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Wall Imaging for Unilateral Intracranial Vertebral Artery Hypoplasia with Three-dimensional High-isotropic Resolution Magnetic Resonance Images

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Chinese Medical Journal 2015年第12期128卷 1601-1606页

作者： Xian-Jin Zhu Wu Wang bin du Lei Liu Xin-Xin He Li-bin Hu Xue-bin Zhang Zun-Jing Liu Wei-Jian Jiang Department of Radiology China-Japan Friendship Hospital Beijing 100029 China New Era Stroke Care and Research Institute The Second Artillery General Hospital of PLA Beijing 100088 China Department of Neurology China-Japan Friendship Hospital Beijing 100029 China International Medicine Center China-Japan Friendship Hospital Beijing 100029 China

Background：There are few studies for evaluating wall characteristics of intracranial vertebral artery hypoplasia （VAH）.The aim of this study was to determine wall characteristics of VAH with three-dimensional volumetric isotropic turbo spin echo acquisition （3D VISTA） images and differentiate between acquired atherosclerotic stenosis and ***：Thirty patients with suspicious VAH by luminograms were retrospectively enrolled between January 2014 and February *** patients were classified as ＂acquired atherosclerotic stenosis＂ or ＂VAH＂ based on 3D VISTA *** wall characteristics of VAH were assessed to determine the presence of atherosclerotic lesions,and the patients were classified into two subgroups （VAH with atherosclerosis and VAH with normal wall）.Wall characteristics of basilar arteries and vertebral arteries were also *** clinical and wall characteristics were compared between the two ***：Five of 30 patients with suspicious VAH were finally diagnosed as acquired atherosclerotic stenosis by 3D VISTA images.25 patients were finally diagnosed as VAH including 16 （64.00%） patients with atherosclerosis and 9 （36.00%） patients with normal *** the 16 patients with atherosclerosis,plaque was found in 9 patients,slight wall thickening in 6 patients,and thrombus and wall thickening in 1 *** with VAH patients with normal wall,VAH patients with atherosclerosis showed atherosclerotic basilar arteries and dominant vertebral arteries more frequently （P =0.000）.Conclusions：Three-dimensional VISTA images enable differentiation between the acquired atherosclerotic stenosis and *** was also prone to atherosclerotic processes.

关键词： Atherosclerosis High Resolution Magnetic Resonance Images Vertebral Artery Hypoplasia

Eu-MOF-Based Fluorescent Ratiometric Sensor by Detecting 3,4,5-Trihydroxybenzoic for Fingerprint Visualization on Porous Objects

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Photonic Sensors 2024年第1期14卷 85-98页

作者： Muwen LIANG Yabin ZHAO Yaping LUO bin du Wei HU bing LIU Xihui MU Zhaoyang TONG Department of Investigation People's Public Security University of ChinaBejing 100038China State Key Laboratory of NBC Protection for Civilian Beijing 102205China

Latent fingerprints(LFPs)at the crime scene are served as important clues to locate the trajectory of criminal behavior and portray the characteristics of the ***,visualizing LFPs is of considerable *** this work,the europium metal-organic framework(Eu-MOF)sensor was successfully constructed for sensitive detection of gallic acid(3,4,5-trihydroxybenzoic acid,GA)and visualization of the sweat *** boric-acid-modified Eu-MOF was prepared by using the simple one-pot solvothermal method using Eu as the metal i ion center and 3,5-dicarboxybenzeneboronic acid(BBDC)as the organic *** sensor showed desirable photoluminescent performance through the chelating of BBDC with Eu3+.The sensor exhibited the satisfactory linear relationship to GA in the range of 1 nM to 20 nM with a low detection limit of 0.34 nM under the optimized *** prepared sensor with ideal selectivity to GA was successfully applied for visualizing LFPs on porous substrates with the high contrast and superior *** the good performance of the sensor,all fingerprint images obtained from 1200 samples presented clear friction ridges and met the identification ***,the sensor had less impact on the subsequent deoxyribonucleic acid(DNA)detection,displaying a promising perspective for applications in extracting physical evidence of site investigation.

关键词： Europium metal-organic framework(Eu-MOF) photoluminescence 3,4,5-trihydroxybenzoic latent fingerprints(LFPs)development

Extract of ginkgo biloba EGb761 inhibits cell apoptosis following spinal cord injury

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Neural Regeneration Research 2010年第22期5卷 1745-1749页

作者： Jiejun Jiao Jiannong Jiang bin du Yuan Mo Ming Zhou Hongquan Zhang Department of Orthopedics Yixing People's Hospital Affiliated to Jiangsu University Yixing 214200 Jiangsu Province China Institute of Pharmaceutics Yangzhou University Yangzhou 225001 Jiangsu Province China

The neuroprotective effects of ginkgo biloba extract have been shown in rats following spinal cord injury （SCI）. However, the precise protective mechanisms remain unclear. In the present study, low-acid water-soluble extract of ginkgo biloba EGb761 was used to treat rats with SCI. Xanthin oxidase, thiobarbituric acid, terminal deoxyribonucleotidyl transferase-mediated duTP-digoxigenin nick end labeling assay, and immunohistochemistry were utilized to detect lipid peroxidation, neural cell apoptosis, and inducible nitric oxide synthase activity in rats with SCI. Results revealed significantly increased superoxide dismutase activity, decreased malondialdehyde content, apoptotic index, and inducible nitric oxide synthase expression in SCI rats following EGb761 treatment. Therefore, EGb761 suppressed lipid peroxidation following SCI, relieved neural cell apoptosis, inhibited inducible nitric oxide synthase expression, and ultimately exerted protective effects on SCI.

关键词： ginkgo biloba spinal cord injury superoxide dismutase apoptosis nitric oxide synthase traditional Chinese medicine neural regeneration

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太阳能平板降膜再生过程的数值模拟

东南大学学报（自然科学版） 2005年第6期35卷 903-906页

作者：杜斌施明恒东南大学动力工程系南京210096

针对太阳能平板集热型再生器中辐射传热和对流传热边界条件,建立了传热传质过程的数学模型,对采用氯化钙溶液的再生过程进行了数值模拟分析,对影响再生过程的各种主要因素做了较详尽的分析.模拟结果表明,较低的溶液入口质量分数和空气... 详细信息

针对太阳能平板集热型再生器中辐射传热和对流传热边界条件,建立了传热传质过程的数学模型,对采用氯化钙溶液的再生过程进行了数值模拟分析,对影响再生过程的各种主要因素做了较详尽的分析.模拟结果表明,较低的溶液入口质量分数和空气入口含湿量以及较高的溶液入口温度能够增大溶液表面和空气间的水蒸气压力差;而增大空气流动Re数和空气/溶液质量流量比可以提高空气、溶液间水分传质系数.采用这些措施都能够得到更好的再生效果.

关键词：降膜再生边界条件传热传质数值分析

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基于多维递阶熵的元胜任力模型实证

北京航空航天大学学报 2010年第6期36卷 700-703,731页

作者：李军锋杜宾北京航空航天大学人事处北京100191 江西财经大学信息管理学院南昌330013

为了提升人力资源效用,减少用人风险,测评个体胜任力,针对七维度的元胜任力模型,提出了多维递阶熵决策模型.首先分析元胜任力性质呈现动态渐变的特征,进行信度和效度检验,然后通过层次分解和维数递进的方式,运用熵模型集结元胜任力的多... 详细信息

为了提升人力资源效用,减少用人风险,测评个体胜任力,针对七维度的元胜任力模型,提出了多维递阶熵决策模型.首先分析元胜任力性质呈现动态渐变的特征,进行信度和效度检验,然后通过层次分解和维数递进的方式,运用熵模型集结元胜任力的多个维度:概念能力、创造力、学习能力、反省能力、情绪能力、沟通能力、解决问题能力,获得综合测评值.最后,人力资源案例的实证研究表明,基于递阶熵计算元胜任力值,验证了元胜任力模型在实际工作中具有有效性和可行性,为提升人力资源效用提供了科学依据.

关键词：递阶熵元胜任力测评多维度

Prevalence and risk factors of enteral nutrition intolerance in intensive care unit patients: a retrospective study

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Chinese Medical Journal 2022年第15期135卷 1814-1820页

作者： Kunrong Yu Na Guo Dingding Zhang Ying Xia Yanling Meng Li Weng bin du Department of Pulmonary and Critical Care Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBejing 100730China Department of Nursing State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CllegeBejing 100730China Department of Medical Intensive Care Unit State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBejing 100730China

Background: Feeding intolerance (FI) among intensive care unit (ICU) patients undergoing early continuous enteral nutrition (EN) is related to poor outcomes. This study aimed to explore the prevalence and risk factors of FI in ICU ***: We retrospectively enrolled 1057 patients who received early continuous EN via a nasogastric tube between January 2014 and August 2019. The prevalence of FI during the first 7 days of ICU stay was calculated, and the risk factors were investigated using multivariate logistic regression ***: The prevalence of FI during the first 7 days of ICU stay was 10.95%. FI occurred in 159 of 1057 (15.04%) patients on ICU day 2, 114 of 977 (11.67%) patients on ICU day 3, and 86 of 715 (12.03%) patients on ICU day 7. Mechanical ventilation (MV) (odds ratio [OR]: 1.928, 95% confidence interval [CI]: 1.064–3.493,P = 0.03) was an independent risk factor for FI defined by a gastric residual volume (GRV) of 200 mL and/or vomiting, and acute renal failure (OR: 3.445, 95% CI: 1.115–10.707,P = 0.032) was an independent risk factor of FI defined by a GRV of 500 mL and/or vomiting. Continuous renal replacement therapy (CRRT) was an independent predictor regardless of the FI defined by a GRV of 200 mL (OR: 2.064, 95% CI: 1.233–3.456,P = 0.006) or 500 mL (OR: 6.199, 95% CI: 2.108–18.228,P = 0.001) in the ICU ***: FI occurs frequently in early ICU days, especially in patients receiving MV and CRRT. However, further investigation of a consensus definition of FI and risk factors is still warranted in future studies.

关键词： Continuous enteral nutrition Feeding intolerance Intensive care unit Risk factor Continuous renal replacement therapy

Notoginsenoside R1 attenuates breast cancer progression by targeting CCND2 and YBX3

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Chinese Medical Journal 2021年第5期134卷 546-554页

作者： Hai-Long Qin Xue-Jun Wang Bi-Xian Yang bin du Xue-Lin Yun College of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyangGuizhou 550000China College of Food and Pharmacy Engineering Guiyang UniversityGuiyangGuizhou 550000China

Background:Breast cancer(BC)is a common malignancy with highly female *** far the function of notoginsenoside R1(NGR1),the extract from Panax notoginseng,has not been clearly elucidated in ***:Optimal culture concentration and time of NGR1 were investigated by cell counting kit-8 *** proliferation ability was measured by colony formation *** assay was used to detect the effect of NGR1 on cell migration and *** apoptosis rate of cells between each group was measured by TUNEL ***:NGR1 treatment has an inhibitory efect on proliferation,migration,invasion,and angiogenesis and a stimulating effect on cell cycle arrest and apoptosis of Michigan Cancer Foundation-7(MCF-7)*** 50%growth inhibitory concentration for MCF-7 cells at 24 h was 148.9 mmol/*** proportions of MCF-7 cells arrested in the G0/G1 phase were 36.94+6.78%,45.06士5.60%,and 59.46+5.60%in the control group,75,and 150 mmol/L groups,***,we revealed that NGR1 treatment attenuates BC progression by targeted downregulating CCND2 and YBX3 ***,YBX3 activates phosphatidylinositol 3-phosphate kinase(PI3K)/protein kinase B(Akt)signaling pathway by activating kirsten rat sarcoma viral oncogene,which is an activator of the PI3K/Akt signaling ***:These results suggest that NGR1 can act as an efficacious drug candidate that targets the YBX3/PI3K/Akt axis in patients with BC.

关键词： Breast cancer Notoginsenoside Rl CCND2 YBX3

一株黄瓜枯萎病拮抗菌的鉴定及发酵培养基的优化

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北方园艺 2017年第3期 132-137页

作者：杜宾太原学院园艺系山西太原030012

采用形态观察和生理生化特性检测方法,结合16SrRNA基因序列分析,将一株黄瓜枯萎病拮抗菌株KC24鉴定为类芽孢杆菌,并对其进行了抑菌谱测试。结果表明:KC24能拮抗多种植物病原菌,具有广谱抗菌活性,利用响应面法对其产芽孢发酵培养基进行... 详细信息

采用形态观察和生理生化特性检测方法,结合16SrRNA基因序列分析,将一株黄瓜枯萎病拮抗菌株KC24鉴定为类芽孢杆菌,并对其进行了抑菌谱测试。结果表明:KC24能拮抗多种植物病原菌,具有广谱抗菌活性,利用响应面法对其产芽孢发酵培养基进行了优化,优化后的发酵液中芽孢数量达13.5×108 cfu·mL^(-1),比优化前提高了107.7%。最优产孢培养基配方为玉米粉20g,豆粕5g,KNO_32.0g,KH_2PO_4 2.59g,NaCl 1.0g,(NH_4)_2SO_4 2.04g,Fe_SO_40.009 1g,MgSO_4·7H_2O 1g,H_2O 1L,pH 7.0。

关键词：黄瓜枯萎病类芽孢杆菌响应面芽孢

文旅融合背景下文化遗产资源推动旅游空间建设的思考

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文化遗产 2021年第2期 32-41页

作者：杜彬云南师范大学地理学部云南省文化和旅游厅非物质文化遗产处云南昆明650500

文化空间作为象征性空间是生活空间在精神文化层面的延伸。文化符号是文化内涵的重要载体和形式,是生成文本意义的标示。由文化遗产资源形成的旅游符号是社会化过程的产物,是人与人、人与社会、人与历史之间互动的结果,旅游者在对旅游... 详细信息

文化空间作为象征性空间是生活空间在精神文化层面的延伸。文化符号是文化内涵的重要载体和形式,是生成文本意义的标示。由文化遗产资源形成的旅游符号是社会化过程的产物,是人与人、人与社会、人与历史之间互动的结果,旅游者在对旅游符号的“阅读”中生成旅游、生活和生命的意义。本文试以云南文化遗产资源为例,从文化景观、文化线路和文化空间三个方面层层深入,对旅游第三空间的生成进行探索性研究,以促推文旅融合发展。

关键词：文化遗产文化景观文化线路文化空间旅游第三空间