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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Two-Dimensional Gap Solitons in Parity-Time Symmetry Moiré Optical Lattices with Rydberg–Rydberg Interaction

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Chinese Physics Letters 2023年第4期40卷 28-33页

作者：黎斌斌赵元徐四六周勤傅其栋叶芳伟花春波陈懋薇胡恒洁周倩倩邱章才 School of Biomedical Engineering and Medical Imaging Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Laboratory of Optoelectronic Information and Intelligent Control Hubei University of Science and TechnologyXianning 437100China School of Electronic and Information Engineering Hubei University of Science and TechnologyXianning 437100China School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China

Realizing single light solitons that are stable in high dimensions is a long-standing goal in research of nonlinear optical ***,we address a scheme to generate stable two-dimensional solitons in a cold Rydberg atomic system with a parity-time(PT) symmetric moiré optical *** uncover the formation,properties,and their dynamics of fundamental and two-pole gap solitons as well as vortical *** PT symmetry,lattice strength,and the degrees of local and nonlocal nonlinearity are tunable and can be used to control *** stability regions of these solitons are evaluated in two numerical ways:linear-stability analysis and time evolutions with *** results provide an insightful understanding of solitons physics in combined versatile platforms of PT-symmetric systems and Rydberg–Rydberg interaction in cold gases.

关键词： Rydberg solitons symmetric

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抗温270℃钻井液聚合物降滤失剂的研制

石油化工 2017年第1期46卷 117-123页

作者：张丽君王旭胡小燕张滨李彬王中华中国石化中原石油工程有限公司钻井工程技术研究院河南濮阳457001

采用水溶液聚合引发体系,合成了抗高温聚合物降滤失剂HR-1。考察了基团比、单体摩尔比、体系p H、总单体用量、交联剂加量、引发剂加量等条件对HR-1性能的影响;并在淡水基浆和水基钻井液中对HR-1的性能进行了评价。采用FTIR,TG,DTG等方... 详细信息

采用水溶液聚合引发体系,合成了抗高温聚合物降滤失剂HR-1。考察了基团比、单体摩尔比、体系p H、总单体用量、交联剂加量、引发剂加量等条件对HR-1性能的影响;并在淡水基浆和水基钻井液中对HR-1的性能进行了评价。采用FTIR,TG,DTG等方法对HR-1进行表征。综合考虑最优合成条件为:基团比为6∶4,单体摩尔比为10∶5,p H>8,总单体用量(w)保持在60%~67%,交联剂加量(w)固定在7.0%~8.5%,引发剂加量(w)为0.3%~0.7%。实验结果表明,HR-1表现出良好的热稳定性和降滤失能力,抗温达270℃,在淡水基浆中HR-1加量为2.0%(w)时,中压滤失量(FL)由46.0 m L降至7.6 m L;抗温270℃钻井液体系高温稳定性好,流变性易于控制,FL小于4.0 m L,高温高压滤失量小于13.0m L。表征结果显示,反应单体发生了接枝共聚反应,并具有较强的热稳定性。

关键词：钻井液聚合物降滤失剂热稳定性滤失量

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化学法制备二氧化锡透明导电膜的研究

山东化工 1998年第1期27卷 14-15,17页

作者：姜斌李斌山东省卫生学校山东省教育学院化学系

本文探讨了化学法制备二氧化锡透明导电膜，这种膜具有透明度高，导电性好等优点，其制备方法简单易行，且效果良好，适合镀制大面积薄膜。

关键词：化学镀导电膜二氧化锡镀膜

潍坊地区人工喷泉中一株军团菌的分子生物学鉴定

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中国病原生物学杂志 2017年第5期12卷 412-415页

作者：杨斌斌李恒管艳伊正君潍坊医学院医学检验学系潍坊医学院医学检验学系纳米医学技术研究所潍坊医学院临床检验诊断学山东省"十二五"高校重点实验室潍坊医学院附属医院山东省临床检验重点专科山东潍坊261053

目的对潍坊地区喷泉水中检测出的1株军团菌进行分子生物学鉴定和系统发育分析,为潍坊市军团菌病的预防和控制提供有益信息。方法于2016年7~9月采集潍坊市不同水源的水样,采用抽滤浓缩法浓缩获得细菌浓缩液,用细菌基因组试剂盒提取浓缩... 详细信息

目的对潍坊地区喷泉水中检测出的1株军团菌进行分子生物学鉴定和系统发育分析,为潍坊市军团菌病的预防和控制提供有益信息。方法于2016年7~9月采集潍坊市不同水源的水样,采用抽滤浓缩法浓缩获得细菌浓缩液,用细菌基因组试剂盒提取浓缩菌液中的总细菌基因组DNA,使用针对军团菌属16SrRNA基因片段的特异性引物PCR特异性扩增军团菌属16SrRNA基因片段并测序,与从GenBank获得的另外31株军团菌的16SrRNA的基因序列进行对比分析,采用MrBayesv3.2软件对16SrRNA基因片段序列数据矩阵进行贝叶斯分析并绘制基因进化树。结果 PCR扩增潍坊市水样军团菌属特异性16SrRNA基因片段(386bp),其中一喷泉水样阳性。测序分析该菌株(命名为WF-S)的16SrRNA基因序列与最新发现的沙特军团菌16SrRNA基因序列的遗传距离较近,相似度达99.4%,在构建的贝叶斯基因进化树中与沙特军团菌以其后验概率0.89聚类为一枝。结论 WF-S为一株沙特军团菌,在潍坊地区首次发现,也是国内首次报道的沙特军团菌。

关键词：军团菌沙特军团菌水环境系统发育学

Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma bin Qi Qingqiang Min Ming li Huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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双级矩阵变换器功率开关开路故障的分析与诊断

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电机与控制学报 2018年第7期22卷 59-68页

作者：邓文浪吴金凤盘宏斌李彬艳唐亚辉严煜坤湘潭大学信息工程学院湖南湘潭411105

针对双级矩阵变换器(TSMC),分别分析了TSMC正常与故障时的运行模式,分析并总结了TSMC在功率开关故障情况下的输出线电压故障特征,在此基础上提出了基于开关组误差电压的TSMC功率开关故障诊断方法,该方法可以根据开关组误差电压锁定故障... 详细信息

针对双级矩阵变换器(TSMC),分别分析了TSMC正常与故障时的运行模式,分析并总结了TSMC在功率开关故障情况下的输出线电压故障特征,在此基础上提出了基于开关组误差电压的TSMC功率开关故障诊断方法,该方法可以根据开关组误差电压锁定故障开关组,并能从故障开关组中准确定位故障开关。该故障诊断方法具有快速、准确、高效等特点。建立了TSMC功率开关故障诊断系统的仿真模型和实验系统,验证了所提故障诊断方法的正确性和可行性。

关键词：双级矩阵变换器功率开关故障输出线电压误差开关组误差电压故障诊断

Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui Fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

长江上游宜宾至江津段周丛藻类群落结构及水质评价

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西南大学学报（自然科学版） 2018年第3期40卷 10-17页

作者：李斌斌李锐谭巧吕红健姚维志西南大学动物科技学院/西南大学渔业资源环境研究中心/水产科学重庆市重点实验室重庆400716

2013年11月至2014年6月,在长江上游宜宾至江津段共采到周丛藻类4门31属82种,硅藻门在种类和数量上均占据优势地位.周丛藻类细胞密度和生物量变幅分别为0.13~13.11×10~5个/cm^2和0.03~7.07 mg/cm^2,总平均值分别为4.23×10~5个/cm^2和1.... 详细信息

2013年11月至2014年6月,在长江上游宜宾至江津段共采到周丛藻类4门31属82种,硅藻门在种类和数量上均占据优势地位.周丛藻类细胞密度和生物量变幅分别为0.13~13.11×10~5个/cm^2和0.03~7.07 mg/cm^2,总平均值分别为4.23×10~5个/cm^2和1.60 mg/cm^2.周丛藻类物种数、细胞密度和生物量均以秋、冬2季最高,夏季最低.从上游到下游,周丛藻类群落结构大体呈现出物种数和多样性指数逐渐减小,而细胞密度和生物量逐渐增加的趋势,水质污染逐渐加重.调查期间周丛藻类的Shannon-Wiener多样性指数、Pielou均匀度指数和Margalef多样性指数的变幅分别为1.57~4.52,0.14~0.50和2.10~3.96.基于周丛藻类多样性指数、污染指数和污染评价值等的水质评价结果大体一致,即长江上游宜宾至江津段水质为β-中污型,且有向α-中污过渡的趋势.

关键词：长江上游周丛藻类群落结构水质评价