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DcR3 and survivin are highly expressed in colorectal carcinoma and closely correlated to its clinicopathologic parameters

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Journal of Zhejiang University-Science B(biomedicine & biotechnology) 2009年第9期10卷 675-682页

作者： Qi-lian LIANG bi-rong wang Guo-hong LI Department of Medical Oncology Affiliated Hospital of Guangdong Medical College Zhanjiang 524001 China

Objective: To investigate the expression of death decoy receptor 3 (DcR3) and survivin in colorectal carcinoma. Methods: Tumor and normal tissues were taken from a total of 100 colorectal carcinoma patients during surgery, and the expression of DcR3 and survivin was examined by immunohistochemistry, Western blotting, and reverse transcription-polymerase chain reaction (RT-PCR) analyses. Results: RT-PCR showed that the expression levels of DcR3 mRNA (0.846±0.242, P<0.01) and survivin mRNA (0.7835±0.2392, P<0.01) in colorectal cancer tissues were significantly higher than those in adjacent normal tissues. Western blotting showed that the expression levels of DcR3 protein (0.795±0.261, P<0.01) and survivin protein (0.6765±0.1351, P<0.01) in tumor tissues were significantly higher than those in non-cancer tissues. The immunohistochemical streptavidin-peroxidase (SP) method showed that the positive expression rates of DcR3 and survivin were 67.0% and 58.0% in colorectal cancer tissues, and 18.0% and 3.0% in non-cancerous colorectal tissues (P<0.05), respectively. The positive correlations of DcR3 (P<0.01) and survivin (P<0.01) to the differentiation of colorectal carcinoma cells, lymph node metastasis, and patho-logical stage were observed. The expression of DcR3 and survivin was found to be positively correlated to clinicopathologic parameters of colorectal carcinoma. Conclusion: The overexpressed DcR3 and survivin in colorectal cancer may contribute to the development of the cancer. The monitoring of these two proteins may be useful for the diagnosis, differentiation, metastasis, and determination of stages of colorectal carcinoma.

关键词： Death decoy receptor 3 (DcR3) Survivin Colorectal carcinoma

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Liquid biopsy:Precise diagnosis and therapy for cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 362-365页

作者： Si-Qin wang Chu-Xing Chai bi-rong wang Feng Zhu Dan Shang Min Li Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Breast and Thyroid Surgery Wuhan Fourth HospitalPuai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

The following letter to the editor highlights the review titled“Liquid biopsy in cholangiocarcinoma:Current status and future perspective”in World J Gastrointest Oncol 2021;13:*** is necessary to realize individuali... 详细信息

关键词： Liquid biopsy Cholangiocarcinoma Diagnosis Therapy Precision medicine

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Prognostic value of serum soluble Fas in patients with locally advanced unresectable rectal cancer receiving concurrent chemoradiotherapy

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Journal of Zhejiang University-Science B(biomedicine & biotechnology) 2010年第12期11卷 912-917页

作者： Qi-lian LIANG Zhou-yu LI Guo-qiang CHEN Zhen-nan LAI bi-rong wang Jie HUANG Center of Oncology Affiliated Hospital of Guangdong Medical College Zhanjiang 524001 China Department of Chemotherapy Affiliated Tumor Hospital of Guangzhou Medical College Guangzhou 510095 China

Objective: This study was designed to detect the changes of serum soluble Fas (sFas) levels in patients with locally advanced unresectable rectal cancer (LAURC),and to explore its prognostic value of ***: Soluble samples were obtained from LAURC subjects,treated by concurrent chemoradiotherapy,before treatment and one month after *** donor serum samples were used as *** concentration was measured by enzyme-linked immunosorbent assay (ELISA).Results: The sFas levels before treatment and one month after treatment were both significantly higher in LAURC subjects than in healthy controls [(8.79±1.39) and (7.74±1.32) vs.(5.53±1.13) ng/L,P8.79 ng/L and 7.74 ng/L and <7.74 ng/L one month after treatment (P<0.01),***: The sFas level is higher in LAURC subjects than in healthy *** chemoradiotherapy can reduce sFas levels in LAURC *** monitoring of sFas may provide prognostic information for LAURC patients.

关键词： Soluble Fas (sFas) Rectal cancer Concurrent chemoradiotherapy Prognosis

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Photodynamic therapy:A next alternative treatment strategy for hepatocellular carcinoma?

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1523-1535页

作者： Feng Zhu bi-rong wang Zheng-Feng Zhu Si-Qin wang Chu-Xing Chai Dan Shang Min Li Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Breast and Thyroid Surgery Wuhan Fourth Hospital(Puai Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

Liver cancer is one of the most common cancers in the world. Of all types of livercancer, hepatocellular carcinoma (HCC) is known to be the most frequent primaryliver malignancy and has seriously compromised the health status of the generalpopulation. Locoregional thermal ablation techniques such as radiofrequency andmicrowave ablation, have attracted attention in clinical practice as an alternativestrategy for HCC treatment. However, their aggressive thermal effect may causeundesirable complications such as hepatic decompensation, hemorrhage, bile ductinjury, extrahepatic organ injuries, and skin burn. In recent years, photodynamictherapy (PDT), a gentle locoregional treatment, has attracted attention in ablationtherapy for patients with superficial or luminal tumors as an alternative treatmentstrategy. However, some inherent defects and extrinsic factors of PDT havelimited its use in clinical practice for deep-seated HCC. In this contribution, theaim is to summarize the current status and challenges of PDT in HCC treatmentand provide potential strategies to overcome these deficiencies in further clinicaltranslational practice.

关键词： Hepatocellular carcinoma Photodynamic therapy Photosensitizers Aggregation-induced emission Targeted therapy Nanoparticles

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Advances in regional nodal management of early-stage breast cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 215-225页

作者： Zhao bi Yongsheng wang Breast Cancer Center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250017China

With the continuous improvement of systemic treatment, reasonable local regional control of early-stage breast cancer can be translated into survival benefits. The optimization of regional nodal management in patients with limited sentinel lymph node(SLN) metastasis needs to be weighed by surgical complications, regional recurrence risk, and lymph node status, as well as other escalating treatment(systemic/radiotherapy) that may result from deescalating surgery. With the effective support and supplementation of systemic therapy and radiotherapy, the management of axillary surgery is developing in a de-escalating trend. The widespread application of neoadjuvant therapy has contributed to optimizing the management of patients with clinically node-negative/imaging nodepositive disease. In clinical practice, it is necessary to consider the residual tumor burden of regional lymph nodes when formulating the optimal irradiation fields in patients with limited positive SLN without axillary lymph node dissection. The combined application of genomic tests and American College of Surgeons Oncology Group Z0011/AMAROS criteria could provide patients with a better strategy of dual de-escalation treatment, which includes the de-escalation of both axillary surgery and systemic treatment. In the era of sentinel lymph node biopsy(SLNB), the regional nodal management of breast cancer should adhere to the concept of “updating ideas, making bold assumptions, and carefully seeking proof”, make full use of the benefits of systemic therapy and radiotherapy to reduce the scope of surgery and complications, and expand the “net benefit” of efficacy and quality of life. This review discusses the optimization of regional nodal management in the era of SLNB, in order to provide reference information for clinicians.

关键词： Breast cancer sentinel lymph node biopsy internal mammary lymph node radiotherapy surgery

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The acceptance of traditional Chinese medicine among patients with Parkinson's disease:A hospital survey

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Journal of Integrative Medicine 2024年第2期22卷 180-187页

作者： Peng wang Jing Hong Zhu-qian Tang bi-zhen Gong Xiao-rong Qi Han Jiang Bo Pan Qi Chen Postgraduate School Medical School of Chinese People’s Liberation ArmyBeijing 100853China Senior Department of Traditional Chinese Medicine the Sixth Medical Center of PLA General HospitalBeijing 100853China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Integrative Oncology the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Dermatology the First Clinical Medical CollegeAnhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

Objective:The efficacy of medications for Parkinson’s disease(PD)tend to decline over time,which has a serious impact on patients’health and quality of *** some extent,traditional Chinese medicine(TCM)can resolve the distressing problem of ineffective dopaminergic medication in PD *** purpose of this study was to investigate the attitude,acceptance,and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary ***:A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023.A self-report questionnaire was developed to investigate PD patients’attitudes and acceptance of TCM based on the *** logistic regression analyses were also performed to further clarify the independent predictors influencing patients’adoption of TCM ***:A total of 397 patients completed the questionnaire,of which 78.09%were willing to be treated with TCM and 21.91%indicated that they were not willing to use *** logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic *** included education level of a bachelor’s degree(odds ratio[OR)=8.554;95%confidence interval[CI]:4.112–17.794;P<0.001,vs junior high school education),living in an urban setting(OR=8.022;95%CI:4.577–14.060;P<0.001,vs rural),having other underlying diseases(OR=5.126;95%CI:3.078–8.537;P<0.001,vs none),having previously used TCM(OR=3.083;95%CI:1.852–5.134;P<0.001,vs not used),believing that TCM therapy is safe(OR=3.530;95%CI:1.446–8.616;P=0.006,vs not thought),believing that TCM therapy is effective(OR=3.859;95%CI:1.482–10.047;P=0.006,vs not understood),and being willing to discuss ongoing TCM therapy with an attending physician(OR=62.468;95%CI:30.350–128.574;P<0.001,vs not informed).Conclusion:This study initially investigated the acceptance

关键词： Parkinson's disease Traditional Chinese medicine Cross-sectional study

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An optimized time-adaptive aerothermal coupling calculation method for aerothermal analysis of disc cavity system

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Chinese Journal of Aeronautics 2024年第9期37卷 164-177页

作者： Shuai bi Junkui MAO Lei wang Feng HAN College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 20016China AECC Aeroengine Control System Institute Wuxi 214063China Integrated Energy Institute Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In order to further achieve the balance between the calculation accuracy and efficiency of the transient analysis of the aero-engine disc cavity system,an Optimized Time-adaptive Aerother-mal Coupling calculation(OTAC)method has been *** combines one-dimensional tran-sient calculation of air system,Conventional Sequence Staggered(CSS)method,Time-adaptive Aerothermal Coupling calculation(TAC)method and differential evolution optimization algorithm to obtain an efficient and high-precision aerothermal coupling calculation method of air *** both the heat conduction in the solid domain and the flow in the fluid domain as unsteady states in the OTAC,the interaction of fluid-solid information within a single coupling time step size was implemented based on the CSS ***,the coupling time step size was automatically adjusted with the number of iterations by using the Proportional-Integral-Deri vative(PID)*** show that when compared with the traditional loosely coupling method with a fixed time step size,the computational accuracy and efficiency of the OTAC method are improved by 8.9%and 30%,*** with the tight coupling calculation,the OTAC method can achieve a speedup of 1 to 2 orders of magnitude,while the calculation error is maintained within 6.1%.

关键词： Air system 1D-3D coupling Conjugate heat transfer Transient calculation Adaptive time step size

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Nondestructive Nonlinear Optical Microscopy Revealed the Blackening Mechanism of Ancient Chinese Jades

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Research 2024年第3期2023卷 391-399页

作者： Yaxin Chen rong wang Minbiao Ji State Key Laboratory of Surface Physics and Department of Physics Human Phenome InstituteAcademy for Engineering and TechnologyKey Laboratory of Micro and Nano Photonic Structures(Ministry of Education)Yiwu Research Institute of Fudan UniversityFudan UniversityShanghai 200433China Department of Cultural Heritage and Museology Fudan UniversityShanghaiChina

Jade is most valued in Chinese culture since ancient times. For unearthed jade artifacts, the alteration color resulting from weathering effects and human activities provides information for cultural heritage conservation, archaeology, and history. Currently, the noninvasive 3-dimensional characterization of jade artifacts with high chemical and spatial resolution remains challenging. In this work, we applied femtosecond pump–probe microscopy and second harmonic generation microscopy techniques to study the black alteration of an ancient jade artifact of the late Spring and Autumn period (546 to 476 BC). The direct cause of the “mercury alteration” phenomena was discovered to be the conversion of metacinnabar from buried cinnabar in the tomb. Furthermore, a 3-dimensional optical reconstruction of the black alteration was achieved, providing a high-resolution method for analyzing the blackening mechanism without the need of sample damage. Our approach opens up new opportunities to extract microscopic spatiochemical information for a broad range of alteration colors in jade artifacts.

关键词： pump Nonlinear buried

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On the Optimal Initial Inner-Core Size for Tropical Cyclone Intensification: An Idealized Numerical Study

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Advances in Atmospheric Sciences 2024年第11期41卷 2141-2155页

作者： rong FEI Yuqing wang School of Atmospheric Sciences and Remote Sensing Wuxi UniversityWuxi 214105China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China International Pacific Research Center Department of Atmospheric SciencesSchool of Ocean and Earth Science and TechnologyUniversity of Hawaii at ManoaHonoluluHawaii 96822USA

Recent observational and numerical studies have revealed the dependence of the intensification rate on the inner-core size of tropical cyclones(TCs). In this study, with the initial inner-core size(i.e., the radius of maximum wind—RMW)varied from 20–180 km in idealized simulations using two different numerical models, we found a nonmonotonic dependence of the lifetime maximum intensification rate(LMIR) on the inner-core size. Namely, there is an optimal innercore size for the LMIR of a TC. Tangential wind budget analysis shows that, compared to large TCs, small TCs have large inward flux of absolute vorticity due to large absolute vorticity inside the RMW. However, small TCs also suffer from strong lateral diffusion across the eyewall, which partly offsets the positive contribution from large inward flux of absolute vorticity. These two competing processes ultimately lead to the TC with an intermediate initial inner-core size having the largest LMIR. Results from sensitivity experiments show that the optimal size varies in the range of 40–120 km and increases with higher sea surface temperature, lower latitude, larger horizontal mixing length, and weaker initial TC intensity. The 40–120 km RMW corresponds to the inner-core size most commonly found for intensifying TCs in observations, suggesting the natural selection of initial TC size for intensification. This study highlights the importance of accurate representation of TC inner-core size to TC intensity forecasts by numerical weather prediction models.

关键词： tropical cyclones intensification inner-core size idealized simulations

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Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

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China Ocean Engineering 2024年第2期38卷 271-284页

作者： ZHOU Li wang Guo-rong WAN Min School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China Energy Equipment Institute Southwest Petroleum UniversityChengdu 610500China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental *** control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control ***,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each *** direction interference observers are designed to track the timevarying boundary *** this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead *** addition,the stability of the closed-loop system is proven by Lyapunov stability *** the system states are bounded,and the vibration offset of the riser converges to a small area of the initial ***,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

关键词： adaptive backstepping control disturbance observer flexible marine riser input dead zone vibration control

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