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Xenografting of human umbilical mesenchymal stem cells from Wharton’s jelly ameliorates mouse spinocerebellar ataxia type 1

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Translational Neurodegeneration 2019年第1期8卷 359-371页

作者： Pei-Jiun Tsai Chang-Ching Yeh Wan-Jhen Huang Ming-Yuan Min Tzu-Hao Huang Tsui-Ling Ko Pei-Yu Huang Tien-Hua Chen Sanford P.C.Hsu bing-wen soong Yu-Show Fu Institute of Anatomy and Cell Biology School of MedicineNational Yang-Ming UniversityTaipeiTaiwanRepublic of China Trauma Center Department of SurgeryVeterans General HospitalTaipeiTaiwanRepublic of China Department of Critical Care Medicine Veterans General HospitalTaipeiTaiwanRepublic of China Department of Obstetrics and Gynecology Veterans General HospitalTaipeiTaiwanRepublic of China Institute of Clinical Medicine National Yang-Ming UniversityTaipeiTaiwanRepublic of China Department of Obstetrics and Gynecology National Yang-Ming UniversityTaipeiTaiwanRepublic of China Department of Life Science National Taiwan UniversityTaipeiTaiwanRepublic of China School of Medicine I-Shou UniversityKaohsiungTaiwanRepublic of China Institute of Physiology School of MedicineNational Yang-Ming UniversityTaipeiTaiwanRepublic of China Division of General Surgery Department of SurgeryVeterans General HospitalTaipeiTaiwanRepublic of China Department of Neurosurgery Neurological InstituteTaipei Veterans General HospitalTaipeiTaiwanRepublic of China School of Medicine National Yang-Ming UniversityTaipeiTaiwanRepublic of China Department of Neurology Shuang Ho Hospitaland Taipei Neuroscience InstituteTaipei Medical UniversityTaipeiTaiwanRepublic of China Department of Neurology Taipei Veterans General HospitalTaipeiTaiwanRepublic of China Brain Research Center National Yang-Ming UniversityTaipeiTaiwanRepublic of China Department of Anatomy and Cell Biology School of MedicineNational Yang-Ming UniversityNo.155Sec.2Li-Nung StreetTaipei 112TaiwanRepublic of China

Background:Spinocerebellar ataxia type 1(SCA1)is an autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in ATXN1 gene resulting in an expansion of polyglutamine repeats in the ATXN1 ***,there has yet been any effective treatment so far for *** study investigated the feasibility of transplanting human umbilical mesenchymal stem cells(HUMSCs)into transgenic SCA1 mice containing an expanded uninterrupted allele with 82 repeats in the ATXN1-coding ***:106 human umbilical mesenchymal stem cells were transplanted into the cerebella at 1 month of ***:HUMSCs displayed significant ameliorating effects in SCA1 mice in terms of motor behaviors in balance beam test and open field test as compared with the untransplanted SCA1 *** transplantation effectively reduced the cerebellar atrophy,salvaged Purkinje cell death,and alleviated molecular layer *** studies showed higher amplitudes of compound motor action potentials as indicated by increasing neuronal-muscular response strength to stimuli after stem cell *** 5 months after transplantation,HUMSCs scattering in the mice cerebella remained viable and secreted cytokines without differentiating into neuronal or glia ***:Our findings provide hope for a new therapeutic direction for the treatment of SCA1.

关键词： Umbilical mesenchymal stem cells Cell transplantation SCA1

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Data Classification with Modified Density Weighted Distance Measure for Diffusion Maps

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Journal of Biosciences and Medicines 2014年第4期2卷 12-18页

作者： Ko-Kung Chen Chih-I Hung bing-wen soong Hsiu-Mei Wu Yu-Te Wu Po-Shan Wang 1Department of Biomedical Imaging and Radiological Sciences National Yang-Ming University Taipei 4Institute of Biophotonics National Yang-Ming University Taipei Department of Biomedical Imaging and Radiological Sciences National Yang-Ming University Taipei Department of Neurology Taipei Veteran General Hospital Taipei Department of Radiology Taipei Veteran General Hospital Taipei The Neurological Institute Taipei Municipal Gan-Dau Hospital New Taipei

Clinical data analysis is of fundamental importance, as classifications and detailed characterizations of diseases help physicians decide suitable management for patients, individually. In our study, we adopt diffusion maps to embed the data into corresponding lower dimensional representation, which integrate the information of potentially nonlinear progressions of the diseases. To deal with nonuniformaity of the data, we also consider an alternative distance measure based on the estimated local density. Performance of this modification is assessed using artificially generated data. Another clinical dataset that comprises metabolite concentrations measured with magnetic resonance spectroscopy was also classified. The algorithm shows improved results compared with conventional Euclidean distance measure.

关键词： Diffusion Maps Density Estimation Spinocerebellar Ataxia

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Flow Structure and Heat Transfer Between Two Disks Rotating Independently

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Journal of Thermal Science 2003年第1期12卷 62-67页

作者： Chyi-Yeou soong Department of Aeronautical Engineering Feng Chia University Seatwen Taiching

In the present paper, fluid flow and convective heat transfer between two co-axial disks rotating independently are dealt with mainly based on the author's recent research on that topic. Three rotational modes, i.e. co-rotation, rotor-stator, and counter-rotation, are considered. Theory of rotating non-isothermal fluids with the presence of disk rotation and thermal effects is addressed. Rotational buoyancy effects on the flow structure development are highlighted. Results of flow visualization and heat transfer measurements are discussed to explore the thermal flow mechanisms involved in the two-disk flows at various rotational and geometric conditions. Potential issues open to the future investigation are also proposed.

关键词： co-rotating disks rotor-stator counter-rotating disks rotational buoyancy swirling/vortical flow heat transfer.

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Dislocation characteristics and dynamic recrystallization in hot deformed AM30 and AZ31 alloys

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Journal of Magnesium and Alloys 2022年第12期10卷 3495-3505页

作者： Hyeon-Woo Son soong-Keun Hyun Metallic Materials Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea

Zn addition to Mg alloys activates non-basal slip or twinning with solute softening *** the other hand,the effects of the Zn solute on the macroscopic dislocation behavior and dynamic recrystallization are not completely ***,it is unclear ifslip can be affected by changes in the c/a ratio of solute *** study was conducted to understand the solute strengthening of Zn addition and its effects on the dislocation characteristics and dynamic recrystallization.A hot torsion test was performed on both AM30 and AZ31 alloys up to a high strain to investigate the Zn solute effect on the dislocation characteristics and dynamic *** dislocation components of the hot torsioned alloys were evaluated by X-ray line profile analysis and electron backscatter *** results showed that the Zn solutes slightly accelerate strain accumulation at the initial stages of hot deformation,which accelerated recrystallization at high *** dislocation characteristics were changed dynamically by Zn addition:fortified-type slip,dislocation arrangement and strain anisotropy *** most important point was that the dislocation characteristics were changed dramatically at the critical strain for recrystallization and high strain *** addition of Zn also acted greatly in these strain *** indicates that the rapid formation of-type slip at the serrated grain boundaries occurs at the initiation of dynamic recrystallization and the increase in the grain triple junction because grain refinement has a great influence on the dislocation characteristics at high strain.

关键词： Magnesium alloy X-ray line profile Solid solution Dislocation density Dynamic recrystallization

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Control of seismic and operational vibrations of rotating machines using semi-active mounts

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Earthquake Engineering and Engineering Vibration 2004年第1期3卷 85-100页

作者： R.Rana T.T.soong Ove Arup & partners Department of Civil Structural.and Environmental EngineeringState University of New York

A dual isolation problem for rotating machines consists of isolation of housing structures from the machine vibrations and protection of machines during an earthquake to maintain their functionality. Desirable characteristics of machine mounts for the above two purposes can differ significantly due to difference in nature of the excitation and performance criteria in the two situations. In this paper, relevant response quantities are identified that may be used to quantify performance and simplified models of rotating machines are presented using which these relevant response quantities may be calculated. Using random vibration approach with a stationary excitation, it is shown that significant improvement in seismic performance is achievable by proper mount design. Results of shaking table experiments performed with a realistic setup using a centrifugal pump are presented. It is concluded that a solution to this dual isolation problem lies in a semi-active mount capable switching its properties from ‘operation-optimum’ to ‘seismic-optimum’ at the onset of a seismic event.

关键词： rotating machines simple modeling seismic control operational control semi-active control

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Transactive Energy Systems in Active Distribution Networks:A Comprehensive Review

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CSEE Journal of Power and Energy Systems 2022年第5期8卷 1302-1317页

作者： Yunyang Zou Yan Xu Xue Feng R.T.Naayagi Boon-Hee soong School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Engineering Cluster Singapore Institute of TechnologySingapore 138683Singapore School of Electrical and Electronic Engineering Newcastle University InternationalSingapore 567739Singapore

Increasing penetration of distributed energy resources(DERs)introduced by different stakeholders,poses an immense challenge to power network *** traditional direct control of local DERs has the risk of violating preferences and privacies of stakeholders.A promising solution for supplydemand coordination is to utilize a transactive energy(TE)based energy management method to indirectly coordinate the local DERs,which enables the distribution-level energy providers,consumers,and prosumers to trade energy with each other through a transactive energy system(TES)trading *** paper provides a comprehensive review of a TES and presents a detailed classification from different perspectives,including TES participants,structure,commodity,clearing method,and solution *** presented detailed component-scale classification can be used as a reference for future TES ***,two additional market tools,i.e.,penalty mechanism and loss allocation mechanism,are discussed as future focus areas,which can be seen as necessary complements to a TES for ensuring feasibility and fairness of energy trading.

关键词： Auction mechanism distributed energy resources distribution locational marginal pricing game theory transactive energy uncertainty

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Remembering soong Ching Ling at the 75th Anniversary of the PRC

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China Today 2024年第11期73卷 72-73页

作者： soong Ching Ling Former Residence Management Center the soong Ching Ling Former Residence Management Center

An exhibition in Beijing pays tribute to a remarkable woman who was a pillar of China’s revolutionary *** Ching Ling,one of the founders of the People’s Republic of China(PRC),passed away in 1981 but her work to support the revolution in China and create a network of loyal friends worldwide for the PRC lives on through the China soong Ching Ling Foundation(CSCLF).soong’s life was defined by the struggle for a new China and her prolific writings and speeches have become important documents in Chinese history.

关键词： PRC Ching exhibition

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Photoelectrochemical evaluation of SILAR-deposited nanoporous BiVO4 photoanodes for solar-driven water splitting

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Nano Materials Science 2020年第3期2卷 227-234页

作者： Siti Nur'ain Haji Yassin Adrian soong Leong Sim James Robert Jennings Faculty of Science Universiti Brunei DarussalamJalan Tungku LinkBE 1410Brunei Darussalam

We report a photoelectrochemical investigation of BiVO4 photoanodes prepared by successive ionic layer adsorption and reaction(SILAR),a facile method that yields uniform nanoporous *** characterization of the phase,morphology,composition,and optical properties of the prepared films,the efficiencies of charge separation(ηsep)and water oxidation(ηox)in solar water splitting cells employing these photoanodes were estimated following a previously reported *** wavelength and illumination direction dependencies were discovered in the derived efficiencies,casting doubt on the validity of the *** alternative approach using a diffusion–reaction model that explicitly considers the efficiency of electron collection resolved the discrepancies and explained the illumination direction dependence of the *** diffusion lengths(Ln)of 0.45μm and 0.55μm were derived for pristine and cobalt phosphate(Co-Pi)modified BiVO4,respectively,which are much shorter than the film thickness of^2.1μ*** Co-Pi treatment also increasedηoxfrom 0.86 to^1,which is the main reason for the overall performance enhancement caused by adding *** findings suggest that there is little scope for improving the performance of SILAR-deposited BiVO4 photoanodes by further catalyzing water oxidation,but enhanced performance is achievable if electron transport can be improved.

关键词： Bismuth vanadate BiVO4 Solar water splitting Electron diffusion length Charge collection efficiency Water oxidation efficiency Charge separation efficiency

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Effects of Mg Enhancement and Heat Treatment on Microstructures and Tensile Properties of Al2Ca-Added ADC12 Die Casting Alloys

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Journal of Materials Science & Technology 2016年第10期32卷 1043-1048页

作者： Gil-Yong Yeom Hyun Kyu Lim Shae K.Kim soong-Keun Hyun Young-Ok Yoon Korea Institute of Industrial Technology lncheon 406-840 South Korea Department of Materials Science and Engineering Inha University lncheon 402-751 South Korea

The effects of Mg enhancement and heat treatment on the microstructures and tensile properties of Al_2Ca-added ADC12 die casting alloys were investigated. 0.3% and 0.5% Mg in the form of a master alloy including a trace amount of Al_2Ca were added to conventional ADC12（383 and AlSi10Cu2Fe） alloy with an initial Mg-content of 0.3% to increase the Mg content to 0.6% and 0.8%, respectively. To avoid heat treatmentinduced surface blisters, shortened solution treatment for 15 min at 490 ℃ and artificial aging for 6 h at 150 ℃ was undertaken. The results show that a 10% improvement in the shape factor of eutectic Si particles was achieved for Al_2Ca-added ADC12 with 0.8% Mg compared to the conventional ADC12 in the as-aged condition. Al_2Ca-added ADC12 with 0.8% Mg exhibited a yield strength of 289 MPa, a tensile strength of 407 MPa, and an elongation of 4.22%.

关键词： Al2Ca ADC12 alloy Heat treatment Die casting Inclusion

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Process Tolerant and Power Efficient SRAM Cell for Internet of Things Applications

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Computers, Materials & Continua 2022年第8期72卷 3425-3446页

作者： T.G.Sargunam Lim Way soong C.M.R.Prabhu Ajay Kumar Singh Faculty of Engineering and Technology Multimedia UniversityMelaka75450Malaysia School of Engineering and Computing Manipal International UniversityNilai71800Malaysia Electronics and Communication Engineering Department NIIT UniversityNeemarana301705India

The use of Internet of Things(IoT)applications become dominant in many *** on-chip data processing and computations are also increasing *** battery enabled and low leakage memory system at subthreshold regime is a critical requirement for these IoT *** cache memory designed on Static Random-Access Memory(SRAM)cell with features such as low power,high speed,and process tolerance are highly important for the IoT memory ***,a process tolerant SRAM cell with low power,improved delay and better stability is presented in this research *** proposed cell comprises 11 transistors designed with symmetric approach for write operations and single ended circuit for read operations that exhibits an average dynamic power saving of 43.55%and 47.75%for write and 35.59%and 36.56%for read operations compared to 6 T and 8 T SRAM *** cell shows an improved write delay of 26.46%and 37.16%over 6 T and 8T and read delay is lowered by 50.64%and 72.90%against 6 T and 10 T *** symmetric design used in core latch to improve the write noise margin(WNM)by 17.78%and 6.67%whereas the single ended separate read circuit improves the Read Static Noise Margin(RSNM)by 1.88x and 0.33x compared to 6 T and 8T *** read power delay product and write power delay product are lower by 1.94x,1.39x and 0.17x,2.02x than 6 T and 8 T cells *** lower variability from 5000 samples validates the robustness of the proposed *** simulations are carried out in Cadence virtuoso simulator tool with Generic Process Design Kit(GPDK)45 nm technology file in this work.

关键词： SRAM cell low power process efficient read stability write ability static noise margin PVT variation internet of things

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