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Cosmic acceleration with bulk viscosity in an anisotropic f(R, Lm) background

Communications in Theoretical Physics 2023年第7期75卷 103-112页

作者： Raja Solanki bina patel Lakhan V Jaybhaye P K Sahoo Department of Mathematics Birla Institute of Technology and Science-PilaniHyderabad CampusHyderabad-500078India Department of Mathematical Sciences P.D.Patel Institute of Applied SciencesCharotar University of Science and Technology(CHARUSAT)ChangaAnand 388421GujaratIndia

In this article,we investigate the observed cosmic acceleration in the framework of a cosmological f(R,Lm)model dominated by bulk viscous matter in an anisotropic *** consider the locally rotationally symmetric Bianchi type I metric and derive the Friedmann equations that drive the gravitational interactions in f((R,Lm)***,we assume the functional form f(R,Lm)=R/2+Lαm,where a is a free model parameter,and then find the exact solutions of field equations corresponding to our viscous matter dominated *** incorporate the updated H(z)data and the Pantheon data to acquire the best-fit values of parameters of our model by utilizing theχ2 minimization technique along with the Markov Chain Monte Carlo random sampling ***,we present the behavior of physical parameters that describe the Universe’s evolution phase,such as density,effective pressure and EoS parameters,skewness parameter,and the statefinder diagnostic *** find that the energy density indicates expected positive behavior,whereas the negative behavior of bulk viscous pressure contributes to the Universe’s *** effective EoS parameter favors the accelerating phase of the Universe’s ***,the skewness parameter shows the anisotropic nature of spacetime during the entire evolution phase of the ***,from the statefinder diagnostic test,we found that our cosmological f(R,Lm)model lies in the quintessence region,and it behaves like a de-Sitter universe in the far *** analyze different energy conditions in order to test the consistency of the obtained *** find that all energy conditions except strong energy condition(SEC)show positive behavior,while the violation of SEC favors the recently observed acceleration with the transition from decelerated to an accelerated epoch of the Universe’s expansion in the recent past.

关键词： LRS Bianchi type I metric f(R Lm)gravity bulk viscosity skewness parameter equation of state parameter statefinder parameter

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Reversal of multidrug resistance and antitumor promoting activity of 3-oxo-6β-hydroxy-β-amyrin isolated from Pistacia integerrima

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BIOCELL 2021年第1期45卷 139-147页

作者： ABDUR RAUF SAUD BAWAZEER MUSLIM RAZA EMAN EL-SHARKAWY MD.HABIBUR RAHMAN MOHAMED A.EL-ESAWI GHIAS UDDIN bina SSIDDIQUI ANEES AHMED KHALIL JOSEPH MOLNAR AKOS CSONKA DIÁNA SZABÓ HAROON KHAN MOHAMMAD SMUBARAK TAIBI BEN HADDA MUDYAWATI KAMARUDDIN SEEMA patel Department of Chemistry University of SwabiAnbar23561Khyber Pakhtunkhwa Pakistan Department of Pharmaceutical Chemistry Faculty of PharmacyUmm Al-Qura UniversityMakkah24211Saudi Arabia State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Chemical Departments Faculty of ScienceNorthern Borders UniversityArar91431Saudi Arabia Department of Pharmacy Southeast UniversityBanani-1213DhakaBangladesh Department of Global Medical Science Wonju College of MedicineYonsei UniversitySeoulSouth Korea Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt Institute of Chemical Sciences University of PeshawarPeshawar25120Pakistan H.E.J.Research Institute of Chemistry International Center for Chemical and Biological SciencesUniversity of KarachiKarachi75270Pakistan University Institute of Diet and Nutritional Sciences Faculty of Allied Health SciencesThe University of LahoreLahore54000Pakistan Department of Medical Microbiology and Immunobiology Faculty of MedicineUniversity of SzegedSzeged6700Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery Faculty of MedicineUniversity of SzegedSzeged6700Hungary Department of Pharmacy Abdul Wali Khan UniversityMardan23200Pakistan Department of Chemistry The University of JordanAmman11942Jordan LCM Laboratory Faculty of SciencesMohamed First UniversityOujda60000Morocco Institution of Health Science of Tahirah Al Baeti Bulukumba South Sulawesi92352Indonesia Bioinformatics and Medical Informatics Research Center San Diego State UniversitySan Diego92182USA

The bioactive triterpenoid 3-oxo-6-β-hydroxy-β-amyrin(1)has been isolated from multiple plant *** this study,chloroform fraction of Pistacia integerrima extract was processed for the isolation of the *** compound identity was confirmed by advanced spectroscopy technique.X-ray crystallography was applied for molecular structure *** addition,compound 1 was screen for its activity on reversal of MDR(multidrug resistance)mediated by P-gp(P-glycoprotein).This was accomplished by using rhodamine123 exclusion on multidrug-resistant human ABCB1 gene transfected mouse T-lymphoma cell *** revealed that MDR reversing effect was comparable to verapamil as positive control in *** of TPA-induced tumor promotion with 3-oxo-6β-hydroxy-β-amyrin led to reduction in the applied anti-tumor promotion *** chemo-preventive effect of 3-oxo-6β-hydroxy-β-amyrin was comparable to curcumin as positive control based on the reduction of immediate early tumor antigen *** docking by applying Autodock Vina 1 and i-GEMDOCK v 2.1 tools indicated that compound 1 gives good docking results,as determined by their fitness score and ***,results showed that compound 1 isolated from Pistacia integerrima precisely attached to a region where co-crystallized ligand for receptor previously *** findings may explain the use of Pistacia integerrima plant extracts as an anticancer agent in folk medicine.

关键词： Pistacia integerrima Anti-tumor properties X-ray crystallography POM Molecular docking

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