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Hypercalciuria switches ca^(2+) signaling in proximal tubular cells,induces oxidative damage to promote calcium nephrolithiasis

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Genes & Diseases 2022年第2期9卷 531-548页

作者： Samuel Shin cliff-Lawrence Ibeh Eugenia Awuah Boadi Bok-Eum choi Sanjit K.Roy bidhan c.bandyopadhyay calcium Signaling Laboratory Research ServiceVeterans Affairs Medical Center50 Irving StreetNWWashingtonDC 20422USA

Proximal tubule(PT)transports most of the renal ca^(2+),which was usually described as paracellular(passive).We found a regulated ca^(2+)entry pathway in PT cells via the apical transient receptor potential canonical 3(TRPc3)channel,which initiates transcellular ca^(2+)*** TRPc3 knockout(−/−)mice were mildly hypercalciuric and displayed luminal calcium phosphate(caP)crystals at Loop of Henle(LOH),no caP+calcium oxalate(caOx)mixed urine crystals were spotted,which are mostly found in calcium nephrolithiasis(caNL).Thus,we used oral calcium gluconate(caG;2%)to raise the PT luminal[ca^(2+)]o further in TRPc3−/−mice for developing such mixed stones to understand the mechanistic role of PT-ca^(2+)signaling in ***,caG-treated mice urine samples presented with numerous mixed crystals with remains of PT cells,which were pronounced in TRPc3−/−mice,indicating PT cell ***,PT cells from caG-treated groups switched their mode of ca^(2+)entry from receptor-operated to store-operated pathway with a sustained rise in intracellular[ca^(2+)]([ca^(2+)]i),indicating the stagnation in PT ca^(2+)***,those PT cells from caG-treated groups demonstrated an upregulation of calcification,inflammation,fibrotic,oxidative stress,and apoptotic genes;effects of which were more robust in TRPc3 ablated ***,kidneys from caG-treated groups exhibited fibrosis,tubular injury and calcifications with significant reactive oxygen species generation in the urine,thus,indicating in vivo *** together,excess PT luminal ca^(2+)due to escalation of hypercalciuria in TRPc3 ablated mice induced surplus caP crystal formation and caused stagnation of PT[ca^(2+)]i,invoking PT cell injury,hence mixed stone formation.

关键词： Apoptosis ca^(2+)þsignaling calcium nephrolithiasis chronic kidney disease Fibrosis Hypercalciuria Inflammation Oxidative stress

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confounding risk factors and preventative measures driving nephrolithiasis global makeup

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World Journal of Nephrology 2018年第7期7卷 129-142页

作者： Samuel Shin Aneil Srivastava Nazira A Alli bidhan c bandyopadhyay calcium Signaling Laboratory Research Service Veterans Affairs Medical Center Washington DC 20422 United States George Washington University Washington DC 20052 United States

Nephrolithiasis is increasing in developed and developing countries at an alarming rate. With the global spike in kidney stone diseases, it is crucial to determine what risk factors are influencing the current global landscape for kidney stones. Our aims for this review are: to identity and analyze the four categories of risk factors in contributing to the global scale of stone formation: lifestyle, genetics, diet, and environment; and discuss preventative measures for kidney stone formation. We also performed data search through the published scientific literature, i.e., PubMed~? and found that there is a significant link between lifestyle and obesity with cases of calcium stones. Food and Agriculture Organization of the United Nations and World Health Organization factor indicators for dietary intake and obesity, along with climate data were used to create the projected total risk world map model for nephrolithiasis risk. complete global analyses of nephrolithiasis deplete of generalizations is nearly insurmountable due to limited sources of medical and demographic information, but we hope this review can provide further elucidation into confounding risk factors and preventative measures for global nephrolithiasis analysis.

关键词： Nephrolithiasis Epidemiology Risk factors Global factors

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c-MEMS-derived glassy carbon electrochemical biosensors for rapid detection of SARS-coV-2 spike protein

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Microsystems & Nanoengineering 2023年第6期9卷 247-260页

作者： Naresh Mandal Raja Mitra bidhan Pramanick School of Electrical Sciences Indian Institute of Technology Goa403401 PondaGoaIndia School of chemical and Materials Sciences Indian Institute of Technology Goa403401 PondaGoaIndia centre of Excellence in Particulates colloids and Interfaces Indian Institute of Technology Goa403401 PondaGoaIndia school of Interdisciplinary Life Sciences Indian Institute of Technology Goa403401 PondaGoaIndia

According to a World Health Organization(WHO)report,the world has experienced more than 766 million cases of positive SARS-coV-2 infection and more than 6.9 million deaths due to cOVID through May *** WHO declared a pandemic due to the rapid spread of the severe acute respiratory syndrome coronavirus 2(SARS-coV-2)virus,and the fight against this pandemic is not over *** reasons for virus spread include the lack of detection kits,appropriate detection techniques,delay in detection,asymptomatic cases and failure in mass *** the last 3 years,several researchers and medical companies have introduced successful test kits to detect the infection of symptomatic patients in real time,which was necessary to monitor the ***,it is also important to have information on asymptomatic cases,which can be obtained by antibody testing for the SARS-coV-2 *** this work,we developed a simple,advantageous immobilization procedure for rapidly detecting the SARS-coV-2 spike ***-MEMS-derived glassy carbon(Gc)is used as the sensor electrode,and the detection is based on covalently linking the SARS-coV-2 antibody to the Gc *** was used as a cross-linker between the antibody and glassy carbon electrode(GcE).The binding was investigated using Fourier transform infrared spectroscopy(FTIR)characterization and cyclic voltammetric(cV)*** impedance spectroscopy(EIS)was utilized to measure the change in total impedance before and after incubation of the SARS-coV-2 antibody with various concentrations of SARS-coV-2 spike *** developed sensor can sense 1 fg/ml to 1µg/ml SARS-coV-2 spike *** detection is label-free,and the chances of false positives are *** calculated LOD was~31 copies of viral RNA/*** coefficient of variation(cV)number is calculated from EIS data at 100 Hz,which is found to be 0.398%.The developed sensor may be used for mass screening because it is cost-effective.

关键词： glassy impedance linking

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conserving the zoological resources of Bangladesh under a changing climate

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Integrative Zoology 2009年第2期4卷 213-219页

作者： bidhan c.DAS Department of Zoology University of RajshahiRajshahiBangladesh

It is now well recognized that Bangladesh is one of the world’s most vulnerable countries to climate change and sea level *** levels of natural resources and a high occurrence of natural disasters further add to the challenges faced by the *** impacts of climate change are anticipated to exacerbate these existing stresses and constitute a serious impediment to poverty reduction and economic *** and biodiversity are important key sectors of the economy and natural resources of the country are selected as the most vulnerable to climate *** is for these reasons that Bangladesh should prepare to conserve its natural resources under changed climatic ***,the development of specific strategies and policies to address the effects of climate change on the ecosystem and on biodiversity has not commenced in ***,I present a detailed review of animal resources of Bangladesh,an outline of the major areas in zoological research to be integrated to adapt to climate change,and identified few components for each of the aforesaid areas in relation to the natural resource conservation and management in the country.

关键词： Bangladesh climate change conservation integrative approach.

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Glassy carbon microneedles-new transdermal drug delivery device derived from a scalable c-MEMS process

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Microsystems & Nanoengineering 2018年第1期4卷 13-23页

作者： Richa Mishra bidhan Pramanick Tapas Kumar Maiti Tarun Kanti Bhattacharyya Advanced Technology Development center IIT KharagpurKharagpurWest Bengal 721302India Department of Mechanical Engineering IIT KharagpurKharagpurWest Bengal 721302India Biotechnology Department IIT KharagpurKharagpurWest Bengal 721302India Department of Electronics and Electrical communication Engineering IIT KharagpurKharagpurWest Bengal 721302India School of Electrical Sciences IIT GoaPondaGoa 403401India

Because carbon is the basic element of all life forms and has been successfully applied as a material for medical applications,it is desirable to investigate carbon for drug delivery applications,as *** this work,we report the fabrication of a hollow carbon microneedle array with flow channels using a conventional carbonmicroelectromechanical system(c-MEMS)*** process utilizes the scalable and irreversible step of pyrolysis,where prepatterned SU-8 microneedles(precursor)are converted to glassy carbon structures in an inert atmosphere at high temperature(900°c)while retaining their original shape upon *** converted to glassy carbon,the microneedles inherit the unique properties of hardness,biocompatibility,and thermal and chemical resistance associated with this material.A comparative study of hardness and Young’s modulus for carbon microneedles and SU-8 microneedles was performed to evaluate the increased strength of the microneedles induced by the c-MEMS process *** shrinkage of the carbon microneedles upon pyrolysis was observed and *** characterizations including energy-dispersive X-ray spectroscopy(EDX)and Raman spectroscopy were carried out to estimate the atomic percentage of carbon in the microneedle structure and its crystalline nature,*** investigations confirm that the microneedles are glassy in *** and bending tests were also performed to determine the maximum forces that the carbon microneedles can withstand,and it was found that these forces were approximately two orders of magnitude higher than the resistive forces presented by skin.A microneedle array was inserted into mouse skin multiple times and was successfully removed without the breakage of any microneedles.

关键词： carbon process needle

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Vitamin c and E supplementation and high intensity interval training induced changes in lipid profile and haematological variables of young males

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Sports Medicine and Health Science 2023年第2期5卷 137-145页

作者： Surojit Sarkar Swapan Kr Dey Gouriprosad Datta Amit bandyopadhyay Department of Physiology Rammohan College1021Raja Ram Mohan SaraniBaithakkhanaKolkata700009West BengalIndia Department of Sports Science University of CalcuttaUniversity Colleges of Science and Technology92A.P.C.RoadKolkata700009West BengalIndia Sports and Exercise Physiology Laboratory Department of PhysiologyUniversity of CalcuttaUniversity Colleges of Science and Technology92A.P.C.RoadKolkata700009West BengalIndia

High intensity interval training(HIIT)causes oxidative stress and haematological *** study was aimed to evaluate the effect of 8 weeks’supplementation of vitamin c and E on HIIT induced changes in lipid profile parameters and haematological *** six male adolescent players were randomly assigned into five age-matched groups,i.e.,control(no exercise+placebo),HIIT(placebo),HIIT+vitamin-c(1000mg/day),HIIT+vitamin-E 400 IU/day)and combined HIIT+vitamin c and *** and evening sessions(90min)of HIIT included 4 phases(15min each)with 3 sets(4min each).Each 4min HIIT set consisted of 2min intense sprint workout(90%–95%of heart rate maximum[HRmax])followed by 1min active recovery(60%–70%HRmax)followed by 1min of complete rest(1:1 work-rest ratio).Lipid profile parameters,haematological variables,endurance capacity and vertical jump were evaluated by standard *** decrease in body weight,fat%,total cholesterol,triglyceride,Total cholesterol/High Density Lipoprotein-cholesterol and significant increase in High Density Lipoprotein-cholesterol,maximal oxygen consumption,vertical jump were observed for all four intervention *** blood cell count,red blood cell count,haemoglobin percentage and haematocrit values were significantly decreased while platelet count and platelet-to-leukocyte ratio(PLR)ratio were increased significantly only for HIIT *** level of tocopherol and ascorbic acid was significantly increased(values were within the normal range)in all the respective vitamin supplemented *** of vitamin c and E secures health protection with suppressed haemolysis and improved inflammatory blood variables with enhanced explosive leg strength and lipid profile parameters without any concomitant change in endurance capacity.

关键词： Sprint interval training Lipid profile Haematological indices Haemolysis Athletes

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Assessing Risk in chemical Plant with Pattern Matching

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chinese Journal of chemical Engineering 2002年第2期10卷 249-253页

作者： P.K.bandyopadhyay S.c.Roy S.N.Sen Department of chemical Engineering Jadavpur University Calcutta-700032 印度

This paper discusses potential application of fuzzy set theory,more specifically, pattern matching, in assessing risk in chemicalplants. Risk factors have been evaluated using linguisticrepresentations of the quantity of the hazardous substance involved,its frequency of interaction with the environment, severity of itsimpact and the uncertainty involved in its detection in advance. Foreach linguistic value there is a corresponding membership functionranging over a universe of discourse. The risk scenario created by ahazard/hazardous situation having highest degree of featural value istaken as the known pattern.

关键词： risk chemical process fuzzy set pattern matching

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