,说明细胞壁中这些物质的含量在染病后减少了;而木质素拉曼散射引起的拉曼峰强度有所上升,说明木质素的含量在染病后有所增加。随后基于纤维素的拉曼指纹波数和显微空间结构信息实现了茶叶健康组织和染病组织细胞壁中纤维素的化学成像分析,结果显示炭疽病侵染不仅导致细胞壁中纤维素的含量大大减少,而且纤维素的有序结构被破坏。由此得出结论:在无需对样本进行染色或复杂的化学处理的情况下,共聚焦显微拉曼可以揭示由炭疽病侵染引起的茶叶细胞壁化学成分和结构的变化,本研究是共聚焦显微拉曼技术首次用于植物病理学中寄主-病原物互作机制的研究,将为深入研究寄主-病原物在细胞层面上的互作机制开辟蹊径。

关键词：茶叶细胞壁炭疽病共聚焦显微拉曼化学成分变化

反相高效液相色谱法分离纯化野蚕黑卵蜂寄主识别利它素

在线全文

学校读者我要写书评

暂无评论

分析化学 2007年第7期35卷 1004-1007页

作者：孙守慧楼兵干杨彤彤高其康沈阳农业大学 2. 浙江大学农业与生物技术学院生物技术研究所浙江大学分析测试中心

采用反相高效液相色谱和酶联免疫分析的方法进行了野蚕黑卵蜂寄主识别利它素分离和免疫活性测定。RP-HPLC的分离条件是:C8反相色谱柱,在柱温30℃、流量1mL/min的条件下,用02min,100%A(5%乙腈+0.05%三氟乙酸);26min,100%A→100%B(95%乙腈... 详细信息

采用反相高效液相色谱和酶联免疫分析的方法进行了野蚕黑卵蜂寄主识别利它素分离和免疫活性测定。RP-HPLC的分离条件是:C8反相色谱柱,在柱温30℃、流量1mL/min的条件下,用02min,100%A(5%乙腈+0.05%三氟乙酸);26min,100%A→100%B(95%乙腈+0.05%三氟乙酸)线性洗脱;68min,100%B进行洗脱,DAD检测波长为280nm。通过比较家蚕和野桑蚕色谱图发现,无论是粗提物还是上清液两者的峰形极其相似,有5个主要的馏分。通过粗提物和低温物理快速分离上清液的色谱图比较,确定了2号峰为低温物理快速法沉淀部分的馏分。收集家蚕的5种主要馏分,分别用利它素抗血清进行ELISA检测,证实2号峰是野蚕黑卵蜂寄主识别利它素,其免疫活性分别是上清液中其它馏分的100倍至1000倍。

关键词：野蚕黑卵蜂寄主识别利它素反相高效液相色谱酶联免疫分析

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

风与结构的耦合作用及风振响应分析

工程力学 2000年第5期17卷 16-22页

作者：楼文娟孙炳楠浙江大学土木系杭州310027

在目前的风振响应计算中，往往不考虑风与结构的耦合作用。但对于超高层建筑、高耸塔桅结构，由于基频较低，风与结构的耦合作用不可忽略。本文基于准定常假定推论出风与结构的耦合作用实质上就是气动阻尼效应，因此只要在阻尼常数中引... 详细信息

在目前的风振响应计算中，往往不考虑风与结构的耦合作用。但对于超高层建筑、高耸塔桅结构，由于基频较低，风与结构的耦合作用不可忽略。本文基于准定常假定推论出风与结构的耦合作用实质上就是气动阻尼效应，因此只要在阻尼常数中引入气动阻尼，就可建立考虑风与结构耦合作用的风振响应模态分析方法。文中采用拟单自由度法，确定了风与结构耦合作用所产生的气动阻尼。并对一工程实例进行了风振响应计算，比较了采用Davenport谱和Kaimal谱对计算结果的差异性，与风洞试验结果相对比表明，采用Kaimal谱并考虑风与结构的耦合作用所得计算结果能与风洞试验结果吻合较好。

关键词：风振响应高耸结构气动阻尼

Energy requirements of Dorper×thin-tailed Han crossbred ewes during non-pregnancy and lactation

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2015年第12期14卷 2605-2617页

作者： lou Can SI bing-wen DENG Kai-dong MA Tao JIANG Cheng-gang TU Yan ZHANG Nai-feng JI Shou-kun CHEN Dan-dan DIAO Qi-yu Feed Research Institute Chinese Academy of Agricultural SciencesKey Laboratory of Feed Biotechnology Ministry of Agriculture College of Animal Science Jinling Institute of Technology

This experiment was conducted to investigate the energy requirement of Dorper×thin-tailed Han crossbred ewes during non-pregnancy and lactation. Fifteen ewes after parturition were randomly assigned to three treatments： ad libitum（100%） feed intake and 80 or 60% ad libitum intake, and another nine non-pregnant ewes were assigned to a blank control group. Digestibility trials were performed in the non-pregnant ewes and in the lactating ewes on the 20 th, 50 th, and 80 th d of lactation. In parallel with the digestibility trial, a respirometry experiment was conducted to determine the methane and carbon dioxide production with an open-circuit respirometry system that was equipped with respiratory chambers. The net energy（NE） and metabolizable energy（ME） requirements for maintenance and growth were calculated using the carbon and nitrogen balance method. The results revealed that the carbon（C） and nitrogen（N） excretions and energy losses at faeces and urine, as well as the output of methane and CO2, increased significantly with decreasing feed intake（P〈0.01）. The apparent digestibilities of C in th e stages of non-pregnancy and early, middle and late lactation were 55.8–58.3%, 62.5–73.8%, 64.8–71.3%, and 61.7–65.0%, respectively, and the apparent digestibilities of N were 45.2–51.3%, 73.7–82.7%, 72.8–80.5%, and 73.6–76.5%, respectively. The corresponding energy apparent digestibilities were 52.0–56.3%, 60.7–76.6%, 61.0–68.8%, and 61.4–67.7%, respectively. The ME/DE（digestible energy） values were 79.5–85.9%, 79.4–83.5%, 81.0%–85.3% and 78.6–82.9%, respectively. The maintenance requirements of NE, ME, and the efficiencies of ME utilisation for maintenance during the stages of non-pregnancy and early, middle and late lactation were 215.5, 253.1, 247.7, and 244.7 k J kg^（–1） BW0.75 d, and 372.4, 327.1, 320.9, and 362.0 k J kg^（–1） BW0.75 d, and 0.58, 0.77, 0.77, and 0.68, respectively. The ME requirement for the growth of non-pregnant ewes was 31.3 MJ kg^（–1） BW gain.

关键词： net energy metabolizable energy ewe lactation digestible energy

Definition and verification of novel metastasis and recurrence related signatures of ccRCC: A multicohort study

在线全文

学校读者我要写书评

暂无评论

Cancer Innovation 2022年第2期1卷 146-167页

作者： Aimin Jiang Qingyang Pang Xinxin gan Anbang Wang Zhenjie Wu bing Liu Peng Luo Le Qu Linhui Wang Department of Urology Changhai HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of Urology Changzheng HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of Urology The Third Affiliated HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of Oncology Zhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Urology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingChina

Background:Cancer metastasis and recurrence remain major challenges in renal carcinoma patient *** are limited biomarkers to predict the metastatic probability of renal cancer,especially in the early-stage ***,our study applied robust machine-learning algorithms to identify metastatic and recurrence-related signatures across multiple renal cancer cohorts,which reached high accuracy in both training and testing ***:Clear cell renal cell carcinoma(ccRCC)patients with primary or metastatic site sequencing information from eight cohorts,including one outhouse cohort,were enrolled in this *** robust machine-learning algorithms were applied to identify metastatic ***,two distinct metastatic-related subtypes were identified and verified;matrix remodeling associated 5(MXRA5),as a promising diagnostic and therapeutic target,was investigated in vivo and in ***:We identified five stable metastasis-related signatures(renin,integrin subunit beta-like 1,MXRA5,mesenchyme homeobox 2,and anoctamin 3)from multicenter ***,we verified the specificity and sensibility of these signatures in external and out-house cohorts,which displayed a satisfactory *** to these metastatic signatures,patients were grouped into two distinct and heterogeneous ccRCC subtypes named metastatic cancer subtype 1(MTCS1)and type 2(MTCS2).MTCS2 exhibited poorer clinical outcomes and metastatic tendencies than *** addition,MTCS2 showed higher immune cell infiltration and immune signature expression but a lower response rate to immune blockade therapy than *** MTCS2 subgroup was more sensitive to saracatinib,sunitinib,and several molecular targeted *** addition,MTCS2 displayed a higher genome mutation burden and ***,we constructed a prognosis model based on subtype biomarkers,which performed well in training and validation ***,MXRA5,as a promising biomarker,significant

关键词： clear cell renal cell carcinoma metastasis recurrence machine learning multiple omics single‐cell sequencing