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World Journal of Stem Cells 2019年第6期11卷 322-336页

作者： Hui Li bing yue Department of Bone and Joint Surgery Renji Hospital Shanghai Jiaotong University School of Medicine

Antimicrobial drugs of several classes play an important role in the treatment of bone and joint infections. In addition to fighting pathogenic microorganisms, the effects of drugs on local tissues and cells are also related to the course and prognosis of bone and joint infections. The multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells (MSCs) is essential for tissue repair after local injury, which is directly related to the recovery of bone, cartilage, and medullary adipose tissue. Our previous studies and the literature indicate that certain antimicrobial agents can regulate the differentiation potential of bone marrow-derived MSCs. Here, in order to systematically analyze the effects of various antimicrobial drugs on local tissue regeneration, we comprehensively review the studies on the effects of these drugs on MSC differentiation, and classify them according to the three differentiation directions (osteogenesis, chondrogenesis, and adipogenesis). Our review demonstrates the specific effects of different antimicrobial agents on bone marrow-derived MSCs and the range of concentrations at which they work, and provides a basis for drug selection at different sites of infection.

关键词： Antimicrobial agents Bone marrow mesenchymal stem cells Osteogenesis Chondrogenesis Adipogenesis

Identification of quantitative trait loci for four morphologic traits under water stress in rice (Oryza sativa L.)

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Journal of Genetics and Genomics 2008年第9期35卷 569-575页

作者： bing yue Weiya Xue Lijun Luo Yongzhong Xing National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research （Wuhan） Huazhong Agricultural University Wuhan 430070 China Shanghai Agrobiological Gene Center Shanghai 201106 China

Late season drought coinciding with the rice booting to heading stage affects the development of plant height, panicle exserfion, and flag leaf size, and causes significant yield loss. In this study, a recombinant inbred line population derived from a cross between paddy and upland cultivars was used for data collection of the morphologic traits under well water and drought stress conditions. Drought stress was applied at the stage of panicle initiation in the field in 2002 and at the booting stage in PVC pipes in 2003. The data from stress conditions and their ratios （trait measured under stress condition/trait measured under well water condition） or differences （trait measured under stress condition minus trait measured under well water condition） were used for QTL analysis. Totally, 17 and 36 QTLs for these traits were identified in 2002 and 2003, respectively, which explained a range of 2.58%-29.82% of the phenotypic variation. Among them, six QTLs were commonly identified in the two years, suggesting that the drought stress in the two years was different. The genetic basis of these traits will provide useful information for improving rice late season drought resistance, and their application as indirect indices in rice late season drought resistance screening was also discussed.

关键词： QTL mapping morphological trait late season drought resistance rice

Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface

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World Journal of Stem Cells 2020年第7期12卷 545-561页

作者： Shi-Cheng Huo bing yue Department of Bone and Joint Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Bone marrow-derived mesenchymal stem cells(BMSCs)play a critical role in the osseointegration of bone and orthopedic ***,osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium’s inherent *** modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell ***,we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its *** will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration,and discuss recent advances in understanding their role in regenerative *** aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface.

关键词： Bone marrow mesenchymal stem cells Osseointegration Orthopedic implant Biofunctionalization

The study of terbium regenerated bacterirhodopsin

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Science China Chemistry 2005年第5期48卷 466-469页

作者： XU bing ZHANG yue HU Kunsheng Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

The localization of Terbium (Tb3+) cations binding to deionized bacteriorhodopsin (bR) has been studied by using spectroscopic methods. It was found that adding Tb3+ cations to deionized bR affects the fluorescence lifetimes of tryptophan (Trp) in bR, the wavelength of fluo-rescence peak shifts “blue” and the peak value of fluorescence decreases. It was also found that adding one Tb3+ cation to deionized bR can restore the purple state from its blue state obviously. The measurements of absorbance, fluorescence and lifetime of fluorescence also show that when more than three Tb3+ cations are added, no further changes can be found. It is suggested that one Tb3+ specific binding site for the color-controlling is located on the exterior of the bR trimer structure to negatively charged lipids near Trp-10 and Trp-12. Three Tb3+ cations binding per bR is needed for the regenerated bR.

关键词： cation binding, fluorescence, bacteriorhodopsin, terbium.

Genome-wide identification, evolution, and expression analysis of RNA-binding glycine-rich protein family in maize

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Journal of Integrative Plant Biology 2014年第10期56卷 1020-1031页

作者： Jianhua Zhangy Yanxin Zhaoy Hailin Xiao Yonglian Zheng bing yue National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

The RNA‐binding glycine‐rich protein（RB‐GRP）family is characterized by the presence of a glycine‐rich domain arranged in（Gly）n‐X repeats and an RNA‐recognition motif（RRM）. RB‐GRPs participate in varied physiological and biochemical processes especially in the stress response of plants. In this study, a total of 23 RB‐GRPs distributed on 10 chromosomes were identified in maize（Zea mays L.）, and they were divided into four subgroups according to their conserved domain architecture. Five pairs of paralogs were identified,while none of them was located on the same chromosomal region, suggesting that segmental duplication is predominant in the duplication events of the RB‐GRPs in maize. Comparative analysis of RB‐GRPs in maize, Arabidopsis（Arabidopsis thaliana L.）, rice（Oryza sativa L.）, and wheat（Triticum aestivum）revealed that two exclusive subgroups were only identified in maize. Expression of eight ZmRB‐GRPs was significantly regulated by at least two kinds of stresses. In addition, cis‐elements predicted in the promoter regions of the ZmRB‐GRPs also indicated that these ZmRB‐GRPs would be involved in stress response of maize. The preliminary genome‐wide analysis of the RB‐GRPs in maize would provide useful information for further study on the function of the ZmRB‐GRPs.

关键词： Gene expression maize motif prediction phylogenetic analysis RNA‐binding glycine‐rich proteins

Trigeminal extracranial thermocoagulation along with patientcontrolled analgesia with esketamine for refractory postherpetic neuralgia after herpes zoster ophthalmicus:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4220-4225页

作者： Jia-Chun Tao bing Huang Ge Luo Zhi-Qiang Zhang bing-yue Xin Ming Yao Department of Anesthesiology and Pain Medicine The Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Primary trigeminal neuralgia can achieve satisfactory results through clinical treatment and *** pathogenesis of neuralgia caused by varicellazoster virus infection of the trigeminal nerve is more complex,and it is still difficult to relieve the pain in some patients simply by drug treatment or surgical *** SUMMARY A 66-year-old woman was hospitalized with herpetic neuralgia after herpes zoster ophthalmicus(varicella-zoster virus infects the ophthalmic branch of the trigeminal nerve).On admission,the patient showed spontaneous,electric shocklike and acupuncture-like severe pain in the left frontal parietal region,and pain could be induced by touching the herpes *** numerical rating scale(NRS)was *** was no significant pain relief after pulsed radiofrequency and thermocoagulation of the ophthalmic branch of the trigeminal *** with patient-controlled intravenous analgesia(PCIA)with esketamine,neuralgia was significantly *** patient had no spontaneous pain or allodynia at discharge,and the NRS score decreased to 2 *** results of follow-up 2 mo after discharge showed that the NRS score was≤3,and the Pittsburgh Sleep Quality Index score was 5 *** were no adverse *** Trigeminal extracranial thermocoagulation combined with esketamine PCIA may be a feasible method for the treatment of refractory herpetic neuralgia after herpes zoster ophthalmicus.

关键词： Herpes zoster ophthalmicus Postherpetic neuralgia Esketamine Patient-controlled intravenous analgesia Case report

Inorganic arsenic contamination of rice from Chinese major rice-producing areas and exposure assessment in Chinese population

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Science China Chemistry 2015年第12期58卷 1898-1905页

作者： Xiaowei Li Ke Xie bing yue Yunyun Gong Yi Shao Xiaohong Shang Yongning Wu Key Laboratory of Food Safety Risk Assessment Ministry of Health China National Center for Food Safety Risk Assessment 3. Food Science and Engineering Department Wuhan Polytechnic University 4. Institute for Global Food Security School of Biological Sciences Queen's University of Belfast

This study examined the total arsenic(Ast) and inorganic arsenic(Asi) content in the main rice growing area of China. The results were compared with other countries and then used for dietary exposure assessment. A total of 446 rice samples from 15 main rice-growing provinces and autonomous regions of China were collected and then divided into unpolished and polished rice. Total arsenic and arsenic species were analyzed in a total of 892 subsamples using inductively coupled plasma-mass spectrometry(ICP-MS) and high performance liquid chromatography(HPLC) coupled ICP-MS, respectively. National Ast means were 255 μg/kg of unpolished rice and 143 μg/kg of polished rice. Asi was found to be the predominant species and mean levels were 209 μg/kg of unpolished rice and 108 μg/kg of polished rice, respectively. Exposure assessment to Asi in polished rice has been calculated for the margin of exposure(MOE), which highlights the fact that Asi levels in the Chinese rice should arouse public health concern.

关键词： arsenic speciation exposure assessment inorganic arsenic rice

Detecting quantitative trait loci for water use efficiency in rice using a recombinant inbred line population

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Chinese Science Bulletin 2011年第14期56卷 1481-1487页

作者： ZHOU GuangSheng LIU Fang CAO JinHua yue bing XIONG LiZhong College of Plant Science and Technology Huazhong Agricultural University Wuhan 430070 China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070. China

Breeding rice with high water use efficiency (WUE) can ameliorate water shortage through water-saving ***,WUE is a complex quantitative trait and very few studies have been conducted to measure WUE *** this study,a recombined inbred line population derived from a cross between an indica lowland rice and upland japonica rice was used to dissect the genetic control of WUE by fine-monitored water supply *** trait loci (QTL) were scanned for 10 traits including heading date (HD),water-consumption per day (water/d),shoot weight gain per day (shootw/d),root weight gain per day (rootw/d),kernel weight gain per day (kernelw/d),average WUE at whole plant level (WUEwhole/d),average WUE for up-ground biomass (WUEup/d),average WUE for grain yield (WUEyield/d),average economic index (econindex/d),and average root/shoot ratio per day (ratio/d).The results show that most of the traits were significantly correlated to each ***-four QTL (LOD ≥ 2.0) were detected for econindex,econindex/d,WUEyield,WUEyield/d,WUEup,WUEup/d,WUEwhole,WUEwhole/d,kernelw,kernelw/d,rootw,and water/d by composite interval *** QTLs are located on chromosomes 1,2,4,6,7,8,and *** QTLs accounted for 4.97%-10.78% of the phenotypic variation *** of these QTLs overlapped with previously reported drought resistance QTLs detected in this *** results provide useful information for further dissection of the genetic basis and marker-assisted selection of WUE in rice.

关键词：水分利用效率数量性状位点重组自交系群体籼型水稻检测分子标记辅助选择水资源短缺问题复合区间作图法

Histological Risk Factors for Lymph Node Metastasis in pT1 Colorectal Cancer:Does Submucosal Invasion Depth Really Matter?

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Current Medical Science 2024年第5期44卷 1026-1035页

作者： bing yue Mei JIA Rui XU Guang-yong CHEN Mu-lan JIN Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijing100050China Department of Pathology Beijing Chaoyang HospitalCapital Medical UniversityBeijing100015China

Objective After endoscopic resection of colorectal cancer with submucosal invasion(pT1 CRC),additional surgical treatment is recommended if deep submucosal invasion(DSI)is *** study aimed to further elucidate the risk factors for lymph node metastasis(LNM)in patients with pT1 CRC,especially the effect of DSI on *** Patients with pT1 CRC who underwent lymph node dissection were *** Chi-square test and multivariate logistic regression were used to analyze the relationship between clinicopathological characteristics and *** submucosal invasion depth(SID)was measured via 4 methods and analyzed with 3 cut-off *** Twenty-eight of the 239 patients presented with LNM(11.7%),and the independent risk factors for LNM included high histological grade(P=0.003),lymphovascular invasion(LVI)(P=0.004),intermediate to high budding(Bd 2/3)(P=0.008),and cancer gland rupture(CGR)(P=0.008).Moreover,the SID,width of submucosal invasion(WSI),and area of submucosal invasion(ASI)were not significantly *** one,two,three or more risk factors were identified,the LNM rates were 1.1%(1/95),12.5%(7/56),and 48.8%(20/41),*** Indicators such as the SID,WSI,and ASI are not risk factors for LNM and are subjective in their measurement,which renders them relatively inconvenient to apply in clinical *** contrast,histological grade,LVI,tumor budding and CGR are relatively straightforward to identify and have been demonstrated to be statistically *** would be prudent to focus on these histological factors rather than subjective measurements.

关键词： lymph node metastasis early colorectal cancer lymph node dissection submucosal invasion depth tumor budding cancer gland rupture

Transcriptome response of wheat Norin 10 to long-term elevated CO_2 under high yield field condition

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Journal of Integrative Agriculture 2016年第9期15卷 2142-2152页

作者： LIN yue-bing SHEN Cheng-guo LIN Er-da HAO Xing-yu HAN Xue Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences/Key Laboratory of Agricultural Environment Ministry of Agriculture Bioinformatics Unit Source Bio Science College of Agronomy Shanxi Agricultural University

The increasing atmospheric carbon dioxide concentration, caused by fossil fuel combustion and deforestation, plays an important role in plant growth and development. Wheat, as a major staple crop, adapts to climate change by tuning its inherent molecular mechanism, which is not well understood. The present study employed the RNA-Seq method to generate transcriptome profiles of the wheat Norin 10 in response to elevated CO_2 in comparison with ambient CO_2. The 10 895 787 high-quality clean reads of Norin 10 were assembled de novo using Trinity（without a reference genome） resulting in a total of 18 206 candidate transcripts with significant BLAST matches. GO enrichment analysis of Norin 10 at different CO_2 concentrations showed that some functional genes related to plastids, precursor metabolites, and energy, thylakoid and photosynthesis were apparently enriched at elevated CO_2（550 μmol mol^–1） in contrast to that at ambient CO_2（400 μmol mol^–1）; these findings were further confirmed by RT-PCR analysis. The findings demonstrated the specific effects of elevated CO_2 during long-term period in free air CO_2 enrichment（FACE） on transcriptome response of the high yielding wheat variety, Norin 10, which has a large spike.

关键词： Norin 10 transcriptome response wheat long term elevated carbon dioxide GO enrichment