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Genome engineering and disease modeling via programmable nucleases for insulin gene therapy;promises of CRISPR/Cas9 technology

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World Journal of Stem Cells 2021年第6期13卷 485-502页

作者： Yunus e eksi Ahter D Sanlioglu Bahar Akkaya bilge.e.in ozturk Salih Sanlioglu Department of Gene and Cell Therapy Akdeniz University Faculty of MedicineAntalya 07058Turkey Department of Ophthalmology University of PittsburghPittsburghPA 15213United States

Targeted genome editing is a continually evolving technology employing programmable nucleases to specifically change,insert,or remove a genomic sequence of *** advanced molecular tools include meganucleases,zinc finger nucleases,transcription activator-like effector nucleases and RNA-guided engineered nucleases(RGeNs),which create double-strand breaks at specific target sites in the genome,and repair DNA either by homologous recombination in the presence of donor DNA or via the error-prone non-homologous end-joining mechanism.A recently discovered group of RGeNs known as CRISPR/Cas9 gene-editing systems allowed precise genome manipulation revealing a causal association between disease genotype and phenotype,without the need for the reengineering of the specific enzyme when targeting different ***/Cas9 has been successfully employed as an ex vivo gene-editing tool in embryonic stem cells and patient-derived stem cells to understand pancreatic beta-cell development and ***-guided nucleases also open the way for the generation of novel animal models for diabetes and allow testing the efficiency of various therapeutic approaches in diabetes,as summarized and exemplified in this manuscript.

关键词： Programmable nucleases CRISPR/Cas9 Stem cells Disease modeling Diabetes Insulin gene therapy

effect of Magnetic Field on a p-Type δ-Doped GaAs Layer

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Chinese Physics Letters 2010年第7期27卷 233-236页

作者： e. ozturk Department of Physics Cumhuriyet University Sivas 58140 Turkey

The energy levels of holes in a p-type δ-doped GaAs structure under a magnetic field are theoretically calculated within the framework of the effective mass approximation for a uniform aceeptor distribution. The electronic structure is calculated by solving the Schrodinger and Poisson equations self-consistently. The effect of the magnetic field on the potential profile changes the degree of the confinement and localization, and thus this behavior can be used to study these systems in regions of interest, without the need to grow many different samples. It is found that the heavy-hole subbands contain many more energy states than the light-hole ones; the population of the heavy-hole levels represents approximately 91 % of all the carriers without magnetic field. With increasing magnetic field the total population of the heavy-holes increases and the number of filled states changes.

关键词： Magnetic field energy Fields Computers Political systems

Nonlinear Optical Rectification, Second and Third Harmonic Generations in Square-Step and Graded-Step Quantum Wells under Intense Laser Field

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Chinese Physics Letters 2019年第6期36卷 93-97页

作者： O.ozturk e.ozturk S.elagoz Department of Nanotechnology engineering Cumhuriyet University Department of Physics Cumhuriyet University ASeLSAN-Microelectronics Guidance & Electro-Optics

For square-step quantum wells(SSQWs) and graded-step quantum wells(GSQWs), the nonlinear optical rectification(NOR), second harmonic generation(SHG) and third harmonic generation(THG) coefficients under an intense laser field(ILF) are analyzed. The found results indicate that ILF can ensure a vital influence on the shape and height of the confined potential profile of both SSQWs and GSQWs, and alterations of the dipole moment matrix elements and the energy levels are adhered on the profile of the confined potential. According to the results, the potential profile and height of the GSQWs are affected more significantly by ILF intensity compared to SSQWs. These results indicate that NOR, SHG and THG coefficients of SSQWs and GSQWs may be calibrated in a preferred energy range and the magnitude of the resonance peak(RP) by tuning the ILF parameter. It is feasible to classify blue or red shifts in RP locations of NOR, SHG and THG coefficients by varying the ILF parameter. Our results can be useful in investigating new ways of manipulating the opto-electronic properties of semiconductor QW devices.

关键词： square-step quantum wells(SSQWs) graded-step quantum wells(GSQWs) nonlinear optical rectification(NOR)

Development of a functional chocolate using gamma-amino butyric acid producer Lacticaseibacillus rhamnosus NRRL B-442

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Food Bioscience 2022年第3期47卷 700-706页

作者： Merve Ozer Burcu ozturk Ali Adnan Hayaloglu Sebnem Tellioglu Harsa İzmir Institute of Technology Faculty of EngineeringDepartment of Food EngineeringGulbahçe Campus35430UrlaİzmirTurkey İnönü University Faculty of EngineeringDepartment of Food Engineering44280MalatyaTurkey

The human microbiota is influenced by the immune and nervous systems of the ***-aminobutyric acid (GABA) is known as bioactive compound and it has important physiological functions,such as anti-hypertensive and antidepressant *** acid bacteria (LAB),especially Lactobacillus species are known as the most important GABA producers because of the food-grade *** purpose of this study is to develop a functional chocolate using microencapsulated GABA producer Lacticaseibacillus rhamnosus NRRL B-442 strain for patients having an anxiety ***-in-oil emulsion technique was conducted for microencapsulation using whey-pullulan *** and free *** cell counts were 6.75 and 7.20 log CFU/g in chocolates,respectively,at the end of 60 *** simulated in vitro digestion analysis,survival rate of microencapsulated bacteria in chocolate samples was found at higher percentage (87%) than free bacteria (75%).Furthermore,microencapsulated *** did not affect the physical,chemical,and sensory properties of ***,*** with the highest GABA producing capability may provide insight for an anxiety disorder patient,since this strain has been thought as having a therapeutic effect.A new functional food model was developed for “GutBrain Axis” phenomena since the chocolate could be accepted as a good carrier for GABA producer bacteria.

关键词： Microencapsulation Anxiety disorder Functional food Simulated digestion

The Synthesis of Arylsulfonylphthalimides and Their Reactions with Several Amines in Acetonitrile

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International Journal of Organic Chemistry 2011年第4期1卷 202-206页

作者： Seyhan ozturk Halil Kutuk 不详

In this study, several N-(p-substituted-arylsulfonyl)phthalimides (1a-e) were synthesized. The synthesized compounds were then examined with respect to their substitution reactions with t-butylamine, diethylamine, cyclohexylamine, and trans-1,2-diaminocyclohexane in acetonitrile. In order to determine the mechanism, substituent effect, activation entropy, and nucleophile effect were used as criteria.

关键词： Arylsulfonyl Phthalimides Mechanism Substituent effect Activation entropy

effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication

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World Journal of Gastroenterology 2016年第15期22卷 4071-4072页

作者： Hakan Demirci Kadir ozturk Omer Kurt Department of Gastroenterology Gulhane Military Medical Academy 06010 Ankara Turkey

We read the article "effects of daily telephone-based re-education before taking medicine on Helicobacter pylori(H. pylori) eradication: A prospective singlecenter study from China" written by Wang et al with great interest. It is reported in American and european guidelines that there is no sufficient test for the diagnosis of H. pylori except culture and that using at least two different tests for diagnosis of H. pylori is recommended. Patients who used antibiotics or bismuth salts in the previous 2 wk were excluded from study. But patients who used probiotics and antioxidant vitamins such as vitamins C and e were not excluded.

关键词： Helicobacter pylori erdication rates Telephone based education

The effects of Porcelain Polishing Techniques on the Color and Surface Texture of Different Porcelain Systems

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Materials Sciences and Applications 2012年第5期3卷 294-300页

作者： Ali Riza Tuncdemir erhan Dilber Haluk Baris Kara A.Nilgun ozturk Department of Prosthodontics Mustafa Kemal UniversityAntakyaTurkey Department of Prosthodontics Faculty of DentistrySelçuk UniversityKonyaTurkey Department of Prosthodontics Medipol UniversityIstanbulTurkey

The aim of this study was to compare the effects of different porcelain polishing techniques on the color change and surface roughness of feldspathic porcelains and lithium disilicate glass-ceramic system. 80 porcelain specimens were divided into two subgroups, each subgroup was divided into 4 groups of 10 specimens. Surfaces were polished with different ceramic polishers. VITA easyshade spectrophotometer was used to measure color differences. Surface roughness was evaluated using a profilometer. The color change and surface roughness of porcelains were statistically analyzed by Two-way ANOVA followed by a Tukey HSD test (α = 05). There were relationships between the porcelain systems and polishing techniques (p 0.05). For △e values, there was relationship between the porcelain systems and polishing techniques (p 0.05). Chairside porcelain polishing systems were not able to provide a porcelain surface as smooth as the glazed surface for the IPS empress and Ceramco 3 porcelains.

关键词： Color Glaze Polish Porcelain Surface Roughness

Aluminum Toxicity:A Case Study on Tobacco(Nicotiana tabacum L.)

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Phyton-International Journal of experimental Botany 2023年第1期92卷 165-192页

作者： Munir ozturk Mert Metin Volkan Altay Tomonori Kawano Alvina Gul Bengu Turkyilmaz Unal Dilek Unal Rouf Ahmad Bhat Moonisa Aslam Dervash Kristina Toderich esra Koc Pedro Garcia Caparros Andleeb Shahzadi Department of Botany and Centre for environmental Studies Ege UniversityIzmir35100Turkiye Graduate School of environmental engineering The University of KitakyushuFukuoka808-0135Japan Department of Biology Faculty of Science and ArtsHatay Mustafa Kemal UniversityHatay31060Turkiye Atta-ur-Rahman School of Applied Biosciences National University of Sciences&TechnologyIslamabad44000Pakistan Department of Biotechnology Faculty of Science and ArtsNigde Omer Halisdemir UniversityNigde51240Turkiye Department of Molecular Biology and Genetics Faculty of Science and ArtsUniversity of Bilecik Seyh EdebaliBilecik11230Turkiye Department of environmental Science Sri Pratap CollegeCluster University SrinagarKashmir190008India Division of environmental Sciences Sher-e-Kashmir University of Agricultural Sciences and TechnologyKashmir190025India International Platform for Dryland Research and education Tottori UniversityTottori680-0001Japan Department of Biology Faculty of ScienceAnkara UniversityAnkara06100Turkiye Department of Superior School engineering University of AlmeríaAlmería04120Spain Department of Medical Pharmacology Cerrahpasa Medicine FacultyIstanbul University-CerrahpasaIstanbul34096Turkiye

Aluminum is an abundant metal in the earth’s crust that turns out to be toxic in acidic *** plants are affected by the presence of aluminum at the whole plant level,at the organ level,and at the cellular *** as a cash crop(Nicotiana tabacum L.)is a widely cultivated plant worldwide and is also a good model organism for *** there are many articles on Al-phytotoxicity in the literature,reviews on a single species that are economically and scientifically important are *** this article,we not only provide the biology associated with tobacco Al-toxicity,but also some essential information regarding the effects of this metal on other plant species(even animals).This review provides information on aluminum localization and uptake process by different staining techniques,as well as the effects of its toxicity at different compartment levels and the physiological consequences derived from *** addition,molecular studies in recent years have reported specific responses to Al toxicity,such as overexpression of various protective ***,this review discusses data on various organelle-based responses,cell death,and other mechanisms,data on tobacco plants and other kingdoms relevant to these studies.

关键词： Aluminum oxidative stress protective proteins ROS tobacco toxicity

半透明带结合试验对控制性超排卵患者行宫内人工受精妊娠结局的预测价值

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世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 25-26页

作者： Arslan M. Morshedi M. ozturk Arslan e. S. Oehninger 党慧敏 The Jones Institute for Reproductive Medicine Department of Obstetrics and Gynecology Eastern Virginia Medical School Norfolk VA United States Dr.

Objective: The hemizona assay(HZA) is an established functional test that examines in vitro sperm-zona pellucida binding capacity with high predictive power for fertilization outcome in IVF. The objective of this study was to evaluate the value of the HZA as a predictor of pregnancy in patients undergoing controlled ovarian hyperstimulation(COH) and intrauterine insemination(IUI). Design: Prospective clinical study. Setting: Academic center. Patient(s): eighty-two couples with unexplained or male factor infertility that underwent 313 IUI cycles. Intervention(s): Basic semen analysis and HZA were performed within three months of starting COH/IUI therapy. Main Outcome Measure(s): Hemizona index(HZI) and clinical pregnancy. Result(s): Overall, patients with an HZI of er pregnancy rate compared to patients with an HZI of ≥30(11.1%vs. 40.6%, respectively; P elative risk for failure to conceive: 1.5[confidence interval 1.2-1.9]). In all patients combined, and in the range of HZI 0-60, the duration of infertility(P=.000) and the HZI(P=.004) were significant determinants of conception(receiver operating characteristics(ROC) analysis). In couples with male infertility, the average path velocity and HZI were significant predictors of conception(P=.001 and P=.005, respectively, ROC analysis). The negative and positive predictive values of the HZA for pregnancy were 93%and 69%, respectively. Logistic regression analysis provided models of HZI(P=.021) and duration of infertility(P=.037) with highest predictability of conception in male factor and unexplained infertility groups, respectively. Conclusion(s): TheHZA predicted pregnancy in the IUI setting with high sensitivity and negative predictive value in couples withmale infertility. Results of this spermfunction test are useful in counseling couples before allocating them into COH/IUI therapy.

关键词：控制性超排卵人工受精透明带妊娠结局预测价值精子透明带结合临床妊娠男方因素男性因素不