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Mendelian randomization analysis of causal relationship between cheese intake and diabetic retinopathy

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1905-1910页

作者： Cheng-Ye Tang Dong-Yong Tang Ying-Qin Yang Yu-bing liang Hao liang Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Ophthalmology the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Department of Anesthesiology Guangxi Medical University Cancer HospitalNanning 530000Guangxi Zhuang Autonomous RegionChina

AIM:To assess whether there is a possible causal link between the intake of cheese and the risk of diabetic retinopathy(DR)utilizing a two-sample Mendelian randomization(MR)***:The research data were obtained from summary statistics of genome-wide association studies(GWAS).Genetic loci closely related to cheese intake were extracted as instrumental variables(IVs),and DR was the outcome *** data were extracted from individuals of European *** data of cheese intake consisted of 451486 samples with 9851867 single nucleotide polymorphisms(SNPs),while the DR data consisted of 206234 samples with 16380446 ***-one genetic loci closely related to cheese intake were selected as *** analysis was performed by inverse-variance weighted(IVW)method and MR-Egger regression *** causal relationship between cheese intake and DR was evaluated using odds ratios(ORs)and 95%confidence intervals(CIs).Egger-intercept test was used to test horizontal pleiotropy and sensitivity analysis was performed by leave-one-out ***:The P value of the IVW method was less than 0.05,indicating a significant negative correlation between cheese intake and ***-Egger regression showed that the intercept was 0.01 with a standard error of 0.022,and a P-value of 0.634,indicating no evidence of horizontal pleiotropy affecting the IVs related to the exposure ***,heterogeneity tests confirmed the absence of heterogeneity,and the“leave-one-out”sensitivity analysis demonstrated that the results were ***:Cheese intake is causally negatively correlated with the occurrence of DR,and cheese intake could reduce the risk of DR.

关键词： cheese intake diabetic retinopathy Mendelian randomization analysis

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Atomic-Scale Insights into Damage Mechanisms of GGr15 Bearing Steel Under Cyclic Shear Fatigue

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1265-1278页

作者： Qiao-Sheng Xia Dong-Peng Hua Qing Zhou Ye-Ran Shi Xiang-Tao Deng Kai-Ju Lu Hai-Feng Wang Xiu-bing liang Zhao-Dong Wang State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China Defense Innovation Institute Academy of Military ScienceBeijing100071China

Alternating shear stress is a critical factor in the accumulation of damage during rolling contact fatigue,severely limiting the service life of ***,the specific mechanisms responsible for the cyclic shear fatigue damage in bearing steel have not been fully *** the mechanical response and microstructural evolution of a model GGr15 bearing steel under cyclic shear loading are investigated through the implementation of molecular dynamics *** samples undergo 30 cycles under three different loading conditions with strains of 6.2%,9.2%,and 12.2%,*** findings indicate that severe cyclic shear deformation results in early cyclic softening and significant accumulation of plastic damage in the bearing ***,samples subjected to higher strain-controlled loading exhibit higher plastic strain energy and shorter fatigue ***,strain localization is identified as the predominant damage mechanism in cyclic shear fatigue of the bearing steel,which accumulates and ultimately results in fatigue ***,simulation results also revealed the microstructural reasons for the strain localization(e.g.,BCC phase transformation into FCC and HCP phase),which well explained the formation of white etching *** study provides fresh atomic-scale insights into the mechanisms of cyclic shear fatigue damage in bearing steels.

关键词： Cyclic shear fatigue Molecular dynamic simulation Bearing steels Plastic damage accumulation

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Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis

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Nano-Micro Letters 2024年第12期16卷 59-80页

作者： Qing Chen Miao Yan Annan Hu bing liang Hongwei Lu Lei Zhou Yiqun Ma Chao Jia Dihan Su Biao Kong Wei Hong Libo Jiang Jian Dong Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai 200032People’s Republic of China Department of Chemistry Fudan UniversityShanghai 200438People’s Republic of China Department of Surgery Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge RoadSingapore 119228Singapore Department of Geriatrics and Gerontology Huadong HospitalFudan UniversityShanghai 200438People’s Republic of China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438People’s Republic of China Department of Orthopaedic Surgery Zhongshan Hospital Wusong Branch Fudan UniversityShanghai 200940People’s Republic of China

Surgery remains the standard treatment for spinal ***,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical *** this study,we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril *** superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC)with easy bleeding characteristics,before spinal surgery in a mouse *** near-infrared irradiation,the self-motile nanorobots penetrate into the deep spinal tumor,releasing Thr in a controlled ***-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding,inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal *** minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth,with potentially reduced surgical complications and enhanced operative outcomes.

关键词： Silk fibroin Nanofibril hydrogels Nanorobots Thrombin Spinal metastasis

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Impact of metabolic syndrome components on clinical outcomes in hypertriglyceridemia-induced acute pancreatitis

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World Journal of Gastroenterology 2024年第35期30卷 3996-4010页

作者： Zhen-Hua Fu Zi-Yue Zhao Yao-bing liang Dong-Yu Cheng Jian-Ming Luo Hai-Xing Jiang Shan-Yu Qin Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The incidence of hypertriglyceridemia(HTG)-induced acute pancreatitis(AP)is steadily increasing in China,becoming the second leading cause of *** complications and outcomes associated with HTG-AP are generally more severe than those seen in AP caused by other ***-AP is closely linked to metabolic dysfunction and frequently coexists with metabolic syndrome or its ***,the impact of metabolic syndrome components on HTGAP clinical outcomes remains *** To investigate the impact of metabolic syndrome component burden on clinical outcomes in *** In this retrospective study of 255 patients diagnosed with HTG-AP at the First Affiliated Hospital of Guangxi Medical University,we collected data on patient demographics,clinical scores,complications,and clinical ***,we analyzed the influence of the presence and number of individual metabolic syndrome components,including obesity,hyperglycemia,hypertension,and low high-density lipoprotein cholesterol(HDL-C),on the aforementioned parameters in HTG-AP *** This study found that metabolic syndrome components were associated with an increased risk of various complications in HTG-AP,with low HDL-C being the most significant risk factor for clinical *** risk of complications increased with the number of metabolic syndrome *** for age and sex,patients with highcomponent metabolic syndrome had significantly higher risks of renal failure[odds ratio(OR)=3.02,95%CI:1.12-8.11)],SAP(OR=5.05,95%CI:2.04-12.49),and intensive care unit admission(OR=6.41,95%CI:2.42-16.97)compared to those without metabolic *** The coexistence of multiple metabolic syndrome components can synergistically worsen the clinical course of HTGAP,making it crucial to monitor these components for effective disease management.

关键词： Hypertriglyceridemia-induced acute pancreatitis Metabolic syndrome High density lipoprotein cholesterol Obesity Hyperglycemia Hypertension Clinical outcomes

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现代高校校园治理共同体构建的伦理向度

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教育理论与实践 2024年第9期44卷 10-14页

作者：梁炳辉广西科技大学马克思主义学院广西柳州545006

高校治理是现代化社会治理体系的重要单元,校园治理是推动高校高质量发展、内涵式提升的关键路径。而建设高校校园治理共同体是优化治理架构、凸显民主公平的现实选择。现代高校校园治理共同体的伦理起源在于校园各类主体的间性,解决哪... 详细信息

高校治理是现代化社会治理体系的重要单元,校园治理是推动高校高质量发展、内涵式提升的关键路径。而建设高校校园治理共同体是优化治理架构、凸显民主公平的现实选择。现代高校校园治理共同体的伦理起源在于校园各类主体的间性,解决哪些主体存在间性的问题催生了伦理差异,解决主体存在何种间性的问题促进了伦理培育,解决主体间性如何缩小的问题实现了伦理共建。公共性则是育人场景中现代高校校园治理共同体的伦理特性,体现在校园空间内的有机共生、教学关系中的平等共存、风险主体上的责任共担、项目进程中的合作共建等方面。文化性则是文明传承中现代高校校园治理共同体的伦理内蕴,包括以礼为内核的治理观、以公为基准的仁爱观、以和为框架的辩证观。实践性则是现代高校校园治理共同体的伦理价值,应当立足公共性强化思想理念,立足积极性丰富治理主体,立足信任性深化治理规则,立足平衡性优化逻辑结构。

关键词：高校校园治理治理共同体公共伦理文化伦理主体间性公共性文化性实践性

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Improving treatment plan and mental health in children with abdominal infection for broad-spectrum bacterial infections

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World Journal of Psychiatry 2024年第9期14卷 1319-1325页

作者： Gui-Bo Wang Xue-Feng Zhang bing liang Jie Lei Jun Xue Department of Pediatric Surgery the First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of General Surgery the First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Pediatric abdominal infection is a common but serious disease that requires timely and effective *** surgical treatment,accurate diagnosis and rational application of antibiotics are the keys to improving treatment *** To investigate the effect of broad-spectrum bacterial detection on postoperative antibiotic *** A total of 100 children with abdominal infection who received surgical treatment in our hospital from September 2020 to July 2021 were *** observation group collected blood samples upon admission and sent them for broad-spectrum bacterial infection nucleic acid testing,and collected pus or exudate during the operation for bacterial culture and drug sensitivity testing;the control group only sent bacterial culture and drug sensitivity testing during the *** White blood cell count,C-reactive protein,procalcitonin,3 days after surgery,showed better postoperative index than the control group(P<0.05).The hospital stay in the observation group was significantly shorter than that in the control *** hospitalization cost in the observation group was significantly lower than that in the control group,and the difference between the two groups was statistically significant(P<0.05).CONCLUSION Early detection of broad-spectrum bacterial infection nucleic acids in pediatric abdominal infections can help identify pathogens sooner and guide the appropriate use of antibiotics,improving treatment outcomes and reducing medical costs to some extent.

关键词： Pediatric abdominal infection Nucleic acid detection of broad-spectrum bacterial infection Bacterial culture Drug sensitivity testing Treatment effect Cost Mental health

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写意木刻——康宁版画中灰色调的拓展与观念重构

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美术 2024年第8期 56-59页

作者：解丹梁冰四川美术学院造型艺术学院

本文围绕康宁20世纪80年代以来在黑白木刻中对灰色调的实践和探索展开,剖析其不同创作阶段对灰色调的视觉转向、观念与象征意义的建构,以及伴随着对“原木”材料属性的挖掘,康宁进一步将灰色调构成中刀痕的书写性与写实性相融合,探寻“... 详细信息

本文围绕康宁20世纪80年代以来在黑白木刻中对灰色调的实践和探索展开,剖析其不同创作阶段对灰色调的视觉转向、观念与象征意义的建构,以及伴随着对“原木”材料属性的挖掘,康宁进一步将灰色调构成中刀痕的书写性与写实性相融合,探寻“超以象外”的意象精神,进而折射出艺术家对版画中最具人文价值的部分。

关键词：灰色调写意版画黑白木刻

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Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis

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Nano-Micro Letters 2024年第12期 67-88页

作者： Qing Chen Miao Yan Annan Hu bing liang Hongwei Lu Lei Zhou Yiqun Ma Chao Jia Dihan Su Biao Kong Wei Hong Libo Jiang Jian Dong Department of Orthopaedic Surgery Zhongshan Hospital Fudan University Department of Chemistry Fudan University Department of Surgery Yong Loo Lin School of Medicine National University of Singapore Department of Geriatrics and Gerontology Huadong Hospital Fudan University State Key Laboratory of Molecular Engineering of Polymers Fudan University Department of Orthopaedic Surgery Zhongshan Hospital Wusong Branch Fudan University

Surgery remains the standard treatment for spinal metastasis. However, uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical outcomes. In this study, we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril hydrogels. This superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC) with easy bleeding characteristics, before spinal surgery in a mouse model. Under near-infrared irradiation, the self-motile nanorobots penetrate into the deep spinal tumor, releasing Thr in a controlled manner. Thr-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding, inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal therapy. Our minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth, with potentially reduced surgical complications and enhanced operative outcomes.

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考虑矿井水流速和时效影响的煤矿地下水库储水系数计算模型

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采矿与安全工程学报 2024年第4期41卷 778-789页

作者：汪北方周铎蒋嘉祺梁冰辽宁工程技术大学矿业学院辽宁阜新123000 煤炭开采水资源保护与利用全国重点实验室北京100011 山东科技大学山东省矿山灾害预防控制重点实验室山东青岛266590 辽宁工程技术大学力学与工程学院辽宁阜新123000

选取神东矿区拟建地下水库22614工作面为研究背景,利用工作面开采相似实验和矿井水浸砂岩加载实验,模拟采场覆岩运动规律和应力分布状态,分析采空区覆岩结构特征,建立考虑矿井水流速和时间效应影响的煤矿地下水库储水系数计算模型。研... 详细信息

选取神东矿区拟建地下水库22614工作面为研究背景,利用工作面开采相似实验和矿井水浸砂岩加载实验,模拟采场覆岩运动规律和应力分布状态,分析采空区覆岩结构特征,建立考虑矿井水流速和时间效应影响的煤矿地下水库储水系数计算模型。研究结果表明:模型工作面开采基本顶初次垮落步距46 cm,基本顶周期垮落步距7~16 cm;采空区覆岩仅存在裂隙带和垮落带,垮落带岩块间存在大量非完全接触的空洞、空隙及欠压实裂缝,是煤矿地下水库最主要的储水空间;采空区岩体承载应力沿走向基本呈“∩”形分布,最大应力趋于1.5 MPa,覆岩位移以走向中心线为对称轴呈“∪”形变化,最大位移为-2.5 cm。基于采空区覆岩关键层运移轨迹构建其底面下沉曲线函数方程,数学量化采空区垮落带体积、垮落带岩体空隙量和吸水量,建立包含岩石碎胀系数等参数构成的煤矿地下水库储水系数计算模型,通过明确砂岩碎胀系数与矿井水流速和时间的数学关系,进一步完善煤矿地下水库储水系数计算模型,并对模型进行实例计算和实验验证,模型计算储水系数0.1965,实验测定储水系数0.2104,证明了计算模型的准确性,可为煤矿地下分布式水库库容设计和储水调度提供重要理论依据。

关键词：关键层岩石碎胀系数矿井水流速度时间效应储水系数

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马来酸酐与烯丙基磺酸钠共聚物的聚合过程及阻垢性能

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油田化学 2024年第2期41卷 335-342页

作者：梁骏逸邹金成李林张熙梁兵四川大学匹兹堡学院四川成都610207 高分子材料工程国家重点实验室(四川大学) 四川大学高分子研究所四川成都610065

为了分析马来酸酐(MA)与烯丙基磺酸钠(SAS)聚合过程的影响因素,在配方和工艺基本不变的情况下,设计了两种变量:中和度和引发剂加量。通过改变其中一个变量,合成了一系列MA/SAS共聚物,采用核磁共振波谱仪和凝胶渗透色谱仪对产物进行了表... 详细信息

为了分析马来酸酐(MA)与烯丙基磺酸钠(SAS)聚合过程的影响因素,在配方和工艺基本不变的情况下,设计了两种变量:中和度和引发剂加量。通过改变其中一个变量,合成了一系列MA/SAS共聚物,采用核磁共振波谱仪和凝胶渗透色谱仪对产物进行了表征。结果表明,MA与SAS共聚活性良好,中和度不超过100%时(相对于MA的物质的量分数),少量引发剂加量(2.4 g过硫酸钠)下就有较高的单体转化率,但仍有6%~8%的单体未聚合。剩余单体的种类和数量与中和度以及引发剂加量息息相关。MA在水溶液中部分水解成了马来酸,尽管马来酸数量较少,但其聚合活性相对较差,导致共聚物的分子量呈双峰分布。添加碱可以中和马来酸,当中和度不超过100%时,马来酸主要变为具有较好聚合活性的马来酸单钠盐,间接促进了MA类单体的聚合;当中和度为200%时,马来酸主要变为马来酸二钠盐,其聚合活性相对较差,严重阻碍了聚合;未中和以及中和度为100%时,需7.0~7.2 g引发剂才能将单体全部转化,而在适当的中和度(约20%)下,用少量引发剂(4.0~4.2 g)就可以获得聚合较完全的共聚物,节约了大约40%的引发剂用量。用较佳条件下合成的MA/SAS共聚物对碳酸钙、磷酸钙和硫酸钙的静态阻垢性能进行了研究,共聚物表现出良好的阻磷酸钙垢和阻硫酸钙垢、较好的阻碳酸钙垢性能,对应的最大阻垢率分别为94.38%、100.00%、59.03%。

关键词：马来酸酐烯丙基磺酸钠中和度无机盐垢阻垢率

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