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Effect of diagenetic variation on the static and dynamic mechanical behavior of coral reef limestone

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International Journal of Mining Science and Technology 2024年第7期34卷 893-908页

作者： Linjian Ma Jiajun Deng Mingyang Wang Jianping Wang bin fang Jiawen Wu State Key Laboratory of Explosion&Impact and Disaster Prevention&Mitigation Army Engineering University of PLANanjing 210007China Naval Research Institute Beijing 100070China

Coral reef limestone at different depositional depths and facies differ remarkably on the textural and mineralogical characteristics,owing to the complex sedimentary *** explore the effects of pore structure and mineral composition associated with diagenetic variation on the mechanical behavior of reef limestone,a series of quasi-static and dynamic compression tests along with microscopic examinations were performed on the reef limestone at shallow and deep burial *** is revealed that the shallow reef limestone(SRL)is classified as a porous aragonite-type carbonate rock with high porosity(55.3±3.2)%and pore *** comparison,the deep reef limestone(DRL)is mainly composed of dense calcite-type calcium carbonate with low porosity(4.9±1.6)%and pore *** DRL strengthened and stiffened by the tight grain framework consistently displays much higher values of the dynamic compressive strength,elastic modulus,brittleness index,and specific energy absorption than those of the *** gap between two types of limestone further increases with an increase in strain *** appears that the failure pattern of SRL is dominated by the inherent defects like weak bonding interfaces and growth lines,revealed by the intricate fracturing network and mixed ***,although the preexisting megapores in DRL may affect the crack propagation on pore tips to a certain distance,it hardly alters the axial splitting failure of DRL under *** stress wave propagation and attenuation in SRL is primarily controlled by the reflection and diffusion caused by plenty mesopores,as well as an energy dissipation in layer-wise pore collapse and adjacent grain crushing,while the stress wave in DRL is highly hinged on the insulation and diffraction induced by the isolated *** process is accompanied by the energy dissipation behavior of inelastic deformation resulted from the pore-emanated microcracking.

关键词： Reef limestone Dynamic behavior Mineral composition Pore structure Wave propagation Energy dissipation

Enhancing the Goos-Hänchen shift based on quasi-bound states in the continuum through material asymmetric dielectric compound gratings

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Chinese Physics B 2024年第3期33卷 393-400页

作者：江孝伟方彬占春连 College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China College of Information Engineering Quzhou College of TechnologyQuzhou 324000China

Quasi-bound state in the continuum(QBIC)resonance is gradually attracting attention and being applied in Goos-Hänchen(GH)shift enhancement due to its high quality(Q)factor and superior optical ***,symmetry-protected QBIC resonance is often achieved by breaking the geometric symmetry,but few cases are achieved by breaking the material *** paper proposes a dielectric compound grating to achieve a high Q factor and high-reflection symmetry-protectede QBIC resonance based on material *** calculations show that the symmetry-protected QBIC resonance achieved by material asymmetry can significantly increase the GH shift up to-980 times the resonance wavelength,and the maximum GH shift is located at the reflection peak with unity *** paper provides a theoretical basis for designing and fabricating high-performance GH shift tunable metasurfaces/dielectric gratings in the future.

关键词： bound state in the continuum Goos-Hänchen shift dielectric compound grating material asymmetry

Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10/JAK1/STAT3 pathway

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2296-2307页

作者： Shan-Shan Xie Yong Zhi Chang-Ming Shao bin-fang Zeng Department of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830017Xinjiang Uygur Autonomous RegionChina

BACKGROUND The Chinese medicine Yangyin Huowei mixture(YYHWM)exhibits good clinical efficacy in the treatment of chronic atrophic gastritis(CAG),but the mechanisms underlying its activity remain *** To investigate the therapeutic effects of YYHWM and its underlying mechanisms in a CAG rat *** Sprague-Dawley rats were allocated into control,model,vitacoenzyme,and low,medium,and high-dose YYHWM *** was induced in rats using Nmethyl-N′-nitro-N-nitrosoguanidine,ranitidine hydrochloride,hunger and satiety perturbation,and ethanol *** an 8-wk intervention period,stomach samples were taken,stained,and examined for histopathological *** was utilized to quantify serum levels of PG-I,PG-II,G-17,IL-1β,IL-6,and TNF-α.Western blot analysis was performed to evaluate protein expression of IL-10,JAK1,and *** The model group showed gastric mucosal layer disruption and inflammatory cell *** with the blank control group,serum levels of PGI,PGII,and G-17 in the model group were significantly reduced(82.41±3.53 vs 38.52±1.71,23.06±0.96 vs 11.06±0.70,and 493.09±12.17 vs 225.52±17.44,P<0.01 for all),whereas those of IL-1β,IL-6,and TNF-αwere significantly increased(30.15±3.07 vs 80.98±4.47,69.05±12.72 vs 110.85±6.68,and 209.24±11.62 vs 313.37±36.77,P<0.01 for all),and the protein levels of IL-10,JAK1,and STAT3 were higher in gastric mucosal tissues(0.47±0.10 vs 1.11±0.09,0.49±0.05 vs 0.99±0.07,and 0.24±0.05 vs 1.04±0.14,P<0.01 for all).Compared with the model group,high-dose YYHWM treatment significantly improved the gastric mucosal tissue damage,increased the levels of PGI,PGII,and G-17(38.52±1.71 vs 50.41±3.53,11.06±0.70 vs 15.33±1.24,and 225.52±17.44 vs 329.22±29.11,P<0.01 for all),decreased the levels of IL-1β,IL-6,and TNF-α(80.98±4.47 vs 61.56±4.02,110.85±6.68 vs 89.20±8.48,and 313.37±36.77 vs 267.30±9.31,P<0.01 for all),and evidently decreased the protein levels of IL-10 and STAT3 in gastric mucosal tissues(1

关键词： Yangyin Huowei mixture IL-10/JAK1/STAT3 pathway Chronic atrophic gastritis Inflammatory factor Gastric secretory function

A mitochondria-targeted H_(2)S-activatable fluorogenic probe for tracking hepatic ischemia-reperfusion injury

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Chinese Chemical Letters 2024年第6期35卷 370-375页

作者： bin fang Jiaqi Yang Limin Wang Haoqin Li Jiaying Guo Jiaxin Zhang Qingyuan Guo Bo Peng Kedi Liu Miaomiao Xi Hua Bai Li Fu Lin Li School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility Huazhong University of Science and TechnologyWuhan 430074China TANK Medicinal Biology Institute of Xi’an Xi’an 710032China

Hepatic ischemia-reperfusion injury(HIRI)is the cause of postoperative hepatic dysfunction and failure,and even *** an important biological effector molecule,hydrogen sulfide(H_(2)S)of mitochondria as a gasotransmitter that is usually used to protect against acute HIRI ***,the exact relationship between HIRI and mitochondrial H_(2)S remains tangled due to the lack of an effective analytical ***,we have fabricated a mitochondria-targeted H_(2)S-activatable fluorogenic probe(Mito-GW)to explore the stability of mitochondrial H_(2)S and track the changes of mitochondrial H_(2)S during the *** virtue of pyridinium electropositivity and its amphiphilicity,Mito-GW could accumulate in *** goes through an analyte-prompted immolation when reacts with H_(2)S,resulting in the releasing of the fluorophore(GW).Therefore,the extent of Mito-GW conversion to GW can be used to evaluate the changes of mitochondrial H_(2)S level in living cells and *** proof-of-principle,we have used MitoGW to demonstrate the mitochondria H_(2)S-levels increase and then decrease during HIRI in vitro and in *** research highlights the tremendous potential of Mito-GW as a mitochondrial H_(2)S fluorogenic probe in elucidating the pathogenesis of HIRI,providing a powerful tool for promoting future research on hepatology.

关键词： Mitochondria-targeted Bioimaging H2S-activatable Fluorogenic probe Hepatic ischemia-reperfusion injury(HIRI)

Deciphering the role of mtHOin hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2024年

作者： bin fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding PanPan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies)Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mt H2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu fangxia Xu Chengcheng Zhou Kaimei Lu bin fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

国外侦查询问中增强证人回忆技术的发展及启示

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公安学研究 2024年第1期7卷 1-19,123页

作者：方斌河南警察学院侦查系郑州450046

回忆是侦查询问的一个基本环节。高质量的侦查乃至诉讼活动均离不开证人对案件事实准确、全面的回忆。然而,侦查人员必须面对的一个现实是:人类的记忆具有脆弱性。尽管自由回忆有利于提升证人对案件事实陈述的准确性,但是仅凭证人个人... 详细信息

回忆是侦查询问的一个基本环节。高质量的侦查乃至诉讼活动均离不开证人对案件事实准确、全面的回忆。然而,侦查人员必须面对的一个现实是:人类的记忆具有脆弱性。尽管自由回忆有利于提升证人对案件事实陈述的准确性,但是仅凭证人个人努力所回忆的信息,无法满足侦查需要。在协助证人回忆的过程中,如何巧妙给出记忆提取线索以增强记忆且避免信息污染,是提升侦查人员询问技巧的一大挑战。尽管认知询问的相关组件能够满足证人记忆“无损”增强的原则,但是,随着时间的推移,其在实践应用中的局限性也日益凸显。近年来,国外相关文献中涌现了大量关于增强证人回忆技术的前沿成果,包括模型陈述、时间线、自我管理访谈、类别聚类以及画图等。这些新技术不仅是对认知询问技术的继承、发展和有益的补充,而且还丰富和扩展了增强证人回忆技术在侦查询问中的应用场景。为此,本文总结并梳理国外在增强证人回忆方面的前沿研究成果。适当借鉴这些成果有助于丰富和完善我国侦查询问的基本理论,提升实务部门的侦查询问水平。

关键词：侦查询问记忆认知询问模型陈述时间线自我管理访谈

Gigahertz-rate-switchable wavefront shaping through integration of metasurfaces with photonic integrated circuit

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Advanced Photonics 2024年第1期6卷 106-114页

作者： Haozong Zhong Yong Zheng Jiacheng Sun Zhizhang Wang Rongbo Wu Ling-en Zhang Youting Liang Qinyi Hua Minghao Ning Jitao Ji bin fang Lin Li Tao Li Ya Cheng Shining Zhu East China Normal University School of Physics and Electronic ScienceState Key Laboratory of Precision SpectroscopyShanghaiChina Nanjing University College of Engineering and Applied SciencesNational Laboratory of Solid State MicrostructuresNanjingChina China Jiliang University College of Optical and Electronic TechnologyHangzhouChina Shanxi University Collaborative Innovation Center of Extreme OpticsTaiyuanChina Chinese Academy of Sciences(CAS) Shanghai Institute of Optics and Fine Mechanics(SIOM)State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-Intense Laser ScienceShanghaiChina

Achieving spatiotemporal control of light at high speeds presents immense possibilities for various applications in communication,computation,metrology,and *** integration of subwavelength metasurfaces and optical waveguides offers a promising approach to manipulate light across multiple degrees of freedom at high speed in compact photonic integrated circuit(PIC)***,we demonstrate a gigahertz-rate-switchable wavefront shaping by integrating metasurface,lithium niobate on insulator photonic waveguides,and electrodes within a PIC *** proofs of concept,we showcase the generation of a focus beam with reconfigurable arbitrary polarizations,switchable focusing with lateral focal positions and focal length,orbital angular momentum light beams as well as Bessel *** measurements indicate modulation speeds of up to the gigahertz *** integrated platform offers a versatile and efficient means of controlling the light field at high speed within a compact system,paving the way for potential applications in optical communication,computation,sensing,and imaging.

关键词： metasurface photonic integrated circuit lithium niobate on insulator high-speed modulation

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自动化渗透测试技术研究综述

软件学报 2024年第5期35卷 2268-2288页

作者：陈可鲁辉方滨兴孙彦斌苏申田志宏广州大学网络空间安全学院广东广州510555

渗透测试是发现重要网络信息系统弱点并进而保护网络安全的重要手段.传统的渗透测试深度依赖人工,并且对测试人员的技术要求很高,从而限制了普及的深度和广度.自动化渗透测试通过将人工智能技术引入渗透测试全过程,在极大地解决对人工... 详细信息

渗透测试是发现重要网络信息系统弱点并进而保护网络安全的重要手段.传统的渗透测试深度依赖人工,并且对测试人员的技术要求很高,从而限制了普及的深度和广度.自动化渗透测试通过将人工智能技术引入渗透测试全过程,在极大地解决对人工的重度依赖基础上降低了渗透测试技术门槛.自动化渗透测试主要可分为基于模型和基于规则的自动渗透测试.二者的研究各有侧重,前者是指利用模型算法模拟黑客攻击,研究重点是攻击场景感知和攻击决策模型;后者则聚焦于攻击规则和攻击场景如何高效适配等方面.主要从攻击场景建模、渗透测试建模和决策推理模型等3个环节深入分析相关自动化渗透测试实现原理,最后从攻防对抗、漏洞组合利用等维度探讨自动化渗透的未来发展方向.

关键词：自动化渗透测试攻击图强化学习 BDI-Agent