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Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling

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World Journal of Diabetes 2024年第2期15卷 287-304页

作者： Huai-Jie Wang li-bin zhang Si-Peng Sun Qing-Tao Yan Zhi-Qin Gao Fang-Ming Fu Mei-Hua Qu Translational Medical Center Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Endocrinology Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Pediatric Surgery Weifang People’s HospitalWeifang 261041Shandong ProvinceChina School of Bioscience and Technology Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Endocrinology Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is often accompanied by impaired glucose utilization in the brain,leading to oxidative stress,neuronal cell injury and *** studies have shown that duodenal jejunal bypass(DJB)surgery significantly improves brain glucose metabolism in T2DM rats,the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in T2DM rats remain *** To investigate the role and metabolism of DJB in improving hypothalamic oxidative stress and inflammation condition in T2DM *** A T2DM rat model was induced via a high-glucose and high-fat diet,combined with a low-dose streptozotocin injection.T2DM rats were divided into DJB operation and Sham operation *** surgical intervention was carried out on T2DM *** differential expression of hypothalamic proteins was analyzed using quantitative proteomics *** related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of T2DM rats were analyzed by flow cytometry,quantitative real-time PCR,Western blotting,and *** Quantitative proteomics analysis showed significant differences in proteins related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of rats with T2DM-DJB after DJB surgery,compared to the T2DM-Sham groups of *** stress-related proteins(glucagon-like peptide 1 receptor,Nrf2,and HO-1)were significantly increased(Plial fibrillary acidic protein and Caspase-3)in the hypothalamus of T2DM rats and upregulated(P<0.05)the expression of neuroprotective factors(C-fos,Ki67,Bcl-2,and BDNF),thereby reducing hypot

关键词： Duodenal jejunal bypass surgery Type 2 diabetes mellitus Neuron apoptosis Inflammatory Oxidative stress Hypothalamic injury

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Emitter-couple logic circuit design based on the threshold-arithmetic algebraic system

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第10期14卷 808-814页

作者： Mao-qun YAO li-bin zhang Hangzhou Institute Service Engineering Hangzhou Normal University School of Information Science and Engineering Hangzhou Normal University

Based on the threshold-arithmetic algebraic system which has been proposed for current-mode circuit design,we propose a systematic methodology for emitter-couple logic(ECL)circuit *** to the traditional methodologies and the theory of differential current switches,the proposed methodology uses the HE map and the characteristics of the internal current signals of ECL circuits to determine the external voltage *** operations of the HE map are direct and simple,and the current signals are easy to add or subtract,which make this methodology more flexible,direct,and effective,and make it possible to design arbitrary binary and multi-valued logic *** example circuits are designed and simulated by HSPICE using 0.18μm TSMC *** results confirm the validity of the proposed methodology.

关键词： Threshold-arithmetic algebraic system HE map ECL circuit Current-mode circuits

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Joint and supremum distributions in the compound binomial model with Markovian environment

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Applied Mathematics(A Journal of Chinese Universities) 2011年第3期26卷 265-279页

作者： YU Yi-bin zhang li-xin zhang Yi Department of Mathematics Zhejiang University Hangzhou 310027 China.

In this paper, we study the compound binomial model in Markovian environment, which is proposed by Cossette, et al. （2003）. We obtain the recursive formula of the joint distributions of T, X（T - 1） and ｜X（T）｜（i.e., the time of ruin, the surplus before ruin and the deficit at ruin） by the method of mass function of up-crossing zero points, as given by liu and Zhao （2007）. By using the same method, the recursive formula of supremum distribution is obtained. An example is included to illustrate the results of the model.

关键词： Compound binomial model Markovian environment joint distribution mass function recursive formula supremum distribution.

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Two-phase sink vortex suction mechanism and penetration dynamic characteristics in ladle teeming process

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Journal of Iron and Steel Research International 2017年第7期24卷 669-677页

作者： Da-peng Tan Ye-sha Ni li-bin zhang Key Laboratory of E & M Ministry of Education & Zhejiang ProvinceZhejiang University of Technology

At the late stage of continuous casting（CC）ladle teeming,sink vortex can suck the liquid slag into tundish,and cause negative influences on the cleanliness of molten *** address this issue,a twophase fluid mechanical modeling method for ladle teeming was ***,a dynamic model for vortex suction process was built,and the profiles of vortex flow field were ***,based on the level set method（LSM）,a two-phase 3Dinterface coupling model for slag entrapment was ***,in combination with high-order essentially non-oscillatory（ENO）and total variation diminishing（TVD）methods,a LSM-based numerical solution method was proposed to obtain the 3Dcoupling evolution regularities in vortex suction *** results show that the vortex with higher kinetic energy can form an expanded sandglass-shape region with larger slag fraction and lower rotating velocity;there is a pressure oscillation phenomenon at the vortex penetration state,which is caused by the energy shock of two-phase vortex penetration coupling.

关键词： Ladle teeming Sink vortex Suction mechanism Two-phase coupling Level set method Pressure oscillation

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Electroless deposition of Ni on template of halloysite and its magnetic property

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中国有色金属学会会刊：英文版 2004年第z1期14卷 152-156页

作者： FU Yu-bin zhang li-de ZHENG Ji-yong Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China Luoyang Ship Material Research Institute Luoyang 471039 China Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China Luoyang Ship Material Research Institute Luoyang 471039 China

Halloysite template, a ceramic substrate, is of a hollow cylindric structure, on which the fine Pd nanoparticles are uniformly formed by the reduction of palldate chloride to initiate electroless deposition. The electroless deposition of Ni is catalyzed by the Pd particles, which results in a uniform layer of Ni-P alloy on halloysite. The alloy is of a nanocrystalline structure, of which the average diameter is about 6 nm. After being heat-treated at 400 ℃, it contains both Ni and Ni12P5 crystal, meanwhile, the Ni crystal gets larger with an average size of 51.9 *** content of phosphorous in the Ni layer has a great influence on crystal structure. The metallized halloysite has a higher inherent coercive force, and a much lower saturation magnetization in its as-plated state, while after heattreatment, the inherent coercive force decreases drastically. These magnetic properties have great relationship with the superparamagnetism of Ni nanocrystalline and the stress anisotropy in Ni layer.

关键词： halloysite template electroless deposition Ni nanocrystalline inherent coercive force

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Ventromedial Thalamus-Projecting DCN Neurons Modulate Associative Sensorimotor Responses in Mice

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Neuroscience Bulletin 2022年第5期38卷 459-473页

作者： Jie zhang Hao Chen li-bin zhang Rong-Rong li bin Wang Qian-Hui zhang liu-Xia Tong Wei-Wei zhang Zhong-Xiang Yao Bo Hu Department of Physiology College of Basic Medical SciencesArmy Medical UniversityChongqing 400038China Experimental Center of Basic Medicine College of Basic Medical SciencesArmy Medical UniversityChongqing 400038China 3948th Hospital of PLA Wusu 833300China College of Basic Medical Sciences Army Medical UniversitySquadron 15Battalion 5Chongqing 400038China Department of Foreign Language College of Basic Medical SciencesArmy Medical UniversityChongqing 400038China Brain and Intelligence Research Key Laboratory of Chongqing Education Commission Army Medical UniversityChongqing 400038China

The deep cerebellar nuclei(DCN)integrate various inputs to the cerebellum and form the final cerebellar outputs critical for associative sensorimotor ***,the functional relevance of distinct neuronal subpopulations within the DCN remains poorly ***,we examined a subpopulation of mouse DCN neurons whose axons specifically project to the ventromedial(Vm)thalamus(DCNVm neurons),and found that these neurons represent a specific subset of DCN units whose activity varies with trace eyeblink conditioning(tEBC),a classical associative sensorimotor learning *** conditioning,the activity of DCNVm neurons signaled the performance of conditioned eyeblink responses(CRs).Optogenetic activation and inhibition of the DCNVm neurons in well-trained mice amplified and diminished the CRs,*** manipulation of the DCNVm neurons had no effects on non-associative motor ***,optogenetic activation of the DCNVm neurons caused rapid elevated firing activity in the cingulate cortex,a brain area critical for bridging the time gap between sensory stimuli and motor execution during ***,our data highlights DCNVm neurons’function and delineates their kinematic parameters that modulate the strength of associative sensorimotor responses.

关键词： Deep cerebellar nuclei Ventromedial thalamus Trace eyeblink conditioning Sensorimotor learning

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Preparation of Uniform Ni-B Amorphous Alloy Catalyst on CNTs and its Performance for Acetylene Selective Hydrogenation

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Chinese Chemical Letters 2006年第1期17卷 109-112页

作者： Chang Yuan HU Feng Yi li Rong bin zhang li HUA Department of Chemistry Nanchang University Nanchang 330047

Uniform Ni-B amorphous alloys about 14 nm have been prepared on CNTs-A support,named Ni-B/CNTs-A. In comparison with the Ni-B/CNTs amorphous catalyst, Ni-B/CNTs-A showed higher nickel loading, determined by ICP and be... 详细信息

关键词： CNTs aniline Ni-B amorphous alloy catalyst acetylene selective hydrogenation.

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Effects of W and Mo Additions on Wet-dry Acid Corrosion Behavior of Low-Alloy Steels Under Different O_2 Concentrations

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Acta Metallurgica Sinica(English Letters) 2016年第10期29卷 951-962页

作者： Qing-He Zhao Wei liu Shuan-Zhu li bin-li zhang Yi-Chun Zhu Min-Xu Lu Corrosion and Protection Center Institute for Advanced Materials and Technology University of Science and Technology Beijing

Effects of W and Mo additions on wet-dry acid corrosion behavior of low-alloy steels under different O2 concentrations were investigated. The results showed that W and Mo-containing steels presented excellent wet-dry cor- rosion resistance under O2 concentrations of both 1 and 5%. The roles of W and Mo played in increasing corrosion resistance of the steels were different. W could improve the thermodynamic stability of the steel substrate, while Mo could promote the formation of protective rust. Interaction between W, Mo and O2 concentration greatly influenced wet-dry acid corrosion of low-alloy steels. W addition was more effective for depressing charge transfer process at the rust/substrate interface and presented higher enhanced effect on increasing corrosion resistance than Mo under O2 concentration of 1%. Mo was more effective on increasing rust compactness and showed higher enhanced effect on increasing corrosion resistance than W under O2 concentration of 5%.

关键词： Wet-dry acid corrosion Steel Corrosion resistance Electrochemical impedance spectroscopy(EIS) Rust

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Effect of Small Content of Chromium on Wet–Dry Acid Corrosion Behavior of Low Alloy Steel

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Acta Metallurgica Sinica(English Letters) 2017年第2期30卷 164-175页

作者： Qing-He Zhao Wei liu Yi-Chun Zhu bin-li zhang Shuan-Zhu li Min-Xu Lu Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China

Effect of small content of chromium（Cr） on wet–dry acid corrosion behavior of low alloy steels has been *** results show that the corrosion resistance of the steels increased with increasing Cr content from 0.10 to0.50 wt%.Higher content of Cr promotes initial corrosion and accelerates the formation of dense and protective rust in long-term *** enhanced protectiveness of the rust is closely related to its *** content of Cr increases the content of amorphous phases and decreases the content of c-Fe OOH in the rust,resulting in the high compactness of the rust and low electrochemical activity in acid *** dopes in rust and depresses the transformation from amorphous phases to a-Fe OOH,as well as the growth process of Fe OOH particles,which is responsible for the enhanced compactness of rust in long-term corrosion.

关键词： Low alloy steel Chromium Corrosion EIS TEM

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Photosynthetic response dynamics in the invasive species Tithonia diversifolia and two co-occurring native shrub species under fluctuating light conditions

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Plant Diversity 2024年第2期46卷 265-273页

作者： Ju li Shu-bin zhang Yang-Ping li CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMengla 666303YunnanChina University of Chinese Academy of Sciences Beijing 100049China

To determine the invasiveness of invasive plants,many studies have compared photosynthetic traits or strategies between invasive and native ***,few studies have compared the photosynthetic dynamics between invasive and native species during light *** compared photosynthetic induction,relaxation dynamics and leaf traits between the invasive species,Tithonia diversifolia and two native species,Clerodendrum bungei and Blumea balsamifera,in full-sun and shady *** photosynthetic dynamics and leaf traits differed among *** showed a slower induction speed and stomatal opening response but had higher average intrinsic water-use efficiency than the two native species in full-sun ***,the slow induction response may be attributed to the longer stomatal length in *** had a significant effect on photosynthetic dynamics in *** and *** but not in *** shady habitat,*** had a faster photosynthetic induction response than in full-sun habitat,leading to a higher average stomatal conductance during photosynthetic induction in *** than in the two native *** contrast,*** had a larger stomatal length and slower photosynthetic induction and relaxation response in shady habitat than in full-sun habitat,resulting in higher carbon gain during photosynthetic ***,in both habitats,*** had an overall higher carbon gain during light fluctuations than the two native *** results indicated that *** can adopt more effective response strategies under fluctuating light environments to maximize carbon gain,which may contribute to its successful invasion.

关键词： Invasive plant Photosynthetic induction Photosynthetic relaxation Carbon gain Stomatal traits Tithonia diversifolia

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