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Peripheral clonal selection shapes the human γδ T-cell repertoire

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Cellular & Molecular Immunology 2017年第9期14卷 733-735页

作者： biagio di Lorenzo Julie Déchanet-Merville Bruno Silva-Santos Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de Lisboa1649-028 LisbonPortugal Instituto Superior Tecnico Universidade de Lisboa1649-028 LisbonPortugal ImmunoConcept CNRS UMR 5164Equipe Labelisée Ligue Contre le CancerUniversity of BordeauxF-33000 BordeauxFrance

γδT cells are often placed at the interface between innate and adaptive *** cells share T-cell receptor(TCR)rearrangements and memory functions1 in common with theirαβT-cell counterparts but differ in terms of the... 详细信息

关键词： Figure kinetics selection

Exergy Analysis of Organic Rankine Cycles with Zeotropic Working Fluids

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Fluid Dynamics & Materials Processing 2023年第3期19卷 593-601页

作者： Antonio Mariani Davide Laiso biagio Morrone Andrea Unich Department of Engineering di Universitàdella Campania“Luigi Vanvitelli”Aversa(CE)Caserta81031Italy

Waste heat recovery is one of the possible solutions to improve the efficiency of internal combustion *** of wasting the exhaust stream of an energy conversion system into the environment,its residual energy content can be usefully recovered,for example in Organic Rankine Cycles(ORC).This technology has been largely consolidated in stationary power plants but not yet for mobile applications,such as road transport,due to the limitations in the layout and to the constraints on the size and weight of the ORC *** ORC system installed on the exhaust line of a bus powered by a natural gas spark ignition engine has been *** thermal power available at engine exhaust has been evaluated by measuring gas temperature and mass flow rate during real driving *** waste thermal power has been considered as heat input for the ORC plant simulation.A detailed heat exchanger model has been developed because it is a crucial component for the ORC *** exergy analysis of the ORC was performed comparing different working fluids:R601,R1233zd(E)and two zeotropic blends of the two organic pure *** model allowed the evaluation of the ORC produced energy over the driving cycle and the potential benefit on the engine efficiency.

关键词： Organic Rankine Cycle zeotropic mixtures exergy analysis waste heat recovery engine efficiency internal combustion engine

Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19

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Journal of Geriatric Cardiology 2021年第5期18卷 338-345页

作者： Vincenzo De Marzo Antonio di biagio Roberta Della Bona Antonio Vena Eleonora Arboscello Harusha Emirjona Sara Mora Mauro Giacomini Giorgio Da Rin Paolo Pelosi Matteo Bassetti Pietro Ameri Italo Porto GECOVID study group Cardiovascular diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Internal Medicine University of GenovaGenovaItaly Infectious diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Health Sciences University of GenovaGenovaItaly Emergency Department IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Informatics BioengineeringRobotics and System EngineeringUniversity of GenovaGenovaItaly Laboratory Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Anesthesia and Intensive Care Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Surgical Sciences and Integrated diagnostics University of GenovaGenovaItaly

BACKGROUND Increases in cardiac troponin(cTn)in coronavirus disease 2019(COVID19)have been associated with worse ***,data about the significance of cTn in elderly subjects with COVID19 are *** From a registry of consecutive patients with COVID19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020,we selected those≥60 yearold and with cTnI measured within three days from the molecular diagnosis of SARSCoV2 *** available,a second cTnI value within 48 h was also *** relationship between increased cTnI and allcause inhospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three *** Of 343 included patients(median age:75.0(68.0−83.0)years,34.7%men),88(25.7%)had cTnI above the upperreference limit(0.046μg/L).Patients with increased cTnI had more comorbidities,greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal ***,they died more(73.9%vs.37.3%,Pdicts a higher risk of *** cTn testing may not confer additional prognostic information.

关键词： patients mortality admitted

Quantitative imaging of the complexity in liquid bubbles’evolution reveals the dynamics of film retraction

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Light(Science & Applications) 2019年第1期8卷 1021-1032页

作者： biagio Mandracchia Zhe Wang Vincenzo Ferraro Massimiliano Maria Villone Ernesto di Maio Pier Luca Maffettone Pietro Ferraro CNR-ISASI Istituto di Scienze Applicate e Sistemi Intelligenti“E.Caianiello”del CNRVia Campi Flegrei 3480078 PozzuoliNapoliItaly College of Applied Sciences Beijing University of Technology100124 BeijingChina dipartimento di Ingegneria Chimica dei Materiali e della Produzione IndustrialeUniversita di Napoli FedericoⅡPiazzale Tecchio 8080125 NapoliItaly

The dynamics and stability of thin liquid films have fascinated scientists over many *** film flows are central to numerous areas of engineering,geophysics,and biophysics and occur over a wide range of lengths,velocities,and liquid property *** spite of many significant developments in this area,we still lack appropriate quantitative experimental tools with the spatial and temporal resolution necessary for a comprehensive study of film *** propose tackling this problem with a holographic technique that combines quantitative phase imaging with a custom setup designed to form and manipulate *** results,gathered on a model aqueous polymeric solution,provide unparalleled insight into bubble dynamics through the combination of a full-field thickness estimation,threedimensional imaging,and a fast acquisition *** unprecedented level of detail offered by the proposed methodology will promote a deeper understanding of the underlying physics of thin film dynamics.

关键词： film dynamics liquid

Physiologic postoperative presepsin kinetics following primary cementless total hip arthroplasty:A prospective observational study

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World Journal of Orthopedics 2023年第7期14卷 547-553页

作者： Davide Bizzoca Andrea Piazzolla Lorenzo Moretti Giovanni Vicenti biagio Moretti Giuseppe Solarino DAI Neuroscienze Organi di Senso e Apparato LocomotoreAOU Consorziale Policlinico di BariBari 70124Italy University of Bari"Aldo Moro" Bari 70124Italy

BACKGROUND Presepsin is an emerging biomarker in the diagnosis of *** the field of orthopaedics,it could be useful in diagnosing and managing periprosthetic joint *** To define the normal postoperative presepsin plasmatic curve,in patients undergoing primary cementless total hip arthroplasty(THA).METHODS Patients undergoing primary cementless THA at our Institute were *** criteria were:Primary osteoarthritis of the hip;urinary catheter time of permanencediseases;chronic kidney diseases;history of recurrent infections or malignant neoplasms;previous surgery in the preceding 12 mo;diabetes mellitus;immunosuppressive drug or corticosteroid *** the patients received the same antibiotic *** the THA were performed by the same surgical and anaesthesia team;total operative time was defined as the time taken from skin incision to completion of skin *** enrollment,anthropometric data,smocking status,osteoarthritis stage according to Kellgren and Lawrence,Harris Hip Score,drugs assumption and comorbidities were *** the patients underwent serial blood tests,including complete blood count,presepsin(PS)and C-reactive protein 24 h before arthroplasty and at 24,48,72 and 96 h postoperatively and at 3,6 and 12-mo *** A total of 96 patients(51 female;45 male;mean age=65.74±5.58)were *** mean PS values were:137.54 pg/mL at baseline,192.08 pg/mL at 24 h post-op;254.85 pg/mL at 48 h post-op;259 pg/mL at 72 h post-op;248.6 pg/mL at 96-h post-op;140.52 pg/mL at 3-mo follow-up;135.55 pg/mL at 6-mo follow-up and 130.11 pg/mL at 12-mo *** two patients(2.08%)a soft-tissue infection was observed;in these patients,higher levels(

关键词： Presepsin Periprosthetic joint infection Total hip arthroplasty Total hip replacement Hip surgery Postoperative care

Anterior vertebral body tethering for idiopathic scoliosis in growing children:A systematic review

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World Journal of Orthopedics 2022年第5期13卷 481-493页

作者： Davide Bizzoca Andrea Piazzolla Lorenzo Moretti Giovanni Vicenti biagio Moretti Giuseppe Solarino UOSD Spinal Deformity Centre AOU Consorziale Policlinico di BariBari 70124Italy Department of Biomedical Sciences and Human Oncology University of Bari“Aldo Moro”Bari 70124Italy Orthopaedic and Trauma Unit AUO Consorziale Policlinico di BariBari 70124Italy Department of Basic Medical Sciences Neuroscience and Sense OrgansOrthopaedic and Trauma UnitUniversity of Bari“Aldo Moro”Bari 70124PugliaItaly

BACKGROUND The management of idiopathic scoliosis(IS)in skeletally immature patients should aim at three-dimensional deformity correction,without compromising spinal and chest *** 2019,the US Food and Drug Administration approved the first instrumentation system for anterior vertebral body tethering(AVBT),under a Humanitarian Device Exception,for skeletally immature patients with curves having a Cobb angle between 35°and 65°.AIM To summarize current evidence about the efficacy and safety of AVBT in the management of IS in skeletally immature *** From January 2014 to January 2021,Ovid Medline,Embase,Cochrane Library,Scopus,Web of Science,Google Scholar and PubMed were searched to identify relevant *** methodological quality of the studies was evaluated and relevant data were *** Seven clinical trials recruiting 163 patients were included in the present *** studies out of seven were classified as high quality,whereas the remaining two studies were classified as moderate quality.A total of 151 of 163 AVBT procedures were performed in the thoracic spine,and the remaining 12 tethering in the lumbar *** 117 of 163(71.8%)patients had a nonprogressive curve at skeletal ***-three of 163(14.11%)patients required unplanned revision surgery within the follow-up *** to posterior spinal fusion(PSF)was performed in 18 of 163(11%)*** AVBT is a promising growth-friendly technique for treatment of IS in growing ***,it has moderate success and perioperative complications,revision and conversion to PSF.

关键词： Idiopathic scoliosis Spinal growth modulation Anterior spinal instrumentation Curve correction Anterior vertebral body tethering Paediatric spine Growing spine Skeletally immature patients Growth-friendly spinal implants

Is osteoporosis risk in anorexia nervosa underestimated? A case report series

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Open Journal of Internal Medicine 2013年第4期3卷 115-118页

作者： Bruno Pacciardi Claudio Cargioli Simone Belli biagio Cotugno Samanta Augusto Luca di Paolo Mauro Mauri Clinical and Experimental Medicine Department (Psychiatry division) University of Pisa Italy

Introduction: Anorexia nervosa (AN) is a mental disorder whose features are deliberate weight loss, disordered body image, and intrusive overvalued fears of gaining weight. Long-term consequences of AN include endocrine dysfunctions leading to secondary amenorrhea, bone loss and/or osteoporosis with an increased risk of bone fracture. Therefore young women with AN may develop a risk for bone fractures comparable to that of postmenopausal women. Methods: In this case report series Bone Mineral Density (BMD) was examined by Dual energy X-ray Absorptiometry (DXA) in 19 hospitalized patients with diagnosis of AN and prolonged amenorrhea. Results: All patients showed a lumbar/femoral bone loss or osteoporosis, with an increased fracture risk comparable to that of postmenopausal women. Conclusions: Our observation suggests that DXA evaluation of anorexic patients with prolonged amenorrhea would be helpful to prevent fracture risk in this population of patients. However, although DXA is almost routinely recommended in women over 65, it is not in young AN patients with prolonged amenorrhea.

关键词： Anorexia Nervosa Amenorrhea Osteoporosis Fracturerisk DXA BMD

Total hip arthroplasty following the failure of intertrochanteric nailing:First implant or salvage surgery?

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World Journal of Orthopedics 2023年第10期14卷 763-770页

作者： Giuseppe Solarino Davide Bizzoca Pasquale Dramisino Giovanni Vicenti Lorenzo Moretti biagio Moretti Andrea Piazzolla University of Bari Aldo Moro Bari 70154Italy Orthopaedic and Trauma Unit Policlinico di Bari Bari 70124Italy UOSD Vertebral Surgery Policlinico di BariBari 70124Italy

BACKGROUND Proximal femur fractures,including both intracapsular(femoral neck fractures)and extracapsular fractures(intertrochanteric femoral fractures,IFFs),affect around 1.5 million people per year *** failures of intertrochanteric nailing in IFFs could be managed with revision total hip arthroplasty(THA).AIM To describe the surgical complexity and the procedure-related complication rates in patients with trochanteric nailing failure and treated with *** Patients referred to our level I trauma center between April 2012 and July 2018 with failed cephalomedullary nailing following trochanteric fractures were retrospectively *** patients underwent a salvage surgical procedure,i.e.,cephalomedullary nail removal and conversion to *** same surgical and anesthesiology team performed the surgical procedures under spinal *** patients underwent clinical and radiographic follow-ups for at least 24 *** and re-operations were *** Seventy-four patients met the inclusion criteria(male:29;female:45;mean age:73.8-years-old;range:65-89)and were included in the current *** average operative time was 117 min(76-192 min).The average blood loss was 585 mL(430-1720 mL).Among the 74 patients,43(58.1%)required transfusion of three or more blood *** patients died within the 4th d after surgery because of pulmonary embolism,and 1 patient died 9 mo after surgery due to ischemic myocardial *** complication rate in the 71 patients who completed the minimum 24-mo follow-up was 22.5%.In 3 cases out of 71(4.2%)periprosthetic acetabular fracture was observed during the *** of these periacetabular fractures occurred *** intraoperative periprosthetic femur fracture was observed in 5 patients out of 71(7.0%).Four of these patients needed a re-operation to fix the fracture with plates and cerclages;in one of these patients,femoral stem revision was also *** 4 patients ou

关键词： Femoral nailing Total hip arthroplasty Proximal femur fractures Osteoporosis Fragility fractures Geriatric patients Hip traumatology Hip replacement

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen biagio di micco Ran ding Siqin dingl Yadong ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise