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Journal of Rare Earths 2022年第12期40卷 1849-1859,I0002页

作者： bing zhao Wenlin Chen Yifeng Tan Fan Li Mengkui Tian College of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China

A series of Ce_(1-x)Ti_(x)O_(2)mixed oxide catalysts were synthesized by sol-gel method and then loading of noble metal(M=Pt,Rh,Ru)was used for soot oxidation.Ti-doped Ce_(1-x)Ti_(x)O_(2)catalysts(x is the molar ratio of Ti/(Ti+Ce)and ranges from 0.1 to 0.5)exhibit much better oxidation performance than CeO_(2)catalyst,and the Ce_(0.9)Ti_(0.1)O_(2)catalyst calcined at 500℃has the best catalysis activity.Each noble metal(1 wt%)was supported on Ce_(0.9)Ti_(0.1)O_(2)(M/C9 T1)and the properties of the catalysts were characterized by X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Raman,Brunauer-Emmett-Teller(BET)method,and H_(2)-temperature programmed reduction(H_(2)-TPR)results.Results show that the introduction of Ti into CeO_(2)forming Ti-O-Ce structure enhances the catalytic activity and increases the number of oxygen vacancies at the catalyst surface.The noble metal is highly dispersed over Ce_(0.9)Ti_(0.1)O_(2),and M/C9 T1 catalysts present enhanced activity in comparison to Ce_(0.9)Ti_(0.1)O_(2).It is found that noble metals can greatly increase the activity of the catalyst and the corresponding oxidation rate of soot can enhance the electron transfer capacity and oxygen adsorption capacity of the catalyst.A small amount of Ti doping in CeO_(2)can significantly improve the activity of the catalyst,while a large amount of Ti reduces the performance of the catalyst because a large amount of Ti is enriched on the surface of the catalyst,which hinders the contact and reaction between the catalyst and the soot.

关键词： Diesel oxidation catalyst Soot oxidation Ce-Ti oxides Rare earths

The role of glutamine metabolism in castration-resistant prostate cancer

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Asian Journal of Andrology 2023年第2期25卷 192-197页

作者： bing zhao Jing Wang Li Chen Hong Wang Chao-zhao Liang Jiaoti Huang Ling-Fan Xu Department of Geriatrics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230002China Department of Urologic Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031China Department of Nursing The First Affiliated Hospital of Anhui Medical UniversityHefei 230001China Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei 230001China Institute of Urology Anhui Medical UniversityHefei 230001China Anhui Province Key Laboratory of Genitourinary Diseases Anhui Medical UniversityHefei 230001China Department of Pathology Duke University School of MedicineDurhamNC 27710USA Duke Cancer Institute Duke University School of MedicineDurhamNC 27710USA

Reprogramming of metabolism is a hallmark of tumors,which has been explored for therapeutic purposes.Prostate cancer(PCa),particularly advanced and therapy-resistant PCa,displays unique metabolic properties.Targeting metabolic vulnerabilities in PCa may benefit patients who have exhausted currently available treatment options and improve clinical outcomes.Among the many nutrients,glutamine has been shown to play a central role in the metabolic reprogramming of advanced PCa.In addition to amino acid metabolism,glutamine is also widely involved in the synthesis of other macromolecules and biomasses.Targeting glutamine metabolic network by maximally inhibiting glutamine utilization in tumor cells may significantly add to treatment options for many patients.This review summarizes the metabolic landscape of PCa,with a particular focus on recent studies of how glutamine metabolism alterations affect therapeutic resistance and disease progression of PCa,and suggests novel therapeutic strategies.

关键词： castration resistance glutamine metabolism prostate cancer tumor metabolism

Risk factors and predictive model of cerebral edema after road traffic accidents-related traumatic brain injury

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Chinese Journal of Traumatology 2024年第3期27卷 153-162页

作者： Di-You Chen Peng-Fei Wu Xi-Yan Zhu Wen-bing zhao Shi-Feng Shao Jing-Ru Xie Dan-Feng Yuan Liang Zhang Kui Li Shu-Nan Wang Hui zhao Institute for Traffc Medicine aping HospitalArmy Medical UniverstyChongqing400042China Department of Radiology Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China Wound Trauma Medical Center State Key Laboratory of TraumnaBurns and Combined lnjuryInstitute of Surgery ResearchDaping HospialArmy Medical UniversityChongqing.400042China

Purpose:Cerebral edema(CE)is the main secondary injury following traumatic brain injury(TBI)caused by road traffic accidents(RTAs).It is challenging to be predicted timely.In this study,we aimed to develop a prediction model for CE by identifying its risk factors and comparing the timing of edema occurrence in TBI patients with varying levels of injuries.Methods:This case-control study included 218 patients with TBI caused by RTAs.The cohort was divided into CE and non-CE groups,according to CT results within 7 days.Demographic data,imaging data,and clinical data were collected and analyzed.Quantitative variables that follow normal distribution were presented as mean±standard deviation,those that do not follow normal distribution were presented as median(Q1,Q3).Categorical variables were expressed as percentages.The Chi-square test and logistic regression analysis were used to identify risk factors for CE.Logistic curve fitting was performed to predict the time to secondary CE in TBI patients with different levels of injuries.The efficacy of the model was evaluated using the receiver operator characteristic curve.Results:According to the study,almost half(47.3%)of the patients were found to have CE.The risk factors associated with CE were bilateral frontal lobe contusion,unilateral frontal lobe contusion,cerebral contusion,subarachnoid hemorrhage,and abbreviated injury scale(AIS).The odds ratio values for these factors were 7.27(95%confidence interval(CI):2.08-25.42,p=0.002),2.85(95%CI:1.11-7.31,p=0.030),2.62(95%CI:1.12-6.13,p=0.027),2.44(95%CI:1.25-4.76,p=0.009),and 1.5(95%CI:1.10-2.04,p=0.009),respectively.We also observed that patients with mild/moderate TBI(AIS≤3)had a 50%probability of developing CE 19.7 h after injury(χ^(2)=13.82,adjusted R2=0.51),while patients with severe TBI(AIS>3)developed CE after 12.5 h(χ^(2)=18.48,adjusted R2=0.54).Finally,we conducted a receiver operator characteristic curve analysis of CE time,which showed an area under the curve of 0.744 and 0.672 for severe and mild/moderate TBI,

关键词： Road traffic accident Traumatic brain injury Cerebral edema Risk factors Time window

Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis

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World Journal of Orthopedics 2024年第4期15卷 363-378页

作者： Xu-Chang Zhou Dong-Xue Wang Chun-Yu Zhang Ya-Jing Yang Ruo-bing zhao Sheng-Yao Liu Guo-Xin Ni School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China Department of Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan 430065Hubei ProvinceChina Department of Spinal Surgery The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina Department of Rehabilitation Medicine The First Affiliated Hospital of Xiamen UniversityXiamen 361003Fujian ProvinceChina

BACKGROUND Regular physical activity during childhood and adolescence is beneficial to bone development,as evidenced by the ability to increase bone density and peak bone mass by promoting bone formation.AIM To investigate the effects of exercise on bone formation in growing mice and to investigate the underlying mechanisms.METHODS 20 growing mice were randomly divided into two groups:Con group(control group,n=10)and Ex group(treadmill exercise group,n=10).Hematoxylin-eosin staining,immunohistochemistry,and micro-CT scanning were used to assess the bone formation-related indexes of the mouse femur.Bioinformatics analysis was used to find potential miRNAs targets of long non-coding RNA H19(lncRNA H19).RT-qPCR and Western Blot were used to confirm potential miRNA target genes of lncRNA H19 and the role of lncRNA H19 in promoting osteogenic differentiation.RESULTS Compared with the Con group,the expression of bone morphogenetic protein 2 was also significantly increased.The micro-CT results showed that 8 wk moderate-intensity treadmill exercise significantly increased bone mineral density,bone volume fraction,and the number of trabeculae,and decreased trabecular segregation in the femur of mice.Inhibition of lncRNA H19 significantly upregulated the expression of miR-149 and suppressed the expression of markers of osteogenic differentiation.In addition,knockdown of lncRNA H19 significantly downregulated the expression of autophagy markers,which is consistent with the results of autophagy-related protein changes detected in mouse femurs by immunofluorescence.CONCLUSION Appropriate treadmill exercise can effectively stimulate bone formation and promote the increase of bone density and bone volume in growing mice,thus enhancing the peak bone mass of mice.The lncRNA H19/miR-149 axis plays an important regulatory role in osteogenic differentiation.

关键词： Exercise Osteogenic differentiation Bone formation Bone mesenchymal stem cells Autophagy

Evaluation of patches for rotator cuff repair:A systematic review and meta-analysis based on animal studies

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Bioactive Materials 2022年第4期7卷 474-491页

作者： Jinwei Yang Yuhao Kang Wanlu zhao Jia Jiang Yanbiao Jiang bing zhao Mingyue Jiao Bo Yuan Jinzhong zhao Bin Ma Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou730000China Reproductive Medicine Center Gansu Provincial Maternity and Child-Care HospitalLanzhou730050China Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China College of Biomedical Engineering Sichuan UniversityChengdu610064China National Engineering Research Center for Biomaterials Chengdu610064China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou730000China

Based on the published animal studies,we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation.74 animal studies were finally included,of which naturally derived biomaterials were applied the most widely(50.0%),rats were the most commonly used animal model(47.0%),and autologous tissue demonstrated the best outcomes in all animal models.The biomechanical properties of naturally derived biomaterials(maximum failure load:WMD 18.68[95%CI 7.71-29.66];P=0.001,and stiffness:WMD 1.30[95%CI 0.01-2.60];P=0.048)was statistically significant in the rabbit model.The rabbit model showed better outcomes even though the injury was severer compared with the rat model.

关键词： Rotator cuff patch Animal model Systematic review Meta-analysis Safety and effectiveness

An approach of dynamic response analysis of nonlinear structures based on least square Volterra kernel function identification

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Transportation Safety and Environment 2023年第2期5卷 1-13页

作者： Zhenhao Zhang Jun Xiong Zhenpeng zhao Fuming Wang Yi Zeng bing zhao Lu Ke School of Civil Engineering Changsha University of Science and TechnologyChangsha 410114HunanChina Guangxi Key Laboratory of Disaster Prevention and Engineering Safety Guangxi UniversityNanning 530004GuangxiChina College of Civil engineering and Architecture Guangxi UniversityNanning 530004GuangxiChina

Analysis of the dynamic response of a complex nonlinear system is always a difficult problem.By using Volterra functional series to describe a nonlinear system,its response analysis can be similar to using Fourier/Laplace transform and linear transfer function method to analyse a linear system’s response.In this paper,a dynamic response analysis method for nonlinear systems based on Volterra series is developed.Firstly,the recursive formula of the least square method is established to solve the Volterra kernel function vector,and the corresponding MATLAB programme is compiled.Then,the Volterra kernel vector corresponding to the nonlinear response of a structure under seismic excitation is identified,and the accuracy and applicability of using the kernel vector to predict the response of a nonlinear structure are analysed.The results show that the Volterra kernel function identified by the derived recursive formula can accurately describe the nonlinear response characteristics of a structure under an excitation.For a general nonlinear system,the first three order Volterra kernel function can relatively accurately express its nonlinear response characteristics.In addition,the obtained Volterra kernel function can be used to accurately predict the nonlinear response of a structure under the similar type of dynamic load.

关键词： nonlinear system Volterra series kernel function dynamic response least square method

Mode-based Damping Torque Analysis in Power System Low-frequency Oscillations

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1337-1347页

作者： Jingtian Bi Huadong Sun Shiyun Xu Ruihua Song bing zhao Qiang Guo the State Key Laboratory of Power Grid Safety and Energy Conservation China Electric Power Research InstituteBeijing 100192China

The mode-based damping torque analysis(M-DTA)method for studying the effect of an external controller on power system low-frequency oscillations is proposed in this paper.First,based on the interconnection model between the system and the controller in the frequency domain,the oscillation loop corresponding to the electromechanical oscillation mode is built,and then the mode-based damping torque of the controller can be calculated.Then,the application of the M-DTA method in the power system is illustrated.The derivation shows that in the single-machine infinite-bus power system,the M-DTA method is completely equivalent to the classical damping torque analysis(C-DTA)method.In the multi-machine power system,the mode-based damping torque directily reflects the effect of the controller on the oscillation mode,overcoming the shortcomings of the C-DTA method in which there is no direct correspondence between the damping torque and the oscillation mode.By deriving the relationship with the residue index,the M-DTA method shows higher accuracy than the residue method in applications,such as controller parameter adjustment.Finally,two example power systems are presented to demonstrate the application of the proposed M-DTA method.Index Terms-Electromechanical oscillation mode,FACTS,interconnection model in the frequency domain,mode-based damping torque analysis(M-DTA),power system low-frequency oscillation,PSS,residue method.

关键词： Electromechanical oscillation mode FACTS interconnection model in the frequency domain mode-based damping torque analysis(M-DTA) power system low-frequency oscillation PSS residue method.

人工智能时代宗教演变初探:“神的机器”与“机器的神”并存

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世界宗教文化 2024年第2期 90-97页

作者：赵冰上海电机学院马克思主义学院

当前,人工智能技术正在给人类社会带来前所未有的巨变。在必将到来的人工智能时代,宗教领域将面临一系列突出问题,例如宗教如何应对随之而来的社会巨变,宗教与人工智能之间如何进行互动。本文认为在宗教数字化趋势下,宗教与人工智能将... 详细信息

当前,人工智能技术正在给人类社会带来前所未有的巨变。在必将到来的人工智能时代,宗教领域将面临一系列突出问题,例如宗教如何应对随之而来的社会巨变,宗教与人工智能之间如何进行互动。本文认为在宗教数字化趋势下,宗教与人工智能将持续进行双向互构,并产生“神的机器”和“机器的神”两种现象,前者体现了宗教行为体期望持续以现有宗教理念、模式去建构甚至驯服人工智能的努力,后者是人们崇拜人工智能本身,或依托人工智能技术建构出供其崇拜的新“神明”的行为。两者将是人工智能时代宗教演变过程中并行不悖的两个发展方向。

关键词：宗教数字化人工智能宗教演变双向互构

Inferring Mycobacterium Tuberculosis Drug Resistance and Transmission using Whole-genome Sequencing in a High TB-burden Setting in China

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Biomedical and Environmental Sciences 2024年第2期37卷 157-169页

作者： FAN Yu Feng LIU Dong Xin CHEN Yi Wang OU Xi Chao MAO Qi Zhi YANG Ting Ting WANG Xi Jiang HE Wen Cong zhao bing LIU Zhen Jiang ABULIMITI Maiweilanjiang AIHEMUTI Maimaitiaili GAO Qian zhao Yan Lin Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China National Tuberculosis Reference Laboratory Chinese Center for Disease Control and PreventionBeijing 102206China Hangzhou Red Cross Hospital Hangzhou 310005ZhejiangChina Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention Urumqi 830026XinjiangChina Tuberculosis Dispensary of Kashgar Prefecture Kashgar 844099XinjiangChina

Objective China is among the 30 countries with a high burden of tuberculosis(TB)worldwide,and TB remains a public health concern.Kashgar Prefecture in the southern Xinjiang Autonomous Region is considered as one of the highest TB burden regions in China.However,molecular epidemiological studies of Kashgar are lacking.Methods A population-based retrospective study was conducted using whole-genome sequencing(WGS)to determine the characteristics of drug resistance and the transmission patterns.Results A total of 1,668 isolates collected in 2020 were classified into lineages 2(46.0%),3(27.5%),and 4(26.5%).The drug resistance rates revealed by WGS showed that the top three drugs in terms of the resistance rate were isoniazid(7.4%,124/1,668),streptomycin(6.0%,100/1,668),and rifampicin(3.3%,55/1,668).The rate of rifampicin resistance was 1.8%(23/1,290)in the new cases and 9.4%(32/340)in the previously treated cases.Known resistance mutations were detected more frequently in lineage 2 strains than in lineage 3 or 4 strains,respectively:18.6%vs.8.7 or 9%,P<0.001.The estimated proportion of recent transmissions was 25.9%(432/1,668).Multivariate logistic analyses indicated that sex,age,occupation,lineage,and drug resistance were the risk factors for recent transmission.Despite the low rate of drug resistance,drug-resistant strains had a higher risk of recent transmission than the susceptible strains(adjusted odds ratio,1.414;95%CI,1.023–1.954;P=0.036).Among all patients with drug-resistant tuberculosis(DR-TB),78.4%(171/218)were attributed to the transmission of DR-TB strains.Conclusion Our results suggest that drug-resistant strains are more transmissible than susceptible strains and that transmission is the major driving force of the current DR-TB epidemic in Kashgar.

关键词： Mycobacterium tuberculosis Whole-genome sequencing(WGS) Transmission Drug resistance Xinjiang

An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis

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Chinese Medical Journal 2022年第12期135卷 1425-1431页

作者： Yanhua Huang Zuoteng Wang bing zhao Yahui Ma Yanan Ou Hao Hu Xiaohe Hou Jintai Yu Lan Tan Department of Neurology Qingdao Municipal HospitalQingdao UniversityQingdaoShandong 266071China Department of Neurology Institute of NeurologyHuashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China

Background:Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis(ICAS).The platelet-to-lymphocyte ratio(PLR)has recently emerged as a potential inflammatory biomarker.This study aimed to explore the association of the PLR with ICAS in a Chinese Han population.Methods:A total of 2134 participants(518 with ICAS,1616 without ICAS)were enrolled in this study.ICAS was defined as atherosclerotic stenosis>50%or the occlusion of several main intracranial arteries.Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS.Additional subgroup analyses were performed according to age(<60 vs.≥60 years)and acute ischemic stroke.Results:Multivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants(P<0.001).Compared with the lowest quartile,the fourth PLR quartile was significantly associated with ICAS(OR 1.705,95%confidence interval 1.278–2.275,P<0.001).In the subgroups stratified by age,an association between the PLR and ICAS was found in the late-life group(P<0.001),but not in the mid-life group(P=0.650).In the subgroups stratified by acute ischemic stroke,the relationship between an elevated PLR and a higher risk of ICAS remained unchanged(stroke group,P<0.001;non-stroke group,P=0.027).Conclusions:An elevated PLR was associated with a higher risk of ICAS in a Chinese Han population.The PLR might serve as a potential biomarker for ICAS in the elderly population.

关键词： Platelet-to-lymphocyte ratio Intracranial atherosclerotic stenosis Atherosclerosis Inflammation