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MicroRNA Profiling of Transgenic Mice with Myocardial Overexpression of Nucleolin

Chinese Medical Journal 2018年第3期131卷 339-346页

作者： Qing-Lan Lyu bi-mei jiang bin Zhou Li Sun Zhong-Yi Tong Yuan-bin Li Yu-Ting Tang Hui Sun mei-Dong Liu Xian-Zhong Xiao Department of Pathophysiology Xiangya School of Basic Medical Sciences Central South University Changsha Hunan 410078 China Department of Rheumatology Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Pathology The Second Xiangya Hospital Central South University Changsha Hunan 410000 China

Background：Nucleolin （NCL） is the most abundant RNA-binding protein in the cell nucleolus and plays an important role in chromatin stability,ribosome assembly,ribosomal RNA maturation,ribosomal DNA transcription,nucleocytoplasmic transport,and regulation of RNA stability and translation *** addition to its anti-apoptotic properties,the underlying mechanisms associated with NCL-related roles in different cellular processes remain *** this study,the effect of NCL on microRNA （miRNA） expression was evaluated by generating transgenic mice with myocardial overexpression of NCL and by analyzing microarrays of mature and precursor miRNAs from ***：Using microinjection ofalpha-MyHc clone 26-NCL plasmids,we generated transgenic mice with myocardial overexpression of NCL firstly,and then mature and precursor miRNAs expression profiles were analyzed in NCL transgenic mice （n =3） and wild-type （WT） mice （n =3） by miRNA *** Package for the Social Sciences version 16.0 software （SPSS,Inc.,Chicago,IL,USA） was used to perform Student＇s t-test,and statistical significance was determined at P 〈 ***：Several miRNAs were found to be differentially expressed,of which 11 were upregulated and 4 were downregulated in transgenic mice with myocardial overexpression of NCL compared to those in WT *** differentially expressed miRNAs were subsequently confirmed and quantified by real-time quantitative reverse transcription-polymerase chain *** analysis was used for the prediction of miRNA ***,in vitro experiments showed that NCL regulated miR-21 expression following hydrogen peroxide ***：Myocardial-protection mechanisms exerted by NCL might be mediated by the miRNAs identified in this study.

关键词： MicroRNA microarray Myocardium Nucleolin Transgenic mice

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Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin Jun Xu Delong jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Contrastive Learning

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Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： mei Zhang Wenhao Li Yangfei Chen Yang jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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Ideal bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia Yu Wang Chun Cheng Yang Qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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生成式人工智能对高校学术研究的影响与应对

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黑龙江高教研究 2025年第1期43卷 9-14页

作者：姜岩宋瑞梅曲阜师范大学山东曲阜273165 山东工商学院山东烟台264005 滨州医学院山东烟台264003

以ChatGPT为代表的生成式人工智能正催生出一种全新的知识生产模式,并颠覆了人类通过学术研究进行知识生产这唯一方式的系统性和平衡性。生成式人工智能凭借其强大的文本生成功能、知识发现功能和审查评议功能不断挤占人类学术研究的主... 详细信息

以ChatGPT为代表的生成式人工智能正催生出一种全新的知识生产模式,并颠覆了人类通过学术研究进行知识生产这唯一方式的系统性和平衡性。生成式人工智能凭借其强大的文本生成功能、知识发现功能和审查评议功能不断挤占人类学术研究的主体角色空间,并以特有的知识生成创新特征对原有学科体系下的知识形态、规训制度和组织建制等三个方面产生显著影响,传统学术研究的原有规范已不再完全适用当前的知识创造环境。基于机器对人类学术研究影响的多角度深入分析,提出通过完善学术研究规范体系、提升学术失范审查技术、构建人机共研学术生态、加快人工智能素养培育等四个步骤,顺应智能技术的快速发展趋势,合理且有效发挥生成式人工智能对人类学术研究正面赋能作用的建议。

关键词： ChatCPT 学术研究知识生产学科模式

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui jiang Hui-Li Kang Yi jiang Hua-Wei Zhang Xiao-mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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A sustained-release microcarrier effectively prolongs and enhances the antibacterial activity of lysozyme

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Journal of Environmental Sciences 2023年第7期129卷 128-138页

作者： mei Du Jingzhang Liu Fengbang Wang Lei bi Chunyan Ma Maoyong Song Guibin jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of ScienceBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Bacterial infections have become a great threat to public health in recent years.A primary lysozyme is a natural antimicrobial protein;however,its widespread application is limited by its ***,we present a poly(N-isopropylacrylamide)hydrogel inverse opal particle(PHIOP)as a microcarrier of lysozyme to prolong and enhance the efficiency against *** PHIOP-based lysozyme(PHIOP-Lys)formulation is temperature-responsive and exhibits long-term sustained release of lysozyme for up to 16 *** shows a potent antibacterial effect toward both Escherichia coli and Staphylococcus aureus,which is even higher than that of free lysozyme in solution at the same ***-Lys were demonstrated to effectively inhibit bacterial infections and enhance wound healing in a full-thickness skin wound rat *** study provides a novel pathway for prolonging the enzymatic activity and antibacterial effects of lysozyme.

关键词： Bacterial infection Lysozyme Temperature-responsive Inverse opal particle Wound healing

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美国在线高等教育动态及启示:基于《美国在线教育发展全景报告》(第8版)的分析

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黑龙江高教研究 2025年第1期43卷 80-90页

作者：王继翔姜珠璧刘薇四川农业大学四川成都610000

由美国著名在线教育质量保证机构Quality Matters(QM)和高等教育研究咨询公司Eduventures Research联合发布的《美国在线教育发展全景报告》,从美国高等教育管理视角全景式地调查了不同层次高等教育机构在线教育的现状、影响和发展趋势... 详细信息

由美国著名在线教育质量保证机构Quality Matters(QM)和高等教育研究咨询公司Eduventures Research联合发布的《美国在线教育发展全景报告》,从美国高等教育管理视角全景式地调查了不同层次高等教育机构在线教育的现状、影响和发展趋势。报告数据源于各样本高校首席信息官,其视角可以为人们了解美国在线教育的发展与趋势提供直观的认识。以2023年推出的《美国在线教育发展全景报告》(第8版)(CHLOE8)为基础,分析并梳理了美国近年来在线教育的发展动态及走向,有助于对世界在线高等教育的主要趋势和关键挑战作出预判,为中国在线高等教育的创新变革提供参考和启示。

关键词：美国在线教育发展动态趋势 CHLOE

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Ischaemic preconditioning-regulated nucleolin protects heart from ischaemia/reperfusion injury by targeting Hsp70

Ischaemic preconditioning-regulated nucleolin protects heart...

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第八届海峡两岸心血管科学研讨会

作者： bi-mei jiang~1,Peng-fei Liang~2,bin Zhang~1,Guang-wen Chen~1,bin Zhou~1, Qing-liu Lv~2,Zi-zhi Tu~1,Gong-hua Deng~1,mei-dong Liu~1,Xian-zhong Xiao~* (1.Department of Pathophysiology,Xiangya School of Medicine,Central South University,Changsha 410008 China 2.Department of Burns and Plastic Surgery. Xiangya Hospital,Central South University,Changsha,410008 China)

＜正＞Rationale Nucleolin plays important roles in various cellular *** previous study has shown that oxidative stress induces the cleavage and downregulation of nucleolin,which is essential for the induction of downstream effector Hsp70 to protect cardiomyocytes from oxidative stress - induced apoptosis. However,the possible roles of nucleolin in ischaemic preconditioning（IP） remain *** To investigate the expression and role of nucleolin in IP - mediated cardiac *** and Results The expression of nucleolin in vivo in IP - treated hearts was detected by western blot and real - time quantitative *** results demonstrated that nucleolin was significantly induced in IP - treated hearts,which was further confirmed in cellular models of *** transfection and RNA interference approaches were also employed in cultured adult rat cardiomyocytes to investigate the roles of *** overexpression of nucleolin was cytoprotective,whereas nucleolin knockdown abrogated the hypoxia and hydrogen peroxide preconditioning mediated cardiomyocyte ***,transgenic mice with cardiac - specific overexpression of nucleolin showed reduced apoptosis and size of infarction in I/R treated hearts in vivo ompared to those in wild - type *** known cardioprotective protein,Hsp70,was identified as an important candidate target for nucleolin,which was validated experimentally by luciferase reporter activity assay and examining the Hsp70 expression after overexpression or knockdown of nucleolin in *** This study has demonstrated that nucleolin is involved in the regulation of IP - mediated cardiac protection via regulation of Hsp70 and may form a novel therapeutic target for ischemic heart diseases.

关键词： ischemia preconditioning nucleolin ischemia/reperfusion Hsp70

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IS: Interest Set to Enhance Flow Transmission in Named-Data Networking

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China Communications 2016年第S1期13卷 65-71页

作者： jiang Xiaoke bi Jun Institute for Network Sciences and Cyberspace Tsinghua University Department of Computer Science and Technology Tsinghua University Tsinghua National Laboratory for Information Science and Technology

Named-data Networking(NDN) is a promising future Internet architecture, which introduces some evolutionary elements into layer-3, e.g., consumer-driven communication, soft state on data forwarding plane and hop-byhop traffic control. And those elements ensure data holders to solely return the requested data within the lifetime of the request, instead of pushing data whenever needed and whatever it is. Despite the dispute on the advantages and their prices, this pattern requires data consumers to keep sending requests at the right moments for continuous data transmission, resulting in significant forwarding cost and sophisticated application design. In this paper, we propose Interest Set(IS) mechanism, which compresses a set of similar Interests into one request, and maintains a relative long-term data returning path with soft state and continuous feedback from upstream. In this way, IS relaxes the above requirement, and scales NDN data forwarding by reducing forwarded requests and soft states that are needed to retrieve a given set of data.

关键词： index terms—named-data networking flow transmission

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