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Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats

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Neural Regeneration Research 2021年第9期16卷 1829-1835页

作者： bing Yang Pang-Bo Wang Ning Mu Kang Ma Shi Wang Chuan-Yan Yang zhong-bing Huang Ying Lai Hua Feng Guang-Fu Yin Tu-Nan Chen Chen-Shi Hu College of Biomedical Engineering Sichuan UniversityChengduSichuan ProvinceChina Department of Neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons;however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remains to be explored. In this study, a conductive graphene oxide composited chitosan scaffold was fabricated by genipin crosslinking and lyophilization. The prepared chitosan-graphene oxide scaffold presented a porous structure with an inner diameter of 18–87 μm, and a conductivity that reached 2.83 mS/cm because of good distribution of the graphene oxide nanosheets, which could be degraded by peroxidase. The chitosan-graphene oxide scaffold was transplanted into a T9 total resected rat spinal cord. The results show that the chitosan-graphene oxide scaffold induces nerve cells to grow into the pores between chitosan molecular chains, inducing angiogenesis in regenerated tissue, and promote neuron migration and neural tissue regeneration in the pores of the scaffold, thereby promoting the repair of damaged nerve tissue. The behavioral and electrophysiological results suggest that the chitosan-graphene oxide scaffold could significantly restore the neurological function of rats. Moreover, the functional recovery of rats treated with chitosangraphene oxide scaffold was better than that treated with chitosan scaffold. The results show that graphene oxide could have a positive role in the recovery of neurological function after spinal cord injury by promoting the degradation of the scaffold, adhesion, and migration of nerve cells to the scaffold. This study was approved by the Ethics Committee of Animal Research at the First Affiliated Hospital of Third Military Medical University(Army Medical University)(approval No. AMUWEC20191327) on August 30, 2019.

关键词： angiogenesis chitosan electrical conduction graphene oxide regeneration repair scaffold spinal cord injury

Experimental Study of Thermoelectric Heat Pump Water Heater with Exhaust Heat Recovery from Kitchens

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湖南大学学报（自然科学版） 2009年第S1期36卷 131-135页

作者： LIU zhong-bing,ZHANG Ling,YANG Zhang,XU Ming,HAN Tian-he(College of Civil Engineering,Hunan University,Changsha,Hunan 410082,China) College of Civil Engineering Hunan University Changsha 410082 China

A new kind of thermoelectric heat pump water heater for kitchens exhaust heat recovery was presented,and its performances were investigated under different operating *** experiment results show that the coefficient of performance decreases and the temperature difference between the hot and cold sides becomes larger with the increase of the operating voltage,but the heating time becomes *** higher the temperature of water,the greater the temperature difference between the hot and cold sides,leading to a smaller coefficient of *** an exhaust temperature of 36 ℃,the coefficient of performance decreases from 1.66 to 1.22 when the temperature of water increases from 28 ℃ to 46 ℃ with operating voltage 16 *** tests illustrate that,compared with the conventional electrical water heaters,the new kind of thermoelectric heat pump water heater is more coefficient.

关键词： thermoelectric heat pump kitchens exhaust water heater coefficient of performance

Chemoselective labeling-based spermatozoa glycan imaging reveals abnormal glycosylation in oligoasthenotspermia

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Chinese Chemical Letters 2024年第4期35卷 475-480页

作者： Lijia Xu Tong zhong Wei Zhao bing Yao Lin Ding Huangxian Ju State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Department of Reproductive Medical Center Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002China Chemistry and Biomedicine Innovation Center(ChemBIC) Nanjing UniversityNanjing 210023China Center of Clinical Laboratory Science The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210009China

Spermatogenesis, maturation, capacitation and fertilization are precisely regulated by glycosylation. However, the relationship between altered glycosylation patterns and the onset and development of reproductive disorders is unclear, mainly limited by the lack of in situ imaging techniques for spermatozoa glycosylation. We developed an efficient and highly specific spermatozoa glycan imaging technique based on the robust chemoselective labeling of sialic acid(Sia) and N-acetyl-D-galactosamine(Gal/GalNAc). We further proposed a “tandem glycan chemoselective labeling” strategy to achieve simultaneous imaging of two types of glycans on spermatozoa. We applied the developed method to the spermatozoa from oligozoospermic patients and diabetic mice and found that these spermatozoa showed higher levels of Sia and Gal/Gal NAc expression than the normal groups. Moreover, spermatozoa from diabetic mice showed a severe decrease in number, viability, and forward motility, suggesting that in vivo glucose metabolism disorders may lead to an elevated level of spermatozoa glycosylation and have a correlation with the development of oligoasthenotspermia. Our work provides a research tool to reveal the relationship between glycosylation modification and spermatozoa quality, and a promising clue for the development of glycan-based reproductive markers.

关键词： Spermatozoa Glycan Chemoselective labeling Oligoasthenotspermia Fluorescence imaging

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游戏式康复在儿童言语语言障碍中的研究进展

中国听力语言康复科学杂志 2024年第5期22卷 499-504页

作者：陈嘉颖王玥葛胜男丁忠冰万勤华东师范大学教育学部康复科学系上海200062

游戏式康复作为新兴的康复方式在我国儿童言语语言障碍领域得到广泛应用,但尚未形成标准体系。本文旨在全面阐述游戏式康复的定义、作用与机制、在临床中的实际应用状况及局限性,以期为后续的理论研究与实践推广奠定理论基础。

关键词：游戏式康复儿童语言障碍言语障碍

A nonlinear wave coupling algorithm and its programing and application in plasma turbulences

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Chinese Physics B 2022年第6期31卷 541-548页

作者： Yong Shen Yu-Hang Shen Jia-Qi Dong Kai-Jun Zhao zhong-bing Shi Ji-Quan Li Southwestern Institute of Physics Chengdu 610041China School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute for Fusion Theory and Simulation Zhejiang UniversityHangzhou 310013China College of Nuclear Science and Engineer East China University of TechnologyNanchang 330013China

The fully developed turbulence can be regarded as a nonlinear system,with wave coupling inside,which causes the nonlinear energy to transfer,and drives the turbulence to develop further or be *** analysis is one of the most effective methods to study turbulence *** order to apply it to the study of the nonlinear wave coupling process of edge plasma turbulence,an efficient algorithm based on spectral analysis technology is proposed to solve the nonlinear wave coupling *** algorithm is based on a mandatory temporal static condition with the nonideal spectra separated from the ideal *** realization idea and programing flow are *** to the characteristics of plasma turbulence,the simulation data are constructed and used to verify the algorithm and its implementation *** simulation results and experimental results show the accuracy of the algorithm and the corresponding program,which can play a great role in the studying the energy transfer in edge plasma *** an application,the energy cascade analysis of typical edge plasma turbulence is carried out by using the results of a case ***,a physical picture of the energy transfer in a kind of fully developed turbulence is constructed,which confirms that the energy transfer in this turbulent system develops from lower-frequency region to higher-frequency region and from linear growing wave to damping wave.

关键词： bispectral analysis wave coupling algorithm plasma turbulence energy cascade

丹酚酸B通过激活TFE3介导的自噬发挥对随机皮瓣的保护作用

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中国药理学通报 2024年第10期40卷 1912-1920页

作者：韩仲兵杨慧文牛海州张宽宽刘洋洋许盼盼孔令提张长春蚌埠医科大学第一附属医院骨科蚌埠医科大学组织移植安徽省重点实验室安徽蚌埠233000

目的观察丹酚酸B(salvianolic acid B,Sal B)促进随机皮瓣存活的作用并初步探讨其可能的机制。方法采用外科手术构建随机皮瓣模型,术后7 d评估皮瓣的外观、水肿程度、颜色和毛发状况。激光多普勒血流测量技术检测随机皮瓣血管网络和血流... 详细信息

目的观察丹酚酸B(salvianolic acid B,Sal B)促进随机皮瓣存活的作用并初步探讨其可能的机制。方法采用外科手术构建随机皮瓣模型,术后7 d评估皮瓣的外观、水肿程度、颜色和毛发状况。激光多普勒血流测量技术检测随机皮瓣血管网络和血流量;HE染色检测随机皮瓣微血管生长情况;免疫组化检测促血管生成因子VEGF、CD34的表达,免疫荧光检测RIPK1、2和LC3Ⅱ的表达,Western blot检测自噬相关蛋白以及信号通路的影响。结果Sal B诱导了随机皮瓣的自噬,促进了血管生成,并减少了坏死性凋亡的发生,显著增加了随机皮瓣的存活率。免疫组化、免疫荧光染色和Western blot检测等实验证实,Sal B通过激活TFE3蛋白诱导了随机皮瓣发生自噬。结论Sal B可通过激活TFE3蛋白促进随机皮瓣细胞发生自噬并降低其坏死凋亡。

关键词：丹酚酸随机皮瓣 TFE3 自噬缺血再灌注损伤血管生成

维普期刊数据库博看期刊

HL-2A装置高β_(N)双输运垒实验的集成分析

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物理学报 2024年第6期73卷 250-257页

作者：李正吉陈伟孙爱萍于利明王卓陈佳乐许健强李继全石中兵蒋敏李永高何小雪杨曾辰李鉴核工业西南物理研究院成都610041 中国科学院等离子体物理研究所合肥230031 61287部队成都610000

HL-2A托卡马克装置在中性束加热条件下获得了稳定的归一化环向比压(β_(N))大于2.5的等离子体,并且实现了瞬态β_(N)=3.05、归一化密度(n_(e,1)/n_(e,G))~0.6、储能(WE)~46 kJ和高约束因子(H_(98))~1.65的高约束性能.本文使用集成模拟平... 详细信息

HL-2A托卡马克装置在中性束加热条件下获得了稳定的归一化环向比压(β_(N))大于2.5的等离子体,并且实现了瞬态β_(N)=3.05、归一化密度(n_(e,1)/n_(e,G))~0.6、储能(WE)~46 kJ和高约束因子(H_(98))~1.65的高约束性能.本文使用集成模拟平台OMFIT对β_(N)=2.83和β_(N)=3.05时刻的等离子体进行了集成模拟,计算得到的WE,n_(e,1)/n_(e,G),H_(98)和β_(N)等与实验参数基本一致,并通过计算发现两种情况下自举电流份额(fBS)分别约达到45%和46%.此外,还进一步分析了HL-2A装置形成离子温度内部输运垒(ITB)的原因:快离子和E×B剪切流使得芯部湍流输运被抑制,改善了约束,从而形成了离子温度ITB.离子温度的ITB与H模边缘输运垒相互协同形成了高β_(N)的等离子体.

关键词： HL-2A 高β_(N) OMFIT集成模拟快离子内部运垒

谐波减速器柔性轴承试验载荷设计与控制方法研究

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机械研究与应用 2024年第3期37卷 1-4页

作者：黎建涛夏中兵杨芳李文超李霜天洛阳轴承研究所有限公司河南洛阳471039 河南科技大学机电工程学院河南洛阳471003

围绕谐波减速器轴承寿命试验需求,搭建了谐波减速器轴承试验装置,结合谐波减速器轴承试验原理,通过计算平均输入转速和平均负载扭矩,确定谐波减速器轴承试验条件,并基于扩张状态观测器与非线性PID建立负载扭矩控制方法。试验结果表明:... 详细信息

围绕谐波减速器轴承寿命试验需求,搭建了谐波减速器轴承试验装置,结合谐波减速器轴承试验原理,通过计算平均输入转速和平均负载扭矩,确定谐波减速器轴承试验条件,并基于扩张状态观测器与非线性PID建立负载扭矩控制方法。试验结果表明:负载扭矩跟踪的均方根误差为0.375,具有较好控制精度,试验机实现了转速、负载扭矩的高精度控制,实现了温升、振动、噪声等指标测试,满足了谐波减速器轴承的试验要求。

关键词：谐波减速器柔性轴承试验条件设计扭矩控制

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言语自然度的研究进展

中国听力语言康复科学杂志 2024年第5期22卷 505-509页

作者：张萌戚克敏丁忠冰李媛媛黄昭鸣天津体育学院教育与心理学院天津301617 华东师范大学教育学部康复科学系上海200062 华东师范大学中国言语听觉康复科学与ICF应用研究院上海200062 天津体育学院运动健康学院天津301617

言语自然度是言语康复领域值得关注的内容。目前,我国言语康复领域涉及言语自然度的研究极少,对言语自然度的概念、评估及干预技术等内容的认识尚不清楚。本文从言语康复临床应用的角度,综述分析了言语自然度的影响因素、评估与治疗方... 详细信息

言语自然度是言语康复领域值得关注的内容。目前,我国言语康复领域涉及言语自然度的研究极少,对言语自然度的概念、评估及干预技术等内容的认识尚不清楚。本文从言语康复临床应用的角度,综述分析了言语自然度的影响因素、评估与治疗方法等内容的研究现状,希望引起言语康复专业人员的关注,为言语自然度临床诊疗工作提供借鉴。

关键词：言语自然度影响因素评估方法治疗方法