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Prevalence of malignant neoplasms in celiac disease patients-a nationwide United States population-based study

World Journal of Clinical Oncology 2024年第8期15卷 1048-1060页

作者： Maryam bilal haider Ali Al Sbihi Sushmitha Nanja Reddy Peter Green Department of Gastroenterology Northshore University Health SystemEvanstonIL 60201United States Department of Hematology/Oncology University of Miami Miller School of MedicineMiamiFL 33101United States Department of Hematology/Oncology Karmanos Cancer Institute/Wayne State UniversityDetroitMI 48235United States Celiac Disease Center Columbia UniversityNew YorkNY 10032United States

BACKGROUND Celiac disease(CeD)is an autoimmune disorder triggered by the immune response to gluten in genetically predisposed *** research has unveiled a heightened risk of developing specific malignant neoplasms(MN)and various malignancies,including gastrointestinal,lymphomas,skin,and others,in individuals with *** To investigate the prevalence of MN in hospitalized CeD patients in the United *** Using data from the National Inpatient Sample spanning two decades,from January 2000 to December 2019,we identified 529842 CeD patients,of which 78128(14.75%)had *** score matching,based on age,sex,race,and calendar year,was employed to compare CeD patients with the general non-CeD population at a 1:1 *** Positive associations were observed for several malignancies,including small intestine,lymphoma,nonmelanoma skin,liver,melanoma skin,pancreas myelodysplastic syndrome,biliary,stomach,and other neuroendocrine tumors(excluding small and large intestine malignant carcinoid),leukemia,uterus,and ***,CeD patients exhibited a reduced risk of respiratory and secondary ***,certain malignancies showed null associations with CeD,including head and neck,nervous system,esophagus,colorectal,anus,breast,malignant carcinoids,bone and connective tissues,myeloma,cervix,and ovary *** Our study is unique in highlighting the detailed results of positive,negative,or null associations between different hematologic and solid malignancies and ***,it offers insights into evolving trends in CeD hospital outcomes,shedding light on advancements in its management over the past two *** findings contribute valuable information to the understanding of CeD’s impact on health and healthcare utilization.

关键词： Celiac disease Malignant neoplasm Autoimmune disorder Hospitalized patients Healthcare utilization Gastrointestinal malignancies Lymphomas Epidemiology

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Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis

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World Journal of Clinical Cases 2023年第4期11卷 764-779页

作者： Maryam bilal haider Brinda Basida Jasleen Kaur Department of Internal Medicine Detroit Medical CenterWayne State UniversitySinai Grace HospitalDetroitMI 48235United States Department of Geriatrics Rohde Island Hospital/Brown UniversityProvidenceRI 02903United States Department of Rheumatology St.Mary’s Ascension/Central Michigan UniversitySaginawMI 48601United States

BACKGROUND Various immune-mediated inflammatory diseases consisting of inflammatory bowel disease(IBD)and rheumatoid arthritis(RA),are found to have a substantial societal burden,increased healthcare costs,and progressive *** suggest that patients with vs without comorbid depression have a more significant disability,a lower likelihood of remission,and reduced adherence to *** interleukin(IL)-1β,tumor necrosis factor-α,and IL-6 contribute to developing depression by the impaired physiological responses to stress,resulting in increased pain,fever,fatigue,and lack thereof of interest,and thus poor long-term *** study emphasizes the timely recognition of the prevalence of major depressive disorder(MDD)in patients with RA and IBD combined,thus preventing *** To identify the prevalence level and temporal trends of depression in hospitalized IBD-RA *** All adult hospitalized patients from January 2000 to December 2019 in the nationwide inpatient sample(NIS)were *** study population included all patients with a primary or secondary IBD-RA overlap disease using corresponding international classification of diseases(ICD)-9 and ICD-10 *** includes Crohn’s disease and ulcerative *** study population was divided into IBD-RA without MDD(controls)and IBD-RA with MDD(cases).For group comparison between MDD vs no MDD,we used Student’s t-test for continuous variables and RaoScott Chi-square tests for categorical *** univariate analyses,we used logistic regression,and for multivariate analysis,we used a weighted multi-level mixed-effects *** attested all hypotheses with two-tailed significance level of 0.05(P<0.05 was considered significant).The outcome is to examine the temporal trends and prevalence of depression in patients with IBD-RA by gender,race,and *** A total of 133315 records were identified with IBD-RA overlap,of which 26155 patients(19.62%)had *** the IBD-RA

关键词： Inflammatory bowel disease Rheumatoid arthritis Depression Multimorbidity Epidemiology Demographics

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Nanobiotechnology： 1D nanomaterial building blocks for cellular interfaces and hybrid tissues

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Nano Research 2018年第10期11卷 5372-5399页

作者： Haitao Liu bilal haider Holden R. Fried Jie Ju Olurotimi Bolonduro Vineeth Raghuram Brian P. Timko Department of Biomedical Engineering Tufts University Medford Massachusetts 02755 USA School of Materials Science and Technology China University ofGeosciences Beijing 100083 China

Solid-state nanomaterials exhibit complementary interactions with biological systems because of their biologically-relevant size scales and rationally tunable electrical, chemical and mechanical properties. In this review, we focus specifically on one-dimensional （1D） nanomaterials such as silicon or gold nanowires or carbon nanotubes. We discuss the nature of the nanomaterial-cell interface, and how that interface may be engineered to enhance or modulate cellular function. We then describe how those unique interfaces may be exploited in three-dimensional （3D） tissue culture to recapitulate the extracellular matrix and promote or complement morphogenesis. Finall~ we describe how 1D nanomaterials may be elucidated as nanoelectronic devices that monitor the chemical or electrical environment of cells or tissue with exquisite spatial and temporal resolution. We discuss prospects for entirely new classes of engineered, hybrid tissues with rationally-designed biological function and two-way, closed-loop electronic communication.

关键词： nanomaterial neuron cardiomyocyte nanoelectronics bioelectronics hybrid tissue

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Hereditary hemochromatosis:Temporal trends,sociodemographic characteristics,and independent risk factor of hepatocellular cancer–nationwide population-based study

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World Journal of Hepatology 2022年第9期14卷 1804-1816页

作者： Maryam bilal haider Ali Al Sbihi Ahmed Jamal Chaudhary Syed M haider Ahmed Iqbal Edhi Department of Internal Medicine Detroit Medical CenterWayne State UniversitySinai Grace HospitalDetroitMI 48235United States System Science Binghamton UniversityBinghamtonNY 13902United States Department of Gastroenterology William Beaumont HospitalRoyal OakMI 48073United States

BACKGROUND Hereditary hemochromatosis(HH)has an increased risk of hepatocellular cancer(HCC)both due to genetic risks and iron overload as iron overload can be carcinogenic;HH impacts the increasing risk of HCC,not only through the development of cirrhosis but concerning hepatic iron deposition,which has been studied further *** To evaluate HH yearly trends,patient demographics,symptoms,comorbidities,and hospital *** secondary aim sheds light on the risk of iron overload for developing HCC in HH patients,independent of liver cirrhosis *** study investigated HH(without cirrhosis)as an independent risk factor for *** We analyzed data from National Inpatient Sample(NIS)Database,the largest national inpatient data collection in the United States,and selected HH and HCC *** was first defined in 2011 International Classification of Disease-9th edition(ICD-9)as a separate diagnosis;the HH cohort is extracted from January 2011 to December 2019 using 275.01(ICD-9)and E83.110(ICD-10)diagnosis codes of *** were excluded from the HH cohort if they had a primary or secondary diagnostic code of cirrhosis(alcoholic,non-alcoholic,and biliary),viralhepatitis,alcoholic liver disease,non-alcoholic fatty liver disease(NAFLD),and non-alcoholic steatohepatitis(NASH).We removed these patients from the HH cohort to rule out bias or ICD-10 diagnostic *** HCC cohort is selected from January 2011 to December 2019 using the ICD-9 and ICD-10 codes of *** selected a non-HCC cohort with the 1:1 fixed ratio nearest neighbor(greedy)propensity score method using the patients'age,gender,and *** performed multivariate analysis for the risk factors of HCC in the HCC and non-HCC matched *** further analyzed HH without cirrhosis(removing HH patients with a diagnosis of cirrhosis)as an independent risk factor of HCC after adjusting all known risk factors of HCC in the multivariate *** During the 2011-2019 period,a total o

关键词： Hereditary hemochromatosis Hepatocellular carcinoma,cirrhosis Hepatitis Diabetes mellitus Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Wilson disease Alpha1-antitrypsin deficiency Blood transfusion Epidemiology Demographics Big data Hospitalization

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Unordered rule discovery using Ant Colony Optimization

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Science China(Information Sciences) 2014年第9期57卷 189-203页

作者： KHAN Salabat BAIG Abdul Rauf ALI Armughan haider bilal KHAN Farman Ali DURRANI Mehr Yahya ISHTIAQ Muhammad Department of Computer Science COMSATS Institute of Information TechnologyAttock CampusPakistan Department of Computer Science National University of Computer and Emerging SciencesIslamabadPakistan Al Imam Mohammad Ibn Saud Islamic University (IMSIU) College of Computer and Information SciencesRiyadhSaudi Arabia

In this article,a novel unordered classification rule list discovery algorithm is presented based on Ant Colony Optimization(ACO).The proposed classifier is compared empirically with two other ACO-based classification techniques on 26 data sets,selected from miscellaneous domains,based on several performance *** opposed to its ancestors,our technique has the flexibility of generating a list of IF-THEN rules with unrestricted *** makes the generated classification model more comprehensible and easily *** results indicate that the performance of the proposed method is statistically significantly better as compared with previous versions of AntMiner based on predictive accuracy and comprehensibility of the classification model.

关键词： classification ant colony optimization data mining unordered rule set comprehensibility pattern recognition

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CLCNKB基因突变致巴特综合征1例报告及文献复习

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中国实用儿科杂志 2021年第8期36卷 637-640页

作者：刘永林刘瑞 bilal haider Shamsi 神木市医院(西北大学附属神木医院)普儿科陕西神木719300

1962年Bartter等因首先报道了2例非裔美国人[1]有代谢性碱中毒、醛固酮增多症、肾小球旁器增生等异常表现,而得名巴特综合征([2]Bartter’ssyndrome,BS)。它是一种遗传性肾小管疾病,主要表现为低钠血症、低钾血症、代谢性碱中毒、高肾... 详细信息

1962年Bartter等因首先报道了2例非裔美国人[1]有代谢性碱中毒、醛固酮增多症、肾小球旁器增生等异常表现,而得名巴特综合征([2]Bartter’ssyndrome,BS)。它是一种遗传性肾小管疾病,主要表现为低钠血症、低钾血症、代谢性碱中毒、高肾素血症,而血压正常或偏低[3]。BS的主要发病机制是髓袢升支粗段上参与Nacl重吸收的转运蛋白功能缺陷,即Na-K-2Cl协同转运蛋白(NKCC2)、顶端钾离子通道(ROMK)或基底外侧氯离子通道(CLCNKB)[4]缺陷。该病是一种常染色体隐性遗传病,多年来,一些表型和基因型变异的BS已被确认[5]。笔者医院确诊1例CLCNKB基因突变所致巴特综合征,现报告如下。

关键词：巴特综合征 CLCNKB基因突变低钾血症代谢性碱中毒

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Investigation of functional,physical,mechanical and thermal properties of TiO2 embedded polyester hybrid composites:A design of experiment(DoE)study

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Progress in Natural Science:Materials International 2018年第3期28卷 266-274页

作者： Muhammad Azeem Munawar Dirk Wolfram Schubert Shahzad Maqsood Khan Muhammad Atiq Ur Rehman Nafisa Gulld Atif Islam Aneela Sabir Muhammad Shafiq bilal haider Mudassar Azam Saba Urooge Khan Monika M.Voigt Institute of Polymer Materials Friedrich-Alexander-University Department of Polymer Engineering and Technology University of the Punjab Bavarian Polymer Institute Institute of Biomaterials Friedrich-Alexander-University Institute of Chemical Engineering and Technology University of the Punjab

This paper presents a study on the Design of Experiments(Do E) approach to optimize the fabrication parameters of titania(TiO2) embedded glass fiber reinforced polyester hybrid composites(HCs). HCs of unsaturated polyester resin(UPR) were fabricated using methyl ethyl ketone peroxide(MEKP) as the curing agent by hand lay-up process(HLUP) and compression molding technique(CMT). The fabrication parameters were optimized by Taguchi Do E(an orthogonal array of L25) using 3 control factors(concentration of TiO2, concentration of MEKP and curing temperature) having 5 levels each. Statistical tools were employed to identify significant factors affecting tensile strengths and its reproducibility during HLUP. It was found that the concentration of TiO2in HCs significantly influenced the tensile strength(TS) followed by MEKP concentration and curing temperature. The highest value of TS was obtained at 3 wt% TiO2, 2 wt% MEKP and 80 °C. Nevertheless, the sensitivity of TiO2concentration was basis for fabrication of polyester titania glass fiber hybrids(PTGFHs), which were further investigated for density and void fractions, linear shrinkage, flexural strength, impact strength, hardness and thermal behaviors. Moreover, cross-linking and hydrogen-bonding between polymeric chains, styrene, silica content of glass fiber and TiO2particles in PTGFHs were confirmed by Fourier transform infrared spectroscopy.

关键词： Hybrid composites Polyester Design of experiment Titania

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婴儿期发病的腓骨肌萎缩症家系PMP22基因突变研究

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中国当代儿科杂志 2011年第10期13卷 799-803页

作者：邢军卫刘亚红 bilal haider SHAMSI 刘小红谭璐徐曼西安交通大学医学院第一附属医院儿科陕西西安710061

目的研究一个婴儿期发病的腓骨肌萎缩症(CMT)家系PMP22基因突变,探讨该家系CMT的遗传学特点。方法应用STR结合多重PCR法对2例CMT患儿及该家系内15名表型正常的成员进行PMP22基因重复突变的分析。同时选择20名健康人做为对照。结果在2名... 详细信息

目的研究一个婴儿期发病的腓骨肌萎缩症(CMT)家系PMP22基因突变,探讨该家系CMT的遗传学特点。方法应用STR结合多重PCR法对2例CMT患儿及该家系内15名表型正常的成员进行PMP22基因重复突变的分析。同时选择20名健康人做为对照。结果在2名CMT患儿及5名家系内表型正常的成员中发现了PMP22基因重复突变,其中5例突变在STR位点D17S921,2例突变在STR位点D17S4A,而家系内其余10名成员及20名健康人未发现突变。结论该CMT家系的致病基因为17p11.2-p12区域内包含PMP22基因的重复突变,其亚型为CMT1A。

关键词：腓骨肌萎缩症遗传 PMP22 突变婴儿

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Priming mesenchymal stem cells to develop “super stem cells”

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World Journal of Stem Cells 2024年第6期16卷 623-640页

作者： Khawaja Husnain haider Department of Basic Sciences Sulaiman AlRajhi UniversityAlQaseem 52736Saudi Arabia

The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment,genetic manipulation,and chemical and pharmacological treatment,each strategy having advantages and *** of these pre-treatment protocols are *** editorial is a continuum of Li et al’s published article and Wan et al’s editorial focusing on the significance of pre-treatment strategies to enhance their stemness,immunoregulatory,and immunosuppressive *** have elaborated on the intricacies of the combinative pre-treatment protocol using pro-inflammatory cytokines and *** a well-defined multi-pronged combinatorial strategy of mesenchymal stem cells(MSCs),pre-treatment based on the mechanistic understanding is expected to develop“Super MSCs”,which will create a transformative shift in MSC-based therapies in clinical settings,potentially revolutionizing the *** optimized,the standardized protocols may be used with slight modifications to pre-treat different stem cells to develop“super stem cells”with augmented stemness,functionality,and reparability for diverse clinical applications with better outcomes.

关键词： Cell survival Cell therapy Preconditioning Pre-treatment Stem cells Super stem cells

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Fuzzy inference system using genetic algorithm and pattern search for predicting roof fall rate in underground coal mines

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International Journal of Coal Science & Technology 2024年第1期11卷 31-41页

作者： Ayush Sahu Satish Sinha haider Banka Department of CSE IIT(ISM)DhanbadJharkhand826004India Department of Sustainability Adani universityAhmedabadGujrat382421India

One of the most dangerous safety hazard in underground coal mines is roof falls during retreat *** falls may cause life-threatening and non-fatal injuries to miners and impede mining and transportation *** a result,a reliable roof fall prediction model is essential to tackle such *** parameters that substantially impact roof falls are ill-defined and intangible,making this an uncertain and challenging research *** National Institute for Occupational Safety and Health assembled a national database of roof performance from 37 coal mines to explore the factors contributing to roof *** acquired for 37 mines is limited due to several restrictions,which increased the likelihood of *** logic is a technique for coping with ambiguity,incompleteness,and ***,In this paper,the fuzzy inference method is presented,which employs a genetic algorithm to create fuzzy rules based on 109 records of roof fall data and pattern search to refine the membership functions of *** performance of the deployed model is evaluated using statistical measures such as the Root-Mean-Square Error,Mean-Absolute-Error,and coefficient of determination(R_(2)).Based on these criteria,the suggested model outperforms the existing models to precisely predict roof fall rates using fewer fuzzy rules.

关键词： Underground coal mining Roof fall Fuzzy logic Genetic algorithm

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