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清远抽水蓄能电站溃坝洪水演进及影响分析

广东水利水电 2024年第5期 56-62,84页

作者：金苗张宜冯彬彬林波周佳麒傅举鹏蔡瀛南方电网调峰调频公司运行分公司广州510635 广东省水利电力勘测设计研究院有限公司广州510635

为研究清远抽水蓄能电站溃坝对下游梯级水库和防洪保护区的影响,利用MIKEFLOOD构建一二维耦合模型对溃坝洪水演进进行模拟。研究共设置12种工况,分析不同因素对溃坝后洪水流量、淹没范围、淹没水深等演进过程的影响。结果显示,溃决形式... 详细信息

为研究清远抽水蓄能电站溃坝对下游梯级水库和防洪保护区的影响,利用MIKEFLOOD构建一二维耦合模型对溃坝洪水演进进行模拟。研究共设置12种工况,分析不同因素对溃坝后洪水流量、淹没范围、淹没水深等演进过程的影响。结果显示,溃决形式(溃口宽度)及溃决水位、溃决历时都是影响溃坝洪水的重要因素,且梯级电站溃坝后对于距离较近且地势较低的楼心村、大楼村影响最为显著,应采取相应预防措施。

关键词：溃坝洪水演进过程分析 MIKE模型梯级水库

Mapping of Sentinel Lymph Node Micrometastasis in Dukes-B Colorectal Carcinoma and Its Clinical Significance

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Clinical oncology and cancer researeh 2009年第5期6卷 347-353页

作者： Xiongfei Yang Tao Wang Weisheng Zhang Lili feng binbin Du Aili Zhang Department of Colorectal Surgery Gansu People's Hospital Lanzhou 730000 Gansu Province. China.

OBJECTIVE To investigate the detection of sentinel lymphnode (SLN) micrometastasis (MM) and the clinical significancein patients with Dukes-B colorectal carcinoma (CRC) using H&Estained *** In a prospective study of 64 patients with Dukes-BCRC undergoing radical surgery,routine H&E staining combinedwith the immunohistochemical SP method was used to detect theexpression of the cytokeratin 20 (CK20) and telomerase (TLMA)in 122 SLNs from 61 of the 64 *** a 3-year follow up,the patients'clinicopathologic parameters data,survival and theirrelationship were collected and *** i) In 6 out of the 61 cases with successful mapping,9SLNs were positive after routine detection using H&E ***) In the other 55 with negative results from H&E staining,thepositive rate of CK20 expression was 27.3% (15/55),and thepositive rate of TLMA 21.8% (12/55),after immunohistochemicalexamination (IHC) on the ***) Detection by combining the 2methods showed that the micrometastasis rate was 38.2% (21/55).iv) The recurrence or metastasis rate of CRC was significantlyhigher in the Dukes-B patients with sentinel lymph nodemicrometastasis (SLNMM) (+) than in those with SLNMM (-)(P<0.05),and simultaneously,the survival rate decreased by alarge margin in the patients with SLNMM (+),compared to thosewith SLNMM (-) (P<0.05).There were significant differences inthe recurrence or metastasis rate of cancer and the survival ratebetween the Dukes-B patients with SLNMM (-) and the Dukes-Cpatients (P<0.05).CONCLUSION Examination of anti-CK20 and anti-TLMA usingimmunohistochemical staining can be used to detect SLNMM,andthe combined examination of the 2 can increase the detection *** detection of SLNMM can precisely determine the Dukes stageof colorectal carcinoma,which is of help in directing postoperativeadjunctive therapy and in assessing prognosis.

关键词： colorectal carcinoma sentinel lymph node micrometastasis.

基于多元教学模式下的中药化学实用技术实践教学研究

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广东化工 2024年第7期51卷 175-177,189页

作者：杨策易东阳冯彬彬李宁张建海蒋坤霞彭小园祖文宇王文祥重庆三峡医药高等专科学校药学院重庆404120

目的:观察高职高专中药化学实用技术在多元模式(BOPPPS-PBL-CBL-TBL)下的实践教学成效。方法:随机分为实验班及对照班,实验组采用BOPPPS-PBL-CBL-TBL多元教学模式,对照组采用LBL传统教学模式。以知识,能力及素质为基点,对研究对象实施... 详细信息

目的:观察高职高专中药化学实用技术在多元模式(BOPPPS-PBL-CBL-TBL)下的实践教学成效。方法:随机分为实验班及对照班,实验组采用BOPPPS-PBL-CBL-TBL多元教学模式,对照组采用LBL传统教学模式。以知识,能力及素质为基点,对研究对象实施成效评价,展开调查问卷进行课程满意度评价,课堂表现收集过程性评价,期末考试成绩定为终结性评价,通过SPSS 22.0软件分析比较两组学生的综合评判结果,旨在评价改革实施效果。结果:实验组学生在调查问卷中反馈高度认可多元模式下的中药化学实用技术教学过程。而传统教学班级学生认可度极少。且终结性评价中实验班比对照班的期末成绩普遍偏高,且具有显著性(P<0.05)。结论:中药化学实用技术以多元模式(BOPPPS-PBL-CBL-TBL)进行教学,可显著提升教学效果,提升学生自研能力,分析及解决问题能力及团队协作能力。

关键词：中药化学实用技术多元教学模式实践教学

Aluminum and Activated Alumina Powder Additions on Microwave Synthesis of Al_(4)SiC_(4)

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China's Refractories 2024年第1期33卷 44-48页

作者： WANG Li LIU Shijie WEI Haoyu MA Juanjuan DONG binbin GENG Shangrui YAN Miaoxin QIN feng GUO Yusen Henan Key Laboratory of Green Building Materials Manufacturing and Intelligent Equipemnt Luoyang Institute of Science and TechnologyLuoyang 471023China

Aiming at improving the properties of magnesia carbon materials,silicon aluminum carbide(Al_(4)SiC_(4))containing materials were prepared using industrial aluminum powder,silicon carbide powder,and graphite as raw materials,and activated alumina powder as an additive,mixing thoroughly,pressing into cylinders and then firing at 1200℃for 30 min in a carbon embedded atmosphere by the microwave *** effects of the aluminum powder addition(20%and 24%,by mass)and activated alumina powder addition(0,3%,5%and 7%,by mass)on the microwave synthesis of Al_(4)SiC_(4) as well as the effect of the obtained Al_(4)SiC_(4) containing material on the properties of magnesia carbon bricks were *** results show that:compared with the samples with 20%aluminum powder,those with 24%aluminum powder generate more Al_(4)SiC_(4).With the activated alumina powder addition increasing from 0 to 7%,the amount of Al_(4)SiC_(4) generated increases first and then *** with the sample without activated alumina powder,the samples with activated alumina powder show lower bulk density and higher apparent *** the activated alumina powder addition increasing from 3%to 7%,the bulk density of the samples increases first and then decreases,while the apparent porosity of the samples shows an opposite *** optimal additions are 24%aluminum powder and 5%activated alumina powder,and Al_(4)SiC_(4) synthesized in this sample has a hexagonal plate *** the synthesized Al_(4)SiC_(4) containing material added,the magnesia carbon brick has slightly increased cold modulus of rupture,basically the same modulus of elasticity and improved oxidation resistance.

关键词： aluminum powder activated alumina powder microwave synthesis Al_(4)SiC_(4) magnesia carbon bricks

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2024年

作者： Yuzhu Li Yumeng Gao feng Tian Yu Wang Yuan Yao Shaoliang Lin Xiang Ma binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence(RTP) materials with a wide range of tunable-emission is significant in expanding the applications of RTP materials. Herein, we rationally designed amphiphilic alternating copolymers poly(1,2-bis(4-alkoxyphenyl)ethane-1,2-dione-alt-(ethylene glycol)x)(P(Bz-alt-EGx)) that combined the advantage of alternating benzil and EGxskeleton, and tunable mainchain conformation. Through a mainchain conformation ordering assembly(COA) process, P(Bz-alt-EGx) self-assembled into well-defined platelets, and such assemblies emitted blue RTP at ca. 425 nm due to the ordered folded-chain conformation and confined microenvironment. In contrast, traditional self-assembly(TA) of P(Bz-alt-EGx) obtained less ordered aggregates, such as asymmetric worms, vesicles, and rod-like micelles. The resultant less ordered aggregates exhibited yellow-green RTP at ca. 550 nm. The wide-tuning RTP emission in solution(between blue and yellow-green, over125 nm) is realized using the P(Bz-alt-EGx) alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

关键词：

Microwave-assisted Synthesis of Al_(4)SiC_(4) and Its Effect on Properties of MgO-C Refractories

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China's Refractories 2024年第1期33卷 14-17页

作者： WANG Li LIU Shijie WEI Haoyu GUO Yanyan GENG Shangrui YAN Miaoxin QIN feng GUO Yusen Ma Juanjuan DONG binbin Henan Key Laboratory of Green Building Materials Manufacturing and Intelligent Equipemnt Luoyang Institute of Science and TechnologyLuoyang 471023China

Al_(4)SiC_(4) was synthesized from Al powder, silicon carbide, and graphite by microwave sintering, and characterized by XRD and SEM. Then the synthesized material was added to the magnesia carbon refractory brick to study its effect on the oxidation resistance, apparent porosity, bulk density, elastic modulus, and modulus of rupture. It is found that Al_(4)SiC_(4) can be synthesized by microwave sintering at 1 300 ℃ and the addition of Al_(4)SiC_(4)-containing material as an antioxidant can enhance the oxidation resistance of the magnesia carbon refractory brick.

关键词： microwave-assisted synthesis Al_(4)SiC_(4) MgO-C refractories oxidation resistance

“肺肠同治”宣白承气汤干预重症急性胰腺炎早期肺损伤的病理学机制

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中国中西医结合消化杂志 2024年第2期32卷 110-114页

作者：王天麟冯彬彬高天婴张雨田杨朝帅韩俊泉曲鹏飞贺燕丽王红李慧臻天津中医药大学第二附属医院急诊科天津300250 天津中医药大学研究生院天津中医药大学第二附属医院普外科天津中医药大学第二附属医院消化科

目的:探讨“肺肠同治”宣白承气汤对重症急性胰腺炎(SAP)早期急性肺损伤(ALI)的影响及作用。方法:将80只SD大鼠随机分为对照组、模型组、宣白承气汤组、宣白组和承气组,每组16只。除对照组外,其余各组以胰胆管注射牛磺胆酸钠的方式制备... 详细信息

目的:探讨“肺肠同治”宣白承气汤对重症急性胰腺炎(SAP)早期急性肺损伤(ALI)的影响及作用。方法:将80只SD大鼠随机分为对照组、模型组、宣白承气汤组、宣白组和承气组,每组16只。除对照组外,其余各组以胰胆管注射牛磺胆酸钠的方式制备SAP模型,于造模后3、6、12、24 h各时间点分别处死4只大鼠取材,观察大鼠胰腺、肺和肠组织的病理学表现及促炎因子IL-1β、IL-6和TNF-α水平。结果:宣白组和承气组的病理学改变相近,宣白承气汤组明显优于宣白组和承气组(P<0.05)。在各时间点,模型组较对照组IL-1β、IL-6和TNF-α水平明显升高,中药各组较模型组明显下降,宣白承气汤组优于宣白组和承气组(P<0.05)。除对照组外,其余各组IL-1β、IL-6和TNF-α水平在第12 h达到高峰。结论:肠道在SAP-ALI发病及防治过程中起着关键作用,宣白承气汤可通过肺肠同治明显减轻SAP-ALI炎症水平,延缓疾病的发生发展。

关键词：肺肠同治宣白承气汤重症急性胰腺炎早期肺损伤病理学

耐碳青霉烯类肺炎克雷伯菌感染与急性胰腺炎严重程度的临床关系

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中华消化外科杂志 2021年第11期20卷 1201-1205页

作者：陈英陈岳亮冯彬彬宋淑萍郭丰浙江大学医学院附属邵逸夫医院重症医学科杭州310016

目的探讨耐碳青霉烯类肺炎克雷伯菌(CRKP)感染与急性胰腺炎严重程度的临床关系。方法采用回顾性描述性研究。收集2017年1月至2018年1月浙江大学医学院附属邵逸夫医院收治的109例急性胰腺炎病人的临床资料;男66例,女43例;年龄为(48±17岁... 详细信息

目的探讨耐碳青霉烯类肺炎克雷伯菌(CRKP)感染与急性胰腺炎严重程度的临床关系。方法采用回顾性描述性研究。收集2017年1月至2018年1月浙江大学医学院附属邵逸夫医院收治的109例急性胰腺炎病人的临床资料;男66例,女43例;年龄为(48±17岁)。无菌采集病人血液、体液或肛拭子样本。病人经综合诊断,分别行胆囊穿刺引流、鼻胆管引流、手术清创以及CT检查介入引流或保守治疗。观察指标:(1)急性胰腺炎严重程度和CRKP检测结果。(2)CRKP感染对急性胰腺炎严重程度的诊断价值。(3)急性胰腺炎治疗方式。(4)预后情况。正态分布的计量资料以x±s表示,组间比较采用t检验。偏态分布计量资料以M(范围)。计数资料以绝对数表示,组间比较采用χ^(2)检验。相关性检验采用Spearman相关分析,采用受试者工作特征(ROC)曲线评价诊断价值。结果(1)急性胰腺炎严重程度和CRKP检测结果:109例病人中,轻度急性胰腺炎37例、中重度急性胰腺炎8例、重度急性胰腺炎64例;轻症45例,重症64例;CRKP阳性48例,CRKP阴性61例。45例轻症病人中,CRKP阳性3例;64例重症病人中,CRKP阳性45例,两者比较,差异有统计学意义(χ^(2)=43.430,P<0.05)。皮尔逊相关分析:CRKP阳性与急性胰腺炎严重程度呈正相关(r=0.631,P<0.05)。CRKP阳性和阴性病人住院时间分别为(66±6)d和(24±3)d,两者比较,差异有统计学意义(t=47.661,P<0.05)。(2)CRKP感染对急性胰腺炎严重程度的诊断价值:CRKP阳性诊断重度急性胰腺炎的ROC曲线下面积、灵敏度、特异度分别为0.799(95%可信区间为0.714~0.885,P<0.05)、0.688、0.911。(3)急性胰腺炎治疗方式:109例病人中,行鼻胆管引流17例、行胆囊穿刺引流19例、行手术清创42例、行CT检查介入引流48例、保守治疗43例,同1例病人可行多种治疗。109例病人中,行≥1种有创治疗66例,CRKP阳性47例;未行有创治疗43例,CRKP阳性1例;两者比较,差异有统计学意义(χ^(2)=50.134,P<0.05)。(4)预后情况:109例病人均获得随访,随访时间为3~9个月,中位随访时间为6个月。随访期间,48例CRKP阳性病人中,15例死亡;61例CRKP阴性病人中,6例死亡;两者比较,差异有统计学意义(χ^(2)=7.919,P<0.05)。结论CRKP阳性与急性胰腺炎严重程度呈正相关,CRKP阳性与住院时间以及操作次数和种类越多有关。

关键词：胰腺炎感染耐碳青霉烯类肺炎克雷伯菌严重程度临床价值

A novel method for AFRPs burrs removal:Principle of mechanochemo-induced fiber fracture

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Chinese Journal of Aeronautics 2024年第7期37卷 522-538页

作者： Jie XU Bo LI Pingfa feng Qiang WANG feng feng Division of Advanced Manufacturing Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Changhe Aircraft Industry(Group)Co.Ltd Jingdezhen 333000China

Burrs generated during the machining of Aramid-Fiber-Reinforced Composites(AFRPs)pose a challenge for the production efficiency of aircraft and helicopter housing *** studies have generally attempted to suppress burrs by referring to delamination suppression *** contrast to stratification,burrs are remediable machining *** such,a mechanochemical method with burrs trimming technological strategy are implemented to effectively combat ***,we clarify the mechanism by which aramid fibers cannot be cut off using analytical and numerical *** addition,the mechanism of fiber fracture with Modified Polyurethane Reactive Polymer(M-PUR),and development of anti-burr devices(thermostatic adhesive sealed generator)are ***,the experimental results show that the reduction rate in burr length is 87%-91%through the mechanochemical *** method not only opens a new avenue to solve the burr problem of aramid fibers but also builds an interdisciplinary bridge between polymer science and composite machining.

关键词： Mechanochemical method Burrs Orthogonal cutting Aramid fiber-reinforced composites Milling