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N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation

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Asian Journal of Andrology 2024年第1期26卷 99-106页

作者： Wei Ding Jun-Hong Fan Li-Ren Zhong Nan-Xiong Wang Lu-Hao Liu Hai-Bo Zhang Li Wang Ming-Qiang Wang bing-lin he An-Yang Wei Department of Urology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002China Department of Urology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Urology Shenzhen Immigration Inspection General Station HospitalShenzhen 518000China Department of Organ Transplantation The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002China

Hyperlipidemia is a major risk factor for erectile dysfunction(ED).Oxidative stress and phenotypic modulation of corpus cavernosum smooth muscle cells(CcSMCs)are the key pathological factors of ED.N-acetylcysteine(NAC)can inhibit oxidative stress;however,whether NAc can alleviate pathological variations in the corpus cavernosum and promote erectile function recovery in hyperlipidemic rats remains unclear.A hyperlipidemia model was established using 27 eight-week-old male Sprague-Dawley(SD)rats fed a high-fat and high-cholesterol diet(hyperlipidemic rats,HR).In addition,9 male SD rats were fed a normal diet to serve as controls(NC).HR rats were divided into three groups:HR,HR+normal saline(NS),and HR+NAC(n=9 for each group;NS or NAc intraperitoneal injections were administered daily for 16 weeks).Subsequently,the lipid profiles,erectile function,oxidative stress,phenotypic modulation markers of ccsMCs,and tissue histology were *** experimental results revealed that erectile function was significantly impaired in the HR and HR+NS groups,but enhanced in the HR+NAC *** lipid levels,over-activated oxidative stress,and multi-organ lesions observed in the HR and HR+NS groups were improved in the HR+NAC ***,the HR group showed significant phenotypic modulation of CCSMCs,which was also inhibited by NAC *** report focuses on the therapeutic effect of NAc in restoring erectile function using a hyperlipidemic rat model by preventing CcSMC phenotypic modulationand attenuating oxidativestress.

关键词： erectile dysfunction hyperlipidemia N-acetylcysteine oxidative stress henotypic modulation

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Facile Synthesis and Adsorption Properties of Phosphonated Cellulose Beads for Selective Removal of Low-density Lipoprotein

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Chinese Chemical Letters 2006年第9期17卷 1193-1196页

作者： Hao Feng YU Guo Qi FU Li LIU bing lin he The Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Nankai University Tianjin 300071

A novel low-density lipoprotein adsorbent was prepared simply by directly phosphonating porous cellulose beads. Tests in vitro demonstrated that this adsorbent showed quite good adsorption performance for selective removal of low-density lipoprotein from human plasma. The effects of preparation conditions on the lipoprotein sorption properties of the resulted adsorbent were investigated. The adsorption dynamics was also examined.

关键词： Cellulose beads phosphonation low-density lipoprotein adsorption hyperlipemia

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The Preparation and Properties of Thermosensitive Hydrogels Based on Chitosan Grafted N-isopropylacrylamide via γ-Radiation

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Chinese Chemical Letters 2004年第10期15卷 1253-1254页

作者： Hong CAI Jing ZHANG Zheng Pu ZHANG Yan Geng ZHANG bing lin he State Key Laboratory of Adsorption and Separation Functional Polymeric Materials Institute of Polymer ChemistryNankai UniversityTianjin300071 The Tianjin Institute of Technological Physics Tianjin 300192

Thermosensitive hydrogels were prepared by graft polymerization of chitosan and N-isopropylacrylamide via 60 Co ?-radiation. The effects of monomer concentration and total irradiation dose on percent grafting and graf... 详细信息

关键词： γ-radiation Chitosan Graft N-isopropylacrylamide Thermosensitive

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SELECTIVE　REDUCTION　OF　NITROARENE　MEDIATED　BY　AN　INSOLUBLE　RESIN　WITH　VIOLOGEN　STRUCTURE　AS　ELECTRON-TRANSFER　CATALYST

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Chinese Chemical Letters 1995年第9期6卷 745-746页

作者： Fu Tian LIU Hong LI bing lin he(Institute of Polymer Chemistry, Nankai University, Tianjin 300071) Nankai Univ Inst Polymer Chem Tianjin 300071 Peoples R China

Abstract: : The substituted nitroarenes were reduced effectively to the corresponding aniline deriva tives by an insoluble resin with viologen structure as an electron-transfer catalyst(ETC) in dichloromethane-resin... 详细信息

关键词： AS ELECTRON-TRANSFER STRUCTURE VIOLOGEN CATALYST WITH BY AN

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EFFECT OF AMPHIPHILIC α-heLICES OF PEPTIDES ON TheIR BINDING TO CALMODUlin

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Chinese Chemical Letters 1995年第2期6卷 117-120页

作者： Li Ping LIU Zhi Dong XIE bing lin he(Institute of Polymer Chemistry, Nankai University, Tianj in 800071) Nankai Univ Inst Polymer Chem Tianjin 300071 Peoples R China

Melittin is a small basic peptide which has a high affinity for calmodulin (CaM). In a previous paper, the authors have demonstrated that the deletion peptide Mel (12～25), that is, Mell5 has almost the same binding activity as tie intact native peptide (1). In this study, three analogues of Mell5,ere synthesized, the role of amphiphilic α-helix of peptides on their binding to CaM were studied. According to the calculation of hydrophobic moment and the analysis of the secondary structure, we proposed that the role of amphiphilic structure is not absolulte, since the dissociation constants for the binding of different analogs to CaM bear no predictable relation to the calculated hydroplobic moment and the average hydropbobicity.

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STUDY ON SORPTION OF UREA BY MEANS OF MNTAL-POLYMER COMPLEXES

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Chinese Chemical Letters 1992年第8期3卷 669-672页

作者： bing lin he Xiao bing ZHAO Institute of Polymer Chemistry,Nankai Universlty,Tianjin,300071

Urea can be sorbed by complexation with metal-polyaerylic acid *** experimental results indicate that the coordination occurs in the 0 atom of urea with Cu(Ⅱ)in Cu(Ⅱ)-polyaerylic acid complex and the sorption capaci... 详细信息

关键词： IC Cu 乞一 STUDY ON SORPTION OF UREA BY MEANS OF MNTAL-POLYMER COMPLEXES 台五

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SYNTheSIS OF POLYMERIC β-CYCLODEXTRIN SUPPORTED BY CROSSlinKED POLY(ACRYLAMIDE-co-VINYLAMINE)AND ITS CATALYSIS OF The HYDROLYSIS OF p-NITROPheNYL ACETATE

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Chinese Journal of Polymer Science 2000年第2期18卷 155-160页

作者： Hong-jun Wang Jian-biao Ma bing-lin he The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China 南开大学吸附分离功能高分子材料国家重点实验室天津

Polymeric β-cyclodextrin (β-CD) supported by crosslinked poly(acrylamide-co-vinylamine) was synthesized as anartificial analog of hydrolytic enzyme and its catalysis of the hydrolysis of p-nitrophenyl acetate (p-NPA) was theninvestigated. The result showed that the polymer-supported β-CD could accelerate the hydrolytic reaction of p-NPA morequickly than β-CD itself and crosslinked poly(acrylamide-co-vinylamine) alone. The acceleration rate of the polymer-supported β-CD was about 10 times as fast as that of free β-CD in 0.01 mol/L phosphate buffer (pH 7.4) containing 32%DMSO at 37±0.1℃ when the molar amount of β-CD units in the polymer was equal to that of free β-CD in the *** enhanced acceleration of thc polymer-supported β-CD should be ascribed to the cooperative contribution of theinclusion effect of β-CD ring and the nucleophilic effect of amino groups on the polymeric support.

关键词： Polymer-supported catalysis β-Cyclodextrin Crosslinked poly(acrylamide-co-vinylamine) Hydrolysis of p-nitrophenyl acetate

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SYNTheSIS AND CHARACTERIZATION OF POLYURETHANE LATEX

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Chinese Chemical Letters 1996年第4期7卷 375-376页

作者： Qing Ye ZHOU Han LI Mou Dao SONG Bang Hua ZHANG bing lin he(Institute of Polymer Chemistry, Nankai University, Tianjin 300071) Institute of Polymer Chemistry Nankai University Tianjin 300071

A method of preparing stable, film-forming polyurethane latices without the use of emulsifying agents is described in this article. The reaction of polypropylene glycol with a stoichiometric ratio(NCO:OH=2:1) of tolylene-diisocyanate in the presence of ketones and catalyst produces an isocyanate terminated prepolymer. Then addition of diethylene glycol as chain extender to prepolymer solution can yield a relatively high molecular weight poly(urethane-ether) which is readily dispersed with aqueous tartaric acid after tartaric acid and water diffuse into the suspended globules of the latex and produces the chain extended urethane. A linear or crosslinked high molecular weight self-emulsifiable polyurethane carl be obtained due to the reaction of the hydroxy group of tartaric acid and little water with isocyanate endgroups. The results of FTIR also show that an expected polyurethane emulsion has been successfully synthesized.

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Intrachain and Interchain Interactions in Polystyrene: Dilute andSemidilutc Solutions

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Chinese Chemical Letters 1999年第11期10卷 961-964页

作者： Xin Song LI Guo Chang WANG bing lin he(Department of Chemical Engineering, Southeast University, Naming 210096)(Institute of Polymer Chemistry, Nankai University, Tianjin 300071) Department of Chemical Engineering Southeast University Nanjing 210096 China Institute of Polymer Chemistry Nankai University Tianjin 300071 China

Excimer formation in pyrenyl labeled polystyrene has been investigated in dilutesolution region. The change of the intensity ratio of excimer to monomer (Ie/Im) with increasingconcentration (C), is interpreted by intrachain and interchain interactions. The double logarithmicPlot of Ie/Im vs C displays two critical points, Cs at about 2.5×10-3g/ml and C+ at about 3.2×10-2g/ml. In dilute region C

关键词： Excimer fluorescence dilute solution chain interaction critical concentration.

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IMMOBILIZATION OF PORCINE PANCREATIC LIPASE ON CROSS-linKED POLYSTYRENE

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Chinese Chemical Letters 1994年第2期5卷 161-164页

作者： Zhi Dong XIE bing lin he (Institute of Polymer Chemistry, Nankai Univeraity, Tianjin 300071)

Forcine gancreatic lipase (PPL), was adsorbed on a series of cross-linked polystyrene of different structures. The specificific activity of immobilized PPL was influenced by the degree of cross-linking and the amount of pore generating *** to scanning electron micrograph and analysis of pore structure, PPL was adsorbed in pore, with diameter about 1×103A

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